Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients
Identifieur interne : 001408 ( Istex/Corpus ); précédent : 001407; suivant : 001409Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients
Auteurs : A. Leznoff ; G. L. SussmanSource :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1989.
Abstract
From a pool of 624 patients with idiopathic chronic urticaria and angioedema, 90 patients had evidence of associated thyroid autoimmunity (TA). Since the number expected by chance alone is 37, given that <6% of normal subjects have TA, the association is significant (p < 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. The authors hypothesize that a subset of idiopathic chronic urticaria and angioedema may be an autoimmune disease.
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DOI: 10.1016/0091-6749(89)90180-2
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Leznoff</name><affiliation><mods:affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Sussman, G L" sort="Sussman, G L" uniqKey="Sussman G" first="G. L." last="Sussman">G. L. Sussman</name><affiliation><mods:affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="ISSN">0091-6749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="66">66</biblScope><biblScope unit="page" to="71">71</biblScope></imprint><idno type="ISSN">0091-6749</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-6749</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From a pool of 624 patients with idiopathic chronic urticaria and angioedema, 90 patients had evidence of associated thyroid autoimmunity (TA). Since the number expected by chance alone is 37, given that <6% of normal subjects have TA, the association is significant (p < 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. The authors hypothesize that a subset of idiopathic chronic urticaria and angioedema may be an autoimmune disease.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>A. Leznoff MD</name><affiliations><json:string>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>G.L. 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Since the number expected by chance alone is 37, given that >6% of normal subjects have TA, the association is significant (p > 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. 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Leznoff, MD, St. Michael's Hospital Annex, 38 Shuter St., Suite 215, Toronto, Ontario, Canada.</note><affiliation>Reprint requests: A. Leznoff, MD, St. Michael's Hospital Annex, 38 Shuter St., Suite 215, Toronto, Ontario, Canada.</affiliation><affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">G.L.</forename><surname>Sussman</surname></persName><roleName type="degree">MD</roleName><affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</affiliation></author><idno type="istex">512F618B35734CE231FAEBFB23BE1DE84194ED03</idno><idno type="DOI">10.1016/0091-6749(89)90180-2</idno><idno type="PII">0091-6749(89)90180-2</idno></analytic><monogr><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="pISSN">0091-6749</idno><idno type="PII">S0091-6749(00)X0309-0</idno><meeting><addName>Forty-sixth Annual Meeting, Baltimore Convention Center Baltimore, Md</addName><date>19900323</date><date>19900328</date></meeting><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989"></date><biblScope unit="volume">84</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="66">66</biblScope><biblScope unit="page" to="71">71</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1989</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>From a pool of 624 patients with idiopathic chronic urticaria and angioedema, 90 patients had evidence of associated thyroid autoimmunity (TA). Since the number expected by chance alone is 37, given that <6% of normal subjects have TA, the association is significant (p < 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. The authors hypothesize that a subset of idiopathic chronic urticaria and angioedema may be an autoimmune disease.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>ICUA</term><term>Idiopathic chronic urticaria and angioedema</term></item><item><term>TA</term><term>Thyroid autoimmunity</term></item><item><term>TMA</term><term>Thyroid microsomal antibodies</term></item><item><term>TGA</term><term>Thyroglobulin antibodies</term></item><item><term>TSH</term><term>Thyroid-stimulating hormone</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-01-05">Modified</change><change when="1989">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/512F618B35734CE231FAEBFB23BE1DE84194ED03/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YMAI</jid><aid>89901802</aid><ce:pii>0091-6749(89)90180-2</ce:pii><ce:doi>10.1016/0091-6749(89)90180-2</ce:doi><ce:copyright type="unknown" year="1989"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Original article</ce:textfn></ce:dochead><ce:title>Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients</ce:title><ce:author-group><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Leznoff</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.L.