Influence of substance P on the behavioral changes induced by haloperidol in rats
Identifieur interne : 001B38 ( Istex/Corpus ); précédent : 001B37; suivant : 001B39Influence of substance P on the behavioral changes induced by haloperidol in rats
Auteurs : Francois B. Jolicoeur ; Daniel B. Rondeau ; Ferdinand Belanger ; George Fouriezos ; André BarbeauSource :
- Peptides [ 0196-9781 ] ; 1980.
Abstract
Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.
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DOI: 10.1016/0196-9781(80)90042-X
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Rondeau</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Belanger, Ferdinand" sort="Belanger, Ferdinand" uniqKey="Belanger F" first="Ferdinand" last="Belanger">Ferdinand Belanger</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Fouriezos, George" sort="Fouriezos, George" uniqKey="Fouriezos G" first="George" last="Fouriezos">George Fouriezos</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Barbeau, Andre" sort="Barbeau, Andre" uniqKey="Barbeau A" first="André" last="Barbeau">André Barbeau</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8329DDE00860AE8428688ABEF4A21467FA942225</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1016/0196-9781(80)90042-X</idno><idno type="url">https://api-v5.istex.fr/document/8329DDE00860AE8428688ABEF4A21467FA942225/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B38</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Influence of substance P on the behavioral changes induced by haloperidol in rats</title><author><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="Francois B." last="Jolicoeur">Francois B. Jolicoeur</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Rondeau, Daniel B" sort="Rondeau, Daniel B" uniqKey="Rondeau D" first="Daniel B." last="Rondeau">Daniel B. Rondeau</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Belanger, Ferdinand" sort="Belanger, Ferdinand" uniqKey="Belanger F" first="Ferdinand" last="Belanger">Ferdinand Belanger</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Fouriezos, George" sort="Fouriezos, George" uniqKey="Fouriezos G" first="George" last="Fouriezos">George Fouriezos</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author><author><name sortKey="Barbeau, Andre" sort="Barbeau, Andre" uniqKey="Barbeau A" first="André" last="Barbeau">André Barbeau</name><affiliation><mods:affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Peptides</title><title level="j" type="abbrev">PEP</title><idno type="ISSN">0196-9781</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page" to="107">107</biblScope></imprint><idno type="ISSN">0196-9781</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0196-9781</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Francois B. Jolicoeur</name><affiliations><json:string>Department of Neurobiology, Clinical Research Institute of Montreal Canada</json:string></affiliations></json:item><json:item><name>Daniel B. Rondeau</name><affiliations><json:string>Department of Neurobiology, Clinical Research Institute of Montreal Canada</json:string></affiliations></json:item><json:item><name>Ferdinand Belanger</name><affiliations><json:string>Department of Neurobiology, Clinical Research Institute of Montreal Canada</json:string></affiliations></json:item><json:item><name>George Fouriezos</name><affiliations><json:string>Department of Neurobiology, Clinical Research Institute of Montreal Canada</json:string></affiliations></json:item><json:item><name>André Barbeau</name><affiliations><json:string>Department of Neurobiology, Clinical Research Institute of Montreal Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Substance P</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuropeptides</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Locomotor activity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Catelepsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Muscular rigidity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α-Methyl-para-tyrosine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>FLA-63</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Phenoxybenzamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Haloperidol</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. 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induced by haloperidol in rats</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1980</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Influence of substance P on the behavioral changes induced by haloperidol in rats</title><author xml:id="author-0000"><persName><forename type="first">Francois B.</forename><surname>Jolicoeur</surname></persName><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Daniel B.</forename><surname>Rondeau</surname></persName><note type="biography">Present address: Department of Psychology, University of Moncton, New Brunswick.</note><affiliation>Present address: Department of Psychology, University of Moncton, New Brunswick.</affiliation><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Ferdinand</forename><surname>Belanger</surname></persName><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation></author><author xml:id="author-0003"><persName><forename type="first">George</forename><surname>Fouriezos</surname></persName><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation></author><author xml:id="author-0004"><persName><forename type="first">André</forename><surname>Barbeau</surname></persName><note type="biography">Send reprint requests to Dr. André Barbeau, Department of Neurobiology, Clinical Research Institute, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7.