A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments
Identifieur interne : 001881 ( Ncbi/Merge ); précédent : 001880; suivant : 001882A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments
Auteurs : Jaimie Schnell ; Marina Steele ; Jordan Bean ; Margaret Neuspiel ; Cécile Girard ; Nataliya Dormann ; Cindy Pearson ; Annie Savoie ; Luc Bourbonnière ; Philip MacdonaldSource :
- Transgenic Research [ 0962-8819 ] ; 2014.
Abstract
During genetic engineering, DNA is inserted into a plant’s genome, and such insertions are often accompanied by the insertion of additional DNA, deletions and/or rearrangements. These genetic changes are collectively known as insertional effects, and they have the potential to give rise to unintended traits in plants. In addition, there are many other genetic changes that occur in plants both spontaneously and as a result of conventional breeding practices. Genetic changes similar to insertional effects occur in plants, namely as a result of the movement of transposable elements, the repair of double-strand breaks by non-homologous end-joining, and the intracellular transfer of organelle DNA. Based on this similarity, insertional effects should present a similar level of risk as these other genetic changes in plants, and it is within the context of these genetic changes that insertional effects must be considered. Increased familiarity with genetic engineering techniques and advances in molecular analysis techniques have provided us with a greater understanding of the nature and impact of genetic changes in plants, and this can be used to refine pre-market assessments of genetically engineered plants and food and feeds derived from genetically engineered plants.
Url:
DOI: 10.1007/s11248-014-9843-7
PubMed: 25344849
PubMed Central: 4274372
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments</title><author><name sortKey="Schnell, Jaimie" sort="Schnell, Jaimie" uniqKey="Schnell J" first="Jaimie" last="Schnell">Jaimie Schnell</name><affiliation><nlm:aff id="Aff1">Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Steele, Marina" sort="Steele, Marina" uniqKey="Steele M" first="Marina" last="Steele">Marina Steele</name><affiliation><nlm:aff id="Aff2">Animal Feed Division, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bean, Jordan" sort="Bean, Jordan" uniqKey="Bean J" first="Jordan" last="Bean">Jordan Bean</name><affiliation><nlm:aff id="Aff3">Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON K1A 0K9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0K9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Neuspiel, Margaret" sort="Neuspiel, Margaret" uniqKey="Neuspiel M" first="Margaret" last="Neuspiel">Margaret Neuspiel</name><affiliation><nlm:aff id="Aff5">Office of the Chief Science Operating Officer, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Girard, Cecile" sort="Girard, Cecile" uniqKey="Girard C" first="Cécile" last="Girard">Cécile Girard</name><affiliation><nlm:aff id="Aff1">Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Dormann, Nataliya" sort="Dormann, Nataliya" uniqKey="Dormann N" first="Nataliya" last="Dormann">Nataliya Dormann</name><affiliation><nlm:aff id="Aff4">Plant Biosafety Office, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Pearson, Cindy" sort="Pearson, Cindy" uniqKey="Pearson C" first="Cindy" last="Pearson">Cindy Pearson</name><affiliation><nlm:aff id="Aff4">Plant Biosafety Office, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Savoie, Annie" sort="Savoie, Annie" uniqKey="Savoie A" first="Annie" last="Savoie">Annie Savoie</name><affiliation><nlm:aff 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Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25344849</idno><idno type="pmc">4274372</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274372</idno><idno type="RBID">PMC:4274372</idno><idno type="doi">10.1007/s11248-014-9843-7</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000726</idno><idno type="wicri:Area/Pmc/Curation">000725</idno><idno type="wicri:Area/Pmc/Checkpoint">000928</idno><idno type="wicri:Area/Ncbi/Merge">001881</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments</title><author><name sortKey="Schnell, Jaimie" sort="Schnell, Jaimie" uniqKey="Schnell J" first="Jaimie" last="Schnell">Jaimie Schnell</name><affiliation><nlm:aff id="Aff1">Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Steele, Marina" sort="Steele, Marina" uniqKey="Steele M" first="Marina" last="Steele">Marina Steele</name><affiliation><nlm:aff id="Aff2">Animal Feed Division, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bean, Jordan" sort="Bean, Jordan" uniqKey="Bean J" first="Jordan" last="Bean">Jordan Bean</name><affiliation><nlm:aff id="Aff3">Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON K1A 0K9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0K9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Neuspiel, Margaret" sort="Neuspiel, Margaret" uniqKey="Neuspiel