La maladie de Parkinson au Canada (serveur d'exploration)

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PROBLEMS RAISED BY ANAESTHESIA FOR THALAMIC AND CORTICAL EXPLORATION IN NEUROSURGERY

Identifieur interne : 000353 ( France/Analysis ); précédent : 000352; suivant : 000354

PROBLEMS RAISED BY ANAESTHESIA FOR THALAMIC AND CORTICAL EXPLORATION IN NEUROSURGERY

Auteurs : G. Vourc'H [France] ; J. Hardy [Canada] ; M. Denavit [France]

Source :

RBID : ISTEX:291A1CC4C742B8A6002A8DA94413D8622ACDCBA5

Abstract

Surgical treatment of Parkinson's disease involves the destruction (by diathermy) of localized areas of the thalamus. The accurate location of those areas is made possible by stereotactic approach; but this does not allow for anatomical variations. Electrical stimulation by unipolar electrodes to produce motor responses is equally inaccurate, due to the diffusion of the current. Our team has tried to apply to man techniques used in the laboratory on the cat. A high degree of accuracy has been achieved in locating the various cerebral structures, and even thalamic nuclei, using bipolar electrodes, recording the activity (spontaneous or evoked potentials) of different groups of cells. However, a major difficulty was to find a suitable anaesthetic, which would induce light anaesthesia, while preserving those activities. It has been found that chloralose and hydroxydione (Viadril) work in a similar way; the former has been used extensively for animal experimentation, since it preserves synaptic responses; the latter has been used on man with satisfactory results, which are presented.

Url:
DOI: 10.1093/bja/35.4.208


Affiliations:


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ISTEX:291A1CC4C742B8A6002A8DA94413D8622ACDCBA5

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{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     ISTEX:291A1CC4C742B8A6002A8DA94413D8622ACDCBA5
   |texte=   PROBLEMS RAISED BY ANAESTHESIA FOR THALAMIC AND CORTICAL EXPLORATION IN NEUROSURGERY
}}

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