The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout
Identifieur interne : 001390 ( Istex/Corpus ); précédent : 001389; suivant : 001391The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout
Auteurs : Judy Sparling ; Stephen SafeSource :
- Toxicology Letters [ 0378-4274 ] ; 1980.
Abstract
A mixture of 2,2',4,4',6,6'-, 2,2',4,4',5',6-, 2,2',4,4',5,5'-, 2',3,4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyls (HCBP) was administered by gastric lavage to rats, guinea pigs, rabbits, Japanese quail and trout, and the concentrations in the fat or whole carcass were determined after 29 days. The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of ortho chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 ortho chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 ortho chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) ortho chloro substituents.
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DOI: 10.1016/0378-4274(80)90080-6
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The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of ortho chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 ortho chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 ortho chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) ortho chloro substituents.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Judy Sparling</name><affiliations><json:string>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</json:string></affiliations></json:item><json:item><name>Stephen Safe</name><affiliations><json:string>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>AHH : aryl hydrocarbon hydroxylase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GC : gas chromatography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HCBP : hexachlorobiphenyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCB : polychlorinated biphenyl</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>A mixture of 2,2',4,4',6,6'-, 2,2',4,4',5',6-, 2,2',4,4',5,5'-, 2',3,4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyls (HCBP) was administered by gastric lavage to rats, guinea pigs, rabbits, Japanese quail and trout, and the concentrations in the fat or whole carcass were determined after 29 days. The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of ortho chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 ortho chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 ortho chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) ortho chloro substituents.</abstract><qualityIndicators><score>3.744</score><pdfWordCount>1620</pdfWordCount><pdfCharCount>10998</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>432 x 648 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>177</abstractWordCount><abstractCharCount>1171</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout</title><pii><json:string>0378-4274(80)90080-6</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Toxicology Letters</title><language><json:string>unknown</json:string></language><publicationDate>1980</publicationDate><issn><json:string>0378-4274</json:string></issn><pii><json:string>S0378-4274(00)X0140-3</json:string></pii><volume>7</volume><issue>1</issue><pages><first>23</first><last>28</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>toxicology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>toxicology</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1980</publicationDate><copyrightDate>1980</copyrightDate><doi><json:string>10.1016/0378-4274(80)90080-6</json:string></doi><id>70E9BECC31647316666DDB0D5017B6A207A16044</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/70E9BECC31647316666DDB0D5017B6A207A16044/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/70E9BECC31647316666DDB0D5017B6A207A16044/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/70E9BECC31647316666DDB0D5017B6A207A16044/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1980</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout</title><author xml:id="author-0000"><persName><forename type="first">Judy</forename><surname>Sparling</surname></persName><affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Stephen</forename><surname>Safe</surname></persName><affiliation>To whom correspondence should be addressed.</affiliation><affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</affiliation></author><idno type="istex">70E9BECC31647316666DDB0D5017B6A207A16044</idno><idno type="DOI">10.1016/0378-4274(80)90080-6</idno><idno type="PII">0378-4274(80)90080-6</idno></analytic><monogr><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="pISSN">0378-4274</idno><idno type="PII">S0378-4274(00)X0140-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="28">28</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1980</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A mixture of 2,2',4,4',6,6'-, 2,2',4,4',5',6-, 2,2',4,4',5,5'-, 2',3,4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyls (HCBP) was administered by gastric lavage to rats, guinea pigs, rabbits, Japanese quail and trout, and the concentrations in the fat or whole carcass were determined after 29 days. The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of ortho chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 ortho chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 ortho chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) ortho chloro substituents.