Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide
Identifieur interne : 001765 ( Istex/Corpus ); précédent : 001764; suivant : 001766Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide
Auteurs : Georges Pelletier ; Fernand Labrie ; Abba J. Kastin ; David Coy ; Andrew V. SchallySource :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1975.
Abstract
Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.
Url:
DOI: 10.1016/0091-3057(75)90191-4
Links to Exploration step
ISTEX:7AF76CD45234E77B290017F1AEA9449E6A603D5CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title><author><name sortKey="Pelletier, Georges" sort="Pelletier, Georges" uniqKey="Pelletier G" first="Georges" last="Pelletier">Georges Pelletier</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Labrie, Fernand" sort="Labrie, Fernand" uniqKey="Labrie F" first="Fernand" last="Labrie">Fernand Labrie</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Kastin, Abba J" sort="Kastin, Abba J" uniqKey="Kastin A" first="Abba J." last="Kastin">Abba J. Kastin</name><affiliation><mods:affiliation>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</mods:affiliation></affiliation><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Coy, David" sort="Coy, David" uniqKey="Coy D" first="David" last="Coy">David Coy</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Schally, Andrew V" sort="Schally, Andrew V" uniqKey="Schally A" first="Andrew V." last="Schally">Andrew V. Schally</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7AF76CD45234E77B290017F1AEA9449E6A603D5C</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1016/0091-3057(75)90191-4</idno><idno type="url">https://api-v5.istex.fr/document/7AF76CD45234E77B290017F1AEA9449E6A603D5C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001765</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001765</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title><author><name sortKey="Pelletier, Georges" sort="Pelletier, Georges" uniqKey="Pelletier G" first="Georges" last="Pelletier">Georges Pelletier</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Labrie, Fernand" sort="Labrie, Fernand" uniqKey="Labrie F" first="Fernand" last="Labrie">Fernand Labrie</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Kastin, Abba J" sort="Kastin, Abba J" uniqKey="Kastin A" first="Abba J." last="Kastin">Abba J. Kastin</name><affiliation><mods:affiliation>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</mods:affiliation></affiliation><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Coy, David" sort="Coy, David" uniqKey="Coy D" first="David" last="Coy">David Coy</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author><author><name sortKey="Schally, Andrew V" sort="Schally, Andrew V" uniqKey="Schally A" first="Andrew V." last="Schally">Andrew V. Schally</name><affiliation><mods:affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="675">675</biblScope><biblScope unit="page" to="679">679</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Georges Pelletier</name><affiliations><json:string>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</json:string><json:string>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</json:string></affiliations></json:item><json:item><name>Fernand Labrie</name><affiliations><json:string>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</json:string><json:string>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</json:string></affiliations></json:item><json:item><name>Abba J. Kastin</name><affiliations><json:string>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</json:string><json:string>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</json:string><json:string>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</json:string></affiliations></json:item><json:item><name>David Coy</name><affiliations><json:string>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</json:string><json:string>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</json:string></affiliations></json:item><json:item><name>Andrew V. Schally</name><affiliations><json:string>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</json:string><json:string>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>MIF</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radioautography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hormone</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Brain</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Peptide</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.</abstract><qualityIndicators><score>4.784</score><pdfWordCount>2808</pdfWordCount><pdfCharCount>9110</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>605 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>123</abstractWordCount><abstractCharCount>939</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title><pii><json:string>0091-3057(75)90191-4</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc. Soc. exp. Biol. Med.</title><language><json:string>unknown</json:string></language><volume>140</volume><pages><first>811</first><last>814</last></pages></serie><host><title>Pharmacology, Biochemistry and Behavior</title><language><json:string>unknown</json:string></language><publicationDate>1975</publicationDate><issn><json:string>0091-3057</json:string></issn><pii><json:string>S0091-3057(00)X0295-X</json:string></pii><volume>3</volume><issue>4</issue><pages><first>675</first><last>679</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>neurosciences</json:string><json:string>behavioral sciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>pharmacologie. traitements medicamenteux</json:string></inist></categories><publicationDate>1975</publicationDate><copyrightDate>1975</copyrightDate><doi><json:string>10.1016/0091-3057(75)90191-4</json:string></doi><id>7AF76CD45234E77B290017F1AEA9449E6A603D5C</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/7AF76CD45234E77B290017F1AEA9449E6A603D5C/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/7AF76CD45234E77B290017F1AEA9449E6A603D5C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/7AF76CD45234E77B290017F1AEA9449E6A603D5C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1975</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title><author xml:id="author-0000"><persName><forename type="first">Georges</forename><surname>Pelletier</surname></persName><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Fernand</forename><surname>Labrie</surname></persName><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Abba J.