Antioxidant potential of hydro-methanolic extract of seed of Caesalpinia bonduc: An in vitro study
Identifieur interne : 000E82 ( Ncbi/Merge ); précédent : 000E81; suivant : 000E83Antioxidant potential of hydro-methanolic extract of seed of Caesalpinia bonduc: An in vitro study
Auteurs : Kishalay Jana [Inde] ; Kausik Chatterjee [Inde] ; Kazi Monjur Ali [Inde] ; Abhinandan Ghosh [Inde] ; Tushar Kanti Bera [Inde] ; Debidas Ghosh [Inde]Source :
- Journal of Advanced Pharmaceutical Technology & Research [ 2231-4040 ] ; 2011.
Abstract
It is well known that the over production of reactive oxygen species is harmful for living organisms and it damages major cellular constituents such as DNA, protein, and lipid. At present, searching of new plant sources having free radical scavenging activity is an important field of research in phytomedicine as natural products are safe and relatively low cost. In this respect, attention has been focused to evaluate the antioxidant potential of hydro-methanolic extract of seed of
Url:
DOI: 10.4103/2231-4040.90884
PubMed: 22247894
PubMed Central: 3255348
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study</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antioxidant potential of hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
: An <italic>in vitro</italic>
study</title>
<author><name sortKey="Jana, Kishalay" sort="Jana, Kishalay" uniqKey="Jana K" first="Kishalay" last="Jana">Kishalay Jana</name>
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<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Programme) Andrology, Endocrinology and Molecular Medicine Laboratory, Vidyasagar University, Midnapore</wicri:regionArea>
<wicri:noRegion>Midnapore</wicri:noRegion>
</affiliation>
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<author><name sortKey="Chatterjee, Kausik" sort="Chatterjee, Kausik" uniqKey="Chatterjee K" first="Kausik" last="Chatterjee">Kausik Chatterjee</name>
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<country xml:lang="fr">Inde</country>
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<author><name sortKey="Ali, Kazi Monjur" sort="Ali, Kazi Monjur" uniqKey="Ali K" first="Kazi Monjur" last="Ali">Kazi Monjur Ali</name>
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<author><name sortKey="Ghosh, Abhinandan" sort="Ghosh, Abhinandan" uniqKey="Ghosh A" first="Abhinandan" last="Ghosh">Abhinandan Ghosh</name>
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<author><name sortKey="Ghosh, Debidas" sort="Ghosh, Debidas" uniqKey="Ghosh D" first="Debidas" last="Ghosh">Debidas Ghosh</name>
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<series><title level="j">Journal of Advanced Pharmaceutical Technology & Research</title>
<idno type="ISSN">2231-4040</idno>
<idno type="eISSN">0976-2094</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p>It is well known that the over production of reactive oxygen species is harmful for living organisms and it damages major cellular constituents such as DNA, protein, and lipid. At present, searching of new plant sources having free radical scavenging activity is an important field of research in phytomedicine as natural products are safe and relatively low cost. In this respect, attention has been focused to evaluate the antioxidant potential of hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
(Caesalpenacae) using different <italic>in vitro</italic>
models. To evaluate the antioxidant activity, extract was examined on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging effect, scavenging of hydrogen peroxide, hydroxyl radical scavenging potential, and anti-lipid peroxidation activity by biochemical methods. Total phenol and flavonoids contents in the said extract were measured biochemically as per standard methods. Results were compared with butylated hydroxyl toluene and α-tocopherol. Results indicated that hydro-methanolic extract has strong scavenging activity on 2, 2-diphenyl-1-picrylhydrazyl radical with IC<sub>50</sub>
value 157.4 μg/ml, hydroxyl radical with IC<sub>50</sub>
value 61.9 μg/ml and hydrogen peroxide with IC<sub>50</sub>
value 64.32 μg/ml. Hydro-methanolic extract also showed notable inhibition in lipid peroxidation having IC<sub>50</sub>
value 58.87 μg/ml. Phytochemical study focused that the extract is rich in phenolic compounds (24.66 mg gallic acid equivalent/g dried extract) and flavonoids (136.65 mg quercetin equivalent/g dried extract). Findings of the experiment indicated that the hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
is a source of natural antioxidants.</p>
</div>
</front>
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<author><name sortKey="De, D" uniqKey="De D">D De</name>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Pharm Technol Res</journal-id>
<journal-id journal-id-type="publisher-id">JAPTR</journal-id>
<journal-title-group><journal-title>Journal of Advanced Pharmaceutical Technology & Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">2231-4040</issn>
