Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium
Identifieur interne : 001517 ( Istex/Corpus ); précédent : 001516; suivant : 001518Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium
Auteurs : Michael G. Heckman ; Alexandra I. Soto-Ortolaza ; Jan O. Aasly ; Nadine Abahuni ; Grazia Annesi ; Justin A. Bacon ; Soraya Bardien ; Maria Bozi ; Alexis Brice ; Laura Brighina ; Jonathan Carr ; Marie-Christine Chartier-Harlin ; Efthimios Dardiotis ; Dennis W. Dickson ; Nancy N. Diehl ; Alexis Elbaz ; Carlo Ferrarese ; Brian Fiske ; J. Mark Gibson ; Rachel Gibson ; Georgios M. Hadjigeorgiou ; Nobutaka Hattori ; John P. A. Ioannidis ; Magdalena Boczarska-Jedynak ; Barbara Jasinska-Myga ; Beom S. Jeon ; Yun Joong Kim ; Christine Klein ; Rejko Kruger ; Elli Kyratzi ; Suzanne Lesage ; Chin-Hsien Lin ; Timothy Lynch ; Demetrius M. Maraganore ; George D. Mellick ; Eugénie Mutez ; Christer Nilsson ; Grzegorz Opala ; Sung Sup Park ; Simona Petrucci ; Andreas Puschmann ; Aldo Quattrone ; Manu Sharma ; Peter A. Silburn ; Young Ho Sohn ; Leonidas Stefanis ; Vera Tadic ; Jessie Theuns ; Hiroyuki Tomiyama ; Ryan J. Uitti ; Enza Maria Valente ; Christine Van Broeckhoven ; Simone Van De Loo ; Demetrios K. Vassilatis ; Carles Vilari O-Güell ; Linda R. White ; Karin Wirdefeldt ; Zbigniew K. Wszolek ; Ruey-Meei Wu ; Faycal Hentati ; Matthew J. Farrer ; Owen A. RossSource :
- Movement Disorders [ 0885-3185 ] ; 2013-10.
Abstract
Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.
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DOI: 10.1002/mds.25600
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation><mods:affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Abahuni, Nadine" sort="Abahuni, Nadine" uniqKey="Abahuni N" first="Nadine" last="Abahuni">Nadine Abahuni</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Bardien, Soraya" sort="Bardien, Soraya" uniqKey="Bardien S" first="Soraya" last="Bardien">Soraya Bardien</name><affiliation><mods:affiliation>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</mods:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><mods:affiliation>General Hospital of Syros, Syros, Greece</mods:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Genetics and Cytogenetics, Hôpital de la Salpêtrière, Assistance Publique‐Hôpitaux de Paris, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Carr, Jonathan" sort="Carr, Jonathan" uniqKey="Carr J" first="Jonathan" last="Carr">Jonathan Carr</name><affiliation><mods:affiliation>Division of Neurology, University of Stellenbosch, Cape Town, South Africa</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation><mods:affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Versailles Saint‐Quentin, Medical Research Unit 1018, Versailles, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><mods:affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name><affiliation><mods:affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Gibson, Rachel" sort="Gibson, Rachel" uniqKey="Gibson R" first="Rachel" last="Gibson">Rachel Gibson</name><affiliation><mods:affiliation>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd, Stevenage, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><mods:affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, California, Stanford, USA</mods:affiliation></affiliation></author><author><name sortKey="Boczarska Edynak, Magdalena" sort="Boczarska Edynak, Magdalena" uniqKey="Boczarska Edynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name><affiliation><mods:affiliation>Department of Neurology, Seoul National University Hospital, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation><mods:affiliation>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Kruger">Rejko Kruger</name><affiliation><mods:affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kyratzi, Elli" sort="Kyratzi, Elli" uniqKey="Kyratzi E" first="Elli" last="Kyratzi">Elli Kyratzi</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Lin, Chin Sien" sort="Lin, Chin Sien" uniqKey="Lin C" first="Chin-Hsien" last="Lin">Chin-Hsien Lin</name><affiliation><mods:affiliation>Department of Neurology, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, North Shore University Health System, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><mods:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation><mods:affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre Hospitalier Regional Universitaire de Lille, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation><mods:affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Park, Sung Sup" sort="Park, Sung Sup" uniqKey="Park S" first="Sung Sup" last="Park">Sung Sup Park</name><affiliation><mods:affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Petrucci, Simona" sort="Petrucci, Simona" uniqKey="Petrucci S" first="Simona" last="Petrucci">Simona Petrucci</name><affiliation><mods:affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Clinical Sciences, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Department of Medical Sciences, Institute of Neurology, University Magna Graecia and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><mods:affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><mods:affiliation>University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sohn, Young Ho" sort="Sohn, Young Ho" uniqKey="Sohn Y" first="Young Ho" last="Sohn">Young Ho Sohn</name><affiliation><mods:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation><mods:affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Vassilatis, Demetrios K" sort="Vassilatis, Demetrios K" uniqKey="Vassilatis D" first="Demetrios K." last="Vassilatis">Demetrios K. Vassilatis</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation><mods:affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name><affiliation><mods:affiliation>University Hospital and Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Wu, Ruey Eei" sort="Wu, Ruey Eei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name><affiliation><mods:affiliation>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name><affiliation><mods:affiliation>Institut de Neurologie, Laboratoire de Neurobiologie Moleculaire, La Rabta, Tunis, Tunisia</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ross.owen@mayo.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/mds.25600</idno><idno type="url">https://api-v5.istex.fr/document/C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001517</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001517</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation><mods:affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Abahuni, Nadine" sort="Abahuni, Nadine" uniqKey="Abahuni N" first="Nadine" last="Abahuni">Nadine Abahuni</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Bardien, Soraya" sort="Bardien, Soraya" uniqKey="Bardien S" first="Soraya" last="Bardien">Soraya Bardien</name><affiliation><mods:affiliation>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</mods:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><mods:affiliation>General Hospital of Syros, Syros, Greece</mods:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Genetics and Cytogenetics, Hôpital de la Salpêtrière, Assistance Publique‐Hôpitaux de Paris, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Carr, Jonathan" sort="Carr, Jonathan" uniqKey="Carr J" first="Jonathan" last="Carr">Jonathan Carr</name><affiliation><mods:affiliation>Division of Neurology, University of Stellenbosch, Cape Town, South Africa</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation><mods:affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Versailles Saint‐Quentin, Medical Research Unit 