In vivo measurement of T2 distributions and water contents in normal human brain
Identifieur interne : 001205 ( Istex/Corpus ); précédent : 001204; suivant : 001206In vivo measurement of T2 distributions and water contents in normal human brain
Auteurs : Kenneth P. Whittall ; Alex L. Mackay ; Douglas A. Graeb ; Robert A. Nugent ; David K. B. Li ; Donald W. PatySource :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 1997-01.
English descriptors
Abstract
Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short T2 components reliable markers for normal myelin.
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DOI: 10.1002/mrm.1910370107
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ISTEX:A70033F804DF3A734733C2194820886A5C27A6B2Le document en format XML
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The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short T2 components reliable markers for normal myelin.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Kenneth P Whittall Ph.D.</name><affiliations><json:string>Departments of Radiology, University of British Columbia, Vancouver, Canada</json:string><json:string>Radiology Research Rm M153, Vancouver Hospital and Health Sciences Centre, UBC Pavilions, 2211 Wesbrook Mall, Vancouver, Canada V6T 285===</json:string></affiliations></json:item><json:item><name>Alex L. Mackay</name><affiliations><json:string>Departments of Radiology, University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>Douglas A. Graeb</name><affiliations><json:string>Departments of Radiology, University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>Robert A. 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Reson. Med.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mrm.v37:1</doi><numberingGroup><numbering type="journalVolume" number="37">37</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1997-01">January 1997</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mrm.1910370107</doi><idGroup><id type="unit" value="MRM1910370107"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Full Paper</title><title type="tocHeading1">Full Papers</title></titleGroup><copyright ownership="publisher">Copyright © 1997 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptReceived" date="1995-11-30"></event><event type="firstOnline" date="2005-12-12"></event><event type="publishedOnlineFinalForm" date="2005-12-12"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">34</numbering><numbering type="pageLast">43</numbering></numberingGroup><correspondenceTo>Radiology Research Rm M153, Vancouver Hospital and Health Sciences Centre, UBC Pavilions, 2211 Wesbrook Mall, Vancouver, Canada V6T 285===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MRM.MRM1910370107.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="9"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="57"></count></countGroup><titleGroup><title type="main" xml:lang="en"><i>In vivo</i> measurement of <i>T</i><sub>2</sub> distributions and water contents in normal human brain</title><title type="short" xml:lang="en"><fi>In Vivo</fi> Measurement of <fi>T</fi><sub>2</sub> Distributions and Water Contents in Normal Human Brain</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Kenneth P</givenNames><familyName>Whittall</familyName><degrees>Ph.D.</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alex L.</givenNames><familyName>Mackay</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Douglas A.</givenNames><familyName>Graeb</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Robert A.</givenNames><familyName>Nugent</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>David K. B.</givenNames><familyName>Li</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Donald W.</givenNames><familyName>Paty</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>Departments of Medicine, University of British Columbia, Vancouver, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><i>T<sub>2</sub></i> relaxation</keyword><keyword xml:id="kwd2">brain white and gray matter</keyword><keyword xml:id="kwd3">water content</keyword><keyword xml:id="kwd4">myelin content</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Using a 32‐echo imaging pulse sequence, T<sub>2</sub> relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T<sub>2</sub> between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T<sub>2</sub> of the main peak for both white and gray matter was from 70 to 86 ms. <i>T</i><sub><i>2</i></sub> distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of <i>T</i><sub><i>2</i></sub> relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short <i>T</i><sub><i>2</i></sub> components reliable markers for normal myelin.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>In vivo measurement of T2 distributions and water contents in normal human brain</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>In Vivo Measurement of T2 Distributions and Water Contents in Normal Human Brain</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>In vivo measurement of T2 distributions and water contents in normal human brain</title></titleInfo><name type="personal"><namePart type="given">Kenneth P</namePart><namePart type="family">Whittall</namePart><namePart type="termsOfAddress">Ph.D.</namePart><affiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</affiliation><affiliation>Radiology Research Rm M153, Vancouver Hospital and Health Sciences Centre, UBC Pavilions, 2211 Wesbrook Mall, Vancouver, Canada V6T 285===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alex L.</namePart><namePart type="family">Mackay</namePart><affiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Douglas A.</namePart><namePart type="family">Graeb</namePart><affiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert A.</namePart><namePart type="family">Nugent</namePart><affiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David K. B.</namePart><namePart type="family">Li</namePart><affiliation>Departments of Radiology, University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald W.</namePart><namePart type="family">Paty</namePart><affiliation>Departments of Medicine, University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Baltimore</placeTerm></place><dateIssued encoding="w3cdtf">1997-01</dateIssued><dateCaptured encoding="w3cdtf">1995-11-30</dateCaptured><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">9</extent><extent unit="tables">3</extent><extent unit="references">57</extent></physicalDescription><abstract lang="en">Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short T2 components reliable markers for normal myelin.</abstract><subject lang="en"><genre>keywords</genre><topic>T2 relaxation</topic><topic>brain white and gray matter</topic><topic>water content</topic><topic>myelin content</topic></subject><relatedItem type="host"><titleInfo><title>Magnetic Resonance in Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Magn. Reson. Med.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Full Paper</topic></subject><identifier type="ISSN">0740-3194</identifier><identifier type="eISSN">1522-2594</identifier><identifier type="DOI">10.1002/(ISSN)1522-2594</identifier><identifier type="PublisherID">MRM</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>34</start><end>43</end><total>10</total></extent></part></relatedItem><identifier type="istex">A70033F804DF3A734733C2194820886A5C27A6B2</identifier><identifier type="DOI">10.1002/mrm.1910370107</identifier><identifier type="ArticleID">MRM1910370107</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1997 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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