Head injuries and Parkinson's disease in a case-control study
Identifieur interne : 000832 ( Istex/Corpus ); précédent : 000831; suivant : 000833Head injuries and Parkinson's disease in a case-control study
Auteurs : M Anne Harris ; Hui Shen ; Stephen A. Marion ; Joseph K C. Tsui ; Kay TeschkeSource :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2013-12.
Abstract
Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.
Url:
DOI: 10.1136/oemed-2013-101444
Links to Exploration step
ISTEX:82DECF0AD4E248BD196BA9CDEF495A7B1143C05FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Head injuries and Parkinson's disease in a case-control study</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name><affiliation><mods:affiliation>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:82DECF0AD4E248BD196BA9CDEF495A7B1143C05F</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/oemed-2013-101444</idno><idno type="url">https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000832</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000832</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Head injuries and Parkinson's disease in a case-control study</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name><affiliation><mods:affiliation>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation><mods:affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-12">2013-12</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="839">839</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">82DECF0AD4E248BD196BA9CDEF495A7B1143C05F</idno><idno type="DOI">10.1136/oemed-2013-101444</idno><idno type="href">oemed-70-839.pdf</idno><idno type="ArticleID">oemed-2013-101444</idno><idno type="PMID">24142978</idno><idno type="local">oemed;70/12/839</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>M Anne Harris</name><affiliations><json:string>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Hui Shen</name><affiliations><json:string>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Stephen A Marion</name><affiliations><json:string>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Joseph K C Tsui</name><affiliations><json:string>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Kay Teschke</name><affiliations><json:string>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item></author><articleId><json:string>oemed-2013-101444</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</abstract><qualityIndicators><score>7.938</score><pdfWordCount>3786</pdfWordCount><pdfCharCount>25206</pdfCharCount><pdfVersion>1.6</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>221</abstractWordCount><abstractCharCount>1509</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Head injuries and Parkinson's disease in a case-control study</title><pmid><json:string>24142978</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Occupational and Environmental Medicine</title><language><json:string>unknown</json:string></language><issn><json:string>1351-0711</json:string></issn><eissn><json:string>1470-7926</json:string></eissn><publisherId><json:string>oem</json:string></publisherId><volume>70</volume><issue>12</issue><pages><first>839</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>public, environmental & occupational health</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>environmental & occupational health</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1136/oemed-2013-101444</json:string></doi><id>82DECF0AD4E248BD196BA9CDEF495A7B1143C05F</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Head injuries and Parkinson's disease in a case-control study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</p></availability><date>2013-09-18</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Head injuries and Parkinson's disease in a case-control study</title><author xml:id="author-1"><persName><forename type="first">M Anne</forename><surname>Harris</surname></persName><affiliation>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-2"><persName><forename type="first">Hui</forename><surname>Shen</surname></persName><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author><author xml:id="author-3"><persName><forename type="first">Stephen A</forename><surname>Marion</surname></persName><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author><author xml:id="author-4"><persName><forename type="first">Joseph K C</forename><surname>Tsui</surname></persName><affiliation>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author><author xml:id="author-5"><persName><forename type="first">Kay</forename><surname>Teschke</surname></persName><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author></analytic><monogr><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="pISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-12"></date><biblScope unit="volume">70</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="839">839</biblScope></imprint></monogr><idno type="istex">82DECF0AD4E248BD196BA9CDEF495A7B1143C05F</idno><idno type="DOI">10.1136/oemed-2013-101444</idno><idno type="href">oemed-70-839.pdf</idno><idno type="ArticleID">oemed-2013-101444</idno><idno type="PMID">24142978</idno><idno type="local">oemed;70/12/839</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-09-18</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</p></abstract></profileDesc><revisionDesc><change when="2013-09-18">Created</change><change when="2013-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">oemed</journal-id><journal-id journal-id-type="nlm-ta">Occup Environ Med</journal-id><journal-id journal-id-type="publisher-id">oem</journal-id><journal-title>Occupational and Environmental