Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.
Identifieur interne : 000070 ( Main/Corpus ); précédent : 000069; suivant : 000071Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.
Auteurs : Carita Ng ; Lingyun Ye ; Stephen G. Noorduyn ; Margaret Hux ; Edward Thommes ; Ron Goeree ; Ardith Ambrose ; Melissa K. Andrew ; Todd Hatchette ; Guy Boivin ; William Bowie ; May Elsherif ; Karen Green ; Jennie Johnstone ; Kevin Katz ; Jason Leblanc ; Mark Loeb ; Donna Mackinnon-Cameron ; Anne Mccarthy ; Janet Mcelhaney ; Allison Mcgeer ; Andre Poirier ; Jeff Powis ; David Richardson ; Rohita Sharma ; Makeda Semret ; Stephanie Smith ; Daniel Smyth ; Grant Stiver ; Sylvie Trottier ; Louis Valiquette ; Duncan Webster ; Shelly A. McneilSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2018.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Canada.
- economics : Influenza, Human.
- epidemiology : Influenza, Human.
- pathology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Health Care Costs, Health Resources, Hospitalization, Humans, Male, Middle Aged, Young Adult.
Abstract
BACKGROUND
Consideration of cost determinants is crucial to inform delivery of public vaccination programs.
OBJECTIVES
To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. To analyze effects of patient/disease characteristics, treatment, and regional differences in costs.
METHODS
Study utilized previously recorded clinical characteristics, resource use, and outcomes of laboratory-confirmed influenza patients admitted to hospitals in the Serious Outcomes Surveillance (SOS), Canadian Immunization Research Network (CIRN), from 2010/11 to 2012/13. Unit costs including hospital overheads were linked to inpatient/outpatient resource utilization before and after admissions.
RESULTS
Dataset included 2943 adult admissions to 17 SOS Network hospitals and 24 Toronto Invasive Bacterial Disease Network hospitals. Mean age was 69.5 years. Average hospital stay was 10.8 days (95% CI: 10.3, 11.3), general ward stays were 9.4 days (95% CI: 9.0, 9.8), and ICU stays were 9.8 days (95% CI: 8.6, 11.1) for the 14% of patients admitted to the ICU. Average cost per case was $14 612 CAD (95% CI: $13 852, $15 372) including $133 (95% CI: $116, $150) for medical care prior to admission, $14 031 (95% CI: $13 295, $14 768) during initial hospital stay, $447 (95% CI: $271, $624) post-discharge, including readmission within 30 days.
CONCLUSION
The cost of laboratory-confirmed influenza was higher than previous estimates, driven mostly by length of stay and analyzing only laboratory-confirmed influenza cases. The true per-patient cost of influenza-related hospitalization has been underestimated, and prevention programs should be evaluated in this context.
DOI: 10.1111/irv.12521
PubMed: 29125689
Links to Exploration step
pubmed:29125689Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.</title><author><name sortKey="Ng, Carita" sort="Ng, Carita" uniqKey="Ng C" first="Carita" last="Ng">Carita Ng</name><affiliation><nlm:affiliation>ICON Plc, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Noorduyn, Stephen G" sort="Noorduyn, Stephen G" uniqKey="Noorduyn S" first="Stephen G" last="Noorduyn">Stephen G. Noorduyn</name><affiliation><nlm:affiliation>GSK, Mississauga, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hux, Margaret" sort="Hux, Margaret" uniqKey="Hux M" first="Margaret" last="Hux">Margaret Hux</name><affiliation><nlm:affiliation>ICON Plc, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Thommes, Edward" sort="Thommes, Edward" uniqKey="Thommes E" first="Edward" last="Thommes">Edward Thommes</name><affiliation><nlm:affiliation>Takeda (formerly GSK), Oakville, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goeree, Ron" sort="Goeree, Ron" uniqKey="Goeree R" first="Ron" last="Goeree">Ron Goeree</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hatchette, Todd" sort="Hatchette, Todd" uniqKey="Hatchette T" first="Todd" last="Hatchette">Todd Hatchette</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name><affiliation><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><affiliation><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation><nlm:affiliation>North York General Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:affiliation>The Ottawa Hospital, Ottawa Hospital Civic Campus, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelhaney, Janet" sort="Mcelhaney, Janet" uniqKey="Mcelhaney J" first="Janet" last="Mcelhaney">Janet Mcelhaney</name><affiliation><nlm:affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><affiliation><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Poirier, Andre" sort="Poirier, Andre" uniqKey="Poirier A" first="Andre" last="Poirier">Andre Poirier</name><affiliation><nlm:affiliation>Centre de santé et de service sociaux de Trois-Rivières, Trois Rivières, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><affiliation><nlm:affiliation>Michael Garron Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Medical Microbiology, William Osler Health System, Brampton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Rohita" sort="Sharma, Rohita" uniqKey="Sharma