The role of the Lewy body in idiopathic Parkinsonism
Identifieur interne : 000F87 ( Istex/Corpus ); précédent : 000F86; suivant : 000F88The role of the Lewy body in idiopathic Parkinsonism
Auteurs : R. De La Fuente-Fernandez ; M. Schulzer ; E. Mak ; A. Kishore ; D. B CalneSource :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1998.
Abstract
We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.
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DOI: 10.1016/S1353-8020(98)00016-9
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The role of the Lewy body in idiopathic Parkinsonism</title><author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R" last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M" last="Schulzer">M. Schulzer</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E" last="Mak">E. Mak</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Kishore, A" sort="Kishore, A" uniqKey="Kishore A" first="A" last="Kishore">A. Kishore</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B" last="Calne">D. B Calne</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:37A896AF767D9035B01F8BCB7A46F4E830F2AC03</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S1353-8020(98)00016-9</idno><idno type="url">https://api-v5.istex.fr/document/37A896AF767D9035B01F8BCB7A46F4E830F2AC03/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000F87</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The role of the Lewy body in idiopathic Parkinsonism</title><author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R" last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M" last="Schulzer">M. Schulzer</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E" last="Mak">E. Mak</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Kishore, A" sort="Kishore, A" uniqKey="Kishore A" first="A" last="Kishore">A. Kishore</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B" last="Calne">D. B Calne</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="77">77</biblScope></imprint><idno type="ISSN">1353-8020</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>R de la Fuente-Fernandez</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</json:string></affiliations></json:item><json:item><name>M Schulzer</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</json:string></affiliations></json:item><json:item><name>E Mak</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</json:string></affiliations></json:item><json:item><name>A Kishore</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</json:string></affiliations></json:item><json:item><name>D.B Calne</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Lewy bodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Idiopathic Parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Modelled incidence rates</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.</abstract><qualityIndicators><score>5.31</score><pdfWordCount>2850</pdfWordCount><pdfCharCount>16508</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>596 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>205</abstractWordCount><abstractCharCount>1269</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>The role of the Lewy body in idiopathic Parkinsonism</title><pii><json:string>S1353-8020(98)00016-9</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Parkinsonism and Related Disorders</title><language><json:string>unknown</json:string></language><publicationDate>1998</publicationDate><issn><json:string>1353-8020</json:string></issn><pii><json:string>S1353-8020(00)X0011-9</json:string></pii><volume>4</volume><issue>2</issue><pages><first>73</first><last>77</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S1353-8020(98)00016-9</json:string></doi><id>37A896AF767D9035B01F8BCB7A46F4E830F2AC03</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/37A896AF767D9035B01F8BCB7A46F4E830F2AC03/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/37A896AF767D9035B01F8BCB7A46F4E830F2AC03/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/37A896AF767D9035B01F8BCB7A46F4E830F2AC03/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">The role of the Lewy body in idiopathic Parkinsonism</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1998 Elsevier Science Ltd</p></availability><date>1998</date></publicationStmt><notesStmt><note type="content">Fig. 1: Age-specific annual incidence rates of IP. I: reported epidemiological results; II: predicted incidence rates under Hypothesis A; III: predicted incidence rates under Hypothesis B.</note><note type="content">Fig. 2: Three hypothetical models for the pathogenesis of IP.</note><note type="content">Table 1: Observed prevalence of ILBS at different ages</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">The role of the Lewy body in idiopathic Parkinsonism</title><author xml:id="author-0000"><persName><forename type="first">R</forename><surname>de la Fuente-Fernandez</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation></author><author xml:id="author-0001"><persName><forename type="first">M</forename><surname>Schulzer</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation></author><author xml:id="author-0002"><persName><forename type="first">E</forename><surname>Mak</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation></author><author xml:id="author-0003"><persName><forename type="first">A</forename><surname>Kishore</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation></author><author