An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors
Identifieur interne : 000287 ( Pmc/Curation ); précédent : 000286; suivant : 000288An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors
Auteurs : Henry A. Gabb ; Catherine BlakeSource :
- Environmental Health Perspectives [ 0091-6765 ] ; 2016.
Abstract
Simultaneous or sequential exposure to multiple environmental stressors can affect chemical toxicity. Cumulative risk assessments consider multiple stressors but it is impractical to test every chemical combination to which people are exposed. New methods are needed to prioritize chemical combinations based on their prevalence and possible health impacts.
We introduce an informatics approach that uses publicly available data to identify chemicals that co-occur in consumer products, which account for a significant proportion of overall chemical load.
Fifty-five asthma-associated and endocrine disrupting chemicals (target chemicals) were selected. A database of 38,975 distinct consumer products and 32,231 distinct ingredient names was created from online sources, and PubChem and the Unified Medical Language System were used to resolve synonymous ingredient names. Synonymous ingredient names are different names for the same chemical (e.g., vitamin E and tocopherol).
Nearly one-third of the products (11,688 products, 30%) contained ≥ 1 target chemical and 5,229 products (13%) contained > 1. Of the 55 target chemicals, 31 (56%) appear in ≥ 1 product and 19 (35%) appear under more than one name. The most frequent three-way chemical combination (2-phenoxyethanol, methyl paraben, and ethyl paraben) appears in 1,059 products. Further work is needed to assess combined chemical exposures related to the use of multiple products.
The informatics approach increased the number of products considered in a traditional analysis by two orders of magnitude, but missing/incomplete product labels can limit the effectiveness of this approach. Such an approach must resolve synonymy to ensure that chemicals of interest are not missed. Commonly occurring chemical combinations can be used to prioritize cumulative toxicology risk assessments.
Gabb HA, Blake C. 2016. An informatics approach to evaluating combined chemical exposures from consumer products: a case study of asthma-associated chemicals and potential endocrine disruptors. Environ Health Perspect 124:1155–1165; http://dx.doi.org/10.1289/ehp.1510529
Url:
DOI: 10.1289/ehp.1510529
PubMed: 26955064
PubMed Central: 4977060
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors</title><author><name sortKey="Gabb, Henry A" sort="Gabb, Henry A" uniqKey="Gabb H" first="Henry A." last="Gabb">Henry A. Gabb</name></author><author><name sortKey="Blake, Catherine" sort="Blake, Catherine" uniqKey="Blake C" first="Catherine" last="Blake">Catherine Blake</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26955064</idno><idno type="pmc">4977060</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977060</idno><idno type="RBID">PMC:4977060</idno><idno type="doi">10.1289/ehp.1510529</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000288</idno><idno type="wicri:Area/Pmc/Curation">000287</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors</title><author><name sortKey="Gabb, Henry A" sort="Gabb, Henry A" uniqKey="Gabb H" first="Henry A." last="Gabb">Henry A. Gabb</name></author><author><name sortKey="Blake, Catherine" sort="Blake, Catherine" uniqKey="Blake C" first="Catherine" last="Blake">Catherine Blake</name></author></analytic><series><title level="j">Environmental Health Perspectives</title><idno type="ISSN">0091-6765</idno><idno type="eISSN">1552-9924</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Simultaneous or sequential exposure to multiple environmental stressors can affect chemical toxicity. Cumulative risk assessments consider multiple stressors but it is impractical to test every chemical combination to which people are exposed. New methods are needed to prioritize chemical combinations based on their prevalence and possible health impacts.</p></sec><sec><title>Objectives:</title><p>We introduce an informatics approach that uses publicly available data to identify chemicals that co-occur in consumer products, which account for a significant proportion of overall chemical load.</p></sec><sec><title>Methods:</title><p>Fifty-five asthma-associated and endocrine disrupting chemicals (target chemicals) were selected. A database of 38,975 distinct consumer products and 32,231 distinct ingredient names was created from online sources, and PubChem and the Unified Medical Language System were used to resolve synonymous ingredient names. Synonymous ingredient names are different names for the same chemical (e.g., vitamin E and tocopherol).</p></sec><sec><title>Results:</title><p>Nearly one-third of the products (11,688 products, 30%) contained ≥ 1 target chemical and 5,229 products (13%) contained > 1. Of the 55 target chemicals, 31 (56%) appear in ≥ 1 product and 19 (35%) appear under more than one name. The most frequent three-way chemical combination (2-phenoxyethanol, methyl paraben, and ethyl paraben) appears in 1,059 products. Further work is needed to assess combined chemical exposures related to the use of multiple products.