</forename><surname>Kastin</surname></persName><affiliation>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</affiliation><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">David</forename><surname>Coy</surname></persName><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Andrew V.</forename><surname>Schally</surname></persName><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation></author><idno type="istex">7AF76CD45234E77B290017F1AEA9449E6A603D5C</idno><idno type="DOI">10.1016/0091-3057(75)90191-4</idno><idno type="PII">0091-3057(75)90191-4</idno></analytic><monogr><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="pISSN">0091-3057</idno><idno type="PII">S0091-3057(00)X0295-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975"></date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="675">675</biblScope><biblScope unit="page" to="679">679</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1975</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>MIF</term></item><item><term>Radioautography</term></item><item><term>Hormone</term></item><item><term>Brain</term></item><item><term>Peptide</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1975">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/7AF76CD45234E77B290017F1AEA9449E6A603D5C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PBB</jid><aid>75901914</aid><ce:pii>0091-3057(75)90191-4</ce:pii><ce:doi>10.1016/0091-3057(75)90191-4</ce:doi><ce:copyright type="unknown" year="1975"></ce:copyright></item-info><head><ce:title>Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of <ce:sup loc="pre">3</ce:sup>H-L-prolyl-L-leucyl glycinamide</ce:title><ce:author-group><ce:author><ce:given-name>Georges</ce:given-name><ce:surname>Pelletier</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Fernand</ce:given-name><ce:surname>Labrie</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Abba J.</ce:given-name><ce:surname>Kastin</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David</ce:given-name><ce:surname>Coy</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Andrew V.</ce:given-name><ce:surname>Schally</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="23" month="12" year="1974"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>MIF</ce:text></ce:keyword><ce:keyword><ce:text>Radioautography</ce:text></ce:keyword><ce:keyword><ce:text>Hormone</ce:text></ce:keyword><ce:keyword><ce:text>Brain</ce:text></ce:keyword><ce:keyword><ce:text>Peptide</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of</title></titleInfo><name type="personal"><namePart type="given">Georges</namePart><namePart type="family">Pelletier</namePart><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fernand</namePart><namePart type="family">Labrie</namePart><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Abba J.</namePart><namePart type="family">Kastin</namePart><affiliation>Send reprint requests to: Abba J. Kastin, Veterans Administration Hospital, 1601 Perdido Street, New Orleans, LA 70146.</affiliation><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Coy</namePart><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew V.</namePart><namePart type="family">Schally</namePart><affiliation>Medical Research Council Group in Molecular Endocrinology Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2 Canada</affiliation><affiliation>Endocrinology Section of the Medical Service and Endocrine and Polypeptide Laboratory Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1975</dateIssued><copyrightDate encoding="w3cdtf">1975</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Tritiated L-prolyl-L-leucyl-glycinamide was injected into the carotid artery or lateral ventricle of rats and the radioactivity localized by radioautography. After intracarotid administration, the radioactivity labeled the meninges, ependymal cells bordering the ventricles, and cells of the choroid plexus, as well as the median eminence and subfornical organ and thus may have reached the cerebrospinal fluid. After intraventricular injection, specific localization of radioactivity was found in cells of the nucleus lateralis septi, nucleus medialis septi, putamen, globus pallidus, indusium griseum, hippocampus, corpus callosum, and meninges. The results after intracarotid injection suggest that L-prolyl-L-leucyl-glycinamide may cross the blood brain barrier and the results after intraventricular injection suggest sites of localization which might be correlated with the previously reported effects of the tripeptide on the brain.</abstract><subject><genre>Keywords</genre><topic>MIF</topic><topic>Radioautography</topic><topic>Hormone</topic><topic>Brain</topic><topic>Peptide</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology, Biochemistry and Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PBB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197507</dateIssued></originInfo><identifier type="ISSN">0091-3057</identifier><identifier type="PII">S0091-3057(00)X0295-X</identifier><part><date>197507</date><detail type="volume"><number>3</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>539</start><end>729</end></extent><extent unit="pages"><start>675</start><end>679</end></extent></part></relatedItem><identifier type="istex">7AF76CD45234E77B290017F1AEA9449E6A603D5C</identifier><identifier type="DOI">10.1016/0091-3057(75)90191-4</identifier><identifier type="PII">0091-3057(75)90191-4</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001765 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001765 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:7AF76CD45234E77B290017F1AEA9449E6A603D5C
|texte= Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide
}}
| This area was generated with Dilib version V0.6.29. |  |