Changes in spontaneous behavior in the dog following oral administration of L-deprenyl
Identifieur interne : 001203 ( Istex/Corpus ); précédent : 001202; suivant : 001204Changes in spontaneous behavior in the dog following oral administration of L-deprenyl
Auteurs : E. Head ; N. W. MilgramSource :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1992.
Abstract
An open-field activity test was developed for studying the effect of a single oral dose (range of 0.1–5 mg/kg) of L-deprenyl on spontaneous behavior in the dog. A computer program was used to quantify observations of locomotor activity, directed sniffing, urination, grooming, inactivity, jumping, rearing, and vocalization during a 10-min baseline and posttreatment session. Three dose-dependent behavioral changes were observed: an overall decrease in directed sniffing, an increase in total locomotor activity in females, and a decrease in frequency of urination in males. These effects were only seen at the dose levels of 2 mg/kg or higher. Computer-assisted tracings of behavioral patterns showed increased stereotypical behavior and decreased exploratory behavior at the high-dose levels. These behavioral effects are most likely due to either increased levels of phenylethylamine resulting from inhibition of monoamine oxidase B and/or production of amphetamines as a result of the metabolism of L-deprenyl.
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DOI: 10.1016/0091-3057(92)90404-4
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A computer program was used to quantify observations of locomotor activity, directed sniffing, urination, grooming, inactivity, jumping, rearing, and vocalization during a 10-min baseline and posttreatment session. Three dose-dependent behavioral changes were observed: an overall decrease in directed sniffing, an increase in total locomotor activity in females, and a decrease in frequency of urination in males. These effects were only seen at the dose levels of 2 mg/kg or higher. Computer-assisted tracings of behavioral patterns showed increased stereotypical behavior and decreased exploratory behavior at the high-dose levels. 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A computer program was used to quantify observations of locomotor activity, directed sniffing, urination, grooming, inactivity, jumping, rearing, and vocalization during a 10-min baseline and posttreatment session. Three dose-dependent behavioral changes were observed: an overall decrease in directed sniffing, an increase in total locomotor activity in females, and a decrease in frequency of urination in males. These effects were only seen at the dose levels of 2 mg/kg or higher. Computer-assisted tracings of behavioral patterns showed increased stereotypical behavior and decreased exploratory behavior at the high-dose levels. These behavioral effects are most likely due to either increased levels of phenylethylamine resulting from inhibition of monoamine oxidase B and/or production of amphetamines as a result of the metabolism of <ce:small-caps>L</ce:small-caps>-deprenyl.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text><ce:small-caps>L</ce:small-caps>-Deprenyl</ce:text></ce:keyword><ce:keyword><ce:text>Dog</ce:text></ce:keyword><ce:keyword><ce:text>Spontaneous activity</ce:text></ce:keyword><ce:keyword><ce:text>Phenylethylamine</ce:text></ce:keyword><ce:keyword><ce:text>Amphetamine</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Changes in spontaneous behavior in the dog following oral administration of L-deprenyl</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Changes in spontaneous behavior in the dog following oral administration of L-deprenyl</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Head</namePart><affiliation>Life Sciences Division, Scarborough Campus, University of Toronto, 1265 Military Trail Road, Scarborough, Ontario, Canada M1C 1A5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.W.</namePart><namePart type="family">Milgram</namePart><affiliation>Life Sciences Division, Scarborough Campus, University of Toronto, 1265 Military Trail Road, Scarborough, Ontario, Canada M1C 1A5</affiliation><description>To whom requests for reprints should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">An open-field activity test was developed for studying the effect of a single oral dose (range of 0.1–5 mg/kg) of L-deprenyl on spontaneous behavior in the dog. A computer program was used to quantify observations of locomotor activity, directed sniffing, urination, grooming, inactivity, jumping, rearing, and vocalization during a 10-min baseline and posttreatment session. Three dose-dependent behavioral changes were observed: an overall decrease in directed sniffing, an increase in total locomotor activity in females, and a decrease in frequency of urination in males. These effects were only seen at the dose levels of 2 mg/kg or higher. Computer-assisted tracings of behavioral patterns showed increased stereotypical behavior and decreased exploratory behavior at the high-dose levels. These behavioral effects are most likely due to either increased levels of phenylethylamine resulting from inhibition of monoamine oxidase B and/or production of amphetamines as a result of the metabolism of L-deprenyl.</abstract><subject><genre>Keywords</genre><topic>L-Deprenyl</topic><topic>Dog</topic><topic>Spontaneous activity</topic><topic>Phenylethylamine</topic><topic>Amphetamine</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology, Biochemistry and Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PBB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199211</dateIssued></originInfo><identifier type="ISSN">0091-3057</identifier><identifier type="PII">S0091-3057(00)X0287-0</identifier><part><date>199211</date><detail type="volume"><number>43</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>661</start><end>977</end></extent><extent unit="pages"><start>749</start><end>757</end></extent></part></relatedItem><identifier type="istex">E117B5074DFFD3A79D45EF923CA0CEDFC9554BB3</identifier><identifier type="DOI">10.1016/0091-3057(92)90404-4</identifier><identifier type="PII">0091-3057(92)90404-4</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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