Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
Identifieur interne : 000081 ( France/Analysis ); précédent : 000080; suivant : 000082Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
Auteurs : Nadine Schweizer [Suède] ; Stéfano Pupe [Suède, Brésil] ; Emma Arvidsson [Suède] ; Karin Nordenankar [Suède] ; Casey J. A. Smith-Anttila [Suède] ; Souha Mahmoudi [Canada] ; Anna Andrén [Suède] ; Sylvie Dumas [France] ; Aparna Rajagopalan [Suède] ; Daniel Lévesque [Canada] ; Richardson N. Leão [Suède, Brésil] ; Sa Wallén-Mackenzie [Suède]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Dopamine (metabolism), Excitatory Postsynaptic Potentials (physiology), Glutamic Acid (metabolism), Homeodomain Proteins (metabolism), Hyperkinesis (etiology), Hyperkinesis (metabolism), Immunohistochemistry, In Situ Hybridization, Maze Learning (physiology), Mice, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Subthalamic Nucleus (metabolism), Synaptic Transmission (physiology), Transcription Factors (metabolism), Vesicular Glutamate Transport Protein 2 (metabolism).
- MESH :
- chemical , metabolism : Dopamine, Glutamic Acid, Homeodomain Proteins, Transcription Factors, Vesicular Glutamate Transport Protein 2.
- etiology : Hyperkinesis.
- metabolism : Hyperkinesis, Subthalamic Nucleus.
- physiology : Excitatory Postsynaptic Potentials, Maze Learning, Synaptic Transmission.
- Animals, Immunohistochemistry, In Situ Hybridization, Mice, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
The subthalamic nucleus (STN) has an important role in locomotion, as evidenced by the successful use of high-frequency stimulation of this structure as treatment for Parkinson disease. There is considerable uncertainty, however, regarding the mechanism through which this effect is achieved. We identified a promoter diversity within this nucleus and observed a movement phenotype displayed as decreased latency in initiation of movement and increased locomotion in both horizontal and vertical planes as a consequence of blunting, but not eliminating, expression of
Url:
DOI: 10.1073/pnas.1323499111
PubMed: 24821804
PubMed Central: 4040590
Affiliations:
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PMC:4040590Le document en format XML
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H3C 3J7</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">Brésil</country>
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<author><name sortKey="Wallen Mackenzie, Sa" sort="Wallen Mackenzie, Sa" uniqKey="Wallen Mackenzie " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name>
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<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2014">2014</date>
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<term>Dopamine (metabolism)</term>
<term>Excitatory Postsynaptic Potentials (physiology)</term>
<term>Glutamic Acid (metabolism)</term>
<term>Homeodomain Proteins (metabolism)</term>
<term>Hyperkinesis (etiology)</term>
<term>Hyperkinesis (metabolism)</term>
<term>Immunohistochemistry</term>
<term>In Situ Hybridization</term>
<term>Maze Learning (physiology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Subthalamic Nucleus (metabolism)</term>
<term>Synaptic Transmission (physiology)</term>
<term>Transcription Factors (metabolism)</term>
<term>Vesicular Glutamate Transport Protein 2 (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Glutamic Acid</term>
<term>Homeodomain Proteins</term>
<term>Transcription Factors</term>
<term>Vesicular Glutamate Transport Protein 2</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hyperkinesis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hyperkinesis</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Excitatory Postsynaptic Potentials</term>
<term>Maze Learning</term>
<term>Synaptic Transmission</term>
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<term>Immunohistochemistry</term>
<term>In Situ Hybridization</term>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>The subthalamic nucleus (STN) has an important role in locomotion, as evidenced by the successful use of high-frequency stimulation of this structure as treatment for Parkinson disease. There is considerable uncertainty, however, regarding the mechanism through which this effect is achieved. We identified a promoter diversity within this nucleus and observed a movement phenotype displayed as decreased latency in initiation of movement and increased locomotion in both horizontal and vertical planes as a consequence of blunting, but not eliminating, expression of <italic>Vglut2</italic>
in the STN of mice. In contrast to various lesion and high-frequency-stimulation studies of the STN, our genetic approach leaves cognitive functions intact. Taken together, our findings could be important for advancing future therapeutic strategies.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>Canada</li>
<li>France</li>
<li>Suède</li>
</country>
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<tree><country name="Suède"><noRegion><name sortKey="Schweizer, Nadine" sort="Schweizer, Nadine" uniqKey="Schweizer N" first="Nadine" last="Schweizer">Nadine Schweizer</name>
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<name sortKey="Andren, Anna" sort="Andren, Anna" uniqKey="Andren A" first="Anna" last="Andrén">Anna Andrén</name>
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<name sortKey="Leao, Richardson N" sort="Leao, Richardson N" uniqKey="Leao R" first="Richardson N." last="Leão">Richardson N. Leão</name>
<name sortKey="Nordenankar, Karin" sort="Nordenankar, Karin" uniqKey="Nordenankar K" first="Karin" last="Nordenankar">Karin Nordenankar</name>
<name sortKey="Pupe, Stefano" sort="Pupe, Stefano" uniqKey="Pupe S" first="Stéfano" last="Pupe">Stéfano Pupe</name>
<name sortKey="Rajagopalan, Aparna" sort="Rajagopalan, Aparna" uniqKey="Rajagopalan A" first="Aparna" last="Rajagopalan">Aparna Rajagopalan</name>
<name sortKey="Smith Anttila, Casey J A" sort="Smith Anttila, Casey J A" uniqKey="Smith Anttila C" first="Casey J. A." last="Smith-Anttila">Casey J. A. Smith-Anttila</name>
<name sortKey="Wallen Mackenzie, Sa" sort="Wallen Mackenzie, Sa" uniqKey="Wallen Mackenzie " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name>
</country>
<country name="Brésil"><noRegion><name sortKey="Pupe, Stefano" sort="Pupe, Stefano" uniqKey="Pupe S" first="Stéfano" last="Pupe">Stéfano Pupe</name>
</noRegion>
<name sortKey="Leao, Richardson N" sort="Leao, Richardson N" uniqKey="Leao R" first="Richardson N." last="Leão">Richardson N. Leão</name>
</country>
<country name="Canada"><noRegion><name sortKey="Mahmoudi, Souha" sort="Mahmoudi, Souha" uniqKey="Mahmoudi S" first="Souha" last="Mahmoudi">Souha Mahmoudi</name>
</noRegion>
<name sortKey="Levesque, Daniel" sort="Levesque, Daniel" uniqKey="Levesque D" first="Daniel" last="Lévesque">Daniel Lévesque</name>
</country>
<country name="France"><noRegion><name sortKey="Dumas, Sylvie" sort="Dumas, Sylvie" uniqKey="Dumas S" first="Sylvie" last="Dumas">Sylvie Dumas</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000081 | SxmlIndent | more
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{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= France |étape= Analysis |type= RBID |clé= PMC:4040590 |texte= Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion }}
Pour générer des pages wiki
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