1018, Versailles, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><mods:affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name><affiliation><mods:affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Gibson, Rachel" sort="Gibson, Rachel" uniqKey="Gibson R" first="Rachel" last="Gibson">Rachel Gibson</name><affiliation><mods:affiliation>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd, Stevenage, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><mods:affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, California, Stanford, USA</mods:affiliation></affiliation></author><author><name sortKey="Boczarska Edynak, Magdalena" sort="Boczarska Edynak, Magdalena" uniqKey="Boczarska Edynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name><affiliation><mods:affiliation>Department of Neurology, Seoul National University Hospital, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation><mods:affiliation>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Kruger">Rejko Kruger</name><affiliation><mods:affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kyratzi, Elli" sort="Kyratzi, Elli" uniqKey="Kyratzi E" first="Elli" last="Kyratzi">Elli Kyratzi</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Lin, Chin Sien" sort="Lin, Chin Sien" uniqKey="Lin C" first="Chin-Hsien" last="Lin">Chin-Hsien Lin</name><affiliation><mods:affiliation>Department of Neurology, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, North Shore University Health System, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><mods:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation><mods:affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre Hospitalier Regional Universitaire de Lille, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation><mods:affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Park, Sung Sup" sort="Park, Sung Sup" uniqKey="Park S" first="Sung Sup" last="Park">Sung Sup Park</name><affiliation><mods:affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Petrucci, Simona" sort="Petrucci, Simona" uniqKey="Petrucci S" first="Simona" last="Petrucci">Simona Petrucci</name><affiliation><mods:affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Clinical Sciences, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Department of Medical Sciences, Institute of Neurology, University Magna Graecia and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><mods:affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><mods:affiliation>University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sohn, Young Ho" sort="Sohn, Young Ho" uniqKey="Sohn Y" first="Young Ho" last="Sohn">Young Ho Sohn</name><affiliation><mods:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation><mods:affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Vassilatis, Demetrios K" sort="Vassilatis, Demetrios K" uniqKey="Vassilatis D" first="Demetrios K." last="Vassilatis">Demetrios K. Vassilatis</name><affiliation><mods:affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation><mods:affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name><affiliation><mods:affiliation>University Hospital and Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Wu, Ruey Eei" sort="Wu, Ruey Eei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name><affiliation><mods:affiliation>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name><affiliation><mods:affiliation>Institut de Neurologie, Laboratoire de Neurobiologie Moleculaire, La Rabta, Tunis, Tunisia</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ross.owen@mayo.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-10">2013-10</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1740">1740</biblScope><biblScope unit="page" to="1744">1744</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705</idno><idno type="DOI">10.1002/mds.25600</idno><idno type="ArticleID">MDS25600</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Michael G. Heckman MS</name><affiliations><json:string>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Alexandra I. Soto‐Ortolaza BSc</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Jan O. Aasly MD</name><affiliations><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>Nadine Abahuni MD</name><affiliations><json:string>Department of Neurology, Goethe University, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Grazia Annesi PhD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Justin A. Bacon BSc</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Soraya Bardien PhD</name><affiliations><json:string>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</json:string></affiliations></json:item><json:item><name>Maria Bozi MD</name><affiliations><json:string>General Hospital of Syros, Syros, Greece</json:string></affiliations></json:item><json:item><name>Alexis Brice MD</name><affiliations><json:string>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</json:string><json:string>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</json:string><json:string>Department of Genetics and Cytogenetics, Hôpital de la Salpêtrière, Assistance Publique‐Hôpitaux de Paris, Paris, France</json:string></affiliations></json:item><json:item><name>Laura Brighina MD, PhD</name><affiliations><json:string>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</json:string></affiliations></json:item><json:item><name>Jonathan Carr MD</name><affiliations><json:string>Division of Neurology, University of Stellenbosch, Cape Town, South Africa</json:string></affiliations></json:item><json:item><name>Marie‐Christine Chartier‐Harlin PhD</name><affiliations><json:string>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</json:string></affiliations></json:item><json:item><name>Efthimios Dardiotis MD</name><affiliations><json:string>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</json:string><json:string>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</json:string></affiliations></json:item><json:item><name>Dennis W. Dickson MD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Nancy N. Diehl BS</name><affiliations><json:string>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Alexis Elbaz MD, PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</json:string><json:string>Université de Versailles Saint‐Quentin, Medical Research Unit 1018, Versailles, France</json:string></affiliations></json:item><json:item><name>Carlo Ferrarese MD, PhD</name><affiliations><json:string>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</json:string></affiliations></json:item><json:item><name>Brian Fiske PhD</name><affiliations><json:string>The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA</json:string></affiliations></json:item><json:item><name>J. Mark Gibson MD</name><affiliations><json:string>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</json:string></affiliations></json:item><json:item><name>Rachel Gibson PhD</name><affiliations><json:string>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd, Stevenage, United Kingdom</json:string></affiliations></json:item><json:item><name>Georgios M. Hadjigeorgiou MD</name><affiliations><json:string>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</json:string><json:string>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</json:string></affiliations></json:item><json:item><name>Nobutaka Hattori MD, PhD</name><affiliations><json:string>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>John P.A. Ioannidis MD, DSc</name><affiliations><json:string>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</json:string><json:string>Stanford Prevention Research Center, Stanford University School of Medicine, California, Stanford, USA</json:string></affiliations></json:item><json:item><name>Magdalena