PROBLEMS RAISED BY ANAESTHESIA FOR THALAMIC AND CORTICAL EXPLORATION IN NEUROSURGERY
Identifieur interne : 000353 ( France/Analysis ); précédent : 000352; suivant : 000354PROBLEMS RAISED BY ANAESTHESIA FOR THALAMIC AND CORTICAL EXPLORATION IN NEUROSURGERY
Auteurs : G. Vourc'H [France] ; J. Hardy [Canada] ; M. Denavit [France]Source :
- BJA: British Journal of Anaesthesia [ 0007-0912 ] ; 1963-04.
Abstract
Surgical treatment of Parkinson's disease involves the destruction (by diathermy) of localized areas of the thalamus. The accurate location of those areas is made possible by stereotactic approach; but this does not allow for anatomical variations. Electrical stimulation by unipolar electrodes to produce motor responses is equally inaccurate, due to the diffusion of the current. Our team has tried to apply to man techniques used in the laboratory on the cat. A high degree of accuracy has been achieved in locating the various cerebral structures, and even thalamic nuclei, using bipolar electrodes, recording the activity (spontaneous or evoked potentials) of different groups of cells. However, a major difficulty was to find a suitable anaesthetic, which would induce light anaesthesia, while preserving those activities. It has been found that chloralose and hydroxydione (Viadril) work in a similar way; the former has been used extensively for animal experimentation, since it preserves synaptic responses; the latter has been used on man with satisfactory results, which are presented.
Url:
DOI: 10.1093/bja/35.4.208
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Checkpoint: 002A95
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- to stream Main, to step Curation: 005542
- to stream Main, to step Exploration: 005542
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<front><div type="abstract">Surgical treatment of Parkinson's disease involves the destruction (by diathermy) of localized areas of the thalamus. The accurate location of those areas is made possible by stereotactic approach; but this does not allow for anatomical variations. Electrical stimulation by unipolar electrodes to produce motor responses is equally inaccurate, due to the diffusion of the current. Our team has tried to apply to man techniques used in the laboratory on the cat. A high degree of accuracy has been achieved in locating the various cerebral structures, and even thalamic nuclei, using bipolar electrodes, recording the activity (spontaneous or evoked potentials) of different groups of cells. However, a major difficulty was to find a suitable anaesthetic, which would induce light anaesthesia, while preserving those activities. It has been found that chloralose and hydroxydione (Viadril) work in a similar way; the former has been used extensively for animal experimentation, since it preserves synaptic responses; the latter has been used on man with satisfactory results, which are presented.</div>
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