The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Identifieur interne : 001200 ( Istex/Corpus ); précédent : 001199; suivant : 001201The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Auteurs : Angela Stewart ; Barbara Collins ; Joyce Mackenzie ; Eva Tomiak ; Shailendra Verma ; Catherine BielajewSource :
- Psycho‐Oncology [ 1057-9249 ] ; 2008-02.
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- KwdEn :
Abstract
Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.
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DOI: 10.1002/pon.1210
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<front><div type="abstract" xml:lang="en">Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</div>
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<titleGroup><title type="main" xml:lang="en">The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study<link href="#fn1"></link>
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<title type="short" xml:lang="en">Cognitive function following chemotherapy for early stage breast cancer</title>
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<creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Angela</givenNames>
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<creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Joyce</givenNames>
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<creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Shailendra</givenNames>
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<creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Catherine</givenNames>
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<affiliation xml:id="af3" countryCode="CA" type="organization"><unparsedAffiliation>Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ont., Canada</unparsedAffiliation>
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<keyword xml:id="kwd5">adjuvant hormonal treatment</keyword>
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<p><i>Purpose</i>
: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients.</p>
<p><i>Patients and methods</i>
: Breast cancer patients scheduled to receive adjuvant chemotherapy (<i>n</i>
= 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (<i>n</i>
= 51) was tested at comparable intervals.</p>
<p><i>Results</i>
: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy.</p>
<p><i>Conclusion</i>
: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</p>
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<noteGroup><note xml:id="fn1"><p>A portion of the baseline data was presented in poster format at the American Neuropsychiatric Association Annual Conference in 2003.</p>
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<name type="personal"><namePart type="given">Angela</namePart>
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<affiliation>The Ottawa Hospital, Civic Campus, Ottawa, Ont., Canada</affiliation>
<affiliation>The Ottawa Hospital, Civic Campus, 1053 Carling Ave, Room A603, Ottawa, Ont., Canada K1Y 4E9</affiliation>
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<name type="personal"><namePart type="given">Eva</namePart>
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<affiliation>Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ont., Canada</affiliation>
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<name type="personal"><namePart type="given">Shailendra</namePart>
<namePart type="family">Verma</namePart>
<affiliation>The Ottawa Hospital Regional Cancer Centre, Ottawa, Ont., Canada</affiliation>
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<name type="personal"><namePart type="given">Catherine</namePart>
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<abstract lang="en">Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</abstract>
<note type="content">*A portion of the baseline data was presented in poster format at the American Neuropsychiatric Association Annual Conference in 2003.</note>
<subject lang="en"><genre>keywords</genre>
<topic>breast cancer</topic>
<topic>oncology</topic>
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<topic>cognitive function</topic>
<topic>adjuvant hormonal treatment</topic>
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