Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren
Identifieur interne : 001315 ( Istex/Corpus ); précédent : 001314; suivant : 001316Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren
Auteurs : Michael Cordes ; Michael Snow ; Sandra Cooper ; Michael Schulzer ; Brian D. Pate ; Thomas J. Ruth ; Donald B. CalneSource :
- Annals of Neurology [ 0364-5134 ] ; 1994-10.
Abstract
Despite postmortem evidence for an age‐related decline in nigrostriatal dopaminergic function, positron emission tomography (PET) studies have produced inconsistent results. This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐L‐[18F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (Ki) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean Ki was significantly lower in grandparents (p = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.
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DOI: 10.1002/ana.410360420
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This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐L‐[18F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (Ki) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean Ki was significantly lower in grandparents (p = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Michael Cordes</name><affiliations><json:string>Strahlenklinik und Poliklinik, Universitatsklinikum Rudolf Virchow, Freie Universitat Berlin, Berlin, Germany</json:string></affiliations></json:item><json:item><name>Dr. Snow</name><affiliations><json:string>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</json:string><json:string>Neurodegenerative Disorders Centre, University Hospital, UBC Site, 2211 Wesbrook Mall, Vancouver, Canada V6T 2B5</json:string></affiliations></json:item><json:item><name>Sandra Cooper</name><affiliations><json:string>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Michael Schulzer</name><affiliations><json:string>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Brian D. 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xml:id="author-6"><persName><forename type="first">Thomas J.</forename><surname>Ruth</surname></persName><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author><author xml:id="author-7"><persName><forename type="first">Donald B.</forename><surname>Calne</surname></persName><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date 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xml:lang="en">Effect of Age on Dopaminergic Function</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael</givenNames><familyName>Cordes</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Barry J.</givenNames><familyName>Snow</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Sandra</givenNames><familyName>Cooper</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Michael</givenNames><familyName>Schulzer</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Brian D.</givenNames><familyName>Pate</familyName></personName></creator><creator xml:id="au6" creatorRole="author" 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This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐<sc>L</sc>‐[<sup>18</sup>F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (<i>K</i><sub><i>i</i></sub>) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean <i>K</i><sub><i>i</i></sub> was significantly lower in grandparents (<i>p</i> = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effect of Age on Dopaminergic Function</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Age‐dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren</title></titleInfo><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Cordes</namePart><affiliation>Strahlenklinik und Poliklinik, Universitatsklinikum Rudolf Virchow, Freie Universitat Berlin, Berlin, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Snow</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><affiliation>Neurodegenerative Disorders Centre, University Hospital, UBC Site, 2211 Wesbrook Mall, Vancouver, Canada V6T 2B5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandra</namePart><namePart type="family">Cooper</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Schulzer</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brian D.</namePart><namePart type="family">Pate</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas J.</namePart><namePart type="family">Ruth</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald B.</namePart><namePart type="family">Calne</namePart><affiliation>Neurodegenerative Disorders Centre and TRIUMF, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1994-10</dateIssued><dateCaptured encoding="w3cdtf">1993-03-29</dateCaptured><dateValid encoding="w3cdtf">1994-04-14</dateValid><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">16</extent></physicalDescription><abstract lang="en">Despite postmortem evidence for an age‐related decline in nigrostriatal dopaminergic function, positron emission tomography (PET) studies have produced inconsistent results. This may be due to differences inmethods or of subject selection. To investigate further the effect of age on dopaminergic function, we performed PET with 6‐L‐[18F]fluorodopa (FD) on 12 pairs of grandchildren and their grandparents. The FD uptake rate constant (Ki) was calculated using a graphical method for the whole striatum to avoid confounding of the results by striatal atrophy. The mean Ki was significantly lower in grandparents (p = 0.020). These PET observations represent in vivo confirmation of postmortem evidence that nigrostriatal dopaminergic function declines with aging.</abstract><relatedItem type="host"><titleInfo><title>Annals of Neurology</title><subTitle>Official Journal of the American Neurological Association and the Child Neurology Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Brief Communication</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>667</start><end>670</end><total>4</total></extent></part></relatedItem><identifier type="istex">C135B33E4F48657C19BE604DF19A551ECBC860AC</identifier><identifier type="DOI">10.1002/ana.410360420</identifier><identifier type="ArticleID">ANA410360420</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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