Boczarska‐Jedynak MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string></affiliations></json:item><json:item><name>Barbara Jasinska‐Myga MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string></affiliations></json:item><json:item><name>Beom S. Jeon MD, PhD</name><affiliations><json:string>Department of Neurology, Seoul National University Hospital, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Yun Joong Kim MD, PhD</name><affiliations><json:string>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</json:string></affiliations></json:item><json:item><name>Christine Klein MD</name><affiliations><json:string>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</json:string></affiliations></json:item><json:item><name>Rejko Kruger MD</name><affiliations><json:string>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Elli Kyratzi MD</name><affiliations><json:string>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</json:string></affiliations></json:item><json:item><name>Suzanne Lesage PhD</name><affiliations><json:string>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</json:string><json:string>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</json:string></affiliations></json:item><json:item><name>Chin‐Hsien Lin MD</name><affiliations><json:string>Department of Neurology, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan</json:string></affiliations></json:item><json:item><name>Timothy Lynch FRCPI</name><affiliations><json:string>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</json:string></affiliations></json:item><json:item><name>Demetrius M. Maraganore MD</name><affiliations><json:string>Department of Neurology, North Shore University Health System, Illinois, Evanston, USA</json:string></affiliations></json:item><json:item><name>George D. Mellick PhD</name><affiliations><json:string>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Brisbane, Australia</json:string></affiliations></json:item><json:item><name>Eugénie Mutez MD</name><affiliations><json:string>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</json:string><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</json:string><json:string>Centre Hospitalier Regional Universitaire de Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Christer Nilsson MD, PhD</name><affiliations><json:string>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Grzegorz Opala MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string></affiliations></json:item><json:item><name>Sung Sup Park MD</name><affiliations><json:string>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Simona Petrucci MD</name><affiliations><json:string>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</json:string></affiliations></json:item><json:item><name>Andreas Puschmann MD, PhD</name><affiliations><json:string>Department of Neurology, Skåne University Hospital, Lund, Sweden</json:string><json:string>Department of Neurology, Clinical Sciences, Lund University, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Aldo Quattrone MD</name><affiliations><json:string>Department of Medical Sciences, Institute of Neurology, University Magna Graecia and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Manu Sharma PhD</name><affiliations><json:string>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Peter A. Silburn PhD</name><affiliations><json:string>University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Brisbane, Australia</json:string></affiliations></json:item><json:item><name>Young Ho Sohn MD, PhD</name><affiliations><json:string>Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Leonidas Stefanis MD</name><affiliations><json:string>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</json:string></affiliations></json:item><json:item><name>Vera Tadic MD</name><affiliations><json:string>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</json:string></affiliations></json:item><json:item><name>Jessie Theuns PhD</name><affiliations><json:string>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</json:string><json:string>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Hiroyuki Tomiyama MD, PhD</name><affiliations><json:string>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Ryan J. Uitti MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Enza Maria Valente MD, PhD</name><affiliations><json:string>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</json:string></affiliations></json:item><json:item><name>Christine Van Broeckhoven PhD</name><affiliations><json:string>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</json:string><json:string>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Simone van de Loo PhD</name><affiliations><json:string>Department of Neurology, Goethe University, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Demetrios K. Vassilatis PhD</name><affiliations><json:string>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</json:string></affiliations></json:item><json:item><name>Carles Vilariño‐Güell PhD</name><affiliations><json:string>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</json:string></affiliations></json:item><json:item><name>Linda R. White PhD</name><affiliations><json:string>University Hospital and Norwegian University of Science and Technology, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>Karin Wirdefeldt MD, PhD</name><affiliations><json:string>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Zbigniew K. Wszolek MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Ruey‐Meei Wu MD</name><affiliations><json:string>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Faycal Hentati MD</name><affiliations><json:string>Institut de Neurologie, Laboratoire de Neurobiologie Moleculaire, La Rabta, Tunis, Tunisia</json:string></affiliations></json:item><json:item><name>Matthew J. Farrer PhD</name><affiliations><json:string>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</json:string></affiliations></json:item><json:item><name>Owen A. Ross PhD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</json:string><json:string>E-mail: ross.owen@mayo.edu</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LRRK2</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>association study</value></json:item></subject><articleId><json:string>MDS25600</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.631</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 809.972 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>315</abstractCharCount><pdfWordCount>3615</pdfWordCount><pdfCharCount>24466</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>43</abstractWordCount></qualityIndicators><title>Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title><corporate><json:item><name>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) Consortium</name></json:item></corporate><genre><json:string>article</json:string></genre><host><title>Movement Disorders</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi><issn><json:string>0885-3185</json:string></issn><eissn><json:string>1531-8257</json:string></eissn><publisherId><json:string>MDS</json:string></publisherId><volume>28</volume><issue>12</issue><pages><first>1740</first><last>1744</last><total>4</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Brief Report</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1002/mds.25600</json:string></doi><id>C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><availability><p>© 2013 Movement Disorder Society© 2013 Movement Disorder Society</p></availability><date>2013-06-18</date></publicationStmt><notesStmt><note>GEO‐PD Consortium</note><note>Original funding for the GEO‐PD</note><note>The Michael J. Fox Foundation for Parkinson's Research Edmond J. Safra Global Genetics Consortia program. The Mayo Clinic is a Morris K. Udall Center of Excellence in PD Research - No. P50 NS072187;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title><author><orgName>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) Consortium</orgName></author><author xml:id="author-1"><persName><forename type="first">Michael G.