Effect of age on caudate dopaminergic function in idiopathic Parkinsonism
Identifieur interne : 000216 ( Istex/Corpus ); précédent : 000215; suivant : 000217Effect of age on caudate dopaminergic function in idiopathic Parkinsonism
Auteurs : R. De La Fuente-Fernández ; A. Kishore ; B. J. Snow ; M. Schulzer ; C. S. Lee ; T. J. Ruth ; A. J. StoesslSource :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1998.
Abstract
Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (Ki) in the caudate nucleus of patients with IP declines with both age (p = 0.002) and duration (p = 0.05) of symptoms. This effect was over and above that of normal aging (p = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.
Url:
DOI: 10.1016/S1353-8020(98)00009-1
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title><author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernández">R. De La Fuente-Fernández</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kishore, A" sort="Kishore, A" uniqKey="Kishore A" first="A." last="Kishore">A. Kishore</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B. J." last="Snow">B. J. Snow</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:12270CFF9B9E887B6EC86B62A36493D51F84196C</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S1353-8020(98)00009-1</idno><idno type="url">https://api-v5.istex.fr/document/12270CFF9B9E887B6EC86B62A36493D51F84196C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000216</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000216</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title><author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernández">R. De La Fuente-Fernández</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kishore, A" sort="Kishore, A" uniqKey="Kishore A" first="A." last="Kishore">A. Kishore</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B. J." last="Snow">B. J. Snow</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name><affiliation><mods:affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="5">5</biblScope></imprint><idno type="ISSN">1353-8020</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (Ki) in the caudate nucleus of patients with IP declines with both age (p = 0.002) and duration (p = 0.05) of symptoms. This effect was over and above that of normal aging (p = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>R. de la Fuente-Fernández</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>A. Kishore</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>B.J. Snow</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>M. Schulzer</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>C.S. Lee</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>T.J. Ruth</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>A.J. Stoessl</name><affiliations><json:string>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Aging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Caudate nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Idiopathic Parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PET</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>[18F]dopa</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (Ki) in the caudate nucleus of patients with IP declines with both age (p = 0.002) and duration (p = 0.05) of symptoms. This effect was over and above that of normal aging (p = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.</abstract><qualityIndicators><score>5.059</score><pdfWordCount>2755</pdfWordCount><pdfCharCount>16436</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>612 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>192</abstractWordCount><abstractCharCount>1135</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title><pii><json:string>S1353-8020(98)00009-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Parkinsonism and Related Disorders</title><language><json:string>unknown</json:string></language><publicationDate>1998</publicationDate><issn><json:string>1353-8020</json:string></issn><pii><json:string>S1353-8020(00)X0012-0</json:string></pii><volume>4</volume><issue>1</issue><pages><first>1</first><last>5</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S1353-8020(98)00009-1</json:string></doi><id>12270CFF9B9E887B6EC86B62A36493D51F84196C</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/12270CFF9B9E887B6EC86B62A36493D51F84196C/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/12270CFF9B9E887B6EC86B62A36493D51F84196C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/12270CFF9B9E887B6EC86B62A36493D51F84196C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1998</date></publicationStmt><notesStmt><note type="content">Section title: Paper</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title><author xml:id="author-0000"><persName><forename type="first">R.</forename><surname>de la Fuente-Fernández</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">A.</forename><surname>Kishore</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0002"><persName><forename type="first">B.J.</forename><surname>Snow</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0003"><persName><forename type="first">M.</forename><surname>Schulzer</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0004"><persName><forename type="first">C.S.</forename><surname>Lee</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0005"><persName><forename type="first">T.J.</forename><surname>Ruth</surname></persName><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><author xml:id="author-0006"><persName><forename type="first">A.J.