Inhibition of cell growth and macromolecule biosynthesis of human promyelocytic leukemic cells by acridone alkaloids
Identifieur interne : 001424 ( Istex/Checkpoint ); précédent : 001423; suivant : 001425Inhibition of cell growth and macromolecule biosynthesis of human promyelocytic leukemic cells by acridone alkaloids
Auteurs : Ting-Chao Chou [États-Unis] ; Cherng-Chyi Tzeng [États-Unis] ; Tian-Shung Wu [République populaire de Chine] ; Kyoichi A. Watanabe [États-Unis] ; Tsann-Long Su [États-Unis]Source :
- Phytotherapy Research [ 0951-418X ] ; 1989.
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Abstract
Acridone alkaloids of plants indigenous to the Orient were isolated and purified, and their chemical structures were determined. A total of 50 acridones and their synthetic derivatives were subjected to rapid screening for inhibition of macromolecular synthesis using radiolabeled precursors of DNA, RNA and protein. These compounds were then studied to examine cell growth inhibition of human promyelocytic leukemic cells (HL‐60). Cytotoxicity was studied using the trypan blue exclusion method. Of 50 compounds evaluated for cell growth inhibition, 12 compounds showed IC50<10 μM; 12 compounds, 10‐20 μM; 8 compounds, 20‐100 μM; and 18 compounds, >100 μM.
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DOI: 10.1002/ptr.2650030604
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Res.</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="1989">1989</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="237">237</biblScope><biblScope unit="page" to="242">242</biblScope></imprint><idno type="ISSN">0951-418X</idno></series><idno type="istex">C7D72FFB7C3B29ACA05902DDC6E15EA6B7E3A489</idno><idno type="DOI">10.1002/ptr.2650030604</idno><idno type="ArticleID">PTR2650030604</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>achronycine</term><term>acridone alkaloids</term><term>biochemical effect</term><term>growth inhibition</term><term>human leukemic cells</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acridone alkaloids of plants indigenous to the Orient were isolated and purified, and their chemical structures were determined. A total of 50 acridones and their synthetic derivatives were subjected to rapid screening for inhibition of macromolecular synthesis using radiolabeled precursors of DNA, RNA and protein. These compounds were then studied to examine cell growth inhibition of human promyelocytic leukemic cells (HL‐60). Cytotoxicity was studied using the trypan blue exclusion method. 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