Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
Identifieur interne : 000036 ( Main/Merge ); précédent : 000035; suivant : 000037Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
Auteurs : Pei Lin ; Jianmei Lu ; Yanfang Wang ; Wen Gu ; Jie Yu ; Ronghua ZhaoSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4′-tetrahydroxy-stilbene-2-
Url:
DOI: 10.1371/journal.pone.0140346
PubMed: 26474417
PubMed Central: 4608713
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000026
- to stream Pmc, to step Curation: 000026
- to stream Pmc, to step Checkpoint: 000030
- to stream Ncbi, to step Merge: 000201
- to stream Ncbi, to step Curation: 000201
- to stream Ncbi, to step Checkpoint: 000201
Links to Exploration step
PMC:4608713Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><author><name sortKey="Lin, Pei" sort="Lin, Pei" uniqKey="Lin P" first="Pei" last="Lin">Pei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lu, Jianmei" sort="Lu, Jianmei" uniqKey="Lu J" first="Jianmei" last="Lu">Jianmei Lu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yanfang" sort="Wang, Yanfang" uniqKey="Wang Y" first="Yanfang" last="Wang">Yanfang Wang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gu, Wen" sort="Gu, Wen" uniqKey="Gu W" first="Wen" last="Gu">Wen Gu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Ronghua" sort="Zhao, Ronghua" uniqKey="Zhao R" first="Ronghua" last="Zhao">Ronghua Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26474417</idno><idno type="pmc">4608713</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608713</idno><idno type="RBID">PMC:4608713</idno><idno type="doi">10.1371/journal.pone.0140346</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000026</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000026</idno><idno type="wicri:Area/Pmc/Curation">000026</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000026</idno><idno type="wicri:Area/Pmc/Checkpoint">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000030</idno><idno type="wicri:Area/Ncbi/Merge">000201</idno><idno type="wicri:Area/Ncbi/Curation">000201</idno><idno type="wicri:Area/Ncbi/Checkpoint">000201</idno><idno type="wicri:Area/Main/Merge">000036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><author><name sortKey="Lin, Pei" sort="Lin, Pei" uniqKey="Lin P" first="Pei" last="Lin">Pei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lu, Jianmei" sort="Lu, Jianmei" uniqKey="Lu J" first="Jianmei" last="Lu">Jianmei Lu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yanfang" sort="Wang, Yanfang" uniqKey="Wang Y" first="Yanfang" last="Wang">Yanfang Wang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gu, Wen" sort="Gu, Wen" uniqKey="Gu W" first="Wen" last="Gu">Wen Gu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Ronghua" sort="Zhao, Ronghua" uniqKey="Zhao R" first="Ronghua" last="Zhao">Ronghua Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4′-tetrahydroxy-stilbene-2-<italic>O</italic>-<italic>β</italic>-<sc>D</sc>-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moller, De" uniqKey="Moller D">DE Moller</name></author><author><name sortKey="Kaufman, Kd" uniqKey="Kaufman K">KD Kaufman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wattacheril, J" uniqKey="Wattacheril J">J Wattacheril</name></author><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matteoni, Ca" uniqKey="Matteoni C">CA Matteoni</name></author><author><name sortKey="Younossi, Zm" uniqKey="Younossi Z">ZM Younossi</name></author><author><name sortKey="Gramlich, T" uniqKey="Gramlich T">T Gramlich</name></author><author><name sortKey="Boparai, N" uniqKey="Boparai N">N Boparai</name></author><author><name sortKey="Liu, Yc" uniqKey="Liu Y">YC Liu</name></author><author><name sortKey="Mccullough, Aj" uniqKey="Mccullough A">AJ McCullough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehal, Wz" uniqKey="Mehal W">WZ Mehal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chassaing, B" uniqKey="Chassaing B">B Chassaing</name></author><author><name sortKey="Etienne Mesmin, L" uniqKey="Etienne Mesmin L">L Etienne-Mesmin</name></author><author><name sortKey="Gewirtz, At" uniqKey="Gewirtz A">AT Gewirtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machado, Mv" uniqKey="Machado M">MV Machado</name></author><author><name sortKey="Cortez Pinto, H" uniqKey="Cortez Pinto H">H Cortez-Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, K" uniqKey="Miura K">K Miura</name></author><author><name sortKey="Seki, E" uniqKey="Seki E">E Seki</name></author><author><name sortKey="Ohnishi, H" uniqKey="Ohnishi