Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease
Identifieur interne : 000373 ( Istex/Corpus ); précédent : 000372; suivant : 000374Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease
Auteurs : Leigh Christopher ; Antonio P. StrafellaSource :
- Journal of Neuropsychology [ 1748-6645 ] ; 2013-09.
Abstract
Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD‐MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD‐MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD‐MCI.
Url:
DOI: 10.1111/jnp.12015
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Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD‐MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD‐MCI.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>dopamine</json:string><json:string>dementia</json:string><json:string>cognitive impairment</json:string><json:string>impairment</json:string><json:string>healthy controls</json:string><json:string>dysfunction</json:string><json:string>cognition</json:string><json:string>neurology</json:string><json:string>cognitive</json:string><json:string>aarsland</json:string><json:string>strafella</json:string><json:string>neuroimaging</json:string><json:string>larsen</json:string><json:string>caudate</json:string><json:string>dopaminergic</json:string><json:string>rinne</json:string><json:string>striatal</json:string><json:string>ndings</json:string><json:string>cholinergic</json:string><json:string>monchi</json:string><json:string>movement disorders</json:string><json:string>executive dysfunction</json:string><json:string>abnormality</json:string><json:string>janvin</json:string><json:string>dlpfc</json:string><json:string>weintraub</json:string><json:string>neuroscience</json:string><json:string>neurotransmitter</json:string><json:string>bohnen</json:string><json:string>leigh christopher</json:string><json:string>striatum</json:string><json:string>moca</json:string><json:string>cognitive function</json:string><json:string>nigrostriatal</json:string><json:string>parkinson disease</json:string><json:string>glucose</json:string><json:string>comt</json:string><json:string>receptor</json:string><json:string>fmri</json:string><json:string>neural activation</json:string><json:string>executive function</json:string><json:string>cingulate</json:string><json:string>neurochemical</json:string><json:string>imaging</json:string><json:string>neurochemical changes</json:string><json:string>cortical activation</json:string><json:string>normal controls</json:string><json:string>imaging studies</json:string><json:string>cognitive performance</json:string><json:string>cognitive decline</json:string><json:string>normal cognition</json:string><json:string>caudate nucleus</json:string><json:string>parkinson</json:string><json:string>grey matter loss</json:string><json:string>grey matter atrophy</json:string><json:string>patients show</json:string><json:string>neurosurgery psychiatry</json:string><json:string>dopamine release</json:string><json:string>glucose metabolism</json:string><json:string>cortical regions</json:string><json:string>cortical</json:string><json:string>executive processes</json:string><json:string>abnormal basal ganglia</json:string><json:string>striatal dopamine depletion</json:string><json:string>extrastriatal regions</json:string><json:string>brain regions</json:string><json:string>motor function</json:string><json:string>metabolic changes</json:string><json:string>memory task</json:string><json:string>cholinergic systems</json:string><json:string>dopamine levels</json:string><json:string>executive tasks</json:string><json:string>brain changes</json:string><json:string>frontal lobe</json:string><json:string>grey matter changes</json:string><json:string>amyloid load</json:string><json:string>serotonergic systems</json:string><json:string>resonance imaging</json:string><json:string>longitudinal study</json:string><json:string>visuospatial function</json:string><json:string>early disease</json:string><json:string>dopaminergic modulation</json:string><json:string>metabolism</json:string></teeft></keywords><author><json:item><name>Leigh Christopher</name><affiliations><json:string>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</json:string><json:string>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Antonio P. 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Safra Foundation</note><note>Parkinson Society Canada</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Leigh</forename><surname>Christopher</surname></persName><affiliation>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</affiliation><affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</affiliation></author><author xml:id="author-2"><persName><forename type="first">Antonio P.</forename><surname>Strafella</surname></persName><email>antonio.strafella@uhnres.utoronto.ca</email><affiliation>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</affiliation><affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</affiliation><affiliation>Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</affiliation></author></analytic><monogr><title level="j">Journal of Neuropsychology</title><title level="j" type="abbrev">J Neuropsychol</title><idno type="pISSN">1748-6645</idno><idno type="eISSN">1748-6653</idno><idno type="DOI">10.1111/(ISSN)1748-6653</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-09"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="225">225</biblScope><biblScope unit="page" to="240">240</biblScope></imprint></monogr><idno type="istex">402B645EF1372B85EC5901F88D2D106C87158AD4</idno><idno type="DOI">10.1111/jnp.12015</idno><idno type="ArticleID">JNP12015</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-02-23</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD‐MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD‐MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD‐MCI.