The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Identifieur interne : 001200 ( Istex/Corpus ); précédent : 001199; suivant : 001201The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Auteurs : Angela Stewart ; Barbara Collins ; Joyce Mackenzie ; Eva Tomiak ; Shailendra Verma ; Catherine BielajewSource :
- Psycho‐Oncology [ 1057-9249 ] ; 2008-02.
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Abstract
Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.
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DOI: 10.1002/pon.1210
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Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. 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Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. 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early stage breast cancer: a prospective study<link href="#fn1"></link></title><title type="short" xml:lang="en">Cognitive function following chemotherapy for early stage breast cancer</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Angela</givenNames><familyName>Stewart</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Barbara</givenNames><familyName>Collins</familyName></personName><contactDetails><email>bcollins@ottawahospital.on.ca</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Joyce</givenNames><familyName>Mackenzie</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Eva</givenNames><familyName>Tomiak</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Shailendra</givenNames><familyName>Verma</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Catherine</givenNames><familyName>Bielajew</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>School of Psychology, University of Ottawa, Ottawa, Ont., Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>The Ottawa Hospital, Civic Campus, Ottawa, Ont., Canada</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CA" type="organization"><unparsedAffiliation>Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ont., Canada</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>The Ottawa Hospital Regional Cancer Centre, Ottawa, Ont., Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">breast cancer</keyword><keyword xml:id="kwd2">oncology</keyword><keyword xml:id="kwd3">adjuvant chemotherapy</keyword><keyword xml:id="kwd4">cognitive function</keyword><keyword xml:id="kwd5">adjuvant hormonal treatment</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><i>Purpose</i>: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients.</p><p><i>Patients and methods</i>: Breast cancer patients scheduled to receive adjuvant chemotherapy (<i>n</i> = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (<i>n</i> = 51) was tested at comparable intervals.</p><p><i>Results</i>: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy.</p><p><i>Conclusion</i>: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>A portion of the baseline data was presented in poster format at the American Neuropsychiatric Association Annual Conference in 2003.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognitive function following chemotherapy for early stage breast cancer</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study</title></titleInfo><name type="personal"><namePart type="given">Angela</namePart><namePart type="family">Stewart</namePart><affiliation>School of Psychology, University of Ottawa, Ottawa, Ont., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Collins</namePart><affiliation>The Ottawa Hospital, Civic Campus, Ottawa, Ont., Canada</affiliation><affiliation>The Ottawa Hospital, Civic Campus, 1053 Carling Ave, Room A603, Ottawa, Ont., Canada K1Y 4E9</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joyce</namePart><namePart type="family">Mackenzie</namePart><affiliation>The Ottawa Hospital, Civic Campus, Ottawa, Ont., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eva</namePart><namePart type="family">Tomiak</namePart><affiliation>Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ont., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shailendra</namePart><namePart type="family">Verma</namePart><affiliation>The Ottawa Hospital Regional Cancer Centre, Ottawa, Ont., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Bielajew</namePart><affiliation>School of Psychology, University of Ottawa, Ottawa, Ont., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-02</dateIssued><dateCaptured encoding="w3cdtf">2006-08-04</dateCaptured><dateValid encoding="w3cdtf">2007-03-07</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">53</extent></physicalDescription><abstract lang="en">Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><note type="content">*A portion of the baseline data was presented in poster format at the American Neuropsychiatric Association Annual Conference in 2003.</note><subject lang="en"><genre>keywords</genre><topic>breast cancer</topic><topic>oncology</topic><topic>adjuvant chemotherapy</topic><topic>cognitive function</topic><topic>adjuvant hormonal treatment</topic></subject><relatedItem type="host"><titleInfo><title>Psycho‐Oncology</title><subTitle>Journal of the Psychological, Social and Behavioral Dimensions of Cancer</subTitle></titleInfo><titleInfo type="abbreviated"><title>Psycho‐Oncology</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Paper</topic></subject><identifier type="ISSN">1057-9249</identifier><identifier type="eISSN">1099-1611</identifier><identifier type="DOI">10.1002/(ISSN)1099-1611</identifier><identifier type="PublisherID">PON</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>122</start><end>130</end><total>9</total></extent></part></relatedItem><identifier type="istex">EC7A36E1EC464149EF55AF24DD86EAC3DB1E293B</identifier><identifier type="DOI">10.1002/pon.1210</identifier><identifier type="ArticleID">PON1210</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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