Citrus fruit extracts reduce advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress in human adipocytes.
Identifieur interne : 000C35 ( Ncbi/Checkpoint ); précédent : 000C34; suivant : 000C36Citrus fruit extracts reduce advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress in human adipocytes.
Auteurs : Deena Ramful ; Evelyne Tarnus ; Philippe Rondeau ; Christine Robert Da Silva ; Theeshan Bahorun ; Emmanuel BourdonSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2010.
English descriptors
- KwdEn :
- Adipocytes (drug effects), Adipocytes (metabolism), Antioxidants (pharmacology), Citrus (chemistry), Down-Regulation (drug effects), Fruit (chemistry), Glycosylation End Products, Advanced (metabolism), Humans, Hydrogen Peroxide (adverse effects), Oxidative Stress (drug effects), Plant Extracts (pharmacology).
- MESH :
- chemical , adverse effects : Hydrogen Peroxide.
- chemical , metabolism : Glycosylation End Products, Advanced.
- chemical , pharmacology : Antioxidants, Plant Extracts.
- chemistry : Citrus, Fruit.
- drug effects : Adipocytes, Down-Regulation, Oxidative Stress.
- metabolism : Adipocytes.
- Humans.
Abstract
Diabetes is a reactive oxygen species (ROS)-mediated pathology, with a worldwide prevalence estimated to double by 2030. A major effort has been launched to find therapeutic means to improve health conditions of diabetic patients. Recent data show that supplemental natural antioxidants represent a potential strategy as adjunct therapy. Despite the major role of adipocytes in the etiology of diabetes, little is known about the effect of natural antioxidants on adipocyte response to oxidative stress. Using a diabetes-like oxidative stress model, the potential protective effect of antioxidative flavedo, albedo, and pulp extracts of (1) tangor Elendale (Citrus reticulata × Citrus sinensis) and (2) tangelo Minneola (C. reticulata × Citrus paradisis) was investigated on human adipocytes. Besides the retardation of free-radical-induced hemolysis of human erythrocytes, non-cytotoxic concentrations of tangelo and tangor flavedo extracts significantly reduced the levels of protein carbonyls in response to advanced glycation end products (AGEs) generated by albumin glycation in SW872 cells. Flavedo extracts lowered carbonyl accumulation in H2O2-treated adipocytes, while tangelo and tangor flavedo, albedo, and pulp extracts suppressed ROS production in SW872 cells with or without the addition of H2O2. Our results clearly show that Mauritian Citrus fruit extracts represent an important source of antioxidants, with a novel antioxidative role at the adipose tissue level.
DOI: 10.1021/jf102762s
PubMed: 20882960
Affiliations:
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pubmed:20882960Le document en format XML
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first="Christine Robert" last="Da Silva">Christine Robert Da Silva</name></author><author><name sortKey="Bahorun, Theeshan" sort="Bahorun, Theeshan" uniqKey="Bahorun T" first="Theeshan" last="Bahorun">Theeshan Bahorun</name></author><author><name sortKey="Bourdon, Emmanuel" sort="Bourdon, Emmanuel" uniqKey="Bourdon E" first="Emmanuel" last="Bourdon">Emmanuel Bourdon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20882960</idno><idno type="pmid">20882960</idno><idno type="doi">10.1021/jf102762s</idno><idno type="wicri:Area/PubMed/Corpus">000801</idno><idno type="wicri:Area/PubMed/Curation">000801</idno><idno type="wicri:Area/PubMed/Checkpoint">000801</idno><idno type="wicri:Area/Ncbi/Merge">000C35</idno><idno type="wicri:Area/Ncbi/Curation">000C35</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Citrus fruit extracts reduce advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress in human adipocytes.</title><author><name sortKey="Ramful, Deena" sort="Ramful, Deena" uniqKey="Ramful D" first="Deena" last="Ramful">Deena Ramful</name><affiliation><nlm:affiliation>Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, Réduit, Republic of Mauritius.