Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
Identifieur interne : 000C24 ( Istex/Corpus ); précédent : 000C23; suivant : 000C25Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
Auteurs : Lili-Naz Hazrati ; Janice C. Wong ; Clement Hamani ; Andres M. Lozano ; Yu-Yan Poon ; Jonathan O. Dostrovsky ; William D. Hutchison ; Cindy Zadikoff ; Elena MoroSource :
- Movement Disorders [ 0885-3185 ] ; 2012-09-01.
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Abstract
Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).
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DOI: 10.1002/mds.25123
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ISTEX:4E08527694FC366880CD1CAD9EDD13BE1A6D9720Le document en format XML
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Hutchison</name><affiliation><mods:affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation><mods:affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Northwestern University, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-09-01">2012-09-01</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1304">1304</biblScope><biblScope unit="page" to="1307">1307</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4E08527694FC366880CD1CAD9EDD13BE1A6D9720</idno><idno type="DOI">10.1002/mds.25123</idno><idno type="ArticleID">MDS25123</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>deep brain stimulation</term><term>neuropathology</term><term>pedunculopontine nucleus</term><term>progressive supranuclear palsy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lili‐Naz Hazrati MD, PhD, FRCPC</name><affiliations><json:string>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Tanz Center for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, 6 Queen's Park Crescent West, Toronto, Ontario, M5S 3H2</json:string></affiliations></json:item><json:item><name>Janice C. Wong MD</name><affiliations><json:string>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Clement Hamani MD, PhD</name><affiliations><json:string>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Andres M. Lozano MD, PhD</name><affiliations><json:string>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Yu‐Yan Poon RN</name><affiliations><json:string>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Jonathan O. Dostrovsky PhD</name><affiliations><json:string>Department of Physiology, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>William D. Hutchison PhD</name><affiliations><json:string>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Cindy Zadikoff MD</name><affiliations><json:string>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Department of Neurology, Northwestern University, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Elena Moro MD, PhD</name><affiliations><json:string>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pedunculopontine nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item></subject><articleId><json:string>MDS25123</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>3.755</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>294</abstractCharCount><pdfWordCount>2775</pdfWordCount><pdfCharCount>18755</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>40</abstractWordCount></qualityIndicators><title>Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation</title><genre><json:string>article</json:string></genre><host><title>Movement Disorders</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi><issn><json:string>0885-3185</json:string></issn><eissn><json:string>1531-8257</json:string></eissn><publisherId><json:string>MDS</json:string></publisherId><volume>27</volume><issue>10</issue><pages><first>1304</first><last>1307</last><total>4</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Brief Report</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1002/mds.25123</json:string></doi><id>4E08527694FC366880CD1CAD9EDD13BE1A6D9720</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/4E08527694FC366880CD1CAD9EDD13BE1A6D9720/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/4E08527694FC366880CD1CAD9EDD13BE1A6D9720/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/4E08527694FC366880CD1CAD9EDD13BE1A6D9720/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2012 Movement Disorder Society</p></availability><date>2012</date></publicationStmt><notesStmt><note type="content">*Funding agencies: CurePSP funded the trial of unilateral PPN‐DBS in PSP patients. The work was supported, in part, by the Canadian Institutes of Health Research (grants to J.O.D. and W.D.H.; grant nos.: MOP‐42505 and 98006).</note><note type="content">*Relevant conflict of interest/financial disclosures: Dr. Hamani is a consultant for St Jude Medical; Dr. Lozano is a consultant for St Jude Medical, Boston Scientific and Medtronic Inc. and holds intellectual property in the field of Deep Brain Stimulation; Dr. Hutchison has received consulting fee or honoraria from Medtronic Inc; Dr. Zadikoff has received payment for lectures from Tera and GSK; Dr. Moro has received honoraria from Medtronic Inc. for consulting services and lecturing, research support from St. Jude Medical, CurePSP, CIHR and educational grant support from Medtronic.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation</title><author xml:id="author-1"><persName><forename type="first">Lili‐Naz</forename><surname>Hazrati</surname></persName><roleName type="degree">MD, PhD, FRCPC</roleName><affiliation>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Tanz Center for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, 6 Queen's Park Crescent West, Toronto, Ontario, M5S 3H2</affiliation></author><author xml:id="author-2"><persName><forename type="first">Janice C.</forename><surname>Wong</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-3"><persName><forename type="first">Clement</forename><surname>Hamani</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-4"><persName><forename type="first">Andres M.</forename><surname>Lozano</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-5"><persName><forename type="first">Yu‐Yan</forename><surname>Poon</surname></persName><roleName type="degree">RN</roleName><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-6"><persName><forename type="first">Jonathan O.</forename><surname>Dostrovsky</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Physiology, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-7"><persName><forename type="first">William D.</forename><surname>Hutchison</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-8"><persName><forename type="first">Cindy</forename><surname>Zadikoff</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Department of Neurology, Northwestern University, Chicago, Illinois, USA</affiliation></author><author xml:id="author-9"><persName><forename type="first">Elena</forename><surname>Moro</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-09-01"></date><biblScope unit="volume">27</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1304">1304</biblScope><biblScope unit="page" to="1307">1307</biblScope></imprint></monogr><idno type="istex">4E08527694FC366880CD1CAD9EDD13BE1A6D9720</idno><idno type="DOI">10.1002/mds.25123</idno><idno type="ArticleID">MDS25123</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).