Dopamine-receptor stimulation: biobehavioral and biochemical consequences
Identifieur interne : 001234 ( Istex/Checkpoint ); précédent : 001233; suivant : 001235Dopamine-receptor stimulation: biobehavioral and biochemical consequences
Auteurs : Frédéric Calon [Canada] ; Abdallah Hadj Tahar [Canada] ; Pierre J. Blanchet [Canada] ; Marc Morissette [Canada] ; Richard Grondin [Canada] ; Martin Goulet [Canada] ; Jean-Pierre Doucet [Canada] ; George S. Robertson [Canada] ; Eric Nestler [États-Unis] ; Thérèse Di Paolo [Canada] ; Paul J. Bédard [Canada]Source :
- Trends in Neurosciences [ 0166-2236 ] ; 2000.
Abstract
The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that l-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (non physiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.
Url:
DOI: 10.1016/S1471-1931(00)00026-4
Affiliations:
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<front><div type="abstract" xml:lang="en">The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that l-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (non physiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.</div>
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