R" first="Rohita" last="Sharma">Rohita Sharma</name><affiliation><nlm:affiliation>GSK, Mississauga, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name><affiliation><nlm:affiliation>McGill University Health Centre, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Stephanie" sort="Smith, Stephanie" uniqKey="Smith S" first="Stephanie" last="Smith">Stephanie Smith</name><affiliation><nlm:affiliation>University of Alberta Hospital, Edmonton, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name><affiliation><nlm:affiliation>The Moncton Hospital, Moncton, NB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Stiver, Grant" sort="Stiver, Grant" uniqKey="Stiver G" first="Grant" last="Stiver">Grant Stiver</name><affiliation><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name><affiliation><nlm:affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name><affiliation><nlm:affiliation>Horizon Health, Saint John, NB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29125689</idno><idno type="pmid">29125689</idno><idno type="doi">10.1111/irv.12521</idno><idno type="wicri:Area/Main/Corpus">000070</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.</title><author><name sortKey="Ng, Carita" sort="Ng, Carita" uniqKey="Ng C" first="Carita" last="Ng">Carita Ng</name><affiliation><nlm:affiliation>ICON Plc, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Noorduyn, Stephen G" sort="Noorduyn, Stephen G" uniqKey="Noorduyn S" first="Stephen G" last="Noorduyn">Stephen G. Noorduyn</name><affiliation><nlm:affiliation>GSK, Mississauga, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hux, Margaret" sort="Hux, Margaret" uniqKey="Hux M" first="Margaret" last="Hux">Margaret Hux</name><affiliation><nlm:affiliation>ICON Plc, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Thommes, Edward" sort="Thommes, Edward" uniqKey="Thommes E" first="Edward" last="Thommes">Edward Thommes</name><affiliation><nlm:affiliation>Takeda (formerly GSK), Oakville, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goeree, Ron" sort="Goeree, Ron" uniqKey="Goeree R" first="Ron" last="Goeree">Ron Goeree</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hatchette, Todd" sort="Hatchette, Todd" uniqKey="Hatchette T" first="Todd" last="Hatchette">Todd Hatchette</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name><affiliation><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><affiliation><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation><nlm:affiliation>North York General Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation><nlm:affiliation>McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation><nlm:affiliation>The Ottawa Hospital, Ottawa Hospital Civic Campus, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelhaney, Janet" sort="Mcelhaney, Janet" uniqKey="Mcelhaney J" first="Janet" last="Mcelhaney">Janet Mcelhaney</name><affiliation><nlm:affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><affiliation><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Poirier, Andre" sort="Poirier, Andre" uniqKey="Poirier A" first="Andre" last="Poirier">Andre Poirier</name><affiliation><nlm:affiliation>Centre de santé et de service sociaux de Trois-Rivières, Trois Rivières, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><affiliation><nlm:affiliation>Michael Garron Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Medical Microbiology, William Osler Health System, Brampton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Rohita" sort="Sharma, Rohita" uniqKey="Sharma R" first="Rohita" last="Sharma">Rohita Sharma</name><affiliation><nlm:affiliation>GSK, Mississauga, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name><affiliation><nlm:affiliation>McGill University Health Centre, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Stephanie" sort="Smith, Stephanie" uniqKey="Smith S" first="Stephanie" last="Smith">Stephanie Smith</name><affiliation><nlm:affiliation>University of Alberta Hospital, Edmonton, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name><affiliation><nlm:affiliation>The Moncton Hospital, Moncton, NB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Stiver, Grant" sort="Stiver, Grant" uniqKey="Stiver G" first="Grant" last="Stiver">Grant Stiver</name><affiliation><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name><affiliation><nlm:affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name><affiliation><nlm:affiliation>Horizon Health, Saint John, NB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Canada (epidemiology)</term><term>Female</term><term>Health Care Costs</term><term>Health Resources</term><term>Hospitalization</term><term>Humans</term><term>Influenza, Human (economics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (pathology)</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Health Care Costs</term><term>Health Resources</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Consideration of cost determinants is crucial to inform delivery of public vaccination programs.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. To analyze effects of patient/disease characteristics, treatment, and regional differences in costs.