A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
Identifieur interne : 002126 ( Istex/Corpus ); précédent : 002125; suivant : 002127A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
Auteurs : M.-C. Carrillo ; S. Kanai ; K. Kitani ; G. O. IvySource :
- Life Sciences [ 0024-3205 ] ; 2000.
Abstract
The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.
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DOI: 10.1016/S0024-3205(00)00838-9
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><author><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name><affiliation><mods:affiliation>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</mods:affiliation></affiliation><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kanai, S" sort="Kanai, S" uniqKey="Kanai S" first="S." last="Kanai">S. Kanai</name><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kitani, K" sort="Kitani, K" uniqKey="Kitani K" first="K." last="Kitani">K. Kitani</name><affiliation><mods:affiliation>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: 81562450183; fax: 81562450184</mods:affiliation></affiliation></author><author><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A0BF68DE380D904402B1EAD0EA8B98548DF4A267</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0024-3205(00)00838-9</idno><idno type="url">https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002126</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><author><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name><affiliation><mods:affiliation>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</mods:affiliation></affiliation><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kanai, S" sort="Kanai, S" uniqKey="Kanai S" first="S." last="Kanai">S. Kanai</name><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kitani, K" sort="Kitani, K" uniqKey="Kitani K" first="K." last="Kitani">K. Kitani</name><affiliation><mods:affiliation>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: 81562450183; fax: 81562450184</mods:affiliation></affiliation></author><author><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name><affiliation><mods:affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="2539">2539</biblScope><biblScope unit="page" to="2548">2548</biblScope></imprint><idno type="ISSN">0024-3205</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M.-C. Carrillo</name><affiliations><json:string>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</json:string><json:string>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>S. Kanai</name><affiliations><json:string>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>K. Kitani</name><affiliations><json:string>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</json:string><json:string>Corresponding author. Tel.: 81562450183; fax: 81562450184</json:string></affiliations></json:item><json:item><name>G.O. Ivy</name><affiliations><json:string>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</json:string><json:string>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>(−)Deprenyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antioxidant enzymes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Survival</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>F-344 rats</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dopaminergic tissues</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</abstract><qualityIndicators><score>6.313</score><pdfWordCount>3865</pdfWordCount><pdfCharCount>21649</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>486 x 720 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>204</abstractWordCount><abstractCharCount>1244</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><pii><json:string>S0024-3205(00)00838-9</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Life Sciences</title><language><json:string>unknown</json:string></language><publicationDate>2000</publicationDate><issn><json:string>0024-3205</json:string></issn><pii><json:string>S0024-3205(00)X0290-1</json:string></pii><volume>67</volume><issue>21</issue><pages><first>2539</first><last>2548</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>medicine, research & experimental</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>pharmacology & pharmacy</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1016/S0024-3205(00)00838-9</json:string></doi><id>A0BF68DE380D904402B1EAD0EA8B98548DF4A267</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©2000 Elsevier Science Inc.</p></availability><date>2000</date></publicationStmt><notesStmt><note type="content">Section title: Original articles</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><author xml:id="author-0000"><persName><forename type="first">M.-C.</forename><surname>Carrillo</surname></persName><affiliation>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</affiliation><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S.</forename><surname>Kanai</surname></persName><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation></author><author xml:id="author-0002"><persName><forename type="first">K.</forename><surname>Kitani</surname></persName><affiliation>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</affiliation><affiliation>Corresponding author. Tel.: 81562450183; fax: 81562450184</affiliation></author><author xml:id="author-0003"><persName><forename type="first">G.O.</forename><surname>Ivy</surname></persName><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation><affiliation>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</affiliation></author><idno type="istex">A0BF68DE380D904402B1EAD0EA8B98548DF4A267</idno><idno type="DOI">10.1016/S0024-3205(00)00838-9</idno><idno type="PII">S0024-3205(00)00838-9</idno></analytic><monogr><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="pISSN">0024-3205</idno><idno type="PII">S0024-3205(00)X0290-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">67</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="2539">2539</biblScope><biblScope unit="page" to="2548">2548</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>(−)Deprenyl</term></item><item><term>Antioxidant enzymes</term></item><item><term>Survival</term></item><item><term>F-344 rats</term></item><item><term>Dopaminergic tissues</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier converted-article found"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LFS</jid><aid>7838</aid><ce:pii>S0024-3205(00)00838-9</ce:pii><ce:doi>10.1016/S0024-3205(00)00838-9</ce:doi><ce:copyright type="full-transfer" year="2000">Elsevier Science Inc.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Original articles</ce:textfn></ce:dochead><ce:title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</ce:title><ce:author-group><ce:author><ce:given-name>M.-C.</ce:given-name><ce:surname>Carrillo</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Kanai</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.</ce:given-name><ce:surname>Kitani</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>G.O.</ce:given-name><ce:surname>Ivy</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: 81562450183; fax: 81562450184</ce:text></ce:correspondence></ce:author-group><ce:date-received day="3" month="12" year="1999"></ce:date-received><ce:date-accepted day="14" month="1" year="2000"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>(−)Deprenyl</ce:text></ce:keyword><ce:keyword><ce:text>Antioxidant enzymes</ce:text></ce:keyword><ce:keyword><ce:text>Survival</ce:text></ce:keyword><ce:keyword><ce:text>F-344 rats</ce:text></ce:keyword><ce:keyword><ce:text>Dopaminergic tissues</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title></titleInfo><name type="personal"><namePart type="given">M.-C.</namePart><namePart type="family">Carrillo</namePart><affiliation>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario, Republica Argentina</affiliation><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kanai</namePart><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kitani</namePart><affiliation>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522, Japan</affiliation><affiliation>Corresponding author. Tel.: 81562450183; fax: 81562450184</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.O.</namePart><namePart type="family">Ivy</namePart><affiliation>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo, Japan</affiliation><affiliation>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</abstract><note type="content">Section title: Original articles</note><subject><genre>Keywords</genre><topic>(−)Deprenyl</topic><topic>Antioxidant enzymes</topic><topic>Survival</topic><topic>F-344 rats</topic><topic>Dopaminergic tissues</topic></subject><relatedItem type="host"><titleInfo><title>Life Sciences</title></titleInfo><titleInfo type="abbreviated"><title>LFS</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20001013</dateIssued></originInfo><identifier type="ISSN">0024-3205</identifier><identifier type="PII">S0024-3205(00)X0290-1</identifier><part><date>20001013</date><detail type="volume"><number>67</number><caption>vol.</caption></detail><detail type="issue"><number>21</number><caption>no.</caption></detail><extent unit="issue pages"><start>2539</start><end>2662</end></extent><extent unit="pages"><start>2539</start><end>2548</end></extent></part></relatedItem><identifier type="istex">A0BF68DE380D904402B1EAD0EA8B98548DF4A267</identifier><identifier type="DOI">10.1016/S0024-3205(00)00838-9</identifier><identifier type="PII">S0024-3205(00)00838-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©2000 Elsevier Science Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Inc., ©2000</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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