Anti-HIV-1 Activity of Eight Monofloral Iranian Honey Types
Identifieur interne : 000C05 ( Main/Curation ); précédent : 000C04; suivant : 000C06Anti-HIV-1 Activity of Eight Monofloral Iranian Honey Types
Auteurs : Mandana BehbahaniSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- Anti-HIV Agents (chemistry), Anti-HIV Agents (isolation & purification), Anti-HIV Agents (pharmacology), Antigens, CD19 (metabolism), Antigens, CD4 (metabolism), Cell Proliferation (drug effects), Cells, Cultured, Flowers (chemistry), Flowers (metabolism), HIV-1 (genetics), HIV-1 (physiology), Honey (analysis), Honey (toxicity), Humans, Iran, Leukocytes, Mononuclear (cytology), Leukocytes, Mononuclear (drug effects), Leukocytes, Mononuclear (metabolism), Plants (chemistry), Plants (metabolism), Pyruvaldehyde (chemistry), Pyruvaldehyde (isolation & purification), Pyruvaldehyde (pharmacology), RNA, Viral (analysis), Real-Time Polymerase Chain Reaction, Virus Replication (drug effects).
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , chemistry : Anti-HIV Agents, Pyruvaldehyde.
- chemical , isolation & purification : Anti-HIV Agents, Pyruvaldehyde.
- chemical , metabolism : Antigens, CD19, Antigens, CD4.
- chemical , pharmacology : Anti-HIV Agents, Pyruvaldehyde.
- geographic : Iran.
- analysis : Honey.
- chemistry : Flowers, Plants.
- cytology : Leukocytes, Mononuclear.
- drug effects : Cell Proliferation, Leukocytes, Mononuclear, Virus Replication.
- genetics : HIV-1.
- metabolism : Flowers, Leukocytes, Mononuclear, Plants.
- physiology : HIV-1.
- toxicity : Honey.
- Cells, Cultured, Humans, Real-Time Polymerase Chain Reaction.
Abstract
Monofloral Iranian honeys from eight floral sources were analyzed to determine their anti-HIV-1 activities as well as their effects on lymphocyte proliferation. The Peripheral Blood Mononuclear Cells (PBMCs) used in this study were prepared from five healthy volunteers who were seronegative for HIV, HCV, HBV and TB. The anti-HIV-1 activity of eight different honeys was performed by quantitative polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit. The results demonstrated that monofloral honeys from
Url:
DOI: 10.1371/journal.pone.0108195
PubMed: 25333699
PubMed Central: 4204822
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001208
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001207
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000914
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000282
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000282
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000282
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001873
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001873
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001873
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000C08
Links to Exploration step
PMC:4204822Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-HIV-1 Activity of Eight Monofloral Iranian Honey Types</title><author><name sortKey="Behbahani, Mandana" sort="Behbahani, Mandana" uniqKey="Behbahani M" first="Mandana" last="Behbahani">Mandana Behbahani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25333699</idno><idno type="pmc">4204822</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204822</idno><idno type="RBID">PMC:4204822</idno><idno type="doi">10.1371/journal.pone.0108195</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001208</idno><idno type="wicri:Area/Pmc/Curation">001207</idno><idno type="wicri:Area/Pmc/Checkpoint">000914</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000282</idno><idno type="wicri:Area/PubMed/Curation">000282</idno><idno type="wicri:Area/PubMed/Checkpoint">000282</idno><idno type="wicri:Area/Ncbi/Merge">001873</idno><idno type="wicri:Area/Ncbi/Curation">001873</idno><idno type="wicri:Area/Ncbi/Checkpoint">001873</idno><idno type="wicri:Area/Main/Merge">000C08</idno><idno type="wicri:Area/Main/Curation">000C05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-HIV-1 Activity of Eight Monofloral Iranian Honey Types</title><author><name sortKey="Behbahani, Mandana" sort="Behbahani, Mandana" uniqKey="Behbahani M" first="Mandana" last="Behbahani">Mandana Behbahani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (chemistry)</term><term>Anti-HIV Agents (isolation & purification)</term><term>Anti-HIV Agents (pharmacology)</term><term>Antigens, CD19 (metabolism)</term><term>Antigens, CD4 (metabolism)</term><term>Cell Proliferation (drug effects)</term><term>Cells, Cultured</term><term>Flowers (chemistry)</term><term>Flowers (metabolism)</term><term>HIV-1 (genetics)</term><term>HIV-1 (physiology)</term><term>Honey (analysis)</term><term>Honey (toxicity)</term><term>Humans</term><term>Iran</term><term>Leukocytes, Mononuclear (cytology)</term><term>Leukocytes, Mononuclear (drug effects)</term><term>Leukocytes, Mononuclear (metabolism)</term><term>Plants (chemistry)</term><term>Plants (metabolism)</term><term>Pyruvaldehyde (chemistry)</term><term>Pyruvaldehyde (isolation & purification)</term><term>Pyruvaldehyde (pharmacology)</term><term>RNA, Viral (analysis)</term><term>Real-Time Polymerase Chain Reaction</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-HIV Agents</term><term>Pyruvaldehyde</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Anti-HIV Agents</term><term>Pyruvaldehyde</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD19</term><term>Antigens, CD4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term><term>Pyruvaldehyde</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Iran</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Honey</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Flowers</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Leukocytes, Mononuclear</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Leukocytes, Mononuclear</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Flowers</term><term>Leukocytes, Mononuclear</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Honey</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term><term>Humans</term><term>Real-Time Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Monofloral Iranian honeys from eight floral sources were analyzed to determine their anti-HIV-1 activities as well as their effects on lymphocyte proliferation. The Peripheral Blood Mononuclear Cells (PBMCs) used in this study were prepared from five healthy volunteers who were seronegative for HIV, HCV, HBV and TB. The anti-HIV-1 activity of eight different honeys was performed by quantitative polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit. The results demonstrated that monofloral honeys from <italic>Petro selinum sativum</italic>, <italic>Nigella sativa</italic>, <italic>Citrus sinensis</italic>, <italic>Zataria multiflora</italic>, <italic>Citrus aurantium</italic> and <italic>Zizyphus mauritiana</italic> flowers had potent anti-HIV-1 activity with half maximal effective concentration (EC<sub>50</sub>) values of 37.5, 88, 70, 88, 105 and 5 µg/ml respectively. However, monofloral Iranian honeys from <italic>Astragalus gummifer</italic> and <italic>Chamaemelum nobile</italic> flowers had weak anti-HIV-1 activity. The frequency and intensity of CD4 expression on PBMCs increased in the presence of all honey types. CD19 marker were also increased after the treatment with monofloral honeys from <italic>Z.multiflora</italic> and <italic>N. sativa</italic>. The anti-HIV-1 agent in monofloral honeys from <italic>P.sativum</italic>, <italic>N. sativa</italic>, <italic>Z. multiflora</italic> and <italic>Z. mauritiana</italic> flowers was detected by spectroscopic analysis as methylglyoxal. Time of drug addition studies demonstrated that the inhibitory effect of methylglyoxal is higher on the late stage of HIV-1 infection. The result demonstrated that methylglyoxal isolated from monofloral honey types is a good candidate for preclinical evaluation of anti-HIV-1 therapies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bessong, Po" uniqKey="Bessong P">PO Bessong</name></author><author><name sortKey="Obi, Cl" uniqKey="Obi C">CL Obi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Little, Sj" uniqKey="Little S">SJ Little</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author><author><name sortKey="Wong, Jk" uniqKey="Wong J">JK Wong</name></author><author><name sortKey="Smith, Dm" uniqKey="Smith D">DM Smith</name></author><author><name sortKey="Pond, Sl" uniqKey="Pond S">SL Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Passaes, Cp" uniqKey="Passaes C">CP Passaes</name></author><author><name sortKey="Saez Ciri N, A" uniqKey="Saez Ciri N A">A Sáez-Cirión</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cos, P" uniqKey="Cos P">P Cos</name></author><author><name sortKey="Maes, L" uniqKey="Maes L">L Maes</name></author><author><name sortKey="Vanden Berghe, D" uniqKey="Vanden Berghe D">D Vanden Berghe</name></author><author><name sortKey="Hermans, N" uniqKey="Hermans N">N Hermans</name></author><author><name sortKey="Pieters, L" uniqKey="Pieters L">L Pieters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Tan, S" uniqKey="Tan S">S Tan</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author><author><name sortKey="Qiu, J" uniqKey="Qiu J">J Qiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Ip" uniqKey="Singh I">IP Singh</name></author><author><name sortKey="Bharate, Sb" uniqKey="Bharate S">SB Bharate</name></author><author><name sortKey="Bhutani, Kk" uniqKey="Bhutani K">KK Bhutani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duke, Nc" uniqKey="Duke N">NC Duke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiaoling, Li" uniqKey="Xiaoling L">Li Xiaoling</name></author><author><name sortKey="Chan, Wk" uniqKey="Chan W">WK Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terrab, A" uniqKey="Terrab A">A Terrab</name></author><author><name sortKey="Diez, Mj" uniqKey="Diez M">MJ Diez</name></author><author><name sortKey="Heredia, Fj" uniqKey="Heredia F">FJ Heredia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez Suarez, Jm" uniqKey="Alvarez Suarez J">JM Alvarez-Suarez</name></author><author><name sortKey="Tulipani, S" uniqKey="Tulipani S">S