<issn pub-type="epub">0976-2094</issn>
<publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22247894</article-id>
<article-id pub-id-type="pmc">3255348</article-id>
<article-id pub-id-type="publisher-id">JAPTR-2-260</article-id>
<article-id pub-id-type="doi">10.4103/2231-4040.90884</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Antioxidant potential of hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
: An <italic>in vitro</italic>
study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jana</surname>
<given-names>Kishalay</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chatterjee</surname>
<given-names>Kausik</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ali</surname>
<given-names>Kazi Monjur</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghosh</surname>
<given-names>Abhinandan</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bera</surname>
<given-names>Tushar Kanti</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghosh</surname>
<given-names>Debidas</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Programme) Andrology, Endocrinology and Molecular Medicine Laboratory, Vidyasagar University, Midnapore, India</aff>
<aff id="aff2"><label>1</label>
Department of Herbal Drug Development, Pharmaceutical Division, Southern Health Improvement Samity (SHIS), Bhangar, West Bengal, India</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Prof. Debidas Ghosh, Department of Bio-Medical Laboratory Science and Management (U.G.C Innovative Department), Vidyasagar University, Midnapore - 721 102, West Bengal, India. E-mail: <email xlink:href="debidas_ghosh@yahoo.co.in">debidas_ghosh@yahoo.co.in</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Oct-Dec</season>
<year>2011</year>
</pub-date>
<volume>2</volume>
<issue>4</issue>
<fpage>260</fpage>
<lpage>265</lpage>
<permissions><copyright-statement>Copyright: © Journal of Advanced Pharmaceutical Technology & Research</copyright-statement>
<copyright-year>2011</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>It is well known that the over production of reactive oxygen species is harmful for living organisms and it damages major cellular constituents such as DNA, protein, and lipid. At present, searching of new plant sources having free radical scavenging activity is an important field of research in phytomedicine as natural products are safe and relatively low cost. In this respect, attention has been focused to evaluate the antioxidant potential of hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
(Caesalpenacae) using different <italic>in vitro</italic>
models. To evaluate the antioxidant activity, extract was examined on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging effect, scavenging of hydrogen peroxide, hydroxyl radical scavenging potential, and anti-lipid peroxidation activity by biochemical methods. Total phenol and flavonoids contents in the said extract were measured biochemically as per standard methods. Results were compared with butylated hydroxyl toluene and α-tocopherol. Results indicated that hydro-methanolic extract has strong scavenging activity on 2, 2-diphenyl-1-picrylhydrazyl radical with IC<sub>50</sub>
value 157.4 μg/ml, hydroxyl radical with IC<sub>50</sub>
value 61.9 μg/ml and hydrogen peroxide with IC<sub>50</sub>
value 64.32 μg/ml. Hydro-methanolic extract also showed notable inhibition in lipid peroxidation having IC<sub>50</sub>
value 58.87 μg/ml. Phytochemical study focused that the extract is rich in phenolic compounds (24.66 mg gallic acid equivalent/g dried extract) and flavonoids (136.65 mg quercetin equivalent/g dried extract). Findings of the experiment indicated that the hydro-methanolic extract of seed of <italic>Caesalpinia bonduc</italic>
is a source of natural antioxidants.</p>
</abstract>
<kwd-group><kwd>Antioxidant</kwd>
<kwd><italic>Caesalpinia bonduc</italic>
</kwd>
<kwd>free radicals</kwd>
<kwd>lipid peroxidation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Inde</li>
</country>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Jana, Kishalay" sort="Jana, Kishalay" uniqKey="Jana K" first="Kishalay" last="Jana">Kishalay Jana</name>
</noRegion>
<name sortKey="Ali, Kazi Monjur" sort="Ali, Kazi Monjur" uniqKey="Ali K" first="Kazi Monjur" last="Ali">Kazi Monjur Ali</name>
<name sortKey="Bera, Tushar Kanti" sort="Bera, Tushar Kanti" uniqKey="Bera T" first="Tushar Kanti" last="Bera">Tushar Kanti Bera</name>
<name sortKey="Chatterjee, Kausik" sort="Chatterjee, Kausik" uniqKey="Chatterjee K" first="Kausik" last="Chatterjee">Kausik Chatterjee</name>
<name sortKey="Ghosh, Abhinandan" sort="Ghosh, Abhinandan" uniqKey="Ghosh A" first="Abhinandan" last="Ghosh">Abhinandan Ghosh</name>
<name sortKey="Ghosh, Debidas" sort="Ghosh, Debidas" uniqKey="Ghosh D" first="Debidas" last="Ghosh">Debidas Ghosh</name>
</country>
</tree>
</affiliations>
</record>
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