</forename><surname>Heckman</surname></persName><roleName type="degree">MS</roleName><affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-2"><persName><forename type="first">Alexandra I.</forename><surname>Soto‐Ortolaza</surname></persName><roleName type="degree">BSc</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-3"><persName><forename type="first">Jan O.</forename><surname>Aasly</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation></author><author xml:id="author-4"><persName><forename type="first">Nadine</forename><surname>Abahuni</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">Grazia</forename><surname>Annesi</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</affiliation></author><author xml:id="author-6"><persName><forename type="first">Justin A.</forename><surname>Bacon</surname></persName><roleName type="degree">BSc</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-7"><persName><forename type="first">Soraya</forename><surname>Bardien</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</affiliation></author><author xml:id="author-8"><persName><forename type="first">Maria</forename><surname>Bozi</surname></persName><roleName type="degree">MD</roleName><affiliation>General Hospital of Syros, Syros, Greece</affiliation></author><author xml:id="author-9"><persName><forename type="first">Alexis</forename><surname>Brice</surname></persName><roleName type="degree">MD</roleName><affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</affiliation><affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Hôpital de la Salpêtrière, Assistance Publique‐Hôpitaux de Paris, Paris, France</affiliation></author><author xml:id="author-10"><persName><forename type="first">Laura</forename><surname>Brighina</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation></author><author xml:id="author-11"><persName><forename type="first">Jonathan</forename><surname>Carr</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Neurology, University of Stellenbosch, Cape Town, South Africa</affiliation></author><author xml:id="author-12"><persName><forename type="first">Marie‐Christine</forename><surname>Chartier‐Harlin</surname></persName><roleName type="degree">PhD</roleName><affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</affiliation></author><author xml:id="author-13"><persName><forename type="first">Efthimios</forename><surname>Dardiotis</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</affiliation></author><author xml:id="author-14"><persName><forename type="first">Dennis W.</forename><surname>Dickson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-15"><persName><forename type="first">Nancy N.</forename><surname>Diehl</surname></persName><roleName type="degree">BS</roleName><affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-16"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</affiliation><affiliation>Université de Versailles Saint‐Quentin, Medical Research Unit 1018, Versailles, France</affiliation></author><author xml:id="author-17"><persName><forename type="first">Carlo</forename><surname>Ferrarese</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation></author><author xml:id="author-18"><persName><forename type="first">Brian</forename><surname>Fiske</surname></persName><roleName type="degree">PhD</roleName><affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA</affiliation></author><author xml:id="author-19"><persName><forename type="first">J. Mark</forename><surname>Gibson</surname></persName><roleName type="degree">MD</roleName><note type="biography">Dr J. M. Gibson passed away during the course of the present study (RIP).</note><affiliation>Dr J. M. Gibson passed away during the course of the present study (RIP).</affiliation><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation></author><author xml:id="author-20"><persName><forename type="first">Rachel</forename><surname>Gibson</surname></persName><roleName type="degree">PhD</roleName><affiliation>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd, Stevenage, United Kingdom</affiliation></author><author xml:id="author-21"><persName><forename type="first">Georgios M.</forename><surname>Hadjigeorgiou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</affiliation></author><author xml:id="author-22"><persName><forename type="first">Nobutaka</forename><surname>Hattori</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</affiliation></author><author xml:id="author-23"><persName><forename type="first">John P.A.</forename><surname>Ioannidis</surname></persName><roleName type="degree">MD, DSc</roleName><affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</affiliation><affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, California, Stanford, USA</affiliation></author><author xml:id="author-24"><persName><forename type="first">Magdalena</forename><surname>Boczarska‐Jedynak</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation></author><author xml:id="author-25"><persName><forename type="first">Barbara</forename><surname>Jasinska‐Myga</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation></author><author xml:id="author-26"><persName><forename type="first">Beom S.</forename><surname>Jeon</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Seoul National University Hospital, Seoul, South Korea</affiliation></author><author xml:id="author-27"><persName><forename type="first">Yun Joong</forename><surname>Kim</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</affiliation></author><author xml:id="author-28"><persName><forename type="first">Christine</forename><surname>Klein</surname></persName><roleName type="degree">MD</roleName><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</affiliation></author><author xml:id="author-29"><persName><forename type="first">Rejko</forename><surname>Kruger</surname></persName><roleName type="degree">MD</roleName><affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</affiliation></author><author xml:id="author-30"><persName><forename type="first">Elli</forename><surname>Kyratzi</surname></persName><roleName type="degree">MD</roleName><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation></author><author xml:id="author-31"><persName><forename type="first">Suzanne</forename><surname>Lesage</surname></persName><roleName type="degree">PhD</roleName><affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</affiliation><affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</affiliation></author><author xml:id="author-32"><persName><forename type="first">Chin‐Hsien</forename><surname>Lin</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan</affiliation></author><author xml:id="author-33"><persName><forename type="first">Timothy</forename><surname>Lynch</surname></persName><roleName type="degree">FRCPI</roleName><affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</affiliation></author><author xml:id="author-34"><persName><forename type="first">Demetrius M.</forename><surname>Maraganore</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, North Shore University Health System, Illinois, Evanston, USA</affiliation></author><author xml:id="author-35"><persName><forename type="first">George D.