Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.
Identifieur interne : 000600 ( PubMed/Corpus ); précédent : 000599; suivant : 000601Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.
Auteurs : Eva Niv ; Yami Shapira ; Ira Akiva ; Evgenia Rokhkind ; Etty Naor ; Mira Arbiv ; Nachum VaismanSource :
- Nutrients [ 2072-6643 ] ; 2012.
English descriptors
- KwdEn :
- Abdominal Pain (physiopathology), Adult, Area Under Curve, Beverages, Blood Pressure, Body Weight, Citrus sinensis, Dietary Supplements, Double-Blind Method, Dyspepsia (physiopathology), Female, Fructans (administration & dosage), Gastrointestinal Tract (physiopathology), Heartburn (physiopathology), Humans, Interviews as Topic, Male, Metabolome, Middle Aged, Surveys and Questionnaires, Vomiting (physiopathology).
- MESH :
- chemical , administration & dosage : Fructans.
- physiopathology : Abdominal Pain, Dyspepsia, Gastrointestinal Tract, Heartburn, Vomiting.
- Adult, Area Under Curve, Beverages, Blood Pressure, Body Weight, Citrus sinensis, Dietary Supplements, Double-Blind Method, Female, Humans, Interviews as Topic, Male, Metabolome, Middle Aged, Surveys and Questionnaires.
Abstract
Levan is a commonly used dietary fiber of the fructans group. Its impact on health remains undetermined. This double blind controlled study aimed to investigate the effect of 8 weeks' daily consumption of 500 mL of natural orange juice enriched with 11.25 g of levan compared to the same amount of natural orange juice without levan on weight, gastrointestinal symptoms and metabolic profiles of 48 healthy volunteers. The statistical analyses compared between- and within-group findings at baseline, 4 weeks and study closure. The compared parameters were: weight, blood pressure, blood laboratory tests, daily number of defecations, scores of stool consistency, abdominal pain, bloating, gas, dyspepsia, vomiting and heartburn. Despite a higher fiber level recorded in the study group, there was no significant difference in the effect of the two kinds of juices on the studied parameters. Both juices decreased systolic and diastolic pressures, increased sodium level (within normal range), stool number, and bloating scores, and decreased gas scores. In conclusion, levan itself had no effect on weight, gastrointestinal symptoms or metabolic profile of healthy volunteers. Its possible effect on obese, hypertensive or hyperlipidemic patients should be investigated in further studies.
DOI: 10.3390/nu4070638
PubMed: 22852055
Links to Exploration step
pubmed:22852055Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.</title><author><name sortKey="Niv, Eva" sort="Niv, Eva" uniqKey="Niv E" first="Eva" last="Niv">Eva Niv</name><affiliation><nlm:affiliation>The Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Center, Tel-Aviv, 76589, Israel. niv_em@netvision.net.il</nlm:affiliation></affiliation></author><author><name sortKey="Shapira, Yami" sort="Shapira, Yami" uniqKey="Shapira Y" first="Yami" last="Shapira">Yami Shapira</name></author><author><name sortKey="Akiva, Ira" sort="Akiva, Ira" uniqKey="Akiva I" first="Ira" last="Akiva">Ira Akiva</name></author><author><name sortKey="Rokhkind, Evgenia" sort="Rokhkind, Evgenia" uniqKey="Rokhkind E" first="Evgenia" last="Rokhkind">Evgenia Rokhkind</name></author><author><name sortKey="Naor, Etty" sort="Naor, Etty" uniqKey="Naor E" first="Etty" last="Naor">Etty Naor</name></author><author><name sortKey="Arbiv, Mira" sort="Arbiv, Mira" uniqKey="Arbiv M" first="Mira" last="Arbiv">Mira Arbiv</name></author><author><name sortKey="Vaisman, Nachum" sort="Vaisman, Nachum" uniqKey="Vaisman N" first="Nachum" last="Vaisman">Nachum Vaisman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22852055</idno><idno type="pmid">22852055</idno><idno type="doi">10.3390/nu4070638</idno><idno type="wicri:Area/PubMed/Corpus">000600</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.