The Value of Positron Emission Tomography in the Clinical Evaluation of Dementia
Identifieur interne : 001198 ( Istex/Corpus ); précédent : 001197; suivant : 001199The Value of Positron Emission Tomography in the Clinical Evaluation of Dementia
Auteurs : Sudeep S. Gill ; Paula A. Rochon ; Mark Guttman ; Andreas LaupacisSource :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2003-02.
English descriptors
Abstract
Positron emission tomography (PET) has been promoted as a means of improving the diagnosis of Alzheimer's disease (AD), but the evidence to support its incremental value is unclear. To assess the evidence regarding the use of PET in the clinical evaluation of AD, a systematic review of the English‐language literature indexed in MEDLINE (1975–January 2001), the Cochrane Library (issue 4, 2000), and health technology assessment (HTA) reports was conducted. Articles identified by this review process were graded for methodological and reporting quality using a standardized grading scheme. Sixteen original articles and seven HTA reports were identified. In general, the articles addressed: using PET to differentiate AD from normal aging or non‐Alzheimer's dementias, PET imaging compared with single positron emission computed tomography imaging, using PET to predict the progression of dementia, and agreement and reliability in the interpretation of PET images. Serious problems with study design and methodology in all articles were identified. Previous HTA reports have generally recommended that PET not be used in the clinical evaluation of dementia. In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered.
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DOI: 10.1046/j.1532-5415.2003.51067.x
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ISTEX:5AB0A6DAF19EB09262E91B65EF9FCEF2DB17B13DLe document en format XML
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To assess the evidence regarding the use of PET in the clinical evaluation of AD, a systematic review of the English‐language literature indexed in MEDLINE (1975–January 2001), the Cochrane Library (issue 4, 2000), and health technology assessment (HTA) reports was conducted. Articles identified by this review process were graded for methodological and reporting quality using a standardized grading scheme. Sixteen original articles and seven HTA reports were identified. In general, the articles addressed: using PET to differentiate AD from normal aging or non‐Alzheimer's dementias, PET imaging compared with single positron emission computed tomography imaging, using PET to predict the progression of dementia, and agreement and reliability in the interpretation of PET images. Serious problems with study design and methodology in all articles were identified. Previous HTA reports have generally recommended that PET not be used in the clinical evaluation of dementia. In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sudeep S. Gill MD, FRCPC</name><affiliations><json:string>Kunin‐Lunenfeld Applied Research Unit, Baycrest Center forGeriatric Care, Toronto, Canada;</json:string></affiliations></json:item><json:item><name>Paula A. 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In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. 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and</affiliation><affiliation>Center forAddiction and Mental Health, Toronto, Canada.</affiliation></author><author xml:id="author-4"><persName><forename type="first">Andreas</forename><surname>Laupacis</surname></persName><roleName type="degree">MD, MSc, FRCPC</roleName><affiliation>Institute for Clinical Evaluative Sciences,</affiliation><affiliation>Department of Medicine,</affiliation></author></analytic><monogr><title level="j">Journal of the American Geriatrics Society</title><title level="j" type="abbrev">Journal of the American Geriatrics Society</title><idno type="pISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><idno type="DOI">10.1111/(ISSN)1532-5415</idno><imprint><publisher>Blackwell Science Inc</publisher><pubPlace>Boston, MA, USA</pubPlace><date type="published" when="2003-02"></date><biblScope unit="volume">51</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="258">258</biblScope><biblScope unit="page" to="264">264</biblScope></imprint></monogr><idno type="istex">5AB0A6DAF19EB09262E91B65EF9FCEF2DB17B13D</idno><idno type="DOI">10.1046/j.1532-5415.2003.51067.x</idno><idno type="ArticleID">jgs51067</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Positron emission tomography (PET) has been promoted as a means of improving the diagnosis of Alzheimer's disease (AD), but the evidence to support its incremental value is unclear. To assess the evidence regarding the use of PET in the clinical evaluation of AD, a systematic review of the English‐language literature indexed in MEDLINE (1975–January 2001), the Cochrane Library (issue 4, 2000), and health technology assessment (HTA) reports was conducted. Articles identified by this