Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules
Identifieur interne : 000B51 ( Istex/Corpus ); précédent : 000B50; suivant : 000B52Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules
Auteurs : John Parkinson ; Yves Brechet ; Richard GordonSource :
- BBA - Molecular Cell Research [ 0167-4889 ] ; 1999.
Abstract
Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.
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DOI: 10.1016/S0167-4889(99)00116-0
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation><mods:affiliation>E-mail: john.parkinson@chem.ed.ac.uk</mods:affiliation></affiliation><affiliation><mods:affiliation>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</mods:affiliation></affiliation></author><author><name sortKey="Brechet, Yves" sort="Brechet, Yves" uniqKey="Brechet Y" first="Yves" last="Brechet">Yves Brechet</name><affiliation><mods:affiliation>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Gordon, Richard" sort="Gordon, Richard" uniqKey="Gordon R" first="Richard" last="Gordon">Richard Gordon</name><affiliation><mods:affiliation>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6291C5847CB7B26CCD2A7447CE57E68436BFF948</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0167-4889(99)00116-0</idno><idno type="url">https://api-v5.istex.fr/document/6291C5847CB7B26CCD2A7447CE57E68436BFF948/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B51</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation><mods:affiliation>E-mail: john.parkinson@chem.ed.ac.uk</mods:affiliation></affiliation><affiliation><mods:affiliation>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</mods:affiliation></affiliation></author><author><name sortKey="Brechet, Yves" sort="Brechet, Yves" uniqKey="Brechet Y" first="Yves" last="Brechet">Yves Brechet</name><affiliation><mods:affiliation>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Gordon, Richard" sort="Gordon, Richard" uniqKey="Gordon R" first="Richard" last="Gordon">Richard Gordon</name><affiliation><mods:affiliation>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">BBA - Molecular Cell Research</title><title level="j" type="abbrev">BBAMCR</title><idno type="ISSN">0167-4889</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">1452</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="89">89</biblScope><biblScope unit="page" to="102">102</biblScope></imprint><idno type="ISSN">0167-4889</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-4889</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>John Parkinson</name><affiliations><json:string>E-mail: john.parkinson@chem.ed.ac.uk</json:string><json:string>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</json:string></affiliations></json:item><json:item><name>Yves Brechet</name><affiliations><json:string>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</json:string></affiliations></json:item><json:item><name>Richard Gordon</name><affiliations><json:string>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Diatom</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Morphogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Diffusion-limited aggregation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Computer simulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Microtubule</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SDV, silica deposition vesicle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>STV, silica transport vesicle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DLA, diffusion-limited aggregation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>K, a tunable parameter used to represent surface tension</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>T, a tunable parameter relating to temperature</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>X, a tunable parameter used to represent surface mobility</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rmax, distance of the furthest point of the growing aggregate from its centre</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.</abstract><qualityIndicators><score>7.064</score><pdfWordCount>6093</pdfWordCount><pdfCharCount>35203</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>14</pdfPageCount><pdfPageSize>596 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>172</abstractWordCount><abstractCharCount>1159</abstractCharCount><keywordCount>12</keywordCount></qualityIndicators><title>Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title><pii><json:string>S0167-4889(99)00116-0</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>BBA - Molecular Cell Research</title><language><json:string>unknown</json:string></language><publicationDate>1999</publicationDate><issn><json:string>0167-4889</json:string></issn><pii><json:string>S0167-4889(00)X0064-X</json:string></pii><volume>1452</volume><issue>1</issue><pages><first>89</first><last>102</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>cell biology</json:string><json:string>biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>biochemistry & molecular biology</json:string></scienceMetrix></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0167-4889(99)00116-0</json:string></doi><id>6291C5847CB7B26CCD2A7447CE57E68436BFF948</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/6291C5847CB7B26CCD2A7447CE57E68436BFF948/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/6291C5847CB7B26CCD2A7447CE57E68436BFF948/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/6291C5847CB7B26CCD2A7447CE57E68436BFF948/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1999 Elsevier Science B.V.</p></availability><date>1999</date></publicationStmt><notesStmt><note type="content">Fig. 1: Typical DLA aggregate consisting of 50 000 particles. Particles are placed on a circular release template of radius Rmax+100 (where Rmax is the distance of the furthest point of the growing aggregate from its centre) and diffuse until they hit the growing structure, whereupon they adhere.