</title><author><name sortKey="Niv, Eva" sort="Niv, Eva" uniqKey="Niv E" first="Eva" last="Niv">Eva Niv</name><affiliation><nlm:affiliation>The Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Center, Tel-Aviv, 76589, Israel. niv_em@netvision.net.il</nlm:affiliation></affiliation></author><author><name sortKey="Shapira, Yami" sort="Shapira, Yami" uniqKey="Shapira Y" first="Yami" last="Shapira">Yami Shapira</name></author><author><name sortKey="Akiva, Ira" sort="Akiva, Ira" uniqKey="Akiva I" first="Ira" last="Akiva">Ira Akiva</name></author><author><name sortKey="Rokhkind, Evgenia" sort="Rokhkind, Evgenia" uniqKey="Rokhkind E" first="Evgenia" last="Rokhkind">Evgenia Rokhkind</name></author><author><name sortKey="Naor, Etty" sort="Naor, Etty" uniqKey="Naor E" first="Etty" last="Naor">Etty Naor</name></author><author><name sortKey="Arbiv, Mira" sort="Arbiv, Mira" uniqKey="Arbiv M" first="Mira" last="Arbiv">Mira Arbiv</name></author><author><name sortKey="Vaisman, Nachum" sort="Vaisman, Nachum" uniqKey="Vaisman N" first="Nachum" last="Vaisman">Nachum Vaisman</name></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdominal Pain (physiopathology)</term><term>Adult</term><term>Area Under Curve</term><term>Beverages</term><term>Blood Pressure</term><term>Body Weight</term><term>Citrus sinensis</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Dyspepsia (physiopathology)</term><term>Female</term><term>Fructans (administration & dosage)</term><term>Gastrointestinal Tract (physiopathology)</term><term>Heartburn (physiopathology)</term><term>Humans</term><term>Interviews as Topic</term><term>Male</term><term>Metabolome</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Vomiting (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fructans</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Abdominal Pain</term><term>Dyspepsia</term><term>Gastrointestinal Tract</term><term>Heartburn</term><term>Vomiting</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Area Under Curve</term><term>Beverages</term><term>Blood Pressure</term><term>Body Weight</term><term>Citrus sinensis</term><term>Dietary Supplements</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Interviews as Topic</term><term>Male</term><term>Metabolome</term><term>Middle Aged</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levan is a commonly used dietary fiber of the fructans group. Its impact on health remains undetermined. This double blind controlled study aimed to investigate the effect of 8 weeks' daily consumption of 500 mL of natural orange juice enriched with 11.25 g of levan compared to the same amount of natural orange juice without levan on weight, gastrointestinal symptoms and metabolic profiles of 48 healthy volunteers. The statistical analyses compared between- and within-group findings at baseline, 4 weeks and study closure. The compared parameters were: weight, blood pressure, blood laboratory tests, daily number of defecations, scores of stool consistency, abdominal pain, bloating, gas, dyspepsia, vomiting and heartburn. Despite a higher fiber level recorded in the study group, there was no significant difference in the effect of the two kinds of juices on the studied parameters. Both juices decreased systolic and diastolic pressures, increased sodium level (within normal range), stool number, and bloating scores, and decreased gas scores. In conclusion, levan itself had no effect on weight, gastrointestinal symptoms or metabolic profile of healthy volunteers. Its possible effect on obese, hypertensive or hyperlipidemic patients should be investigated in further studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22852055</PMID><DateCreated><Year>2012</Year><Month>8</Month><Day>1</Day></DateCreated><DateCompleted><Year>2012</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>7</Issue><PubDate><Year>2012</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Nutrients</Title><ISOAbbreviation>Nutrients</ISOAbbreviation></Journal><ArticleTitle>Effect of levan supplement in orange juice on weight, gastrointestinal symptoms and metabolic profile of healthy subjects: results of an 8-week clinical trial.</ArticleTitle><Pagination><MedlinePgn>638-47</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/nu4070638</ELocationID><Abstract><AbstractText>Levan is a commonly used dietary fiber of the fructans group. Its impact on health remains undetermined. This double blind controlled study aimed to investigate the effect of 8 weeks' daily consumption of 500 mL of natural orange juice enriched with 11.25 g of levan compared to the same amount of natural orange juice without levan on weight, gastrointestinal symptoms and metabolic profiles of 48 healthy volunteers. The statistical analyses compared between- and within-group findings at baseline, 4 weeks and study closure. The compared parameters were: weight, blood pressure, blood laboratory tests, daily number of defecations, scores of stool consistency, abdominal pain, bloating, gas, dyspepsia, vomiting and heartburn. Despite a higher fiber level recorded in the study group, there was no significant difference in the effect of the two kinds of juices on the studied parameters. Both juices decreased systolic and diastolic pressures, increased sodium level (within normal range), stool number, and bloating scores, and decreased gas scores. In conclusion, levan itself had no effect on weight, gastrointestinal symptoms or metabolic profile of healthy volunteers. Its possible effect on obese, hypertensive or hyperlipidemic patients should be investigated in further studies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Niv</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Center, Tel-Aviv, 76589, Israel. niv_em@netvision.net.