H">H Ohnishi</name></author><author><name sortKey="Brenner, Da" uniqKey="Brenner D">DA Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broering, R" uniqKey="Broering R">R Broering</name></author><author><name sortKey="Lu, M" uniqKey="Lu M">M Lu</name></author><author><name sortKey="Schlaak, Jf" uniqKey="Schlaak J">JF Schlaak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heinrichsdorff, J" uniqKey="Heinrichsdorff J">J Heinrichsdorff</name></author><author><name sortKey="Olefsky, Jm" uniqKey="Olefsky J">JM Olefsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorkbacka, H" uniqKey="Bjorkbacka H">H Björkbacka</name></author><author><name sortKey="Kunjathoor, Vv" uniqKey="Kunjathoor V">VV Kunjathoor</name></author><author><name sortKey="Moore, Kj" uniqKey="Moore K">KJ Moore</name></author><author><name sortKey="Koehn, S" uniqKey="Koehn S">S Koehn</name></author><author><name sortKey="Ordija, Cm" uniqKey="Ordija C">CM Ordija</name></author><author><name sortKey="Lee, Ma" uniqKey="Lee M">MA Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seki, E" uniqKey="Seki E">E Seki</name></author><author><name sortKey="Brenner, Da" uniqKey="Brenner D">DA Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zivkovic, Am" uniqKey="Zivkovic A">AM Zivkovic</name></author><author><name sortKey="German, Jb" uniqKey="German J">JB German</name></author><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bugianesi, E" uniqKey="Bugianesi E">E Bugianesi</name></author><author><name sortKey="Gentilcore, E" uniqKey="Gentilcore E">E Gentilcore</name></author><author><name sortKey="Manini, R" uniqKey="Manini R">R Manini</name></author><author><name sortKey="Natale, S" uniqKey="Natale S">S Natale</name></author><author><name sortKey="Vanni, E" uniqKey="Vanni E">E Vanni</name></author><author><name sortKey="Villanova, N" uniqKey="Villanova N">N Villanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belfort, R" uniqKey="Belfort R">R Belfort</name></author><author><name sortKey="Harrison, Sa" uniqKey="Harrison S">SA Harrison</name></author><author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name></author><author><name sortKey="Darland, C" uniqKey="Darland C">C Darland</name></author><author><name sortKey="Finch, J" uniqKey="Finch J">J Finch</name></author><author><name sortKey="Hardies, J" uniqKey="Hardies J">J Hardies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author><author><name sortKey="Kowdley, Kv" uniqKey="Kowdley K">KV Kowdley</name></author><author><name sortKey="Mccullough, A" uniqKey="Mccullough A">A McCullough</name></author><author><name sortKey="Diehl, Am" uniqKey="Diehl A">AM Diehl</name></author><author><name sortKey="Bass, Nm" uniqKey="Bass N">NM Bass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Lavine, Je" uniqKey="Lavine J">JE Lavine</name></author><author><name sortKey="Diehl, Am" uniqKey="Diehl A">AM Diehl</name></author><author><name sortKey="Brunt, Em" uniqKey="Brunt E">EM Brunt</name></author><author><name sortKey="Cusi, K" uniqKey="Cusi K">K Cusi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baur, Ja" uniqKey="Baur J">JA Baur</name></author><author><name sortKey="Pearson, Kj" uniqKey="Pearson K">KJ Pearson</name></author><author><name sortKey="Price, Nl" uniqKey="Price N">NL Price</name></author><author><name sortKey="Jamieson, Ha" uniqKey="Jamieson H">HA Jamieson</name></author><author><name sortKey="Lerin, C" uniqKey="Lerin C">C Lerin</name></author><author><name sortKey="Kalra, A" uniqKey="Kalra A">A Kalra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito Nagahata, T" uniqKey="Ito Nagahata T">T Ito-Nagahata</name></author><author><name sortKey="Kurihara, C" uniqKey="Kurihara C">C Kurihara</name></author><author><name sortKey="Hasebe, M" uniqKey="Hasebe M">M Hasebe</name></author><author><name sortKey="Ishii, A" uniqKey="Ishii A">A Ishii</name></author><author><name sortKey="Yamashita, K" uniqKey="Yamashita K">K Yamashita</name></author><author><name sortKey="Iwabuchi, M" uniqKey="Iwabuchi M">M Iwabuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Pang, X" uniqKey="Pang X">X Pang</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Kang, C" uniqKey="Kang C">C Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Wg" uniqKey="Wang W">WG Wang</name></author><author><name sortKey="He, Yr" uniqKey="He Y">YR He</name></author><author><name sortKey="Lin, P" uniqKey="Lin P">P Lin</name></author><author><name sortKey="Li, Yf" uniqKey="Li Y">YF Li</name></author><author><name sortKey="Sun, Rf" uniqKey="Sun R">RF Sun</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldsmith, Jr" uniqKey="Goldsmith J">JR Goldsmith</name></author><author><name sortKey="Sartor, Rb" uniqKey="Sartor R">RB Sartor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author><author><name sortKey="Fan, Jg" uniqKey="Fan J">JG Fan</name></author><author><name sortKey="Wang, Gl" uniqKey="Wang G">GL Wang</name></author><author><name sortKey="Wu, Wq" uniqKey="Wu W">WQ Wu</name></author><author><name sortKey="Jiang, Jm" uniqKey="Jiang J">JM Jiang</name></author><author><name sortKey="Shi, Q" uniqKey="Shi Q">Q Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Jg" uniqKey="Fan J">JG Fan</name></author><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author><author><name sortKey="Xu, Zj" uniqKey="Xu Z">ZJ Xu</name></author><author><name sortKey="Tia, Ly" uniqKey="Tia L">LY Tia</name></author><author><name sortKey="Ding, Xd" uniqKey="Ding X">XD Ding</name></author><author><name sortKey="Li, Ms" uniqKey="Li M">MS Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburne, M" uniqKey="Ashburne M">M Ashburne</name></author><author><name sortKey="Ball, Ca" uniqKey="Ball C">CA Ball</name></author><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author><author><name sortKey="Botstein, D" uniqKey="Botstein D">D Botstein</name></author><author><name sortKey="Butler, H" uniqKey="Butler H">H Butler</name></author><author><name sortKey="Cherry, Jm" uniqKey="Cherry J">JM Cherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caporaso, Jg" uniqKey="Caporaso J">JG Caporaso</name></author><author><name sortKey="Kuczynski, J" uniqKey="Kuczynski J">J Kuczynski</name></author><author><name sortKey="Stombaugh, J" uniqKey="Stombaugh J">J Stombaugh</name></author><author><name sortKey="Bittinger, K" uniqKey="Bittinger K">K Bittinger</name></author><author><name sortKey="Bushman, Fd" uniqKey="Bushman F">FD Bushman</name></author><author><name sortKey="Costello, Ek" uniqKey="Costello E">EK Costello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mago, T" uniqKey="Mago T">T Magoč</name></author><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Chi, Y" uniqKey="Chi Y">Y Chi</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Jr" uniqKey="Turner J">JR Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuhashi, M" uniqKey="Furuhashi M">M Furuhashi</name></author><author><name sortKey="Hotamisligil, Gs" uniqKey="Hotamisligil G">GS Hotamisligil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stahl, A" uniqKey="Stahl A">A Stahl</name></author><author><name sortKey="Gimeno, Re" uniqKey="Gimeno R">RE Gimeno</name></author><author><name sortKey="Tartaglia, La" uniqKey="Tartaglia L">LA Tartaglia</name></author><author><name sortKey="Lodish, Hf" uniqKey="Lodish H">HF Lodish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, A" uniqKey="Feng A">A Feng</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Lin, P" uniqKey="Lin P">P Lin</name></author><author><name sortKey="Lu, Jm" uniqKey="Lu J">JM Lu</name></author><author><name sortKey="Wang, Wg" uniqKey="Wang W">WG Wang</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author><author><name sortKey="Zhao, Rh" uniqKey="Zhao R">RH Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, X" uniqKey="Dai X">X Dai</name></author><author><name sortKey="Lv, Z" uniqKey="Lv Z">Z Lv</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivera, Ca" uniqKey="Rivera C">CA Rivera</name></author><author><name sortKey="Adegboyega, P" uniqKey="Adegboyega P">P Adegboyega</name></author><author><name sortKey="Rooijen, Nv" uniqKey="Rooijen N">NV Rooijen</name></author><author><name sortKey="Tagalicud, A" uniqKey="Tagalicud A">A Tagalicud</name></author><author><name sortKey="Allman, M" uniqKey="Allman M">M Allman</name></author><author><name sortKey="Wallace, M" uniqKey="Wallace M">M Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baffy, G" uniqKey="Baffy G">G Baffy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name></author><author><name sortKey="Moschen, Ar" uniqKey="Moschen A">AR Moschen</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Linguistique/explor/TamazightV2/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000036 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000036 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Linguistique
|area= TamazightV2
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:4608713
|texte= Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:26474417" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a TamazightV2
| This area was generated with Dilib version V0.6.33. |  |