</note><note type="content">Fig. 2: Morphology maps of aggregates grown using different values of surface tension (K) and temperature (T) factors. The three maps show the effect of growth under conditions of altered surface mobility. (A) X=0.01; (B) X=1.0; (C) X=100. Aggregates consisted of 10 000 particles and were grown using a value of 100 for L. Blank spaces indicate that the clusters would not form (see text).</note><note type="content">Fig. 3: Typical centric diatom morphologies. (a) Cyclotella cryptica (Tafel 738 upper left from [29], with permission, bar=1 μm); (b) Cyclotella pseudostelligea (Tafel 740 upper left from [29], with permission, bar=1 μm); (c) Cyclotella comta (Tafel 23 bottom right from [30], with permission, bar=1 μm); (d) Stepahnodiscus astraea (Tafel 315 bottom left from [31], with permission, bar=1 μm); (e) Cyclotella meneghiniana (Tafel 213 bottom left from [32], with permission, bar=10 μm); (f) Cyclotella striata (Tafel 118 top left from [33], with permission, bar=1 μm); (g) Cyclotella pseudostelligea, with ‘atypical centre’ (Tafel 741 upper right from [29], with permission, bar=1 μm).</note><note type="content">Fig. 4: Morphology maps of aggregates grown using 24 specific sites of release for the particles using a range of different values for the surface tension (K) and temperature (T) factors. (A) X=0.01; (B) X=1.0. The release sites were equally spaced around the release template throughout the simulation. New particles were placed at random on one of these sites. Aggregates consist of 50 000 particles.</note><note type="content">Fig. 5: Morphology maps of aggregates investigating the influence of the amount of movement of the sites of release (Y) and the minimum distance separating two neighbouring sites of release (Z). (A) 24 sites of release: 50 000 particles. (B) 48 sites of release: 100 000 particles. Aggregates were grown with K=20, T=1.43 and L=1.0.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title><author xml:id="author-0000"><persName><forename type="first">John</forename><surname>Parkinson</surname></persName><email>john.parkinson@chem.ed.ac.uk</email><note type="correspondence"><p>Corresponding author</p></note><affiliation>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Yves</forename><surname>Brechet</surname></persName><affiliation>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Richard</forename><surname>Gordon</surname></persName><affiliation>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</affiliation></author><idno type="istex">6291C5847CB7B26CCD2A7447CE57E68436BFF948</idno><idno type="DOI">10.1016/S0167-4889(99)00116-0</idno><idno type="PII">S0167-4889(99)00116-0</idno></analytic><monogr><title level="j">BBA - Molecular Cell Research</title><title level="j" type="abbrev">BBAMCR</title><idno type="pISSN">0167-4889</idno><idno type="PII">S0167-4889(00)X0064-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">1452</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="89">89</biblScope><biblScope unit="page" to="102">102</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Diatom</term></item><item><term>Morphogenesis</term></item><item><term>Diffusion-limited aggregation</term></item><item><term>Computer simulation</term></item><item><term>Microtubule</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>SDV, silica deposition vesicle</term></item><item><term>STV, silica transport vesicle</term></item><item><term>DLA, diffusion-limited aggregation</term></item><item><term>K, a tunable parameter used to represent surface tension</term></item><item><term>T, a tunable parameter relating to temperature</term></item><item><term>X, a tunable parameter used to represent surface mobility</term></item><item><term>Rmax, distance of the furthest point of the growing aggregate from its centre</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-08-02">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/6291C5847CB7B26CCD2A7447CE57E68436BFF948/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr2ab" NDATA="IMAGE" name="gr2ab"></istex:entity><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="gr3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="gr4"></istex:entity><istex:entity SYSTEM="gr5" NDATA="IMAGE" name="gr5"></istex:entity><istex:entity SYSTEM="gr2c" NDATA="IMAGE" name="gr2c"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BBAMCR</jid><aid>14541</aid><ce:pii>S0167-4889(99)00116-0</ce:pii><ce:doi>10.1016/S0167-4889(99)00116-0</ce:doi><ce:copyright type="full-transfer" year="1999">Elsevier Science B.V.</ce:copyright></item-info><head><ce:title>Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</ce:title><ce:author-group><ce:author><ce:given-name>John</ce:given-name><ce:surname>Parkinson</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>john.parkinson@chem.ed.ac.uk</ce:e-address></ce:author><ce:author><ce:given-name>Yves</ce:given-name><ce:surname>Brechet</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Richard</ce:given-name><ce:surname>Gordon</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author</ce:text></ce:correspondence></ce:author-group><ce:date-received day="18" month="5" year="1999"></ce:date-received><ce:date-revised day="2" month="8" year="1999"></ce:date-revised><ce:date-accepted day="16" month="8" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Diatom</ce:text></ce:keyword><ce:keyword><ce:text>Morphogenesis</ce:text></ce:keyword><ce:keyword><ce:text>Diffusion-limited aggregation</ce:text></ce:keyword><ce:keyword><ce:text>Computer simulation</ce:text></ce:keyword><ce:keyword><ce:text>Microtubule</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>SDV, silica deposition vesicle</ce:text></ce:keyword><ce:keyword><ce:text>STV, silica transport vesicle</ce:text></ce:keyword><ce:keyword><ce:text>DLA, diffusion-limited aggregation</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>K</ce:italic>, a tunable parameter used to represent surface tension</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>T</ce:italic>, a tunable parameter relating to temperature</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>X</ce:italic>, a tunable parameter used to represent surface