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Study utilized previously recorded clinical characteristics, resource use, and outcomes of laboratory-confirmed influenza patients admitted to hospitals in the Serious Outcomes Surveillance (SOS), Canadian Immunization Research Network (CIRN), from 2010/11 to 2012/13. Unit costs including hospital overheads were linked to inpatient/outpatient resource utilization before and after admissions.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Dataset included 2943 adult admissions to 17 SOS Network hospitals and 24 Toronto Invasive Bacterial Disease Network hospitals. Mean age was 69.5 years. Average hospital stay was 10.8 days (95% CI: 10.3, 11.3), general ward stays were 9.4 days (95% CI: 9.0, 9.8), and ICU stays were 9.8 days (95% CI: 8.6, 11.1) for the 14% of patients admitted to the ICU. Average cost per case was $14 612 CAD (95% CI: $13 852, $15 372) including $133 (95% CI: $116, $150) for medical care prior to admission, $14 031 (95% CI: $13 295, $14 768) during initial hospital stay, $447 (95% CI: $271, $624) post-discharge, including readmission within 30 days.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The cost of laboratory-confirmed influenza was higher than previous estimates, driven mostly by length of stay and analyzing only laboratory-confirmed influenza cases. The true per-patient cost of influenza-related hospitalization has been underestimated, and prevention programs should be evaluated in this context.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29125689</PMID><DateCompleted><Year>2019</Year><Month>01</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>03</Month></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.</ArticleTitle><Pagination><MedlinePgn>232-240</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/irv.12521</ELocationID><Abstract><AbstractText Label="BACKGROUND">Consideration of cost determinants is crucial to inform delivery of public vaccination programs.</AbstractText><AbstractText Label="OBJECTIVES">To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. To analyze effects of patient/disease characteristics, treatment, and regional differences in costs.</AbstractText><AbstractText Label="METHODS">Study utilized previously recorded clinical characteristics, resource use, and outcomes of laboratory-confirmed influenza patients admitted to hospitals in the Serious Outcomes Surveillance (SOS), Canadian Immunization Research Network (CIRN), from 2010/11 to 2012/13. Unit costs including hospital overheads were linked to inpatient/outpatient resource utilization before and after admissions.</AbstractText><AbstractText Label="RESULTS">Dataset included 2943 adult admissions to 17 SOS Network hospitals and 24 Toronto Invasive Bacterial Disease Network hospitals. Mean age was 69.5 years. Average hospital stay was 10.8 days (95% CI: 10.3, 11.3), general ward stays were 9.4 days (95% CI: 9.0, 9.8), and ICU stays were 9.8 days (95% CI: 8.6, 11.1) for the 14% of patients admitted to the ICU. Average cost per case was $14 612 CAD (95% CI: $13 852, $15 372) including $133 (95% CI: $116, $150) for medical care prior to admission, $14 031 (95% CI: $13 295, $14 768) during initial hospital stay, $447 (95% CI: $271, $624) post-discharge, including readmission within 30 days.</AbstractText><AbstractText Label="CONCLUSION">The cost of laboratory-confirmed influenza was higher than previous estimates, driven mostly by length of stay and analyzing only laboratory-confirmed influenza cases. The true per-patient cost of influenza-related hospitalization has been underestimated, and prevention programs should be evaluated in this context.</AbstractText><CopyrightInformation>© 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Carita</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>ICON Plc, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Lingyun</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noorduyn</LastName><ForeName>Stephen G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>GSK, Mississauga, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hux</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>ICON Plc, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thommes</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Takeda (formerly GSK), Oakville, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goeree</LastName><ForeName>Ron</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ambrose</LastName><ForeName>Ardith</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrew</LastName><ForeName>Melissa K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hatchette</LastName><ForeName>Todd</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boivin</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowie</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of British Columbia, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>ElSherif</LastName><ForeName>May</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnstone</LastName><ForeName>Jennie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>North