Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.
Identifieur interne : 000158 ( PubMed/Curation ); précédent : 000157; suivant : 000159Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.
Auteurs : Gema Pereira-Caro [Espagne] ; Christine M. Oliver [Australie] ; Rangika Weerakkody [Australie] ; Tanoj Singh [Australie] ; Michael Conlon [Australie] ; Gina Borges [États-Unis] ; Luz Sanguansri [Australie] ; Trevor Lockett [Australie] ; Susan A. Roberts [États-Unis] ; Alan Crozier [États-Unis] ; Mary Ann Augustin [Australie]Source :
- Free radical biology & medicine [ 1873-4596 ] ; 2015.
English descriptors
- KwdEn :
- Administration, Oral, Adolescent, Adult, Aged, Bifidobacterium (physiology), Biological Availability, Citrus sinensis (chemistry), Drug Compounding, Female, Flavanones (administration & dosage), Flavanones (pharmacokinetics), Fruit and Vegetable Juices, Humans, Male, Middle Aged, Probiotics (administration & dosage), Young Adult.
- MESH :
- chemical , administration & dosage : Flavanones.
- administration & dosage : Probiotics.
- chemistry : Citrus sinensis.
- chemical , pharmacokinetics : Flavanones.
- physiology : Bifidobacterium.
- Administration, Oral, Adolescent, Adult, Aged, Biological Availability, Drug Compounding, Female, Fruit and Vegetable Juices, Humans, Male, Middle Aged, Young Adult.
Abstract
Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered Bifidobacterium longum R0175 on the colonic microflora and bioavailability of OJ flavanones in healthy volunteers. In an acute study volunteers drank OJ with and without the microencapsulated probiotic, whereas the chronic effects were examined when OJ was consumed after daily supplementation with the probiotic over 4 weeks. Bioavailability, assessed by 0-24h urinary excretion, was similar when OJ was consumed with and without acute probiotic intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main urinary flavanone metabolites. The overall urinary excretion of these metabolites after OJ ingestion and acute probiotic intake corresponded to 22% of intake, whereas excretion of key colon-derived phenolic and aromatic acids was equivalent to 21% of the ingested OJ (poly)phenols. Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%. Neither the probiotic bacterial profiles of stools nor the stool moisture, weight, pH, or levels of short-chain fatty acids and phenols differed significantly between treatments. These findings highlight the positive effect of chronic, but not acute, intake of microencapsulated B. longum R0175 on the bioavailability of OJ flavanones.
DOI: 10.1016/j.freeradbiomed.2015.03.010
PubMed: 25801290
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Oliver</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Weerakkody, Rangika" sort="Weerakkody, Rangika" uniqKey="Weerakkody R" first="Rangika" last="Weerakkody">Rangika Weerakkody</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Singh, Tanoj" sort="Singh, Tanoj" uniqKey="Singh T" first="Tanoj" last="Singh">Tanoj Singh</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Conlon, Michael" sort="Conlon, Michael" uniqKey="Conlon M" first="Michael" last="Conlon">Michael Conlon</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Adelaide, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Adelaide, SA</wicri:regionArea></affiliation></author><author><name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of California at Davis, Davis, CA 95616</wicri:regionArea></affiliation></author><author><name sortKey="Sanguansri, Luz" sort="Sanguansri, Luz" uniqKey="Sanguansri L" first="Luz" last="Sanguansri">Luz Sanguansri</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Lockett, Trevor" sort="Lockett, Trevor" uniqKey="Lockett T" first="Trevor" last="Lockett">Trevor Lockett</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, North Ryde, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, North Ryde, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30313, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30313</wicri:regionArea></affiliation></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of California at Davis, Davis, CA 95616</wicri:regionArea></affiliation></author><author><name sortKey="Augustin, Mary Ann" sort="Augustin, Mary Ann" uniqKey="Augustin M" first="Mary Ann" last="Augustin">Mary Ann Augustin</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia. Electronic address: maryann.augustin@csiro.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="eISSN">1873-4596</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Bifidobacterium (physiology)</term><term>Biological Availability</term><term>Citrus sinensis (chemistry)</term><term>Drug Compounding</term><term>Female</term><term>Flavanones (administration & dosage)</term><term>Flavanones (pharmacokinetics)</term><term>Fruit and Vegetable Juices</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probiotics (administration & dosage)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Probiotics</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bifidobacterium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Biological Availability</term><term>Drug Compounding</term><term>Female</term><term>Fruit and Vegetable Juices</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered Bifidobacterium longum R0175 on the colonic microflora and bioavailability of OJ flavanones in healthy volunteers. In an acute study volunteers drank OJ with and without the microencapsulated probiotic, whereas the chronic effects were examined when OJ was consumed after daily supplementation with the probiotic over 4 weeks. Bioavailability, assessed by 0-24h urinary excretion, was similar when OJ was consumed with and without acute probiotic intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main urinary flavanone metabolites. The overall urinary excretion of these metabolites after OJ ingestion and acute probiotic intake corresponded to 22% of intake, whereas excretion of key colon-derived phenolic and aromatic acids was equivalent to 21% of the ingested OJ (poly)phenols. Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%. Neither the probiotic bacterial profiles of stools nor the stool moisture, weight, pH, or levels of short-chain fatty acids and phenols differed significantly between treatments. These findings highlight the positive effect of chronic, but not acute, intake of microencapsulated B. longum R0175 on the bioavailability of OJ flavanones.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25801290</PMID><DateCreated><Year>2015</Year><Month>6</Month><Day>5</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>6</Month><Day>5</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4596</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Free radical biology & medicine</Title><ISOAbbreviation>Free Radic. Biol. Med.</ISOAbbreviation></Journal><ArticleTitle>Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.</ArticleTitle><Pagination><MedlinePgn>206-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.freeradbiomed.2015.03.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0891-5849(15)00122-7</ELocationID><Abstract><AbstractText>Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered Bifidobacterium longum R0175 on the colonic microflora and bioavailability of OJ flavanones in healthy volunteers. In an acute study volunteers drank OJ with and without the microencapsulated probiotic, whereas the chronic effects were examined when OJ was consumed after daily supplementation with the probiotic over 4 weeks. Bioavailability, assessed by 0-24h urinary excretion, was similar when OJ was consumed with and without acute probiotic intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main urinary flavanone metabolites. The overall urinary excretion of these metabolites after OJ ingestion and acute probiotic intake corresponded to 22% of intake, whereas excretion of key colon-derived phenolic and aromatic acids was equivalent to 21% of the ingested OJ (poly)phenols. Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%. Neither the probiotic bacterial profiles of stools nor the stool moisture, weight, pH, or levels of short-chain fatty acids and phenols differed significantly between treatments. These findings highlight the positive effect of chronic, but not acute, intake of microencapsulated B. longum R0175 on the bioavailability of OJ flavanones.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pereira-Caro</LastName><ForeName>Gema</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Technology, Postharvest and Food Industry, IFAPA-Alameda del Obispo, Córdoba, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliver</LastName><ForeName>Christine M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weerakkody</LastName><ForeName>Rangika</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Tanoj</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conlon</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borges</LastName><ForeName>Gina</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanguansri</LastName><ForeName>Luz</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lockett</LastName><ForeName>Trevor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, North Ryde, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Susan A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30313, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crozier</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augustin</LastName><ForeName>Mary Ann</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia. Electronic address: maryann.augustin@csiro.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Mar</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Free Radic Biol Med</MedlineTA><NlmUniqueID>8709159</NlmUniqueID><ISSNLinking>0891-5849</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001644" MajorTopicYN="N">Bifidobacterium</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004339" MajorTopicYN="N">Drug Compounding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067030" MajorTopicYN="N">Fruit and Vegetable Juices</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019936" MajorTopicYN="N">Probiotics</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bioavailability</Keyword><Keyword MajorTopicYN="N">Flavanones</Keyword><Keyword MajorTopicYN="N">Free radicals</Keyword><Keyword MajorTopicYN="N">Microencapsulated probiotic</Keyword><Keyword MajorTopicYN="N">Orange juice</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>3</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>3</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25801290</ArticleId><ArticleId IdType="pii">S0891-5849(15)00122-7</ArticleId><ArticleId IdType="doi">10.1016/j.freeradbiomed.2015.03.010</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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