Sensorimotor adaptation of speech in Parkinson's disease
Identifieur interne : 000364 ( Istex/Corpus ); précédent : 000363; suivant : 000365Sensorimotor adaptation of speech in Parkinson's disease
Auteurs : Fatemeh Mollaei ; Douglas M. Shiller ; Vincent L. GraccoSource :
- Movement Disorders [ 0885-3185 ] ; 2013-10.
Abstract
The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society
Url:
DOI: 10.1002/mds.25588
Links to Exploration step
ISTEX:AA10CC17B261B66E7D5733AF00258FEB3698A1E0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Communication Sciences and Disorders, McGill University, Quebec, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M." last="Shiller">Douglas M. Shiller</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>CHU Sainte‐Justine Research Center, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>École d'Orthophonie et d'Audiologie, Université de Montréal, Quebec, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L." last="Gracco">Vincent L. Gracco</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Haskins Laboratories, Connecticut, New Haven, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: vincent.gracco@mcgill.ca</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AA10CC17B261B66E7D5733AF00258FEB3698A1E0</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/mds.25588</idno><idno type="url">https://api-v5.istex.fr/document/AA10CC17B261B66E7D5733AF00258FEB3698A1E0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000364</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000364</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Communication Sciences and Disorders, McGill University, Quebec, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M." last="Shiller">Douglas M. Shiller</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>CHU Sainte‐Justine Research Center, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>École d'Orthophonie et d'Audiologie, Université de Montréal, Quebec, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L." last="Gracco">Vincent L. Gracco</name><affiliation><mods:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Haskins Laboratories, Connecticut, New Haven, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: vincent.gracco@mcgill.ca</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-10">2013-10</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1668">1668</biblScope><biblScope unit="page" to="1674">1674</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AA10CC17B261B66E7D5733AF00258FEB3698A1E0</idno><idno type="DOI">10.1002/mds.25588</idno><idno type="ArticleID">MDS25588</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Fatemeh Mollaei BA</name><affiliations><json:string>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</json:string><json:string>School of Communication Sciences and Disorders, McGill University, Quebec, Montreal, Canada</json:string></affiliations></json:item><json:item><name>Douglas M. Shiller PhD</name><affiliations><json:string>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</json:string><json:string>CHU Sainte‐Justine Research Center, Montreal, Quebec, Canada</json:string><json:string>École d'Orthophonie et d'Audiologie, Université de Montréal, Quebec, Montreal, Canada</json:string></affiliations></json:item><json:item><name>Vincent L. Gracco PhD</name><affiliations><json:string>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</json:string><json:string>School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada</json:string><json:string>Haskins Laboratories, Connecticut, New Haven, USA</json:string><json:string>E-mail: vincent.gracco@mcgill.ca</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>sensorimotor adaptation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>speech production</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>speech motor learning</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>auditory feedback</value></json:item></subject><articleId><json:string>MDS25588</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society</abstract><qualityIndicators><score>6.65</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 809.972 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1391</abstractCharCount><pdfWordCount>4250</pdfWordCount><pdfCharCount>26663</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>200</abstractWordCount></qualityIndicators><title>Sensorimotor adaptation of speech in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><title>Movement Disorders</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi><issn><json:string>0885-3185</json:string></issn><eissn><json:string>1531-8257</json:string></eissn><publisherId><json:string>MDS</json:string></publisherId><volume>28</volume><issue>12</issue><pages><first>1668</first><last>1674</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1002/mds.25588</json:string></doi><id>AA10CC17B261B66E7D5733AF00258FEB3698A1E0</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/AA10CC17B261B66E7D5733AF00258FEB3698A1E0/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/AA10CC17B261B66E7D5733AF00258FEB3698A1E0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/AA10CC17B261B66E7D5733AF00258FEB3698A1E0/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><availability><p>© 2013 Movement Disorder Society© 2013 Movement Disorder Society</p></availability><date>2013-06-18</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Fatemeh</forename><surname>Mollaei</surname></persName><roleName type="degree">BA</roleName><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>School of Communication Sciences and Disorders, McGill University, Quebec, Montreal, Canada</affiliation></author><author xml:id="author-2"><persName><forename type="first">Douglas M.</forename><surname>Shiller</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>CHU Sainte‐Justine Research Center, Montreal, Quebec, Canada</affiliation><affiliation>École d'Orthophonie et d'Audiologie, Université de Montréal, Quebec, Montreal, Canada</affiliation></author><author xml:id="author-3"><persName><forename type="first">Vincent L.