review process were graded for methodological and reporting quality using a standardized grading scheme. Sixteen original articles and seven HTA reports were identified. In general, the articles addressed: using PET to differentiate AD from normal aging or non‐Alzheimer's dementias, PET imaging compared with single positron emission computed tomography imaging, using PET to predict the progression of dementia, and agreement and reliability in the interpretation of PET images. Serious problems with study design and methodology in all articles were identified. Previous HTA reports have generally recommended that PET not be used in the clinical evaluation of dementia. In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Alzheimer's disease</term></item><item><term>dementia</term></item><item><term>positron emission tomography</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2003-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/5AB0A6DAF19EB09262E91B65EF9FCEF2DB17B13D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Inc</publisherName><publisherLoc>Boston, MA, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1532-5415</doi><issn type="print">0002-8614</issn><issn type="electronic">1532-5415</issn><idGroup><id type="product" value="JGS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF AMERICAN GERIATRICS SOCIETY">Journal of the American Geriatrics Society</title><title type="short">Journal of the American Geriatrics Society</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/jgs.2003.51.issue-2</doi><numberingGroup><numbering type="journalVolume" number="51">51</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2003-02">February 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0025800" status="forIssue"><doi origin="wiley">10.1046/j.1532-5415.2003.51067.x</doi><idGroup><id type="supplier" value="jgs51067"></id><id type="unit" value="JGS51067"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Progress in Geriatrics</title></titleGroup><eventGroup><event type="firstOnline" date="2003-01-31"></event><event type="publishedOnlineFinalForm" date="2003-01-31"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="258">258</numbering><numbering type="pageLast" number="264">264</numbering></numberingGroup><correspondenceTo>Address correspondence to Dr. Sudeep S. Gill, Baycrest Center for Geriatric Care, 3560 Bathurst Street, Room 714 Posluns Building, Toronto, ON, M6A 2E1, Canada. E‐mail: <email normalForm="gill_sudeep@hotmail.com">gill_sudeep@hotmail.com</email></correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendices</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:JGS.JGS51067.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="5748"></count><count type="linksPubMed" number="19"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">The Value of Positron Emission Tomography in the Clinical Evaluation of Dementia</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Sudeep S.</givenNames><familyName>Gill</familyName><degrees>MD, FRCPC</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2 #a3 #a4"><personName><givenNames>Paula A.</givenNames><familyName>Rochon</familyName><degrees>MD, MPH, FRCPC</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3 #a5 #a6 #a7"><personName><givenNames>Mark</givenNames><familyName>Guttman</familyName><degrees>MD, FRCPC</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2 #a3"><personName><givenNames>Andreas</givenNames><familyName>Laupacis</familyName><degrees>MD, MSc, FRCPC</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="CA"><unparsedAffiliation> Kunin‐Lunenfeld Applied Research Unit, Baycrest Center for
Geriatric Care, Toronto, Canada;</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Institute for Clinical Evaluative Sciences,</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Medicine,</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Public Health Sciences,</unparsedAffiliation></affiliation><affiliation xml:id="a5"><unparsedAffiliation>Division of Neurology, and</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="CA"><unparsedAffiliation>Department of Psychiatry, National Parkinson Foundation Center of Excellence, University of Toronto, Toronto, Canada; and</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="CA"><unparsedAffiliation> Center for