Medicine</journal-title><abbrev-journal-title abbrev-type="publisher">Occup Environ Med</abbrev-journal-title><abbrev-journal-title>Occup Environ Med</abbrev-journal-title><issn pub-type="ppub">1351-0711</issn><issn pub-type="epub">1470-7926</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">oemed-2013-101444</article-id><article-id pub-id-type="doi">10.1136/oemed-2013-101444</article-id><article-id pub-id-type="other">oemed;70/12/839</article-id><article-id pub-id-type="other">oemed;oemed-2013-101444</article-id><article-id pub-id-type="pmid">24142978</article-id><article-id pub-id-type="other">839</article-id><article-id pub-id-type="other">oemed-2013-101444</article-id><article-categories><subj-group subj-group-type="heading"><subject>Workplace</subject></subj-group><series-title>Original article</series-title></article-categories><title-group><article-title>Head injuries and Parkinson's disease in a case-control study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Harris</surname><given-names>M Anne</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Marion</surname><given-names>Stephen A</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Tsui</surname><given-names>Joseph K C</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Teschke</surname><given-names>Kay</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib></contrib-group><aff id="af1"><label>1</label><institution>School of Occupational and Public Health, Ryerson University</institution>, <addr-line>Toronto, Ontario</addr-line>, <country>Canada</country></aff><aff id="af2"><label>2</label><institution>School of Population and Public Health, University of British Columbia</institution>, <addr-line>Vancouver, British Columbia</addr-line>, <country>Canada</country></aff><aff id="af3"><label>3</label><institution>Pacific Parkinson's Research Centre, University of British Columbia</institution>, <addr-line>Vancouver, British Columbia</addr-line>, <country>Canada</country></aff><author-notes><corresp><label>Correspondence to</label> Dr M Anne Harris, School of Occupational and Public Health, Ryerson University, 350 Victoria Street, Podium Building, Toronto, ON, Canada M5B 2K3; <email>anne.harris@ryerson.ca</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>18</day><month>09</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>18</day><month>9</month><year>2013</year></pub-date><volume>70</volume><volume-id pub-id-type="other">70</volume-id><volume-id pub-id-type="other">70</volume-id><issue>12</issue><issue-id pub-id-type="other">oemed;70/12</issue-id><issue-id pub-id-type="other">12</issue-id><issue-id pub-id-type="other">70/12</issue-id><fpage>839</fpage><history><date date-type="received"><day>10</day><month>2</month><year>2013</year></date><date date-type="rev-recd"><day>24</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>16</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-70-839.pdf"></self-uri><abstract><sec><title>Background</title><p>Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms.</p></sec><sec><title>Methods</title><p>We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history.</p></sec><sec><title>Results</title><p>Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant.</p></sec><sec><title>Conclusions</title><p>This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Head injuries and Parkinson's disease in a case-control study</title><partName>Original article</partName></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Head injuries and Parkinson's disease in a case-control study</title><partName>Original article</partName></titleInfo><name type="personal"><namePart type="given">M Anne</namePart><namePart type="family">Harris</namePart><affiliation>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hui</namePart><namePart type="family">Shen</namePart><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen A</namePart><namePart type="family">Marion</namePart><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph K C</namePart><namePart type="family">Tsui</namePart><affiliation>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kay</namePart><namePart type="family">Teschke</namePart><affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-12</dateIssued><dateCreated encoding="w3cdtf">2013-09-18</dateCreated><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</abstract><relatedItem type="host"><titleInfo><title>Occupational and Environmental Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Occup Environ Med</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1351-0711</identifier><identifier type="eISSN">1470-7926</identifier><identifier type="PublisherID">oem</identifier><identifier type="PublisherID-hwp">oemed</identifier><identifier type="PublisherID-nlm-ta">Occup Environ Med</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>839</start></extent></part></relatedItem><identifier type="istex">82DECF0AD4E248BD196BA9CDEF495A7B1143C05F</identifier><identifier type="DOI">10.1136/oemed-2013-101444</identifier><identifier type="href">oemed-70-839.pdf</identifier><identifier type="ArticleID">oemed-2013-101444</identifier><identifier type="PMID">24142978</identifier><identifier type="local">oemed;70/12/839</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api-v5.istex.fr/document/82DECF0AD4E248BD196BA9CDEF495A7B1143C05F/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000832 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000832 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:82DECF0AD4E248BD196BA9CDEF495A7B1143C05F
|texte= Head injuries and Parkinson's disease in a case-control study
}}
| This area was generated with Dilib version V0.6.29. |  |