xml:id="author-0004"><persName><forename type="first">D.B</forename><surname>Calne</surname></persName><note type="correspondence"><p>Corresponding author. Tel.: +1-604-822-7967; fax: +1-604-822-7866</p></note><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation></author><idno type="istex">37A896AF767D9035B01F8BCB7A46F4E830F2AC03</idno><idno type="DOI">10.1016/S1353-8020(98)00016-9</idno><idno type="PII">S1353-8020(98)00016-9</idno></analytic><monogr><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="pISSN">1353-8020</idno><idno type="PII">S1353-8020(00)X0011-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="77">77</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Lewy bodies</term></item><item><term>Idiopathic Parkinsonism</term></item><item><term>Modelled incidence rates</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/37A896AF767D9035B01F8BCB7A46F4E830F2AC03/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PRD</jid><aid>119</aid><ce:pii>S1353-8020(98)00016-9</ce:pii><ce:doi>10.1016/S1353-8020(98)00016-9</ce:doi><ce:copyright year="1998" type="full-transfer">Elsevier Science Ltd</ce:copyright></item-info><head><ce:title>The role of the Lewy body in idiopathic Parkinsonism</ce:title><ce:author-group><ce:author><ce:given-name>R</ce:given-name><ce:surname>de la Fuente-Fernandez</ce:surname></ce:author><ce:author><ce:given-name>M</ce:given-name><ce:surname>Schulzer</ce:surname></ce:author><ce:author><ce:given-name>E</ce:given-name><ce:surname>Mak</ce:surname></ce:author><ce:author><ce:given-name>A</ce:given-name><ce:surname>Kishore</ce:surname></ce:author><ce:author><ce:given-name>D.B</ce:given-name><ce:surname>Calne</ce:surname><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +1-604-822-7967; fax: +1-604-822-7866</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Lewy bodies</ce:text></ce:keyword><ce:keyword><ce:text>Idiopathic Parkinsonism</ce:text></ce:keyword><ce:keyword><ce:text>Modelled incidence rates</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The role of the Lewy body in idiopathic Parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The role of the Lewy body in idiopathic Parkinsonism</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">de la Fuente-Fernandez</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schulzer</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mak</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kishore</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.B</namePart><namePart type="family">Calne</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5</affiliation><description>Corresponding author. Tel.: +1-604-822-7967; fax: +1-604-822-7866</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We have explored the role of Lewy bodies in idiopathic Parkinsonism (IP) to determine whether they are linked to cell death, or to a reactive and protective process associated with cell survival. We start with a definition of IP that is not dependent upon the presence of Lewy bodies. We have derived a mathematical model that predicts the age-specific annual incidence rates of IP under the assumption that the disorder arises from the `Incidental Lewy Body State' (ILBS). We have compared these predicted rates with the corresponding rates expected from our model assuming that IP develops in normal subjects. Both of these predictions were then matched against the observed age-specific incidence rates for IP. The predicted rates based upon the premise that ILBS is linked to IP yielded a far closer fit to the observed data. Our analysis indicates that ILBS is sufficient to account for all cases of IP. Our findings further suggest that ILBS may also predispose to other neurodegenerative disorders that are characterized by neuronal loss and the presence of Lewy bodies in various regions of the brain. Finally, we conclude that Lewy bodies are likely to be associated with neuronal death, rather than representing a reactive, protective response to cell damage.</abstract><note type="content">Fig. 1: Age-specific annual incidence rates of IP. I: reported epidemiological results; II: predicted incidence rates under Hypothesis A; III: predicted incidence rates under Hypothesis B.</note><note type="content">Fig. 2: Three hypothetical models for the pathogenesis of IP.</note><note type="content">Table 1: Observed prevalence of ILBS at different ages</note><subject><genre>Keywords</genre><topic>Lewy bodies</topic><topic>Idiopathic Parkinsonism</topic><topic>Modelled incidence rates</topic></subject><relatedItem type="host"><titleInfo><title>Parkinsonism and Related Disorders</title></titleInfo><titleInfo type="abbreviated"><title>PRD</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199808</dateIssued></originInfo><identifier type="ISSN">1353-8020</identifier><identifier type="PII">S1353-8020(00)X0011-9</identifier><part><date>199808</date><detail type="volume"><number>4</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>51</start><end>106</end></extent><extent unit="pages"><start>73</start><end>77</end></extent></part></relatedItem><identifier type="istex">37A896AF767D9035B01F8BCB7A46F4E830F2AC03</identifier><identifier type="DOI">10.1016/S1353-8020(98)00016-9</identifier><identifier type="PII">S1353-8020(98)00016-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 Elsevier Science Ltd</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Ltd, ©1998</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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