</forename><surname>Gracco</surname></persName><roleName type="degree">PhD</roleName><email>vincent.gracco@mcgill.ca</email><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada</affiliation><affiliation>Haskins Laboratories, Connecticut, New Haven, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-10"></date><biblScope unit="volume">28</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1668">1668</biblScope><biblScope unit="page" to="1674">1674</biblScope></imprint></monogr><idno type="istex">AA10CC17B261B66E7D5733AF00258FEB3698A1E0</idno><idno type="DOI">10.1002/mds.25588</idno><idno type="ArticleID">MDS25588</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-06-18</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>sensorimotor adaptation</term></item><item><term>speech production</term></item><item><term>Parkinson's disease</term></item><item><term>speech motor learning</term></item><item><term>auditory feedback</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-12-19">Received</change><change when="2013-05-10">Registration</change><change when="2013-06-18">Created</change><change when="2013-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/AA10CC17B261B66E7D5733AF00258FEB3698A1E0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="mds25588"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi>10.1002/mds.v28.12</doi><copyright ownership="thirdParty">© 2013 Movement Disorder Society</copyright><numberingGroup><numbering type="journalVolume" number="28">28</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2013-10">October 2013</coverDate></publicationMeta><publicationMeta level="unit" position="130" type="article" status="forIssue"><doi>10.1002/mds.25588</doi><idGroup><id type="unit" value="MDS25588"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">© 2013 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2012-12-19"></event><event type="manuscriptRevised" date="2013-03-19"></event><event type="manuscriptAccepted" date="2013-05-10"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2013-06-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.6 mode:FullText" date="2013-10-25"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-07-16"></event><event type="firstOnline" date="2013-07-16"></event><event type="publishedOnlineFinalForm" date="2013-10-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst">1668</numbering><numbering type="pageLast">1674</numbering></numberingGroup><correspondenceTo><b>Correspondence to</b>: Dr. Vincent L. Gracco, Centre for Research on Brain, Language & Music, McGill University, 3640 de la Montagne, Montreal, Quebec, H3G2A8, Canada; <email>vincent.gracco@mcgill.ca</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS25588.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Sensorimotor adaptation of speech in Parkinson's disease</title><title type="short">Speech Motor Adaptation</title><title type="shortAuthors">Mollaei et al.</title></titleGroup><creators><creator affiliationRef="#mds25588-aff-0001 #mds25588-aff-0002" creatorRole="author" xml:id="mds25588-cr-0001"><personName><givenNames>Fatemeh</givenNames> <familyName>Mollaei</familyName><degrees>BA</degrees></personName></creator><creator affiliationRef="#mds25588-aff-0001 #mds25588-aff-0003 #mds25588-aff-0004" creatorRole="author" xml:id="mds25588-cr-0002"><personName><givenNames>Douglas M.</givenNames> <familyName>Shiller</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25588-aff-0001 #mds25588-aff-0002 #mds25588-aff-0005" corresponding="yes" creatorRole="author" xml:id="mds25588-cr-0003"><personName><givenNames>Vincent L.</givenNames> <familyName>Gracco</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation countryCode="CA" type="organization" xml:id="mds25588-aff-0001"><orgName>Centre for Research on Brain, Language and Music</orgName><address><city>Montreal</city><countryPart>Quebec</countryPart><country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="mds25588-aff-0002"><orgDiv>School of Communication Sciences and Disorders</orgDiv><orgName>McGill University</orgName><address><city>Montreal</city><countryPart>Quebec</countryPart><country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="mds25588-aff-0003"><orgName>CHU Sainte‐Justine Research Center</orgName><address><city>Montreal</city><countryPart>Quebec</countryPart><country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="mds25588-aff-0004"><orgDiv>École d'Orthophonie et d'Audiologie</orgDiv><orgName>Université de Montréal</orgName><address><city>Montreal</city><countryPart>Quebec</countryPart><country>Canada</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25588-aff-0005"><orgName>Haskins Laboratories</orgName><address><city>New Haven</city><countryPart>Connecticut</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="mds25588-kwd-0001">sensorimotor adaptation</keyword><keyword xml:id="mds25588-kwd-0002">speech production</keyword><keyword xml:id="mds25588-kwd-0003">Parkinson<i>'</i>s disease</keyword><keyword xml:id="mds25588-kwd-0004">speech motor learning</keyword><keyword xml:id="mds25588-kwd-0005">auditory feedback</keyword></keywordGroup><abstractGroup><abstract type="main"><title type="main">ABSTRACT</title><p>The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson<i>'</i>s disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="mds25588-note-0001"><p><b>Funding agencies</b>: This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada, the Canadian Institutes of Health Research, and the National Institutes of Health (NIDCD‐R01DC012502).</p></note><note xml:id="mds25588-note-0002"><p><b>Relevant conflicts of interest/financial disclosures</b>: Nothing to report.</p></note><note xml:id="mds25588-note-0003"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Sensorimotor adaptation of speech in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Speech Motor Adaptation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Sensorimotor adaptation of speech in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Fatemeh</namePart><namePart type="family">Mollaei</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>School of Communication Sciences and Disorders, McGill University, Quebec, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Douglas M.</namePart><namePart type="family">Shiller</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>CHU Sainte‐Justine Research Center, Montreal, Quebec, Canada</affiliation><affiliation>École d'Orthophonie et d'Audiologie, Université de Montréal, Quebec, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincent L.</namePart><namePart type="family">Gracco</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada</affiliation><affiliation>School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada</affiliation><affiliation>Haskins Laboratories, Connecticut, New Haven, USA</affiliation><affiliation>E-mail: vincent.gracco@mcgill.ca</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-10</dateIssued><dateCreated encoding="w3cdtf">2013-06-18</dateCreated><dateCaptured encoding="w3cdtf">2012-12-19</dateCaptured><dateValid encoding="w3cdtf">2013-05-10</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society</abstract><subject><genre>keywords</genre><topic>sensorimotor adaptation</topic><topic>speech production</topic><topic>Parkinson's disease</topic><topic>speech motor learning</topic><topic>auditory feedback</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1668</start><end>1674</end><total>7</total></extent></part></relatedItem><identifier type="istex">AA10CC17B261B66E7D5733AF00258FEB3698A1E0</identifier><identifier type="DOI">10.1002/mds.25588</identifier><identifier type="ArticleID">MDS25588</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 Movement Disorder Society© 2013 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000364 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000364 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:AA10CC17B261B66E7D5733AF00258FEB3698A1E0
|texte= Sensorimotor adaptation of speech in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |