Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants.
Identifieur interne : 000168 ( PubMed/Corpus ); précédent : 000167; suivant : 000169Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants.
Auteurs : Protus Arrey Tarkang ; Faith A. Okalebo ; Juma D. Siminyu ; William N. Ngugi ; Amos M. Mwaura ; Jackson Mugweru ; Gabriel A. Agbor ; Anastasia N. GuantaiSource :
- BMC complementary and alternative medicine [ 1472-6882 ] ; 2015.
English descriptors
- KwdEn :
- Analgesics (pharmacology), Analgesics (therapeutic use), Angiosperms, Animals, Anti-Inflammatory Agents (pharmacology), Anti-Inflammatory Agents (therapeutic use), Antimalarials (pharmacology), Antimalarials (therapeutic use), Antipyretics (pharmacology), Antipyretics (therapeutic use), Cameroon, Carrageenan, Drug Combinations, Edema (drug therapy), Fever (drug therapy), Inflammation (drug therapy), Malaria (complications), Malaria (drug therapy), Mice, Pain (drug therapy), Pain Measurement, Phytotherapy, Plant Bark, Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Leaves (drug effects), Rats, Wistar.
- MESH :
- chemical , pharmacology : Analgesics, Anti-Inflammatory Agents, Antimalarials, Antipyretics, Plant Extracts.
- chemical , therapeutic use : Analgesics, Anti-Inflammatory Agents, Antimalarials, Antipyretics, Plant Extracts.
- geographic : Cameroon, Carrageenan, Drug Combinations.
- complications : Malaria.
- drug effects : Plant Leaves.
- drug therapy : Edema, Fever, Inflammation, Malaria, Pain.
- Angiosperms, Animals, Mice, Pain Measurement, Phytotherapy, Plant Bark, Rats, Wistar.
Abstract
Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and safety profile. This study aimed at evaluating the antipyretic, anti-inflammatory and antinociceptive activities of the constituent plants of Nefang which are relevant to the symptomatic treatment of malaria fever.
DOI: 10.1186/s12906-015-0703-7
PubMed: 26055261
Links to Exploration step
pubmed:26055261Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants.</title><author><name sortKey="Tarkang, Protus Arrey" sort="Tarkang, Protus Arrey" uniqKey="Tarkang P" first="Protus Arrey" last="Tarkang">Protus Arrey Tarkang</name><affiliation><nlm:affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. ptarkang@yahoo.co.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Okalebo, Faith A" sort="Okalebo, Faith A" uniqKey="Okalebo F" first="Faith A" last="Okalebo">Faith A. Okalebo</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. okalebof@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Siminyu, Juma D" sort="Siminyu, Juma D" uniqKey="Siminyu J" first="Juma D" last="Siminyu">Juma D. Siminyu</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. juma.simiyu@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Ngugi, William N" sort="Ngugi, William N" uniqKey="Ngugi W" first="William N" last="Ngugi">William N. Ngugi</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. njihiamn@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Mwaura, Amos M" sort="Mwaura, Amos M" uniqKey="Mwaura A" first="Amos M" last="Mwaura">Amos M. Mwaura</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. amos.mwaura@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Mugweru, Jackson" sort="Mugweru, Jackson" uniqKey="Mugweru J" first="Jackson" last="Mugweru">Jackson Mugweru</name><affiliation><nlm:affiliation>Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Medicine, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya. mugweruj@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Agbor, Gabriel A" sort="Agbor, Gabriel A" uniqKey="Agbor G" first="Gabriel A" last="Agbor">Gabriel A. Agbor</name><affiliation><nlm:affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. agogae@yahoo.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Guantai, Anastasia N" sort="Guantai, Anastasia N" uniqKey="Guantai A" first="Anastasia N" last="Guantai">Anastasia N. Guantai</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. anguantai@yahoo.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26055261</idno><idno type="pmid">26055261</idno><idno type="doi">10.1186/s12906-015-0703-7</idno><idno type="wicri:Area/PubMed/Corpus">000168</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants.</title><author><name sortKey="Tarkang, Protus Arrey" sort="Tarkang, Protus Arrey" uniqKey="Tarkang P" first="Protus Arrey" last="Tarkang">Protus Arrey Tarkang</name><affiliation><nlm:affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. ptarkang@yahoo.co.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Okalebo, Faith A" sort="Okalebo, Faith A" uniqKey="Okalebo F" first="Faith A" last="Okalebo">Faith A. Okalebo</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. okalebof@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Siminyu, Juma D" sort="Siminyu, Juma D" uniqKey="Siminyu J" first="Juma D" last="Siminyu">Juma D. Siminyu</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. juma.simiyu@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Ngugi, William N" sort="Ngugi, William N" uniqKey="Ngugi W" first="William N" last="Ngugi">William N. Ngugi</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. njihiamn@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Mwaura, Amos M" sort="Mwaura, Amos M" uniqKey="Mwaura A" first="Amos M" last="Mwaura">Amos M. Mwaura</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. amos.mwaura@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Mugweru, Jackson" sort="Mugweru, Jackson" uniqKey="Mugweru J" first="Jackson" last="Mugweru">Jackson Mugweru</name><affiliation><nlm:affiliation>Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Medicine, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya. mugweruj@uonbi.ac.ke.</nlm:affiliation></affiliation></author><author><name sortKey="Agbor, Gabriel A" sort="Agbor, Gabriel A" uniqKey="Agbor G" first="Gabriel A" last="Agbor">Gabriel A. Agbor</name><affiliation><nlm:affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. agogae@yahoo.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Guantai, Anastasia N" sort="Guantai, Anastasia N" uniqKey="Guantai A" first="Anastasia N" last="Guantai">Anastasia N. Guantai</name><affiliation><nlm:affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. anguantai@yahoo.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC complementary and alternative medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analgesics (pharmacology)</term><term>Analgesics (therapeutic use)</term><term>Angiosperms</term><term>Animals</term><term>Anti-Inflammatory Agents (pharmacology)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Antimalarials (pharmacology)</term><term>Antimalarials (therapeutic use)</term><term>Antipyretics (pharmacology)</term><term>Antipyretics (therapeutic use)</term><term>Cameroon</term><term>Carrageenan</term><term>Drug Combinations</term><term>Edema (drug therapy)</term><term>Fever (drug therapy)</term><term>Inflammation (drug therapy)</term><term>Malaria (complications)</term><term>Malaria (drug therapy)</term><term>Mice</term><term>Pain (drug therapy)</term><term>Pain Measurement</term><term>Phytotherapy</term><term>Plant Bark</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Plant Leaves (drug effects)</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics</term><term>Anti-Inflammatory Agents</term><term>Antimalarials</term><term>Antipyretics</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Analgesics</term><term>Anti-Inflammatory Agents</term><term>Antimalarials</term><term>Antipyretics</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Cameroon</term><term>Carrageenan</term><term>Drug Combinations</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plant Leaves</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Edema</term><term>Fever</term><term>Inflammation</term><term>Malaria</term><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Angiosperms</term><term>Animals</term><term>Mice</term><term>Pain Measurement</term><term>Phytotherapy</term><term>Plant Bark</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and safety profile. This study aimed at evaluating the antipyretic, anti-inflammatory and antinociceptive activities of the constituent plants of Nefang which are relevant to the symptomatic treatment of malaria fever.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26055261</PMID><DateCreated><Year>2015</Year><Month>6</Month><Day>9</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>05</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1472-6882</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><PubDate><Year>2015</Year><Month>Jun</Month><Day>09</Day></PubDate></JournalIssue><Title>BMC complementary and alternative medicine</Title><ISOAbbreviation>BMC Complement Altern Med</ISOAbbreviation></Journal><ArticleTitle>Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants.</ArticleTitle><Pagination><MedlinePgn>174</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12906-015-0703-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and safety profile. This study aimed at evaluating the antipyretic, anti-inflammatory and antinociceptive activities of the constituent plants of Nefang which are relevant to the symptomatic treatment of malaria fever.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Antipyretic activities were determined by the D-Amphetamine induced pyrexia and Brewer's Yeast induced hyperpyrexia methods. Anti-inflammatory activities were investigated using the carrageenan-induced rat paw edema method. Antinociceptive activities were determined by mechanical nociception in the tail pressure and thermal nociception in the radiant heat tail flick and hot plate methods. Data was analysed using the one way ANOVA followed by Neuman-Keuls multiple comparison test.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Best percentage inhibition of induced pyrexia (amphetamine/brewer's yeast; p < 0.05) was exhibited by Cc (95/97) followed by Og (85/94), MiL (90/89), MiB (88/84) and Cs (82/89). Cc and Og exhibited comparable activities to paracetamol (100/95). Anti-inflammatory studies revealed paw edema inhibition (%) as follows (p < 0.05): Indomethacin (47), MiL (40), Cp (30), MiB (28) and Og (22), suggesting best activity by MiL. Antinociceptive studies revealed significant (p < 0.01) pain inhibition (%) as follows: Paracetamol (97), Og (113), MiL (108), Pg (84) and MiB (88). Og and MiL exhibited the best activities.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results obtained suggest that the constituent plants possess biologically active compounds with antipyretic, anti-inflammatory and antinociceptive activities. These activities are essential in the symptomatic treatment of malaria fever, thereby justifying the folk use of Nefang. This would be useful in its subsequent development for clinical application.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tarkang</LastName><ForeName>Protus Arrey</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. ptarkang@yahoo.co.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. ptarkang@yahoo.co.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okalebo</LastName><ForeName>Faith A</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. okalebof@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siminyu</LastName><ForeName>Juma D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. juma.simiyu@uonbi.ac.ke.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngugi</LastName><ForeName>William N</ForeName><Initials>WN</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. njihiamn@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mwaura</LastName><ForeName>Amos M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. amos.mwaura@uonbi.ac.ke.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mugweru</LastName><ForeName>Jackson</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Medicine, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya. mugweruj@uonbi.ac.ke.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agbor</LastName><ForeName>Gabriel A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P. O. Box 6163, Yaoundé, Cameroon. agogae@yahoo.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guantai</LastName><ForeName>Anastasia N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P. O. Box 19676-00202, Nairobi, Kenya. anguantai@yahoo.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Jun</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Complement Altern Med</MedlineTA><NlmUniqueID>101088661</NlmUniqueID><ISSNLinking>1472-6882</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000700">Analgesics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D058633">Antipyretics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>9000-07-1</RegistryNumber><NameOfSubstance UI="D002351">Carrageenan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Ethnopharmacol. 2001 Jun;76(1):45-8</RefSource><PMID Version="1">11378280</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Malar J. 2014;13:456</RefSource><PMID Version="1">25421605</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Ethnopharmacol. 2003 Mar;85(1):131-7</RefSource><PMID Version="1">12576211</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Ethnopharmacol. 2004 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MajorTopicYN="Y">Angiosperms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058633" MajorTopicYN="N">Antipyretics</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002163" MajorTopicYN="N" 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IdType="doi">10.1186/s12906-015-0703-7</ArticleId><ArticleId IdType="pii">10.1186/s12906-015-0703-7</ArticleId><ArticleId IdType="pmc">PMC4459057</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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