</note><affiliation>Send reprint requests to Dr. André Barbeau, Department of Neurobiology, Clinical Research Institute, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7.</affiliation><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation></author><idno type="istex">8329DDE00860AE8428688ABEF4A21467FA942225</idno><idno type="DOI">10.1016/0196-9781(80)90042-X</idno><idno type="PII">0196-9781(80)90042-X</idno></analytic><monogr><title level="j">Peptides</title><title level="j" type="abbrev">PEP</title><idno type="pISSN">0196-9781</idno><idno type="PII">S0196-9781(00)X0084-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980"></date><biblScope unit="volume">1</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page" to="107">107</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1980</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Substance P</term></item><item><term>Neuropeptides</term></item><item><term>Locomotor activity</term></item><item><term>Catelepsy</term></item><item><term>Muscular rigidity</term></item><item><term>α-Methyl-para-tyrosine</term></item><item><term>FLA-63</term></item><item><term>Phenoxybenzamine</term></item><item><term>Haloperidol</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1980">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/8329DDE00860AE8428688ABEF4A21467FA942225/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PEP</jid><aid>8090042X</aid><ce:pii>0196-9781(80)90042-X</ce:pii><ce:doi>10.1016/0196-9781(80)90042-X</ce:doi><ce:copyright type="unknown" year="1980"></ce:copyright></item-info><head><ce:title>Influence of substance P on the behavioral changes induced by haloperidol in rats</ce:title><ce:author-group><ce:author><ce:given-name>Francois B.</ce:given-name><ce:surname>Jolicoeur</ce:surname></ce:author><ce:author><ce:given-name>Daniel B.</ce:given-name><ce:surname>Rondeau</ce:surname><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ferdinand</ce:given-name><ce:surname>Belanger</ce:surname></ce:author><ce:author><ce:given-name>George</ce:given-name><ce:surname>Fouriezos</ce:surname></ce:author><ce:author><ce:given-name>André</ce:given-name><ce:surname>Barbeau</ce:surname><ce:cross-ref refid="COR1"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Neurobiology, Clinical Research Institute of Montreal Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>2</ce:label><ce:text>Send reprint requests to Dr. André Barbeau, Department of Neurobiology, Clinical Research Institute, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Present address: Department of Psychology, University of Moncton, New Brunswick.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="27" month="2" year="1980"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Substance P</ce:text></ce:keyword><ce:keyword><ce:text>Neuropeptides</ce:text></ce:keyword><ce:keyword><ce:text>Locomotor activity</ce:text></ce:keyword><ce:keyword><ce:text>Catelepsy</ce:text></ce:keyword><ce:keyword><ce:text>Muscular rigidity</ce:text></ce:keyword><ce:keyword><ce:text>α-Methyl-para-tyrosine</ce:text></ce:keyword><ce:keyword><ce:text>FLA-63</ce:text></ce:keyword><ce:keyword><ce:text>Phenoxybenzamine</ce:text></ce:keyword><ce:keyword><ce:text>Haloperidol</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Influence of substance P on the behavioral changes induced by haloperidol in rats</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Influence of substance P on the behavioral changes induced by haloperidol in rats</title></titleInfo><name type="personal"><namePart type="given">Francois B.</namePart><namePart type="family">Jolicoeur</namePart><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel B.</namePart><namePart type="family">Rondeau</namePart><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation><description>Present address: Department of Psychology, University of Moncton, New Brunswick.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ferdinand</namePart><namePart type="family">Belanger</namePart><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George</namePart><namePart type="family">Fouriezos</namePart><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">André</namePart><namePart type="family">Barbeau</namePart><affiliation>Department of Neurobiology, Clinical Research Institute of Montreal Canada</affiliation><description>Send reprint requests to Dr. André Barbeau, Department of Neurobiology, Clinical Research Institute, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1980</dateIssued><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.</abstract><subject><genre>Keywords</genre><topic>Substance P</topic><topic>Neuropeptides</topic><topic>Locomotor activity</topic><topic>Catelepsy</topic><topic>Muscular rigidity</topic><topic>α-Methyl-para-tyrosine</topic><topic>FLA-63</topic><topic>Phenoxybenzamine</topic><topic>Haloperidol</topic></subject><relatedItem type="host"><titleInfo><title>Peptides</title></titleInfo><titleInfo type="abbreviated"><title>PEP</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198021</dateIssued></originInfo><identifier type="ISSN">0196-9781</identifier><identifier type="PII">S0196-9781(00)X0084-8</identifier><part><date>198021</date><detail type="volume"><number>1</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>122</end></extent><extent unit="pages"><start>103</start><end>107</end></extent></part></relatedItem><identifier type="istex">8329DDE00860AE8428688ABEF4A21467FA942225</identifier><identifier type="DOI">10.1016/0196-9781(80)90042-X</identifier><identifier type="PII">0196-9781(80)90042-X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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