</nlm:affiliation><wicri:noCountry code="subField">Republic of Mauritius</wicri:noCountry></affiliation></author><author><name sortKey="Tarnus, Evelyne" sort="Tarnus, Evelyne" uniqKey="Tarnus E" first="Evelyne" last="Tarnus">Evelyne Tarnus</name></author><author><name sortKey="Rondeau, Philippe" sort="Rondeau, Philippe" uniqKey="Rondeau P" first="Philippe" last="Rondeau">Philippe Rondeau</name></author><author><name sortKey="Da Silva, Christine Robert" sort="Da Silva, Christine Robert" uniqKey="Da Silva C" first="Christine Robert" last="Da Silva">Christine Robert Da Silva</name></author><author><name sortKey="Bahorun, Theeshan" sort="Bahorun, Theeshan" uniqKey="Bahorun T" first="Theeshan" last="Bahorun">Theeshan Bahorun</name></author><author><name sortKey="Bourdon, Emmanuel" sort="Bourdon, Emmanuel" uniqKey="Bourdon E" first="Emmanuel" last="Bourdon">Emmanuel Bourdon</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes (drug effects)</term><term>Adipocytes (metabolism)</term><term>Antioxidants (pharmacology)</term><term>Citrus (chemistry)</term><term>Down-Regulation (drug effects)</term><term>Fruit (chemistry)</term><term>Glycosylation End Products, Advanced (metabolism)</term><term>Humans</term><term>Hydrogen Peroxide (adverse effects)</term><term>Oxidative Stress (drug effects)</term><term>Plant Extracts (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hydrogen Peroxide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycosylation End Products, Advanced</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Adipocytes</term><term>Down-Regulation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diabetes is a reactive oxygen species (ROS)-mediated pathology, with a worldwide prevalence estimated to double by 2030. A major effort has been launched to find therapeutic means to improve health conditions of diabetic patients. Recent data show that supplemental natural antioxidants represent a potential strategy as adjunct therapy. Despite the major role of adipocytes in the etiology of diabetes, little is known about the effect of natural antioxidants on adipocyte response to oxidative stress. Using a diabetes-like oxidative stress model, the potential protective effect of antioxidative flavedo, albedo, and pulp extracts of (1) tangor Elendale (Citrus reticulata × Citrus sinensis) and (2) tangelo Minneola (C. reticulata × Citrus paradisis) was investigated on human adipocytes. Besides the retardation of free-radical-induced hemolysis of human erythrocytes, non-cytotoxic concentrations of tangelo and tangor flavedo extracts significantly reduced the levels of protein carbonyls in response to advanced glycation end products (AGEs) generated by albumin glycation in SW872 cells. Flavedo extracts lowered carbonyl accumulation in H2O2-treated adipocytes, while tangelo and tangor flavedo, albedo, and pulp extracts suppressed ROS production in SW872 cells with or without the addition of H2O2. Our results clearly show that Mauritian Citrus fruit extracts represent an important source of antioxidants, with a novel antioxidative role at the adipose tissue level.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bahorun, Theeshan" sort="Bahorun, Theeshan" uniqKey="Bahorun T" first="Theeshan" last="Bahorun">Theeshan Bahorun</name><name sortKey="Bourdon, Emmanuel" sort="Bourdon, Emmanuel" uniqKey="Bourdon E" first="Emmanuel" last="Bourdon">Emmanuel Bourdon</name><name sortKey="Da Silva, Christine Robert" sort="Da Silva, Christine Robert" uniqKey="Da Silva C" first="Christine Robert" last="Da Silva">Christine Robert Da Silva</name><name sortKey="Ramful, Deena" sort="Ramful, Deena" uniqKey="Ramful D" first="Deena" last="Ramful">Deena Ramful</name><name sortKey="Rondeau, Philippe" sort="Rondeau, Philippe" uniqKey="Rondeau P" first="Philippe" last="Rondeau">Philippe Rondeau</name><name sortKey="Tarnus, Evelyne" sort="Tarnus, Evelyne" uniqKey="Tarnus E" first="Evelyne" last="Tarnus">Evelyne Tarnus</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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