M" first="Margaret" last="Neuspiel">Margaret Neuspiel</name><affiliation><nlm:aff id="Aff5">Office of the Chief Science Operating Officer, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Girard, Cecile" sort="Girard, Cecile" uniqKey="Girard C" first="Cécile" last="Girard">Cécile Girard</name><affiliation><nlm:aff id="Aff1">Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Dormann, Nataliya" sort="Dormann, Nataliya" uniqKey="Dormann N" first="Nataliya" last="Dormann">Nataliya Dormann</name><affiliation><nlm:aff id="Aff4">Plant Biosafety Office, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Pearson, Cindy" sort="Pearson, Cindy" uniqKey="Pearson C" first="Cindy" last="Pearson">Cindy Pearson</name><affiliation><nlm:aff id="Aff4">Plant Biosafety Office, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Savoie, Annie" sort="Savoie, Annie" uniqKey="Savoie A" first="Annie" last="Savoie">Annie Savoie</name><affiliation><nlm:aff id="Aff2">Animal Feed Division, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bourbonniere, Luc" sort="Bourbonniere, Luc" uniqKey="Bourbonniere L" first="Luc" last="Bourbonnière">Luc Bourbonnière</name><affiliation><nlm:aff id="Aff3">Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON K1A 0K9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0K9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Macdonald, Philip" sort="Macdonald, Philip" uniqKey="Macdonald P" first="Philip" last="Macdonald">Philip Macdonald</name><affiliation><nlm:aff id="Aff1">Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1A 0Y9 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Transgenic Research</title><idno type="ISSN">0962-8819</idno><idno type="eISSN">1573-9368</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During genetic engineering, DNA is inserted into a plant’s genome, and such insertions are often accompanied by the insertion of additional DNA, deletions and/or rearrangements. These genetic changes are collectively known as insertional effects, and they have the potential to give rise to unintended traits in plants. In addition, there are many other genetic changes that occur in plants both spontaneously and as a result of conventional breeding practices. Genetic changes similar to insertional effects occur in plants, namely as a result of the movement of transposable elements, the repair of double-strand breaks by non-homologous end-joining, and the intracellular transfer of organelle DNA. Based on this similarity, insertional effects should present a similar level of risk as these other genetic changes in plants, and it is within the context of these genetic changes that insertional effects must be considered. Increased familiarity with genetic engineering techniques and advances in molecular analysis techniques have provided us with a greater understanding of the nature and impact of genetic changes in plants, and this can be used to refine pre-market assessments of genetically engineered plants and food and feeds derived from genetically engineered plants.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, Kl" uniqKey="Adams K">KL Adams</name></author><author><name sortKey="Wendel, Jf" uniqKey="Wendel J">JF Wendel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahloowalia, Bs" uniqKey="Ahloowalia B">BS Ahloowalia</name></author><author><name sortKey="Maluszynski, M" uniqKey="Maluszynski M">M Maluszynski</name></author><author><name sortKey="Nichterlein, K" uniqKey="Nichterlein K">K Nichterlein</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Transgenic Res</journal-id><journal-id journal-id-type="iso-abbrev">Transgenic Res</journal-id><journal-title-group><journal-title>Transgenic Research</journal-title></journal-title-group><issn pub-type="ppub">0962-8819</issn><issn pub-type="epub">1573-9368</issn><publisher><publisher-name>Springer International Publishing</publisher-name><publisher-loc>Cham</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25344849</article-id><article-id pub-id-type="pmc">4274372</article-id><article-id pub-id-type="publisher-id">9843</article-id><article-id pub-id-type="doi">10.1007/s11248-014-9843-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schnell</surname><given-names>Jaimie</given-names></name><address><email>jaimie.schnell@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Steele</surname><given-names>Marina</given-names></name><address><email>marina.steele@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Bean</surname><given-names>Jordan</given-names></name><address><email>jordan.bean@hc-sc.gc.ca</email></address><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Neuspiel</surname><given-names>Margaret</given-names></name><address><email>margaret.neuspiel@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib contrib-type="author"><name><surname>Girard</surname><given-names>Cécile</given-names></name><address><email>cecile.girard@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dormann</surname><given-names>Nataliya</given-names></name><address><email>nataliya.dormann@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Pearson</surname><given-names>Cindy</given-names></name><address><email>cindy.pearson@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Savoie</surname><given-names>Annie</given-names></name><address><email>annie.savoie@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Bourbonnière</surname><given-names>Luc</given-names></name><address><email>luc.bourbonniere@hc-sc.gc.ca</email></address><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Macdonald</surname><given-names>Philip</given-names></name><address><phone>613-773-5288</phone><email>philip.macdonald@inspection.gc.ca</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Plant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</aff><aff id="Aff2"><label></label>Animal Feed Division, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</aff><aff id="Aff3"><label></label>Food Directorate, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON K1A 0K9 Canada</aff><aff id="Aff4"><label></label>Plant Biosafety Office, Canadian Food Inspection Agency, 59 Camelot Drive, Ottawa, ON K1A 0Y9 Canada</aff><aff id="Aff5"><label></label>Office of the Chief Science Operating Officer, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON K1A 0Y9 Canada</aff></contrib-group><pub-date pub-type="epub"><day>26</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><volume>24</volume><fpage>1</fpage><lpage>17</lpage><history><date date-type="received"><day>22</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>16</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>© The Author(s) 2014</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p></license></permissions><abstract id="Abs1"><p>During genetic engineering, DNA is inserted into a plant’s genome, and such insertions are often accompanied by the insertion of additional DNA, deletions and/or rearrangements. These genetic changes are collectively known as insertional effects, and they have the potential to give rise to unintended traits in plants. In addition, there are many other genetic changes that occur in plants both spontaneously and as a result of conventional breeding practices. Genetic changes similar to insertional effects occur in plants, namely as a result of the movement of transposable elements, the repair of double-strand breaks by non-homologous end-joining, and the intracellular transfer of organelle DNA. Based on this similarity, insertional effects should present a similar level of risk as these other genetic changes in plants, and it is within the context of these genetic changes that insertional effects must be considered. Increased familiarity with genetic engineering techniques and advances in molecular analysis techniques have provided us with a greater understanding of the nature and impact of genetic changes in plants, and this can be used to refine pre-market assessments of genetically engineered plants and food and feeds derived from genetically engineered plants.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Insertional effects</kwd><kwd>Novel trait</kwd><kwd>Unintended trait</kwd><kwd>Genetic engineering</kwd><kwd>Conventional breeding</kwd><kwd>Pre-market assessment</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer International Publishing Switzerland 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bean, Jordan" sort="Bean, Jordan" uniqKey="Bean J" first="Jordan" last="Bean">Jordan Bean</name><name sortKey="Bourbonniere, Luc" sort="Bourbonniere, Luc" uniqKey="Bourbonniere L" first="Luc" last="Bourbonnière">Luc Bourbonnière</name><name sortKey="Dormann, Nataliya" sort="Dormann, Nataliya" uniqKey="Dormann N" first="Nataliya" last="Dormann">Nataliya Dormann</name><name sortKey="Girard, Cecile" sort="Girard, Cecile" uniqKey="Girard C" first="Cécile" last="Girard">Cécile Girard</name><name sortKey="Macdonald, Philip" sort="Macdonald, Philip" uniqKey="Macdonald P" first="Philip" last="Macdonald">Philip Macdonald</name><name sortKey="Neuspiel, Margaret" sort="Neuspiel, Margaret" uniqKey="Neuspiel M" first="Margaret" last="Neuspiel">Margaret Neuspiel</name><name sortKey="Pearson, Cindy" sort="Pearson, Cindy" uniqKey="Pearson C" first="Cindy" last="Pearson">Cindy Pearson</name><name sortKey="Savoie, Annie" sort="Savoie, Annie" uniqKey="Savoie A" first="Annie" last="Savoie">Annie Savoie</name><name sortKey="Schnell, Jaimie" sort="Schnell, Jaimie" uniqKey="Schnell J" first="Jaimie" last="Schnell">Jaimie Schnell</name><name sortKey="Steele, Marina" sort="Steele, Marina" uniqKey="Steele M" first="Marina" last="Steele">Marina Steele</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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