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Special Issue Paper</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-07-25">Received</change><change when="2013-02-23">Created</change><change when="2013-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/402B645EF1372B85EC5901F88D2D106C87158AD4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jnp12015" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1748-6653</doi><issn type="print">1748-6645</issn><issn type="electronic">1748-6653</issn><idGroup><id type="product" value="JNP"></id></idGroup><titleGroup><title sort="JOURNAL OF NEUROPSYCHOLOGY" type="main">Journal of Neuropsychology</title><title type="short">J Neuropsychol</title></titleGroup></publicationMeta><publicationMeta level="part" position="09102"><doi origin="wiley">10.1111/jnp.2013.7.issue-2</doi><titleGroup><title type="specialIssueTitle">Parkinson's Disease and Cognition <i>Guest edited by Nicky Edelstyn and Ellen Poliakoff</i></title></titleGroup><copyright ownership="thirdParty">Copyright © 2013 The British Psychological Society</copyright><numberingGroup><numbering type="journalVolume" number="7">7</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2013-09">September 2013</coverDate></publicationMeta><publicationMeta level="unit" position="60" status="forIssue" type="article"><doi>10.1111/jnp.12015</doi><idGroup><id type="unit" value="JNP12015"></id></idGroup><countGroup><count number="16" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Special Issue Paper</title><title type="tocHeading1"><i>Special issue papers</i></title></titleGroup><copyright ownership="thirdParty">© 2013 The British Psychological Society</copyright><eventGroup><event date="2012-07-25" type="manuscriptReceived"></event><event date="2013-02-07" type="manuscriptRevised"></event><event agent="SPS" date="2013-02-23" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-04-01"></event><event type="firstOnline" date="2013-04-01"></event><event type="publishedOnlineFinalForm" date="2013-09-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">225</numbering><numbering type="pageLast">240</numbering></numberingGroup><correspondenceTo>Correspondence should be addressed to Antonio P. Strafella, Toronto Western Hospital and Institute, CAMH‐ Research Imaging Centre, University of Toronto, Toronto, ON M5T 2S8 Canada (e‐mails: <email>antonio.strafella@uhnres.utoronto.ca</email>; <email>antonio.strafella@camhpet.ca</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JNP.JNP12015.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</title><title type="shortAuthors">Leigh Christopher and Antonio P. Strafella</title></titleGroup><creators><creator affiliationRef="#jnp12015-aff-0001 #jnp12015-aff-0002" creatorRole="author" xml:id="jnp12015-cr-0001"><personName><givenNames>Leigh</givenNames> <familyName>Christopher</familyName></personName></creator><creator affiliationRef="#jnp12015-aff-0001 #jnp12015-aff-0002 #jnp12015-aff-0003" corresponding="yes" creatorRole="author" xml:id="jnp12015-cr-0002"><personName><givenNames>Antonio P.</givenNames> <familyName>Strafella</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="CA" type="organization" xml:id="jnp12015-aff-0001"><orgDiv>Division of Brain, Imaging and Behaviour – Systems Neuroscience</orgDiv> <orgDiv>Toronto Western Research Institute</orgDiv> <orgName>UHN</orgName> <orgName>University of Toronto</orgName> <address><countryPart>Ontario</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jnp12015-aff-0002"><orgDiv>Research Imaging Centre</orgDiv> <orgDiv>Centre for Addiction and Mental Health</orgDiv> <orgName>University of Toronto</orgName> <address><countryPart>Ontario</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jnp12015-aff-0003"><orgDiv>Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital</orgDiv> <orgName>UHN</orgName> <orgName>University of Toronto</orgName> <address><countryPart>Ontario</countryPart> <country>Canada</country></address></affiliation></affiliationGroup><fundingInfo><fundingAgency>Canadian Institutes of Health Research</fundingAgency><fundingNumber>MOP 110962</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Canada Research Chair program</fundingAgency></fundingInfo><fundingInfo><fundingAgency>E.J. Safra Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Parkinson Society Canada</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jnp12015-abs-0001" xml:lang="en"><p>Cognitive impairment occurs frequently in Parkinson's disease (<fc>PD</fc>) and the concept of Mild Cognitive Impairment in <fc>PD</fc> (<fc>PD</fc>‐<fc>MCI</fc>) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in <fc>PD</fc> patients without dementia using neuroimaging techniques including structural <fc>MRI</fc>, functional <fc>MRI</fc> and <fc>PET</fc> imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in <fc>PD</fc>, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as <fc>PD</fc>‐<fc>MCI</fc>, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural <fc>MRI</fc> investigating grey and white matter changes, functional <fc>MRI</fc> to examine changes in neural activation and <fc>PET</fc> imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in <fc>PD</fc> without dementia and <fc>PD</fc>‐<fc>MCI</fc>.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Leigh</namePart><namePart type="family">Christopher</namePart><affiliation>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</affiliation><affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio P.</namePart><namePart type="family">Strafella</namePart><affiliation>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</affiliation><affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</affiliation><affiliation>Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</affiliation><affiliation>E-mail: antonio.strafella@uhnres.utoronto.ca</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-09</dateIssued><dateCreated encoding="w3cdtf">2013-02-23</dateCreated><dateCaptured encoding="w3cdtf">2012-07-25</dateCaptured><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD‐MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD‐MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD‐MCI.</abstract><note type="funding">Canadian Institutes of Health Research - No. MOP 110962; </note><note type="funding">Canada Research Chair program</note><note type="funding">E.J. Safra Foundation</note><note type="funding">Parkinson Society Canada</note><relatedItem type="host"><titleInfo><title>Journal of Neuropsychology</title></titleInfo><titleInfo type="abbreviated"><title>J Neuropsychol</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Special Issue Paper</topic></subject><identifier type="ISSN">1748-6645</identifier><identifier type="eISSN">1748-6653</identifier><identifier type="DOI">10.1111/(ISSN)1748-6653</identifier><identifier type="PublisherID">JNP</identifier><part><date>2013</date><detail type="title"><title>Parkinson's Disease and Cognition Guest edited by Nicky Edelstyn and Ellen Poliakoff</title></detail><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>225</start><end>240</end><total>16</total></extent></part></relatedItem><identifier type="istex">402B645EF1372B85EC5901F88D2D106C87158AD4</identifier><identifier type="DOI">10.1111/jnp.12015</identifier><identifier type="ArticleID">JNP12015</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 The British Psychological Society© 2013 The British Psychological Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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