</forename><surname>Mellick</surname></persName><roleName type="degree">PhD</roleName><affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Brisbane, Australia</affiliation></author><author xml:id="author-36"><persName><forename type="first">Eugénie</forename><surname>Mutez</surname></persName><roleName type="degree">MD</roleName><affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</affiliation><affiliation>Centre Hospitalier Regional Universitaire de Lille, Lille, France</affiliation></author><author xml:id="author-37"><persName><forename type="first">Christer</forename><surname>Nilsson</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden</affiliation></author><author xml:id="author-38"><persName><forename type="first">Grzegorz</forename><surname>Opala</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation></author><author xml:id="author-39"><persName><forename type="first">Sung Sup</forename><surname>Park</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea</affiliation></author><author xml:id="author-40"><persName><forename type="first">Simona</forename><surname>Petrucci</surname></persName><roleName type="degree">MD</roleName><affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</affiliation></author><author xml:id="author-41"><persName><forename type="first">Andreas</forename><surname>Puschmann</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</affiliation><affiliation>Department of Neurology, Clinical Sciences, Lund University, Lund, Sweden</affiliation></author><author xml:id="author-42"><persName><forename type="first">Aldo</forename><surname>Quattrone</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Medical Sciences, Institute of Neurology, University Magna Graecia and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</affiliation></author><author xml:id="author-43"><persName><forename type="first">Manu</forename><surname>Sharma</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</affiliation></author><author xml:id="author-44"><persName><forename type="first">Peter A.</forename><surname>Silburn</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Brisbane, Australia</affiliation></author><author xml:id="author-45"><persName><forename type="first">Young Ho</forename><surname>Sohn</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</affiliation></author><author xml:id="author-46"><persName><forename type="first">Leonidas</forename><surname>Stefanis</surname></persName><roleName type="degree">MD</roleName><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation></author><author xml:id="author-47"><persName><forename type="first">Vera</forename><surname>Tadic</surname></persName><roleName type="degree">MD</roleName><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</affiliation></author><author xml:id="author-48"><persName><forename type="first">Jessie</forename><surname>Theuns</surname></persName><roleName type="degree">PhD</roleName><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation></author><author xml:id="author-49"><persName><forename type="first">Hiroyuki</forename><surname>Tomiyama</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</affiliation></author><author xml:id="author-50"><persName><forename type="first">Ryan J.</forename><surname>Uitti</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-51"><persName><forename type="first">Enza Maria</forename><surname>Valente</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</affiliation></author><author xml:id="author-52"><persName><forename type="first">Christine</forename><surname>Van Broeckhoven</surname></persName><roleName type="degree">PhD</roleName><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation></author><author xml:id="author-53"><persName><forename type="first">Simone</forename><surname>van de Loo</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-54"><persName><forename type="first">Demetrios K.</forename><surname>Vassilatis</surname></persName><roleName type="degree">PhD</roleName><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation></author><author xml:id="author-55"><persName><forename type="first">Carles</forename><surname>Vilariño‐Güell</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</affiliation></author><author xml:id="author-56"><persName><forename type="first">Linda R.</forename><surname>White</surname></persName><roleName type="degree">PhD</roleName><affiliation>University Hospital and Norwegian University of Science and Technology, Trondheim, Norway</affiliation></author><author xml:id="author-57"><persName><forename type="first">Karin</forename><surname>Wirdefeldt</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</affiliation></author><author xml:id="author-58"><persName><forename type="first">Zbigniew K.</forename><surname>Wszolek</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author><author xml:id="author-59"><persName><forename type="first">Ruey‐Meei</forename><surname>Wu</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</affiliation></author><author xml:id="author-60"><persName><forename type="first">Faycal</forename><surname>Hentati</surname></persName><roleName type="degree">MD</roleName><affiliation>Institut de Neurologie, Laboratoire de Neurobiologie Moleculaire, La Rabta, Tunis, Tunisia</affiliation></author><author xml:id="author-61"><persName><forename type="first">Matthew J.</forename><surname>Farrer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</affiliation></author><author xml:id="author-62"><persName><forename type="first">Owen A.</forename><surname>Ross</surname></persName><roleName type="degree">PhD</roleName><email>ross.owen@mayo.edu</email><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-10"></date><biblScope unit="volume">28</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1740">1740</biblScope><biblScope unit="page" to="1744">1744</biblScope></imprint></monogr><idno type="istex">C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705</idno><idno type="DOI">10.1002/mds.25600</idno><idno type="ArticleID">MDS25600</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-06-18</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.</p></abstract><abstract><p>The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine‐rich repeat kinase 2 gene across 23 different sites in 15 countries.</p></abstract><abstract><p>Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K‐R1398H‐K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups.</p></abstract><abstract><p>Establishing individual patient‐based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. © 2013 International Parkinson and Movement Disorder Society</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>Parkinson's disease</term></item><item><term>LRRK2</term></item><item><term>genetics</term></item><item><term>association study</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-08-20">Received</change><change when="2013-01-27">Registration</change><change when="2013-06-18">Created</change><change when="2013-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="mds25600"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi>10.1002/mds.v28.12</doi><copyright ownership="thirdParty">© 2013 Movement Disorder Society</copyright><numberingGroup><numbering type="journalVolume" number="28">28</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2013-10">October 2013</coverDate></publicationMeta><publicationMeta level="unit" position="240" type="article" status="forIssue"><doi>10.1002/mds.25600</doi><idGroup><id type="unit" value="MDS25600"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">© 2013 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2012-08-20"></event><event type="manuscriptRevised" date="2012-11-07"></event><event type="manuscriptAccepted" date="2013-01-27"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2013-06-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.6 mode:FullText" date="2013-10-25"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-08-02"></event><event type="firstOnline" date="2013-08-02"></event><event type="publishedOnlineFinalForm" date="2013-10-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst">1740</numbering><numbering type="pageLast">1744</numbering></numberingGroup><correspondenceTo><b>Correspondence to:</b> Dr. Owen A. Ross, Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224; <email>ross.owen@mayo.