Tulipani</name></author><author><name sortKey="Romandini, S" uniqKey="Romandini S">S Romandini</name></author><author><name sortKey="Bertoli, E" uniqKey="Bertoli E">E Bertoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lusby, Pe" uniqKey="Lusby P">PE Lusby</name></author><author><name sortKey="Coombes, Al" uniqKey="Coombes A">AL Coombes</name></author><author><name sortKey="Wilkinson, Jm" uniqKey="Wilkinson J">JM Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grainger, Mnc" uniqKey="Grainger M">MNC Grainger</name></author><author><name sortKey="Manley Harris, M" uniqKey="Manley Harris M">M Manley-Harris</name></author><author><name sortKey="Fauzi, Nam" uniqKey="Fauzi N">NAM Fauzi</name></author><author><name sortKey="Farid, Mm" uniqKey="Farid M">MM Farid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norman, Ar" uniqKey="Norman A">AR Norman</name></author><author><name sortKey="Cicero, B" uniqKey="Cicero B">B Cicero</name></author><author><name sortKey="Eloi, Sgm" uniqKey="Eloi S">SGM Eloi</name></author><author><name sortKey="Tariq, Mb" uniqKey="Tariq M">MB Tariq</name></author><author><name sortKey="Patricia, A" uniqKey="Patricia A">A Patricia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Waili, Ns" uniqKey="Al Waili N">NS Al-Waili</name></author><author><name sortKey="Al Waili, Tn" uniqKey="Al Waili T">TN Al-Waili</name></author><author><name sortKey="Al Waili, An" uniqKey="Al Waili A">AN Al-Waili</name></author><author><name sortKey="Saloom, Ks" uniqKey="Saloom K">KS Saloom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulu, A" uniqKey="Mulu A">A Mulu</name></author><author><name sortKey="Diro, E" uniqKey="Diro E">E Diro</name></author><author><name sortKey="Tekleselassie, H" uniqKey="Tekleselassie H">H Tekleselassie</name></author><author><name sortKey="Belyhun, Y" uniqKey="Belyhun Y">Y Belyhun</name></author><author><name sortKey="Anagaw, B" uniqKey="Anagaw B">B Anagaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gheldof, N" uniqKey="Gheldof N">N Gheldof</name></author><author><name sortKey="Engeseth, Nj" uniqKey="Engeseth N">NJ Engeseth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Dm" uniqKey="Morgan D">DM Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouet, F" uniqKey="Rouet F">F Rouet</name></author><author><name sortKey="Ekouevi, Dk" uniqKey="Ekouevi D">DK Ekouevi</name></author><author><name sortKey="Chaix, Ml" uniqKey="Chaix M">ML Chaix</name></author><author><name sortKey="Burgard, M" uniqKey="Burgard M">M Burgard</name></author><author><name sortKey="Inwoley, A" uniqKey="Inwoley A">A Inwoley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Legoff, J" uniqKey="Legoff J">J Legoff</name></author><author><name sortKey="Bouhlal, H" uniqKey="Bouhlal H">H Bouhlal</name></author><author><name sortKey="Gresenguet, G" uniqKey="Gresenguet G">G Grésenguet</name></author><author><name sortKey="Weiss, H" uniqKey="Weiss H">H Weiss</name></author><author><name sortKey="Khonde, N" uniqKey="Khonde N">N Khonde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tao, J" uniqKey="Tao J">J Tao</name></author><author><name sortKey="Hu, Qx" uniqKey="Hu Q">QX Hu</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Li, Rr" uniqKey="Li R">RR Li</name></author><author><name sortKey="Li, Xy" uniqKey="Li X">XY Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donarski, Ja" uniqKey="Donarski J">JA Donarski</name></author><author><name sortKey="Roberts, Dpt" uniqKey="Roberts D">DPT Roberts</name></author><author><name sortKey="Charlton, Aj" uniqKey="Charlton A">AJ Charlton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez Suarez, Jm" uniqKey="Alvarez Suarez J">JM Alvarez-Suarez</name></author><author><name sortKey="Tulipani, S" uniqKey="Tulipani S">S Tulipani</name></author><author><name sortKey="Diaz, D" uniqKey="Diaz D">D Díaz</name></author><author><name sortKey="Estevez, Y" uniqKey="Estevez Y">Y Estevez</name></author><author><name sortKey="Romandini, S" uniqKey="Romandini S">S Romandini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meda, A" uniqKey="Meda A">A Meda</name></author><author><name sortKey="Lamien, Ce" uniqKey="Lamien C">CE Lamien</name></author><author><name sortKey="Romito, M" uniqKey="Romito M">M Romito</name></author><author><name sortKey="Millogo, J" uniqKey="Millogo J">J Millogo</name></author><author><name sortKey="Nacoulma, Og" uniqKey="Nacoulma O">OG Nacoulma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jayaraman, S" uniqKey="Jayaraman S">S Jayaraman</name></author><author><name sortKey="Shah, K" uniqKey="Shah K">K Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdel Fattah, Ns" uniqKey="Abdel Fattah N">NS Abdel Fattah</name></author><author><name sortKey="Nada, Oh" uniqKey="Nada O">OH Nada</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C05 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000C05 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:4204822
|texte= Anti-HIV-1 Activity of Eight Monofloral Iranian Honey Types
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:25333699" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |