In vivo magnetic resonance spectroscopy of brain and muscle in a type of mitochondrial encephalomyopathy (MERRF)
Identifieur interne : 000F07 ( Istex/Corpus ); précédent : 000F06; suivant : 000F08In vivo magnetic resonance spectroscopy of brain and muscle in a type of mitochondrial encephalomyopathy (MERRF)
Auteurs : P. M. Matthews ; S. F. Berkovic ; E. A. Shoubridge ; F. Andermann ; G. Karpati ; S. Carpenter ; S. ArnoldSource :
- Annals of Neurology [ 0364-5134 ] ; 1991-04.
Abstract
Phosphorus magnetic resonance spectroscopy allows noninvasive measurement of the intracellular phosphate‐containing metabolites and intracellular pH in localized volumes of human muscle and brain in vivo. This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (p < 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (p < 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. In contrast to results from muscle, however, the relative phosphate metabolite concentrations and intracellular pH in central volumes of the brains of these patients were normal, despite evidence from our previous positron emission tomography studies suggesting that there is diffuse impairment of cerebral oxidative metabolism.
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DOI: 10.1002/ana.410290416
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This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (p < 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (p < 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. In contrast to results from muscle, however, the relative phosphate metabolite concentrations and intracellular pH in central volumes of the brains of these patients were normal, despite evidence from our previous positron emission tomography studies suggesting that there is diffuse impairment of cerebral oxidative metabolism.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>P. M. Matthews MD, DPhil</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>S. F. Berkovic MD, FRACP</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>E. A. Shoubridge PhD</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>F. Andermann MD, FRCP(C)</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>G. Karpati MD, FRCP(C)</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>S. Carpenter MD</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string></affiliations></json:item><json:item><name>Dr Arnold MD, FRCP(C)</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Canada</json:string><json:string>Montreal Neurological Institute, McGill University, 3801 University St, Montreal, PQ, H3A‐2B4 Canada</json:string></affiliations></json:item></author><articleId><json:string>ANA410290416</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>shortCommunication</json:string></originalGenre><abstract>Phosphorus magnetic resonance spectroscopy allows noninvasive measurement of the intracellular phosphate‐containing metabolites and intracellular pH in localized volumes of human muscle and brain in vivo. This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). 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This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (p < 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (p < 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. 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L.</givenNames><familyName>Arnold</familyName><degrees>MD, FRCP(C)</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Phosphorus magnetic resonance spectroscopy allows noninvasive measurement of the intracellular phosphate‐containing metabolites and intracellular pH in localized volumes of human muscle and brain in vivo. This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (<i>p</i> < 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (<i>p</i> < 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. In contrast to results from muscle, however, the relative phosphate metabolite concentrations and intracellular pH in central volumes of the brains of these patients were normal, despite evidence from our previous positron emission tomography studies suggesting that there is diffuse impairment of cerebral oxidative metabolism.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>In vivo magnetic resonance spectroscopy of brain and muscle in a type of mitochondrial encephalomyopathy (MERRF)</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>In Vivo MRS in MERRF</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>In vivo magnetic resonance spectroscopy of brain and muscle in a type of mitochondrial encephalomyopathy (MERRF)</title></titleInfo><name type="personal"><namePart type="given">P. 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A.</namePart><namePart type="family">Shoubridge</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Andermann</namePart><namePart type="termsOfAddress">MD, FRCP(C)</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Karpati</namePart><namePart type="termsOfAddress">MD, FRCP(C)</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Carpenter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr</namePart><namePart type="family">Arnold</namePart><namePart type="termsOfAddress">MD, FRCP(C)</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Canada</affiliation><affiliation>Montreal Neurological Institute, McGill University, 3801 University St, Montreal, PQ, H3A‐2B4 Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1991-04</dateIssued><dateCaptured encoding="w3cdtf">1990-06-08</dateCaptured><dateValid encoding="w3cdtf">1990-09-30</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">15</extent></physicalDescription><abstract lang="en">Phosphorus magnetic resonance spectroscopy allows noninvasive measurement of the intracellular phosphate‐containing metabolites and intracellular pH in localized volumes of human muscle and brain in vivo. This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (p < 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (p < 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. In contrast to results from muscle, however, the relative phosphate metabolite concentrations and intracellular pH in central volumes of the brains of these patients were normal, despite evidence from our previous positron emission tomography studies suggesting that there is diffuse impairment of cerebral oxidative metabolism.</abstract><relatedItem type="host"><titleInfo><title>Annals of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Brief Communication</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>435</start><end>438</end><total>4</total></extent></part></relatedItem><identifier type="istex">08AB0A671039B4423A6751A6B74CE5FCD201AD7F</identifier><identifier type="DOI">10.1002/ana.410290416</identifier><identifier type="ArticleID">ANA410290416</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1991 American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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