</ce:given-name><ce:surname>Sussman</ce:surname><ce:degrees>MD</ce:degrees></ce:author><ce:affiliation><ce:textfn>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Reprint requests: A. Leznoff, MD, St. Michael's Hospital Annex, 38 Shuter St., Suite 215, Toronto, Ontario, Canada.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="29" month="9" year="1988"></ce:date-received><ce:date-revised day="5" month="1" year="1989"></ce:date-revised><ce:date-accepted day="27" month="1" year="1989"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>From a pool of 624 patients with idiopathic chronic urticaria and angioedema, 90 patients had evidence of associated thyroid autoimmunity (TA). Since the number expected by chance alone is 37, given that <6% of normal subjects have TA, the association is significant (<ce:italic>p</ce:italic> < 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. The authors hypothesize that a subset of idiopathic chronic urticaria and angioedema may be an autoimmune disease.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>ICUA</ce:text><ce:keyword><ce:text>Idiopathic chronic urticaria and angioedema</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TA</ce:text><ce:keyword><ce:text>Thyroid autoimmunity</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TMA</ce:text><ce:keyword><ce:text>Thyroid microsomal antibodies</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TGA</ce:text><ce:keyword><ce:text>Thyroglobulin antibodies</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TSH</ce:text><ce:keyword><ce:text>Thyroid-stimulating hormone</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Leznoff</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</affiliation><description>Reprint requests: A. Leznoff, MD, St. Michael's Hospital Annex, 38 Shuter St., Suite 215, Toronto, Ontario, Canada.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.L.</namePart><namePart type="family">Sussman</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the Divisions of Allergy and Clinical Immunology, St. Michael's Hospital and Wellesley Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1989</dateIssued><dateModified encoding="w3cdtf">1989-01-05</dateModified><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">From a pool of 624 patients with idiopathic chronic urticaria and angioedema, 90 patients had evidence of associated thyroid autoimmunity (TA). Since the number expected by chance alone is 37, given that <6% of normal subjects have TA, the association is significant (p < 0.01; chi-square test). Age and sex distribution was typical of patients with TA. Clinically, most patients suffered relentless and severe urticaria and/or angioedema. With the exception of thyroid function and thyroid antibody tests, other laboratory tests were not rewarding. In most cases, treatment with 1 thyroxine did not improve urticaria or angioedema, but a few patients demonstrated a dramatic response. Awareness of the association resulted in the identification of previously undiagnosed thyroid disease. The authors hypothesize that a subset of idiopathic chronic urticaria and angioedema may be an autoimmune disease.</abstract><note type="content">Section title: Original article</note><subject><genre>Abbreviations</genre><topic>ICUA : Idiopathic chronic urticaria and angioedema</topic><topic>TA : Thyroid autoimmunity</topic><topic>TMA : Thyroid microsomal antibodies</topic><topic>TGA : Thyroglobulin antibodies</topic><topic>TSH : Thyroid-stimulating hormone</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Allergy and Clinical Immunology</title></titleInfo><titleInfo type="abbreviated"><title>YMAI</title></titleInfo><name type="conference"><namePart>Forty-sixth Annual Meeting, Baltimore Convention Center Baltimore, Md</namePart><namePart type="date">19900323</namePart><namePart type="date">19900328</namePart></name><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198907</dateIssued></originInfo><identifier type="ISSN">0091-6749</identifier><identifier type="PII">S0091-6749(00)X0309-0</identifier><part><date>198907</date><detail type="issue"><title>Forty-sixth Annual Meeting, Baltimore Convention Center Baltimore, Md</title></detail><detail type="volume"><number>84</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>A1</start><end>A46</end></extent><extent unit="issue pages"><start>A51</start><end>A58</end></extent><extent unit="issue pages"><start>A67</start><end>A74</end></extent><extent unit="issue pages"><start>A75</start><end>A76</end></extent><extent unit="issue pages"><start>1</start><end>132</end></extent><extent unit="pages"><start>66</start><end>71</end></extent></part></relatedItem><identifier type="istex">512F618B35734CE231FAEBFB23BE1DE84194ED03</identifier><identifier type="DOI">10.1016/0091-6749(89)90180-2</identifier><identifier type="PII">0091-6749(89)90180-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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