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shapira</LastName><ForeName>Yami</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Akiva</LastName><ForeName>Ira</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Rokhkind</LastName><ForeName>Evgenia</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Naor</LastName><ForeName>Etty</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Arbiv</LastName><ForeName>Mira</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Vaisman</LastName><ForeName>Nachum</ForeName><Initials>N</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>Jul</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Nutrients</MedlineTA><NlmUniqueID>101521595</NlmUniqueID><ISSNLinking>2072-6643</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005630">Fructans</NameOfSubstance></Chemical><Chemical><RegistryNumber>9013-95-0</RegistryNumber><NameOfSubstance UI="C072599">levan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Adv Appl Microbiol. 1990;35:171-94</RefSource><PMID Version="1">2205081</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr. 1995 Jun;125(6):1401-12</RefSource><PMID Version="1">7782892</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr Sci Vitaminol (Tokyo). 1995 Jun;41(3):281-91</RefSource><PMID Version="1">7472673</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr. 1998 Jan;128(1):11-9</RefSource><PMID Version="1">9430596</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Nutr. 2005 Aug;82(2):471-6</RefSource><PMID Version="1">16087995</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Wei Sheng Yan Jiu. 2010 Mar;39(2):172-6</RefSource><PMID Version="1">20459030</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S</RefSource><PMID Version="1">17951501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2008;337:a2313</RefSource><PMID Version="1">19008265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Fam Med. 2009 Mar-Apr;7(2):157-63</RefSource><PMID Version="1">19273871</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Clin Nutr. 2009 Nov;63(11):1277-89</RefSource><PMID Version="1">19690573</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2010 May 5;102(9):614-26</RefSource><PMID Version="1">20407088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Exp Allergy. 2006 Jan;36(1):94-101</RefSource><PMID Version="1">16393271</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D015746" MajorTopicYN="N">Abdominal Pain</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004415" MajorTopicYN="N">Dyspepsia</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005630" MajorTopicYN="N">Fructans</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D041981" MajorTopicYN="N">Gastrointestinal Tract</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006356" MajorTopicYN="N">Heartburn</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007407" MajorTopicYN="N">Interviews as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055442" MajorTopicYN="Y">Metabolome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014839" MajorTopicYN="N">Vomiting</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3407986</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">dietary fibers</Keyword><Keyword MajorTopicYN="N">fructans</Keyword><Keyword MajorTopicYN="N">levan</Keyword><Keyword MajorTopicYN="N">orange juice</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>5</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>6</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>6</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22852055</ArticleId><ArticleId IdType="doi">10.3390/nu4070638</ArticleId><ArticleId IdType="pii">nutrients-04-00638</ArticleId><ArticleId IdType="pmc">PMC3407986</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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