mobility</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>R</ce:italic><ce:inf>max</ce:inf>, distance of the furthest point of the growing aggregate from its centre</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Centric diatom morphogenesis: a model based on a DLA algorithm investigating the potential role of microtubules</title></titleInfo><name type="personal"><namePart type="given">John</namePart><namePart type="family">Parkinson</namePart><affiliation>E-mail: john.parkinson@chem.ed.ac.uk</affiliation><affiliation>Edinburgh centre for Protein Technology, Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, UK</affiliation><description>Corresponding author</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Brechet</namePart><affiliation>Laboratoire de Thermodynamique et Physico-Chimie Metallurgiques, ENSEEG, 1130 Rue de la Piscine, Domaine Universitaire, BP 75, 38402 Saint-Martin-D’Heres Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Gordon</namePart><affiliation>Department of Radiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Man., Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateModified encoding="w3cdtf">1999-08-02</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Diatoms are single-celled algae which possess characteristic rigid cell walls (frustules) composed of amorphous silica. Frustule formation occurs within a specialised organelle termed the silica deposition vesicle (SDV). During diatom morphogenesis, silica particles are transported to the SDV by silica transport vesicles. Once released within the SDV, the particles are then thought to diffuse until they encounter part of the growing aggregate upon which they adhere. The particles may then undergo a further period of surface relocalisation (sintering) which leads to a smoothing of the surface. A number of computer simulations based on a modified diffusion-limited aggregation (DLA) algorithm, have been undertaken to investigate the potential role of microtubules (which are known to be associated with the periphery of the SDV) in localising deposition of new siliceous material. Based on our findings, we present a new model of diatom morphogenesis which is able to account for many morphological features of diatoms including the influence of environmental effects such as changes in pH and salinity, and the formation of a regular branched pattern.</abstract><note type="content">Fig. 1: Typical DLA aggregate consisting of 50 000 particles. Particles are placed on a circular release template of radius Rmax+100 (where Rmax is the distance of the furthest point of the growing aggregate from its centre) and diffuse until they hit the growing structure, whereupon they adhere.</note><note type="content">Fig. 2: Morphology maps of aggregates grown using different values of surface tension (K) and temperature (T) factors. The three maps show the effect of growth under conditions of altered surface mobility. (A) X=0.01; (B) X=1.0; (C) X=100. Aggregates consisted of 10 000 particles and were grown using a value of 100 for L. Blank spaces indicate that the clusters would not form (see text).</note><note type="content">Fig. 3: Typical centric diatom morphologies. (a) Cyclotella cryptica (Tafel 738 upper left from [29], with permission, bar=1 μm); (b) Cyclotella pseudostelligea (Tafel 740 upper left from [29], with permission, bar=1 μm); (c) Cyclotella comta (Tafel 23 bottom right from [30], with permission, bar=1 μm); (d) Stepahnodiscus astraea (Tafel 315 bottom left from [31], with permission, bar=1 μm); (e) Cyclotella meneghiniana (Tafel 213 bottom left from [32], with permission, bar=10 μm); (f) Cyclotella striata (Tafel 118 top left from [33], with permission, bar=1 μm); (g) Cyclotella pseudostelligea, with ‘atypical centre’ (Tafel 741 upper right from [29], with permission, bar=1 μm).</note><note type="content">Fig. 4: Morphology maps of aggregates grown using 24 specific sites of release for the particles using a range of different values for the surface tension (K) and temperature (T) factors. (A) X=0.01; (B) X=1.0. The release sites were equally spaced around the release template throughout the simulation. New particles were placed at random on one of these sites. Aggregates consist of 50 000 particles.</note><note type="content">Fig. 5: Morphology maps of aggregates investigating the influence of the amount of movement of the sites of release (Y) and the minimum distance separating two neighbouring sites of release (Z). (A) 24 sites of release: 50 000 particles. (B) 48 sites of release: 100 000 particles. Aggregates were grown with K=20, T=1.43 and L=1.0.</note><subject><genre>Keywords</genre><topic>Diatom</topic><topic>Morphogenesis</topic><topic>Diffusion-limited aggregation</topic><topic>Computer simulation</topic><topic>Microtubule</topic></subject><subject><genre>Abbreviations</genre><topic>SDV, silica deposition vesicle</topic><topic>STV, silica transport vesicle</topic><topic>DLA, diffusion-limited aggregation</topic><topic>K, a tunable parameter used to represent surface tension</topic><topic>T, a tunable parameter relating to temperature</topic><topic>X, a tunable parameter used to represent surface mobility</topic><topic>Rmax, distance of the furthest point of the growing aggregate from its centre</topic></subject><relatedItem type="host"><titleInfo><title>BBA - Molecular Cell Research</title></titleInfo><titleInfo type="abbreviated"><title>BBAMCR</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19991013</dateIssued></originInfo><identifier type="ISSN">0167-4889</identifier><identifier type="PII">S0167-4889(00)X0064-X</identifier><part><date>19991013</date><detail type="volume"><number>1452</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>102</end></extent><extent unit="pages"><start>89</start><end>102</end></extent></part></relatedItem><identifier type="istex">6291C5847CB7B26CCD2A7447CE57E68436BFF948</identifier><identifier type="DOI">10.1016/S0167-4889(99)00116-0</identifier><identifier type="PII">S0167-4889(99)00116-0</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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