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS25600.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Population‐specific frequencies for <i>LRRK2</i> susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title><title type="short">Frequency of LRRK2 Variants in PD</title><title type="shortAuthors">Heckman et al.</title></titleGroup><creators><creator affiliationRef="#mds25600-aff-0001" creatorRole="author" xml:id="mds25600-cr-0001"><personName><givenNames>Michael G.</givenNames> <familyName>Heckman</familyName><degrees>MS</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0002" creatorRole="author" xml:id="mds25600-cr-0002"><personName><givenNames>Alexandra I.</givenNames> <familyName>Soto‐Ortolaza</familyName><degrees>BSc</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0003" creatorRole="author" xml:id="mds25600-cr-0003"><personName><givenNames>Jan O.</givenNames> <familyName>Aasly</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0004" creatorRole="author" xml:id="mds25600-cr-0004"><personName><givenNames>Nadine</givenNames> <familyName>Abahuni</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0005" creatorRole="author" xml:id="mds25600-cr-0005"><personName><givenNames>Grazia</givenNames> <familyName>Annesi</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0002" creatorRole="author" xml:id="mds25600-cr-0006"><personName><givenNames>Justin A.</givenNames> <familyName>Bacon</familyName><degrees>BSc</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0006" creatorRole="author" xml:id="mds25600-cr-0007"><personName><givenNames>Soraya</givenNames> <familyName>Bardien</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0007" creatorRole="author" xml:id="mds25600-cr-0008"><personName><givenNames>Maria</givenNames> <familyName>Bozi</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0008 #mds25600-aff-0009 #mds25600-aff-0010 #mds25600-aff-0011" creatorRole="author" xml:id="mds25600-cr-0009"><personName><givenNames>Alexis</givenNames> <familyName>Brice</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0012" creatorRole="author" xml:id="mds25600-cr-0010"><personName><givenNames>Laura</givenNames> <familyName>Brighina</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0013" creatorRole="author" xml:id="mds25600-cr-0011"><personName><givenNames>Jonathan</givenNames> <familyName>Carr</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0014 #mds25600-aff-0015" creatorRole="author" xml:id="mds25600-cr-0012"><personName><givenNames>Marie‐Christine</givenNames> <familyName>Chartier‐Harlin</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0016 #mds25600-aff-0017" creatorRole="author" xml:id="mds25600-cr-0013"><personName><givenNames>Efthimios</givenNames> <familyName>Dardiotis</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0002" creatorRole="author" xml:id="mds25600-cr-0014"><personName><givenNames>Dennis W.</givenNames> <familyName>Dickson</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0001" creatorRole="author" xml:id="mds25600-cr-0015"><personName><givenNames>Nancy N.</givenNames> <familyName>Diehl</familyName><degrees>BS</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0018 #mds25600-aff-0019" creatorRole="author" xml:id="mds25600-cr-0016"><personName><givenNames>Alexis</givenNames> <familyName>Elbaz</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0012" creatorRole="author" xml:id="mds25600-cr-0017"><personName><givenNames>Carlo</givenNames> <familyName>Ferrarese</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0020" creatorRole="author" xml:id="mds25600-cr-0018"><personName><givenNames>Brian</givenNames> <familyName>Fiske</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0021" noteRef="#mds25600-note-0004" creatorRole="author" xml:id="mds25600-cr-0019"><personName><givenNames>J. Mark</givenNames> <familyName>Gibson</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0022" creatorRole="author" xml:id="mds25600-cr-0020"><personName><givenNames>Rachel</givenNames> <familyName>Gibson</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0016 #mds25600-aff-0017" creatorRole="author" xml:id="mds25600-cr-0021"><personName><givenNames>Georgios M.</givenNames> <familyName>Hadjigeorgiou</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0023" creatorRole="author" xml:id="mds25600-cr-0022"><personName><givenNames>Nobutaka</givenNames> <familyName>Hattori</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0024 #mds25600-aff-0025" creatorRole="author" xml:id="mds25600-cr-0023"><personName><givenNames>John P.A.</givenNames> <familyName>Ioannidis</familyName><degrees>MD, DSc</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0026" creatorRole="author" xml:id="mds25600-cr-0024"><personName><givenNames>Magdalena</givenNames><familyName>Boczarska‐Jedynak</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0026" creatorRole="author" xml:id="mds25600-cr-0025"><personName><givenNames>Barbara</givenNames> <familyName>Jasinska‐Myga</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0027" creatorRole="author" xml:id="mds25600-cr-0026"><personName><givenNames>Beom S.</givenNames> <familyName>Jeon</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0028" creatorRole="author" xml:id="mds25600-cr-0027"><personName><givenNames>Yun Joong</givenNames> <familyName>Kim</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0029" creatorRole="author" xml:id="mds25600-cr-0028"><personName><givenNames>Christine</givenNames> <familyName>Klein</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0030" creatorRole="author" xml:id="mds25600-cr-0029"><personName><givenNames>Rejko</givenNames> <familyName>Kruger</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0031" creatorRole="author" xml:id="mds25600-cr-0030"><personName><givenNames>Elli</givenNames> <familyName>Kyratzi</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0008 #mds25600-aff-0009 #mds25600-aff-0010" creatorRole="author" xml:id="mds25600-cr-0031"><personName><givenNames>Suzanne</givenNames> <familyName>Lesage</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0032" creatorRole="author" xml:id="mds25600-cr-0032"><personName><givenNames>Chin‐Hsien</givenNames> <familyName>Lin</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0033" creatorRole="author" xml:id="mds25600-cr-0033"><personName><givenNames>Timothy</givenNames> <familyName>Lynch</familyName><degrees>FRCPI</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0034" creatorRole="author" xml:id="mds25600-cr-0034"><personName><givenNames>Demetrius M.</givenNames> <familyName>Maraganore</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0035" creatorRole="author" xml:id="mds25600-cr-0035"><personName><givenNames>George D.