TAL Effectors Target the C-Terminal Domain of RNA Polymerase II (CTD) by Inhibiting the Prolyl-Isomerase Activity of a CTD-Associated Cyclophilin
Identifieur interne : 001073 ( Ncbi/Checkpoint ); précédent : 001072; suivant : 001074TAL Effectors Target the C-Terminal Domain of RNA Polymerase II (CTD) by Inhibiting the Prolyl-Isomerase Activity of a CTD-Associated Cyclophilin
Auteurs : Mariane Noronha Domingues ; Bruna Medeia De Campos ; Maria Luiza Peixoto De Oliveira ; Uli Quirino De Mello ; Celso Eduardo BenedettiSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Transcriptional activator-like (TAL) effectors of plant pathogenic bacteria function as transcription factors in plant cells. However, how TAL effectors control transcription in the host is presently unknown. Previously, we showed that TAL effectors of the citrus canker pathogen
Url:
DOI: 10.1371/journal.pone.0041553
PubMed: 22911812
PubMed Central: 3401100
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TAL Effectors Target the C-Terminal Domain of RNA Polymerase II (CTD) by Inhibiting the Prolyl-Isomerase Activity of a CTD-Associated Cyclophilin</title><author><name sortKey="Domingues, Mariane Noronha" sort="Domingues, Mariane Noronha" uniqKey="Domingues M" first="Mariane Noronha" last="Domingues">Mariane Noronha Domingues</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Campos, Bruna Medeia" sort="De Campos, Bruna Medeia" uniqKey="De Campos B" first="Bruna Medeia" last="De Campos">Bruna Medeia De Campos</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Oliveira, Maria Luiza Peixoto" sort="De Oliveira, Maria Luiza Peixoto" uniqKey="De Oliveira M" first="Maria Luiza Peixoto" last="De Oliveira">Maria Luiza Peixoto De Oliveira</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Mello, Uli Quirino" sort="De Mello, Uli Quirino" uniqKey="De Mello U" first="Uli Quirino" last="De Mello">Uli Quirino De Mello</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Benedetti, Celso Eduardo" sort="Benedetti, Celso Eduardo" uniqKey="Benedetti C" first="Celso Eduardo" last="Benedetti">Celso Eduardo Benedetti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22911812</idno><idno type="pmc">3401100</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401100</idno><idno type="RBID">PMC:3401100</idno><idno type="doi">10.1371/journal.pone.0041553</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001120</idno><idno type="wicri:Area/Pmc/Curation">001119</idno><idno type="wicri:Area/Pmc/Checkpoint">000C17</idno><idno type="wicri:Area/Ncbi/Merge">001073</idno><idno type="wicri:Area/Ncbi/Curation">001073</idno><idno type="wicri:Area/Ncbi/Checkpoint">001073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">TAL Effectors Target the C-Terminal Domain of RNA Polymerase II (CTD) by Inhibiting the Prolyl-Isomerase Activity of a CTD-Associated Cyclophilin</title><author><name sortKey="Domingues, Mariane Noronha" sort="Domingues, Mariane Noronha" uniqKey="Domingues M" first="Mariane Noronha" last="Domingues">Mariane Noronha Domingues</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Campos, Bruna Medeia" sort="De Campos, Bruna Medeia" uniqKey="De Campos B" first="Bruna Medeia" last="De Campos">Bruna Medeia De Campos</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Oliveira, Maria Luiza Peixoto" sort="De Oliveira, Maria Luiza Peixoto" uniqKey="De Oliveira M" first="Maria Luiza Peixoto" last="De Oliveira">Maria Luiza Peixoto De Oliveira</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="De Mello, Uli Quirino" sort="De Mello, Uli Quirino" uniqKey="De Mello U" first="Uli Quirino" last="De Mello">Uli Quirino De Mello</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Benedetti, Celso Eduardo" sort="Benedetti, Celso Eduardo" uniqKey="Benedetti C" first="Celso Eduardo" last="Benedetti">Celso Eduardo Benedetti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Transcriptional activator-like (TAL) effectors of plant pathogenic bacteria function as transcription factors in plant cells. However, how TAL effectors control transcription in the host is presently unknown. Previously, we showed that TAL effectors of the citrus canker pathogen <italic>Xanthomonas citri</italic>, named PthAs, targeted the citrus protein complex comprising the thioredoxin CsTdx, ubiquitin-conjugating enzymes CsUev/Ubc13 and cyclophilin CsCyp. Here we show that CsCyp complements the function of Cpr1 and Ess1, two yeast cyclophilins that regulate transcription by the isomerization of proline residues of the regulatory C-terminal domain (CTD) of RNA polymerase II. We also demonstrate that CsCyp, CsTdx, CsUev and four PthA variants interact with the citrus CTD and that CsCyp co-immunoprecipitate with the CTD in citrus cell extracts and with PthA2 transiently expressed in sweet orange epicotyls. The interactions of CsCyp with the CTD and PthA2 were inhibited by cyclosporin A (CsA), a cyclophilin inhibitor. Moreover, we present evidence that PthA2 inhibits the peptidyl-prolyl <italic>cis-trans</italic> isomerase (PPIase) activity of CsCyp in a similar fashion as CsA, and that silencing of CsCyp, as well as treatments with CsA, enhance canker lesions in <italic>X. citri</italic>-infected leaves. Given that CsCyp appears to function as a negative regulator of cell growth and that Ess1 negatively regulates transcription elongation in yeast, we propose that PthAs activate host transcription by inhibiting the PPIase activity of CsCyp on the CTD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brunings, Am" uniqKey="Brunings A">AM Brunings</name></author><author><name sortKey="Gabriel, Dw" uniqKey="Gabriel D">DW Gabriel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cernadas, Ra" uniqKey="Cernadas R">RA Cernadas</name></author><author><name sortKey="Camillo, Lr" uniqKey="Camillo L">LR Camillo</name></author><author><name sortKey="Benedetti, Ce" uniqKey="Benedetti C">CE Benedetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cernadas, Ra" uniqKey="Cernadas R">RA Cernadas</name></author><author><name sortKey="Benedetti, Ce" uniqKey="Benedetti C">CE 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Reid</name></author><author><name sortKey="Liu, Wf" uniqKey="Liu W">WF Liu</name></author><author><name sortKey="S Gaard, Tm" uniqKey="S Gaard T">TM Søgaard</name></author><author><name sortKey="Erdjument Bromage, H" uniqKey="Erdjument Bromage H">H Erdjument-Bromage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jouvet, N" uniqKey="Jouvet N">N Jouvet</name></author><author><name sortKey="Poschmann, J" uniqKey="Poschmann J">J Poschmann</name></author><author><name sortKey="Douville, J" uniqKey="Douville J">J Douville</name></author><author><name sortKey="Bulet, L" uniqKey="Bulet L">L Bulet</name></author><author><name sortKey="Ramotar, D" uniqKey="Ramotar D">D Ramotar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimori, F" uniqKey="Fujimori F">F Fujimori</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Uchida, C" uniqKey="Uchida C">C 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Palancade</name></author><author><name sortKey="Lang, A" uniqKey="Lang A">A Lang</name></author><author><name sortKey="Bensaude, O" uniqKey="Bensaude O">O Bensaude</name></author><author><name sortKey="Eick, D" uniqKey="Eick D">D Eick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberti, M" uniqKey="Roberti M">M Roberti</name></author><author><name sortKey="Polosa, Pl" uniqKey="Polosa P">PL Polosa</name></author><author><name sortKey="Bruni, F" uniqKey="Bruni F">F Bruni</name></author><author><name sortKey="Manzari, C" uniqKey="Manzari C">C Manzari</name></author><author><name sortKey="Deceglie, S" uniqKey="Deceglie S">S Deceglie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camara, Y" uniqKey="Camara Y">Y Cámara</name></author><author><name sortKey="Asin Cayuela, J" uniqKey="Asin Cayuela J">J Asin-Cayuela</name></author><author><name sortKey="Park, Cb" uniqKey="Park C">CB Park</name></author><author><name 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uniqKey="Domingues M" first="Mariane Noronha" last="Domingues">Mariane Noronha Domingues</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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