Alterations of neuronal activity in the superior colliculus of rotating animals
Identifieur interne : 001324 ( Istex/Checkpoint ); précédent : 001323; suivant : 001325Alterations of neuronal activity in the superior colliculus of rotating animals
Auteurs : M. O Hebb ; H. A RobertsonSource :
- Neuroscience [ 0306-4522 ] ; 1999.
Abstract
We have investigated the relationship between alterations in neuronal activity in the superior colliculus and behavioral responses which occur following disruption of basal ganglia circuitry. These changes were analysed following unilateral suppression of the immediate early genes, c-fos and ngfi-a, in the striatum and/or the globus pallidus. Animals with unilateral suppression of immediate early gene expression in the striatum exhibited robust circling activity, following administration of d-amphetamine, that was directed towards the side of suppression. The intensity of rotation was inversely related to the length of the recovery period following antisense infusion and increased significantly when the globus pallidus was infused simultaneously with the striatum. The difference between ipsiversive (towards the antisense-infused hemisphere) and contraversive rotations was calculated and animals were grouped by number according to their ipsiversive bias: I, <50 turns; II, 50–500 turns; III, 500–1000 turns; IV, >1000 turns. Immunohistochemical localization of Fos was used as an indicator of neuronal activity in the superior colliculus. While group I animals showed diffuse Fos-like immunoreactivity throughout the intermediate layers of the superior colliculus, those animals in groups II–IV showed increasing suppression of Fos-like immunoreactivity in the stratum album intermediale and marked enhancement in the stratum griseum intermediale. Correlation and regression analysis revealed a significant positive relationship between the number of ipsiversive rotations and the number of Fos-positive nuclei in the stratum griseum intermediale of the ipsilateral superior colliculus. These data suggest that the degree of rotation elicited in an animal may depend on reciprocal suppression/stimulation of adjacent intermediate strata of the superior colliculus. This study provides the first demonstration, using Fos immunohistochemistry, of changes in tectal activity produced by alterations in basal ganglia function. These findings support previous electrophysiological studies in this region and suggest that the nigrotectal projection may be an important site of altered basal ganglia output.
Url:
DOI: 10.1016/S0306-4522(98)00434-5
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:E1CC48C1C9D2A2B282490052FE3C4017A00D865ELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Alterations of neuronal activity in the superior colliculus of rotating animals</title><author><name sortKey="Hebb, M O" sort="Hebb, M O" uniqKey="Hebb M" first="M. O" last="Hebb">M. O Hebb</name></author><author><name sortKey="Robertson, H A" sort="Robertson, H A" uniqKey="Robertson H" first="H. A" last="Robertson">H. A Robertson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E1CC48C1C9D2A2B282490052FE3C4017A00D865E</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0306-4522(98)00434-5</idno><idno type="url">https://api-v5.istex.fr/document/E1CC48C1C9D2A2B282490052FE3C4017A00D865E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002650</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002650</idno><idno type="wicri:Area/Istex/Curation">002650</idno><idno type="wicri:Area/Istex/Checkpoint">001324</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001324</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Alterations of neuronal activity in the superior colliculus of rotating animals</title><author><name sortKey="Hebb, M O" sort="Hebb, M O" uniqKey="Hebb M" first="M. O" last="Hebb">M. O Hebb</name><affiliation><wicri:noCountry code="subField">4H7</wicri:noCountry></affiliation></author><author><name sortKey="Robertson, H A" sort="Robertson, H A" uniqKey="Robertson H" first="H. A" last="Robertson">H. A Robertson</name><affiliation><wicri:noCountry code="subField">4H7</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience</title><title level="j" type="abbrev">NSC</title><idno type="ISSN">0306-4522</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="423">423</biblScope><biblScope unit="page" to="432">432</biblScope></imprint><idno type="ISSN">0306-4522</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have investigated the relationship between alterations in neuronal activity in the superior colliculus and behavioral responses which occur following disruption of basal ganglia circuitry. These changes were analysed following unilateral suppression of the immediate early genes, c-fos and ngfi-a, in the striatum and/or the globus pallidus. Animals with unilateral suppression of immediate early gene expression in the striatum exhibited robust circling activity, following administration of d-amphetamine, that was directed towards the side of suppression. The intensity of rotation was inversely related to the length of the recovery period following antisense infusion and increased significantly when the globus pallidus was infused simultaneously with the striatum. The difference between ipsiversive (towards the antisense-infused hemisphere) and contraversive rotations was calculated and animals were grouped by number according to their ipsiversive bias: I, <50 turns; II, 50–500 turns; III, 500–1000 turns; IV, >1000 turns. Immunohistochemical localization of Fos was used as an indicator of neuronal activity in the superior colliculus. While group I animals showed diffuse Fos-like immunoreactivity throughout the intermediate layers of the superior colliculus, those animals in groups II–IV showed increasing suppression of Fos-like immunoreactivity in the stratum album intermediale and marked enhancement in the stratum griseum intermediale. Correlation and regression analysis revealed a significant positive relationship between the number of ipsiversive rotations and the number of Fos-positive nuclei in the stratum griseum intermediale of the ipsilateral superior colliculus. These data suggest that the degree of rotation elicited in an animal may depend on reciprocal suppression/stimulation of adjacent intermediate strata of the superior colliculus. This study provides the first demonstration, using Fos immunohistochemistry, of changes in tectal activity produced by alterations in basal ganglia function. These findings support previous electrophysiological studies in this region and suggest that the nigrotectal projection may be an important site of altered basal ganglia output.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hebb, M O" sort="Hebb, M O" uniqKey="Hebb M" first="M. O" last="Hebb">M. O Hebb</name><name sortKey="Robertson, H A" sort="Robertson, H A" uniqKey="Robertson H" first="H. A" last="Robertson">H. A Robertson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001324 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001324 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:E1CC48C1C9D2A2B282490052FE3C4017A00D865E
|texte= Alterations of neuronal activity in the superior colliculus of rotating animals
}}
| This area was generated with Dilib version V0.6.29. |  |