</p></abstract><abstract><p>Two patients with PSP underwent unilateral PPN‐DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location.</p></abstract><abstract><p>Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN.</p></abstract><abstract><p>We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes. © 2012 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>deep brain stimulation</term></item><item><term>neuropathology</term></item><item><term>pedunculopontine nucleus</term></item><item><term>progressive supranuclear palsy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-03-15">Received</change><change when="2012-06-28">Registration</change><change when="2012-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/4E08527694FC366880CD1CAD9EDD13BE1A6D9720/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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C.</givenNames><familyName>Wong</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Clement</givenNames><familyName>Hamani</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Andres M.</givenNames><familyName>Lozano</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Yu‐Yan</givenNames><familyName>Poon</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Jonathan O.</givenNames><familyName>Dostrovsky</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>William D.</givenNames><familyName>Hutchison</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3 #af5"><personName><givenNames>Cindy</givenNames><familyName>Zadikoff</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Elena</givenNames><familyName>Moro</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CA" type="organization"><unparsedAffiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>Department of Physiology, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Northwestern University, Chicago, Illinois, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">deep brain stimulation</keyword><keyword xml:id="kwd2">neuropathology</keyword><keyword xml:id="kwd3">pedunculopontine nucleus</keyword><keyword xml:id="kwd4">progressive supranuclear palsy</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Two patients with PSP underwent unilateral PPN‐DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes. © 2012 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Funding agencies</b>: CurePSP funded the trial of unilateral PPN‐DBS in PSP patients. The work was supported, in part, by the Canadian Institutes of Health Research (grants to J.O.D. and W.D.H.; grant nos.: MOP‐42505 and 98006).</p></note><note xml:id="fn2"><p><b>Relevant conflict of interest/financial disclosures</b>: Dr. Hamani is a consultant for St Jude Medical; Dr. Lozano is a consultant for St Jude Medical, Boston Scientific and Medtronic Inc. and holds intellectual property in the field of Deep Brain Stimulation; Dr. Hutchison has received consulting fee or honoraria from Medtronic Inc; Dr. Zadikoff has received payment for lectures from Tera and GSK; Dr. Moro has received honoraria from Medtronic Inc. for consulting services and lecturing, research support from St. Jude Medical, CurePSP, CIHR and educational grant support from Medtronic.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pathology of PPN‐DBS in PSP</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation</title></titleInfo><name type="personal"><namePart type="given">Lili‐Naz</namePart><namePart type="family">Hazrati</namePart><namePart type="termsOfAddress">MD, PhD, FRCPC</namePart><affiliation>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Tanz Center for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, 6 Queen's Park Crescent West, Toronto, Ontario, M5S 3H2</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Janice C.</namePart><namePart type="family">Wong</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clement</namePart><namePart type="family">Hamani</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu‐Yan</namePart><namePart type="family">Poon</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan O.</namePart><namePart type="family">Dostrovsky</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Physiology, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William D.</namePart><namePart type="family">Hutchison</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Neurosurgery, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cindy</namePart><namePart type="family">Zadikoff</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Department of Neurology, Northwestern University, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Center, University of Toronto, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2012-09-01</dateIssued><dateCaptured encoding="w3cdtf">2012-03-15</dateCaptured><dateValid encoding="w3cdtf">2012-06-28</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">25</extent><extent unit="words">3698</extent></physicalDescription><abstract>Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).</abstract><abstract>Two patients with PSP underwent unilateral PPN‐DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location.</abstract><abstract>Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN.</abstract><abstract>We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes. © 2012 Movement Disorder Society</abstract><note type="content">*Funding agencies: CurePSP funded the trial of unilateral PPN‐DBS in PSP patients. The work was supported, in part, by the Canadian Institutes of Health Research (grants to J.O.D. and W.D.H.; grant nos.: MOP‐42505 and 98006).</note><note type="content">*Relevant conflict of interest/financial disclosures: Dr. Hamani is a consultant for St Jude Medical; Dr. Lozano is a consultant for St Jude Medical, Boston Scientific and Medtronic Inc. and holds intellectual property in the field of Deep Brain Stimulation; Dr. Hutchison has received consulting fee or honoraria from Medtronic Inc; Dr. Zadikoff has received payment for lectures from Tera and GSK; Dr. Moro has received honoraria from Medtronic Inc. for consulting services and lecturing, research support from St. Jude Medical, CurePSP, CIHR and educational grant support from Medtronic.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>keywords</genre><topic>deep brain stimulation</topic><topic>neuropathology</topic><topic>pedunculopontine nucleus</topic><topic>progressive supranuclear palsy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1304</start><end>1307</end><total>4</total></extent></part></relatedItem><identifier type="istex">4E08527694FC366880CD1CAD9EDD13BE1A6D9720</identifier><identifier type="DOI">10.1002/mds.25123</identifier><identifier type="ArticleID">MDS25123</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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