</givenNames> <familyName>Mellick</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25600-aff-0014 #mds25600-aff-0015 #mds25600-aff-0036" creatorRole="author" xml:id="mds25600-cr-0036"><personName><givenNames>Eugénie</givenNames> <familyName>Mutez</familyName><degrees>MD</degrees></personName></creator><creator 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Columbia</orgName><address><city>Vancouver</city><city>British Columbia</city><country>Canada</country></address></affiliation><affiliation countryCode="NO" type="organization" xml:id="mds25600-aff-0049"><orgName>University Hospital and Norwegian University of Science and Technology</orgName><address><city>Trondheim</city><country>Norway</country></address></affiliation><affiliation countryCode="SE" type="organization" xml:id="mds25600-aff-0050"><orgDiv>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics</orgDiv><orgName>Karolinska Institute</orgName><address><city>Stockholm</city><country>Sweden</country></address></affiliation><affiliation countryCode="TW" type="organization" xml:id="mds25600-aff-0051"><orgDiv>Department of Neurology</orgDiv><orgName>National Taiwan University Hospital, College of Medicine, National Taiwan University</orgName><address><city>Taipei</city><country>Taiwan</country></address></affiliation><affiliation countryCode="TN" type="organization" xml:id="mds25600-aff-0052"><orgDiv>Institut de Neurologie</orgDiv><orgName>Laboratoire de Neurobiologie Moleculaire</orgName><address><street>La Rabta</street><city>Tunis</city><country>Tunisia</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="mds25600-kwd-0001">Parkinson's disease</keyword><keyword xml:id="mds25600-kwd-0002">LRRK2</keyword><keyword xml:id="mds25600-kwd-0003">genetics</keyword><keyword xml:id="mds25600-kwd-0004">association study</keyword></keywordGroup><fundingInfo><fundingAgency>GEO‐PD Consortium</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Original funding for the GEO‐PD</fundingAgency></fundingInfo><fundingInfo><fundingAgency>The Michael J. Fox Foundation for Parkinson's Research Edmond J. Safra Global Genetics Consortia program. The Mayo Clinic is a Morris K. Udall Center of Excellence in PD Research</fundingAgency><fundingNumber>P50 NS072187</fundingNumber></fundingInfo><supportingInformation><p>Additional Supporting Information may be found in the online version of this article.</p><supportingInfoItem><mediaResource alt="application" href="urn-x:wiley:08853185:media:mds25600:mds25600-sup-0001-suppappendix"></mediaResource><caption>Supporting Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application" href="urn-x:wiley:08853185:media:mds25600:mds25600-sup-0002-supptables"></mediaResource><caption>Supporting Table 1. Country‐specific minor allele frequencies and results of association analysis for p.M1646T in Caucasians</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main"><title type="main">ABSTRACT</title><section xml:id="mds25600-sec-0001"><title type="main">Background</title><p>Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.</p></section><section xml:id="mds25600-sec-0002"><title type="main">Methods</title><p>The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine‐rich repeat kinase 2 gene across 23 different sites in 15 countries.</p></section><section xml:id="mds25600-sec-0003"><title type="main">Results</title><p>Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K‐R1398H‐K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups.</p></section><section xml:id="mds25600-sec-0004"><title type="main">Conclusions</title><p>Establishing individual patient‐based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. © 2013 International Parkinson and Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="mds25600-note-0001"><p><b>Funding agencies:</b> The present study and original funding for the GEO‐PD Consortium was supported by grants from the Michael J. Fox Foundation. The Mayo Clinic is a Morris K. Udall Center of Excellence in PD Research (P50 NS072187).</p></note><note xml:id="mds25600-note-0002"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="mds25600-note-0003"><p>Full financial disclosures and author roles may be found in the Acknowledgments section online.</p></note><note xml:id="mds25600-note-0004"><p>Dr J. M. Gibson passed away during the course of the present study (RIP).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Frequency of LRRK2 Variants in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Population‐specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium</title></titleInfo><name type="personal"><namePart type="given">Michael G.</namePart><namePart type="family">Heckman</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandra I.</namePart><namePart type="family">Soto‐Ortolaza</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan O.</namePart><namePart type="family">Aasly</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nadine</namePart><namePart type="family">Abahuni</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grazia</namePart><namePart type="family">Annesi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Justin A.</namePart><namePart type="family">Bacon</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Soraya</namePart><namePart type="family">Bardien</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Bozi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>General Hospital of Syros, Syros, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Brice</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</affiliation><affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Hôpital de la Salpêtrière, Assistance Publique‐Hôpitaux de Paris, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Brighina</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan</namePart><namePart type="family">Carr</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurology, University of Stellenbosch, Cape Town, South Africa</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Christine</namePart><namePart type="family">Chartier‐Harlin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Efthimios</namePart><namePart type="family">Dardiotis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dennis W.</namePart><namePart type="family">Dickson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nancy N.</namePart><namePart type="family">Diehl</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Biostatistics Unit, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Elbaz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</affiliation><affiliation>Université de Versailles Saint‐Quentin, Medical Research Unit 1018, Versailles, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Ferrarese</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neuroscience‐Section of Neurology, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brian</namePart><namePart type="family">Fiske</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. Mark</namePart><namePart type="family">Gibson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation><description>Dr J. M. Gibson passed away during the course of the present study (RIP).</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rachel</namePart><namePart type="family">Gibson</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd, Stevenage, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georgios M.</namePart><namePart type="family">Hadjigeorgiou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, Center for Research and Technology‐Thessaly, Larissa, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nobutaka</namePart><namePart type="family">Hattori</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John P.A.</namePart><namePart type="family">Ioannidis</namePart><namePart type="termsOfAddress">MD, DSc</namePart><affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</affiliation><affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, California, Stanford, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Magdalena</namePart><namePart type="family">Boczarska‐Jedynak</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Jasinska‐Myga</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beom S.