Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease
Identifieur interne : 001399 ( Istex/Corpus ); précédent : 001398; suivant : 001400Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease
Auteurs : Valérie Cochen De Cock ; Sophie Bayard ; Huan Yu ; Magda Grini ; Bertrand Carlander ; Ron Postuma ; Mahmoud Charif ; Yves DauvilliersSource :
- Movement Disorders [ 0885-3185 ] ; 2012-05.
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Abstract
Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD. © 2012 Movement Disorder Society
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DOI: 10.1002/mds.24969
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The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD. © 2012 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Valérie Cochen De Cock MD, PhD</name><affiliations><json:string>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>INSERM U1061, Montpellier, France</json:string></affiliations></json:item><json:item><name>Sophie Bayard PhD</name><affiliations><json:string>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>INSERM U1061, Montpellier, France</json:string></affiliations></json:item><json:item><name>Huan Yu MD, PhD</name><affiliations><json:string>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</json:string></affiliations></json:item><json:item><name>Magda Grini MD</name><affiliations><json:string>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string></affiliations></json:item><json:item><name>Bertrand Carlander MD</name><affiliations><json:string>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string></affiliations></json:item><json:item><name>Ron Postuma MD</name><affiliations><json:string>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Mahmoud Charif MD</name><affiliations><json:string>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string></affiliations></json:item><json:item><name>Yves Dauvilliers PD, PhD</name><affiliations><json:string>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</json:string><json:string>INSERM U1061, Montpellier, France</json:string><json:string>Unité des troubles du sommeil, service de neurologie, hôpital Gui de Chauliac, 80 av Augustin Fliche, 34235 Montpellier, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>suggested immobilization test</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>restless legs syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>periodic limb movements</value></json:item></subject><articleId><json:string>MDS24969</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. 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disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2012 Movement Disorder Society</p></availability><date>2012</date></publicationStmt><notesStmt><note>Full Financial Disclosures and Author Roles</note><note type="content">*Relevant conflicts of interest/financial disclosures: Yves Dauvilliers has received funds for speaking and board engagements with UCB pharma, Cephalon, Jazz, Novartis, and Bioprojet.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Valérie Cochen</forename><surname>De Cock</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>INSERM U1061, Montpellier, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Sophie</forename><surname>Bayard</surname></persName><roleName type="degree">PhD</roleName><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>INSERM U1061, Montpellier, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Huan</forename><surname>Yu</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</affiliation></author><author xml:id="author-4"><persName><forename type="first">Magda</forename><surname>Grini</surname></persName><roleName type="degree">MD</roleName><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Bertrand</forename><surname>Carlander</surname></persName><roleName type="degree">MD</roleName><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Ron</forename><surname>Postuma</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Ontario, 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This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD. © 2012 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>suggested immobilization test</term></item><item><term>Parkinson's disease</term></item><item><term>restless legs syndrome</term></item><item><term>periodic limb movements</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-10-11">Received</change><change when="2012-02-19">Registration</change><change when="2012-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/0D36CC0760082AC1DD29DA6DDD6FCE1BE8CEF795/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/mds.v27.6</doi><numberingGroup><numbering type="journalVolume" number="27">27</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2012-05">May 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="160" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.24969</doi><idGroup><id type="unit" value="MDS24969"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2012 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2011-10-11"></event><event type="manuscriptRevised" date="2012-02-01"></event><event type="manuscriptAccepted" date="2012-02-19"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.1.5 mode:FullText" date="2012-05-30"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-03-21"></event><event type="firstOnline" date="2012-03-21"></event><event type="publishedOnlineFinalForm" date="2012-05-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">743</numbering><numbering type="pageLast">749</numbering></numberingGroup><correspondenceTo>Unité des troubles du sommeil, service de neurologie, hôpital Gui de Chauliac, 80 av Augustin Fliche, 34235 Montpellier, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS24969.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="39"></count><count type="wordTotal" number="6028"></count></countGroup><titleGroup><title type="main" xml:lang="en">Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease<link href="#fn1"></link><link href="#fn2"></link></title><title type="short" xml:lang="en">SIT in RLS Plus PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Valérie Cochen</givenNames><familyName>De Cock</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Sophie</givenNames><familyName>Bayard</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Huan</givenNames><familyName>Yu</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Magda</givenNames><familyName>Grini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Bertrand</givenNames><familyName>Carlander</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Ron</givenNames><familyName>Postuma</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Mahmoud</givenNames><familyName>Charif</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Yves</givenNames><familyName>Dauvilliers</familyName><degrees>PD, PhD</degrees></personName><contactDetails><email>ydauvilliers@yahoo.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>INSERM U1061, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CN" type="organization"><unparsedAffiliation>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CA" type="organization"><unparsedAffiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Ontario, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">suggested immobilization test</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">restless legs syndrome</keyword><keyword xml:id="kwd4">periodic limb movements</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds24969:MDS_24969_sm_SuppInfo"></mediaResource><caption>Full Financial Disclosures and Author Roles</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD. © 2012 <i>Movement</i> Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures</b>: Yves Dauvilliers has received funds for speaking and board engagements with UCB pharma, Cephalon, Jazz, Novartis, and Bioprojet.</p></note><note xml:id="fn2"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SIT in RLS Plus PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Valérie Cochen</namePart><namePart type="family">De Cock</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>INSERM U1061, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sophie</namePart><namePart type="family">Bayard</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>INSERM U1061, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Huan</namePart><namePart type="family">Yu</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Magda</namePart><namePart type="family">Grini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bertrand</namePart><namePart type="family">Carlander</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ron</namePart><namePart type="family">Postuma</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mahmoud</namePart><namePart type="family">Charif</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Dauvilliers</namePart><namePart type="termsOfAddress">PD, PhD</namePart><affiliation>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France</affiliation><affiliation>INSERM U1061, Montpellier, France</affiliation><affiliation>Unité des troubles du sommeil, service de neurologie, hôpital Gui de Chauliac, 80 av Augustin Fliche, 34235 Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2012-05</dateIssued><dateCaptured encoding="w3cdtf">2011-10-11</dateCaptured><dateValid encoding="w3cdtf">2012-02-19</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">39</extent><extent unit="words">6028</extent></physicalDescription><abstract lang="en">Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD. © 2012 Movement Disorder Society</abstract><note type="additional physical form">Full Financial Disclosures and Author Roles</note><note type="content">*Relevant conflicts of interest/financial disclosures: Yves Dauvilliers has received funds for speaking and board engagements with UCB pharma, Cephalon, Jazz, Novartis, and Bioprojet.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>keywords</genre><topic>suggested immobilization test</topic><topic>Parkinson's disease</topic><topic>restless legs syndrome</topic><topic>periodic limb movements</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>743</start><end>749</end><total>7</total></extent></part></relatedItem><identifier type="istex">0D36CC0760082AC1DD29DA6DDD6FCE1BE8CEF795</identifier><identifier type="DOI">10.1002/mds.24969</identifier><identifier type="ArticleID">MDS24969</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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