</forename><surname>Stoessl</surname></persName><note type="correspondence"><p>Corresponding author. Neurodegenerative Disorders Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5. Tel.: (604) 822-7967; fax: (604) 822-7866</p></note><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation></author><idno type="istex">12270CFF9B9E887B6EC86B62A36493D51F84196C</idno><idno type="DOI">10.1016/S1353-8020(98)00009-1</idno><idno type="PII">S1353-8020(98)00009-1</idno></analytic><monogr><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="pISSN">1353-8020</idno><idno type="PII">S1353-8020(00)X0012-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="5">5</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (Ki) in the caudate nucleus of patients with IP declines with both age (p = 0.002) and duration (p = 0.05) of symptoms. This effect was over and above that of normal aging (p = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Aging</term></item><item><term>Caudate nucleus</term></item><item><term>Idiopathic Parkinsonism</term></item><item><term>PET</term></item><item><term>[18F]dopa</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/12270CFF9B9E887B6EC86B62A36493D51F84196C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PRD</jid><aid>98000091</aid><ce:pii>S1353-8020(98)00009-1</ce:pii><ce:doi>10.1016/S1353-8020(98)00009-1</ce:doi><ce:copyright type="unknown" year="1998"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Paper</ce:textfn></ce:dochead><ce:title>Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</ce:title><ce:author-group><ce:author><ce:given-name>R.</ce:given-name><ce:surname>de la Fuente-Fernández</ce:surname></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Kishore</ce:surname></ce:author><ce:author><ce:given-name>B.J.</ce:given-name><ce:surname>Snow</ce:surname></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Schulzer</ce:surname></ce:author><ce:author><ce:given-name>C.S.</ce:given-name><ce:surname>Lee</ce:surname></ce:author><ce:author><ce:given-name>T.J.</ce:given-name><ce:surname>Ruth</ce:surname></ce:author><ce:author><ce:given-name>A.J.</ce:given-name><ce:surname>Stoessl</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Neurodegenerative Disorders Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5. Tel.: (604) 822-7967; fax: (604) 822-7866</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (<ce:italic>Ki</ce:italic>) in the caudate nucleus of patients with IP declines with both age (<ce:italic>p</ce:italic> = 0.002) and duration (<ce:italic>p</ce:italic> = 0.05) of symptoms. This effect was over and above that of normal aging (<ce:italic>p</ce:italic> = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Aging</ce:text></ce:keyword><ce:keyword><ce:text>Caudate nucleus</ce:text></ce:keyword><ce:keyword><ce:text>Idiopathic Parkinsonism</ce:text></ce:keyword><ce:keyword><ce:text>PET</ce:text></ce:keyword><ce:keyword><ce:text>[<ce:sup loc="pre">18</ce:sup>F]dopa</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effect of age on caudate dopaminergic function in idiopathic Parkinsonism</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">de la Fuente-Fernández</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kishore</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.J.</namePart><namePart type="family">Snow</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schulzer</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.S.</namePart><namePart type="family">Lee</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.J.</namePart><namePart type="family">Ruth</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.J.</namePart><namePart type="family">Stoessl</namePart><affiliation>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada</affiliation><description>Corresponding author. Neurodegenerative Disorders Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5. Tel.: (604) 822-7967; fax: (604) 822-7866</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Aging has long been implicated in the pathogenesis of Idiopathic Parkinsonism (IP). However, postmortem studies have demonstrated that the pathological changes in aging and IP affect the dopaminergic function in putamen and caudate nuclei differently. This has been considered by some authors as evidence against the role of aging in IP. We performed fluorodopa (FD) positron emission tomography (PET) in 36 patients with IP and 25 normal controls to test the hypothesis that the effect of aging on the striatal dopaminergic function in IP differs from the effect of aging in normal controls. We found that the FD uptake constant (Ki) in the caudate nucleus of patients with IP declines with both age (p = 0.002) and duration (p = 0.05) of symptoms. This effect was over and above that of normal aging (p = 0.007). We did not find a similar superimposed effect of age in the putamen. We conclude that the effect of aging on the dopaminergic function in the caudate nucleus in IP differs from that in normal aging. Whether this abnormal aging precedes and even predisposes to IP or is triggered by pathogenetic factors in IP is unclear.</abstract><note type="content">Section title: Paper</note><subject><genre>Keywords</genre><topic>Aging</topic><topic>Caudate nucleus</topic><topic>Idiopathic Parkinsonism</topic><topic>PET</topic><topic>[18F]dopa</topic></subject><relatedItem type="host"><titleInfo><title>Parkinsonism and Related Disorders</title></titleInfo><titleInfo type="abbreviated"><title>PRD</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199806</dateIssued></originInfo><identifier type="ISSN">1353-8020</identifier><identifier type="PII">S1353-8020(00)X0012-0</identifier><part><date>199806</date><detail type="volume"><number>4</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>50</end></extent><extent unit="pages"><start>1</start><end>5</end></extent></part></relatedItem><identifier type="istex">12270CFF9B9E887B6EC86B62A36493D51F84196C</identifier><identifier type="DOI">10.1016/S1353-8020(98)00009-1</identifier><identifier type="PII">S1353-8020(98)00009-1</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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