</namePart><namePart type="family">Jeon</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Seoul National University Hospital, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yun Joong</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Klein</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rejko</namePart><namePart type="family">Kruger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elli</namePart><namePart type="family">Kyratzi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suzanne</namePart><namePart type="family">Lesage</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université Pierre et Marie Curie‐Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, Medical Research Unit S975, Paris, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 975, Paris, France</affiliation><affiliation>Centre National de la Recherche Scientifique, Medical Research Unit 7225, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chin‐Hsien</namePart><namePart type="family">Lin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, National Taiwan University Hospital Yun‐Lin Branch, Yun‐Lin, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy</namePart><namePart type="family">Lynch</namePart><namePart type="termsOfAddress">FRCPI</namePart><affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetrius M.</namePart><namePart type="family">Maraganore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, North Shore University Health System, Illinois, Evanston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George D.</namePart><namePart type="family">Mellick</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Brisbane, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugénie</namePart><namePart type="family">Mutez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University Lille Nord de France, Centre de Recherche Jean‐Pierre Aubert, Lille, France</affiliation><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 837, Lille, France</affiliation><affiliation>Centre Hospitalier Regional Universitaire de Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christer</namePart><namePart type="family">Nilsson</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grzegorz</namePart><namePart type="family">Opala</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sung Sup</namePart><namePart type="family">Park</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simona</namePart><namePart type="family">Petrucci</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Puschmann</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</affiliation><affiliation>Department of Neurology, Clinical Sciences, Lund University, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Medical Sciences, Institute of Neurology, University Magna Graecia and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Manu</namePart><namePart type="family">Sharma</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department for Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter A.</namePart><namePart type="family">Silburn</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Brisbane, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Young Ho</namePart><namePart type="family">Sohn</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leonidas</namePart><namePart type="family">Stefanis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vera</namePart><namePart type="family">Tadic</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Luebeck, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jessie</namePart><namePart type="family">Theuns</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroyuki</namePart><namePart type="family">Tomiyama</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ryan J.</namePart><namePart type="family">Uitti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Enza Maria</namePart><namePart type="family">Valente</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Van Broeckhoven</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Laboratory of Neurogenetics, Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simone</namePart><namePart type="family">van de Loo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetrios K.</namePart><namePart type="family">Vassilatis</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carles</namePart><namePart type="family">Vilariño‐Güell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Linda R.</namePart><namePart type="family">White</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University Hospital and Norwegian University of Science and Technology, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karin</namePart><namePart type="family">Wirdefeldt</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zbigniew K.</namePart><namePart type="family">Wszolek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ruey‐Meei</namePart><namePart type="family">Wu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Faycal</namePart><namePart type="family">Hentati</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institut de Neurologie, Laboratoire de Neurobiologie Moleculaire, La Rabta, Tunis, Tunisia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthew J.</namePart><namePart type="family">Farrer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Genetics, University of British Columbia, VancouverBritish Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Owen A.</namePart><namePart type="family">Ross</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Florida, Jacksonville, USA</affiliation><affiliation>E-mail: ross.owen@mayo.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) Consortium</namePart></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-10</dateIssued><dateCreated encoding="w3cdtf">2013-06-18</dateCreated><dateCaptured encoding="w3cdtf">2012-08-20</dateCaptured><dateValid encoding="w3cdtf">2013-01-27</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease.</abstract><abstract>The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine‐rich repeat kinase 2 gene across 23 different sites in 15 countries.</abstract><abstract>Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K‐R1398H‐K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups.</abstract><abstract>Establishing individual patient‐based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. © 2013 International Parkinson and Movement Disorder Society</abstract><note type="funding">GEO‐PD Consortium</note><note type="funding">Original funding for the GEO‐PD</note><note type="funding">The Michael J. Fox Foundation for Parkinson's Research Edmond J. Safra Global Genetics Consortia program. The Mayo Clinic is a Morris K. Udall Center of Excellence in PD Research - No. P50 NS072187; </note><subject><genre>keywords</genre><topic>Parkinson's disease</topic><topic>LRRK2</topic><topic>genetics</topic><topic>association study</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov Disord.</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information - Supporting Table 1. Country‐specific minor allele frequencies and results of association analysis for p.M1646T in Caucasians - </note><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1740</start><end>1744</end><total>4</total></extent></part></relatedItem><identifier type="istex">C6C03F04C791F2BAFA0887DE4DFC20A9DAE7F705</identifier><identifier type="DOI">10.1002/mds.25600</identifier><identifier type="ArticleID">MDS25600</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 Movement Disorder Society© 2013 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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