</p></sec><sec><title>Conclusions:</title><p>The informatics approach increased the number of products considered in a traditional analysis by two orders of magnitude, but missing/incomplete product labels can limit the effectiveness of this approach. Such an approach must resolve synonymy to ensure that chemicals of interest are not missed. Commonly occurring chemical combinations can be used to prioritize cumulative toxicology risk assessments.</p></sec><sec><title>Citation:</title><p>Gabb HA, Blake C. 2016. An informatics approach to evaluating combined chemical exposures from consumer products: a case study of asthma-associated chemicals and potential endocrine disruptors. 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Yang</name></author><author><name sortKey="Yaniger, Si" uniqKey="Yaniger S">SI Yaniger</name></author><author><name sortKey="Jordan, Vc" uniqKey="Jordan V">VC Jordan</name></author><author><name sortKey="Klein, Dj" uniqKey="Klein D">DJ Klein</name></author><author><name sortKey="Bittner, Gd" uniqKey="Bittner G">GD Bittner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Environ Health Perspect</journal-id><journal-id journal-id-type="iso-abbrev">Environ. Health Perspect</journal-id><journal-id journal-id-type="publisher-id">EHP</journal-id><journal-title-group><journal-title>Environmental Health Perspectives</journal-title></journal-title-group><issn pub-type="ppub">0091-6765</issn><issn pub-type="epub">1552-9924</issn><publisher><publisher-name>National Institute of Environmental Health Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26955064</article-id><article-id pub-id-type="pmc">4977060</article-id><article-id pub-id-type="publisher-id">ehp.1510529</article-id><article-id pub-id-type="doi">10.1289/ehp.1510529</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gabb</surname><given-names>Henry A.</given-names></name><xref ref-type="corresp" rid="cor1">†</xref></contrib><contrib contrib-type="author"><name><surname>Blake</surname><given-names>Catherine</given-names></name></contrib><aff id="aff1"><addr-line>Graduate School of Library and Information Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><label>†</label>Address correspondence to H.A. Gabb, Graduate School of Library and Information Science, University of Illinois at Urbana-Champaign, 501 E. Daniel St., Champaign, IL 61820 USA. Telephone: (217) 419-2625. E-mail: <email xlink:href="gabbiii2@illinois.edu">gabbiii2@illinois.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>8</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2016</year></pub-date><volume>124</volume><issue>8</issue><fpage>1155</fpage><lpage>1165</lpage><history><date date-type="received"><day>24</day><month>7</month><year>2015</year></date><date date-type="rev-recd"><day>25</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>18</day><month>2</month><year>2016</year></date><date date-type="accepted"><day>08</day><month>3</month><year>2016</year></date></history><permissions><license xlink:href="http://creativecommons.org/publicdomain/mark/1.0/" license-type="public-domain"><license-p>Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.</license-p></license></permissions><abstract><sec><title>Background:</title><p>Simultaneous or sequential exposure to multiple environmental stressors can affect chemical toxicity. Cumulative risk assessments consider multiple stressors but it is impractical to test every chemical combination to which people are exposed. New methods are needed to prioritize chemical combinations based on their prevalence and possible health impacts.</p></sec><sec><title>Objectives:</title><p>We introduce an informatics approach that uses publicly available data to identify chemicals that co-occur in consumer products, which account for a significant proportion of overall chemical load.</p></sec><sec><title>Methods:</title><p>Fifty-five asthma-associated and endocrine disrupting chemicals (target chemicals) were selected. A database of 38,975 distinct consumer products and 32,231 distinct ingredient names was created from online sources, and PubChem and the Unified Medical Language System were used to resolve synonymous ingredient names. Synonymous ingredient names are different names for the same chemical (e.g., vitamin E and tocopherol).</p></sec><sec><title>Results:</title><p>Nearly one-third of the products (11,688 products, 30%) contained ≥ 1 target chemical and 5,229 products (13%) contained > 1. Of the 55 target chemicals, 31 (56%) appear in ≥ 1 product and 19 (35%) appear under more than one name. The most frequent three-way chemical combination (2-phenoxyethanol, methyl paraben, and ethyl paraben) appears in 1,059 products. Further work is needed to assess combined chemical exposures related to the use of multiple products.</p></sec><sec><title>Conclusions:</title><p>The informatics approach increased the number of products considered in a traditional analysis by two orders of magnitude, but missing/incomplete product labels can limit the effectiveness of this approach. Such an approach must resolve synonymy to ensure that chemicals of interest are not missed. Commonly occurring chemical combinations can be used to prioritize cumulative toxicology risk assessments.</p></sec><sec><title>Citation:</title><p>Gabb HA, Blake C. 2016. An informatics approach to evaluating combined chemical exposures from consumer products: a case study of asthma-associated chemicals and potential endocrine disruptors. Environ Health Perspect 124:1155–1165; http://dx.doi.org/10.1289/ehp.1510529</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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