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>AHH</term><term>aryl hydrocarbon hydroxylase</term></item><item><term>GC</term><term>gas chromatography</term></item><item><term>HCBP</term><term>hexachlorobiphenyl</term></item><item><term>PCB</term><term>polychlorinated biphenyl</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1980">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/70E9BECC31647316666DDB0D5017B6A207A16044/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TOXLET</jid><aid>80900806</aid><ce:pii>0378-4274(80)90080-6</ce:pii><ce:doi>10.1016/0378-4274(80)90080-6</ce:doi><ce:copyright type="unknown" year="1980"></ce:copyright></item-info><head><ce:title>The effects of <ce:italic>ortho</ce:italic> chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout</ce:title><ce:author-group><ce:author><ce:given-name>Judy</ce:given-name><ce:surname>Sparling</ce:surname></ce:author><ce:author><ce:given-name>Stephen</ce:given-name><ce:surname>Safe</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="9" month="5" year="1980"></ce:date-received><ce:date-accepted day="3" month="6" year="1980"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>A mixture of 2,2',4,4',6,6'-, 2,2',4,4',5',6-, 2,2',4,4',5,5'-, 2',3,4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyls (HCBP) was administered by gastric lavage to rats, guinea pigs, rabbits, Japanese quail and trout, and the concentrations in the fat or whole carcass were determined after 29 days. The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of <ce:italic>ortho</ce:italic> chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 <ce:italic>ortho</ce:italic> chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 <ce:italic>ortho</ce:italic> chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) <ce:italic>ortho</ce:italic> chloro substituents.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>AHH</ce:text><ce:keyword><ce:text>aryl hydrocarbon hydroxylase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>GC</ce:text><ce:keyword><ce:text>gas chromatography</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>HCBP</ce:text><ce:keyword><ce:text>hexachlorobiphenyl</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PCB</ce:text><ce:keyword><ce:text>polychlorinated biphenyl</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, japanese quail, guinea pig and trout</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The effects of</title></titleInfo><name type="personal"><namePart type="given">Judy</namePart><namePart type="family">Sparling</namePart><affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen</namePart><namePart type="family">Safe</namePart><affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry,Environmental Biochemistry Unit, University of Guelph, Guelph, Ont., N1G 2W1 Canada</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1980</dateIssued><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">A mixture of 2,2',4,4',6,6'-, 2,2',4,4',5',6-, 2,2',4,4',5,5'-, 2',3,4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyls (HCBP) was administered by gastric lavage to rats, guinea pigs, rabbits, Japanese quail and trout, and the concentrations in the fat or whole carcass were determined after 29 days. The total HCBP levels in rat, rabbit and guinea pig fatty tissue were 8.27, 6.84 and 4.74 ppm, respectively: whereas 3.02 and 2.15 ppm of the HCBPs were detected in the trout and Japanese quail carcasses. The extent of ortho chloro substitution markedly affected the levels of the individual HCBP isomers retained in the test animals; the rabbit and guinea pig preferentially retained the HCBPs with 0,1 and 2 ortho chloro substituents, the Japanese quail retained only the 3,3',4,4',5,5'-HCBP isomer, whereas no striking preferences in HCBP isomer retention in the rat and trout were observed. The marked differences in the retention of HCBP isomers with 0, 1, 2, 3 and 4 ortho chloro substitution by different animal species should be considered in chronic toxicity studies since the most toxic polychlorinated biphenyls have minimal (1 or 0) ortho chloro substituents.</abstract><subject><genre>Abbreviations</genre><topic>AHH : aryl hydrocarbon hydroxylase</topic><topic>GC : gas chromatography</topic><topic>HCBP : hexachlorobiphenyl</topic><topic>PCB : polychlorinated biphenyl</topic></subject><relatedItem type="host"><titleInfo><title>Toxicology Letters</title></titleInfo><titleInfo type="abbreviated"><title>TOXLET</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198011</dateIssued></originInfo><identifier type="ISSN">0378-4274</identifier><identifier type="PII">S0378-4274(00)X0140-3</identifier><part><date>198011</date><detail type="volume"><number>7</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>95</end></extent><extent unit="pages"><start>23</start><end>28</end></extent></part></relatedItem><identifier type="istex">70E9BECC31647316666DDB0D5017B6A207A16044</identifier><identifier type="DOI">10.1016/0378-4274(80)90080-6</identifier><identifier type="PII">0378-4274(80)90080-6</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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