Addiction and Mental Health, Toronto, Canada.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Alzheimer's disease</keyword><keyword xml:id="k2">dementia</keyword><keyword xml:id="k3">positron emission tomography</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- J Am Geriatr Soc 51:258–264, 2003. --><p>Positron emission tomography (PET) has been promoted as a means of improving the diagnosis of Alzheimer's disease (AD), but the evidence to support its incremental value is unclear. To assess the evidence regarding the use of PET in the clinical evaluation of AD, a systematic review of the English‐language literature indexed in MEDLINE (1975–January 2001), the Cochrane Library (issue 4, 2000), and health technology assessment (HTA) reports was conducted. Articles identified by this review process were graded for methodological and reporting quality using a standardized grading scheme. Sixteen original articles and seven HTA reports were identified. In general, the articles addressed: using PET to differentiate AD from normal aging or non‐Alzheimer's dementias, PET imaging compared with single positron emission computed tomography imaging, using PET to predict the progression of dementia, and agreement and reliability in the interpretation of PET images. Serious problems with study design and methodology in all articles were identified. Previous HTA reports have generally recommended that PET not be used in the clinical evaluation of dementia. In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The Value of Positron Emission Tomography in the Clinical Evaluation of Dementia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The Value of Positron Emission Tomography in the Clinical Evaluation of Dementia</title></titleInfo><name type="personal"><namePart type="given">Sudeep S.</namePart><namePart type="family">Gill</namePart><namePart type="termsOfAddress">MD, FRCPC</namePart><affiliation>Kunin‐Lunenfeld Applied Research Unit, Baycrest Center forGeriatric Care, Toronto, Canada;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paula A.</namePart><namePart type="family">Rochon</namePart><namePart type="termsOfAddress">MD, MPH, FRCPC</namePart><affiliation>Kunin‐Lunenfeld Applied Research Unit, Baycrest Center forGeriatric Care, Toronto, Canada;</affiliation><affiliation>Institute for Clinical Evaluative Sciences,</affiliation><affiliation>Department of Medicine,</affiliation><affiliation>Public Health Sciences,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark</namePart><namePart type="family">Guttman</namePart><namePart type="termsOfAddress">MD, FRCPC</namePart><affiliation>Department of Medicine,</affiliation><affiliation>Division of Neurology, and</affiliation><affiliation>Department of Psychiatry, National Parkinson Foundation Center of Excellence, University of Toronto, Toronto, Canada; and</affiliation><affiliation>Center forAddiction and Mental Health, Toronto, Canada.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Laupacis</namePart><namePart type="termsOfAddress">MD, MSc, FRCPC</namePart><affiliation>Institute for Clinical Evaluative Sciences,</affiliation><affiliation>Department of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science Inc</publisher><place><placeTerm type="text">Boston, MA, USA</placeTerm></place><dateIssued encoding="w3cdtf">2003-02</dateIssued><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">31</extent><extent unit="words">5748</extent></physicalDescription><abstract lang="en">Positron emission tomography (PET) has been promoted as a means of improving the diagnosis of Alzheimer's disease (AD), but the evidence to support its incremental value is unclear. To assess the evidence regarding the use of PET in the clinical evaluation of AD, a systematic review of the English‐language literature indexed in MEDLINE (1975–January 2001), the Cochrane Library (issue 4, 2000), and health technology assessment (HTA) reports was conducted. Articles identified by this review process were graded for methodological and reporting quality using a standardized grading scheme. Sixteen original articles and seven HTA reports were identified. In general, the articles addressed: using PET to differentiate AD from normal aging or non‐Alzheimer's dementias, PET imaging compared with single positron emission computed tomography imaging, using PET to predict the progression of dementia, and agreement and reliability in the interpretation of PET images. Serious problems with study design and methodology in all articles were identified. Previous HTA reports have generally recommended that PET not be used in the clinical evaluation of dementia. In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered.</abstract><subject lang="en"><genre>keywords</genre><topic>Alzheimer's disease</topic><topic>dementia</topic><topic>positron emission tomography</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the American Geriatrics Society</title></titleInfo><titleInfo type="abbreviated"><title>Journal of the American Geriatrics Society</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0002-8614</identifier><identifier type="eISSN">1532-5415</identifier><identifier type="DOI">10.1111/(ISSN)1532-5415</identifier><identifier type="PublisherID">JGS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>258</start><end>264</end><total>7</total></extent></part></relatedItem><identifier type="istex">5AB0A6DAF19EB09262E91B65EF9FCEF2DB17B13D</identifier><identifier type="DOI">10.1046/j.1532-5415.2003.51067.x</identifier><identifier type="ArticleID">jgs51067</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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