York General Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leblanc</LastName><ForeName>Jason</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loeb</LastName><ForeName>Mark</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-2315-5390</Identifier><AffiliationInfo><Affiliation>McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacKinnon-Cameron</LastName><ForeName>Donna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Ottawa Hospital, Ottawa Hospital Civic Campus, Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElhaney</LastName><ForeName>Janet</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGeer</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poirier</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre de santé et de service sociaux de Trois-Rivières, Trois Rivières, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powis</LastName><ForeName>Jeff</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Michael Garron Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Medical Microbiology, William Osler Health System, Brampton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Rohita</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>GSK, Mississauga, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semret</LastName><ForeName>Makeda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>McGill University Health Centre, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Alberta Hospital, Edmonton, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Moncton Hospital, Moncton, NB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stiver</LastName><ForeName>Grant</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of British Columbia, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trottier</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valiquette</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Webster</LastName><ForeName>Duncan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Horizon Health, Saint John, NB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNeil</LastName><ForeName>Shelly A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Serious Outcomes Surveillance Network of the Canadian Immunization Research Network (CIRN) Investigators</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>Toronto Invasive Bacterial Diseases Network (TIBDN) Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Influenza Other Respir Viruses</MedlineTA><NlmUniqueID>101304007</NlmUniqueID><ISSNLinking>1750-2640</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017048" MajorTopicYN="Y">Health Care Costs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006295" MajorTopicYN="Y">Health Resources</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Canada</Keyword><Keyword MajorTopicYN="Y">burden of illness</Keyword><Keyword MajorTopicYN="Y">direct service costs</Keyword><Keyword MajorTopicYN="Y">disease surveillance</Keyword><Keyword MajorTopicYN="Y">hospital costs</Keyword><Keyword MajorTopicYN="Y">human</Keyword><Keyword MajorTopicYN="Y">influenza</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29125689</ArticleId><ArticleId IdType="doi">10.1111/irv.12521</ArticleId><ArticleId IdType="pmc">PMC5820421</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Vaccine. 2007 Jun 28;25(27):5086-96</Citation><ArticleIdList><ArticleId IdType="pubmed">17544181</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Methods Med Res. 2007 Jun;16(3):219-42</Citation><ArticleIdList><ArticleId IdType="pubmed">17621469</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2004 Sep 15;292(11):1333-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15367555</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Med. 2008 Jul 30;27(17):3227-46</Citation><ArticleIdList><ArticleId IdType="pubmed">18203127</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Other Respir Viruses. 2008 Jan;2(1):1-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19453488</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Infect Dis J. 2006 Sep;25(9):795-800</Citation><ArticleIdList><ArticleId IdType="pubmed">16940836</ArticleId></ArticleIdList></Reference><Reference><Citation>CMAJ. 2005 Aug 30;173(5):489-95</Citation><ArticleIdList><ArticleId IdType="pubmed">16129869</ArticleId></ArticleIdList></Reference><Reference><Citation>Health Rep. 2013 Sep;24(9):10-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24258362</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2015 Feb 05;20(5):21024</Citation><ArticleIdList><ArticleId IdType="pubmed">25677052</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Trials. 2007;4(2):154-61</Citation><ArticleIdList><ArticleId IdType="pubmed">17456514</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeCanadaV3/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= GrippeCanadaV3
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:29125689
|texte= Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:29125689" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a GrippeCanadaV3
| This area was generated with Dilib version V0.6.35. |  |