TamazightV2, Francis, Corpus, bibRecord, 000034

INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS

Identifieur interne : 000034 ( Francis/Corpus ); précédent : 000033; suivant : 000035

INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS

Auteurs : Sabeh Frigi ; Hajer Ennafaa ; Lotfi Cherni ; AMEL EL GAAIED

Source :

Anthropologie : (Brno) [ 0323-1119 ] ; 2009.

RBID : Francis:11-0316128

Descripteurs français

Pascal (Inist)
- Afrique du Nord, Tunisie, Polymorphisme, Caractère, Génétique, Génétique des populations, Méthode quantitative, Comparaison, Berbère, Séquence.

English descriptors

KwdEn :
- Berber, Character, Comparison, Genetics, North Africa, Polymorphism, Population genetics, Quantitative method, Tunisia.

Abstract

MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Anthropologie : (Brno)`
A05				`@2 47`
A06				`@2 1-2`
A08	`01`	`1`	`ENG`	`@1 INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS`
A11	`01`	`1`		`@1 FRIGI (Sabeh)`
A11	`02`	`1`		`@1 ENNAFAA (Hajer)`
A11	`03`	`1`		`@1 CHERNI (Lotfi)`
A11	`04`	`1`		`@1 AMEL EL GAAIED`
A14	`01`			`@1 Laboratory of Molecular genetics, Immunology and Human Pathology Faculty of Sciences of Tunis University El Manar @2 1060 Tunis @3 TUN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A20				`@1 107-118`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 23697 @5 354000192533690110`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 1 p.1/4`
A47	`01`	`1`		`@0 11-0316128`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Anthropologie : (Brno)`
A66	`01`			`@0 CZE`
A68	`01`	`1`	`FRE`	`@1 L'ENQUÊTE SUR LES POLYMORPHISMS DANS LA RÉGION HYPERVARIABLE II (HVII) SEQUENCES D'ADN MITOCHONDRIAL HUMAIN DANS DEUX POPULATIONS AFRICAINES-NORD`
C01	`01`		`ENG`	@0 MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.
C02	`01`	`N`		`@0 52922 @1 III`
C02	`02`	`N`		`@0 529`
C03	`01`	`N`	`FRE`	`@0 Afrique du Nord @2 NG @5 01`
C03	`01`	`N`	`ENG`	`@0 North Africa @2 NG @5 01`
C03	`02`	`N`	`FRE`	`@0 Tunisie @2 NG @5 02`
C03	`02`	`N`	`ENG`	`@0 Tunisia @2 NG @5 02`
C03	`03`	`N`	`FRE`	`@0 Polymorphisme @5 03`
C03	`03`	`N`	`ENG`	`@0 Polymorphism @5 03`
C03	`04`	`S`	`FRE`	`@0 Caractère @5 04`
C03	`04`	`S`	`ENG`	`@0 Character @5 04`
C03	`05`	`N`	`FRE`	`@0 Génétique @5 05`
C03	`05`	`N`	`ENG`	`@0 Genetics @5 05`
C03	`06`	`N`	`FRE`	`@0 Génétique des populations @2 NI @5 06`
C03	`06`	`N`	`ENG`	`@0 Population genetics @2 NI @5 06`
C03	`07`	`N`	`FRE`	`@0 Méthode quantitative @5 07`
C03	`07`	`N`	`ENG`	`@0 Quantitative method @5 07`
C03	`08`	`N`	`FRE`	`@0 Comparaison @5 08`
C03	`08`	`N`	`ENG`	`@0 Comparison @5 08`
C03	`09`	`N`	`FRE`	`@0 Berbère @2 NN @5 09`
C03	`09`	`N`	`ENG`	`@0 Berber @2 NN @5 09`
C03	`10`	`N`	`FRE`	`@0 Séquence @4 INC @5 28`
N21				`@1 213`

Format Inist (serveur)

NO :	FRANCIS 11-0316128 INIST
FT :	(L'ENQUÊTE SUR LES POLYMORPHISMS DANS LA RÉGION HYPERVARIABLE II (HVII) SEQUENCES D'ADN MITOCHONDRIAL HUMAIN DANS DEUX POPULATIONS AFRICAINES-NORD)
ET :	INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS
AU :	FRIGI (Sabeh); ENNAFAA (Hajer); CHERNI (Lotfi); AMEL EL GAAIED
AF :	Laboratory of Molecular genetics, Immunology and Human Pathology Faculty of Sciences of Tunis University El Manar/1060 Tunis/Tunisie (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Anthropologie : (Brno); ISSN 0323-1119; Tchèque, République; Da. 2009; Vol. 47; No. 1-2; Pp. 107-118; Bibl. 1 p.1/4
LA :	Anglais
EA :	MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.
CC :	52922; 529
FD :	Afrique du Nord; Tunisie; Polymorphisme; Caractère; Génétique; Génétique des populations; Méthode quantitative; Comparaison; Berbère; Séquence
ED :	North Africa; Tunisia; Polymorphism; Character; Genetics; Population genetics; Quantitative method; Comparison; Berber
LO :	INIST-23697.354000192533690110
ID :	11-0316128

Links to Exploration step

Francis:11-0316128

Le document en format XML

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<front><div type="abstract" xml:lang="en">MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.</div>
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<fC01 i1="01" l="ENG"><s0>MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.</s0>
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<server><NO>FRANCIS 11-0316128 INIST</NO>
<FT>(L'ENQUÊTE SUR LES POLYMORPHISMS DANS LA RÉGION HYPERVARIABLE II (HVII) SEQUENCES D'ADN MITOCHONDRIAL HUMAIN DANS DEUX POPULATIONS AFRICAINES-NORD)</FT>
<ET>INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS</ET>
<AU>FRIGI (Sabeh); ENNAFAA (Hajer); CHERNI (Lotfi); AMEL EL GAAIED</AU>
<AF>Laboratory of Molecular genetics, Immunology and Human Pathology Faculty of Sciences of Tunis University El Manar/1060 Tunis/Tunisie (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Anthropologie : (Brno); ISSN 0323-1119; Tchèque, République; Da. 2009; Vol. 47; No. 1-2; Pp. 107-118; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>MtDNA analysis has been focused mainly on the first hypervariable region (HVI). This paper deals with polymorphisms in the HVII of two Tunisian populations (Sejnane and Takrouna). Particular attention was paid to nucleotide site 73 which is particularly informative when studying European populations as well as polymorphisms in a mononucleotide repeat poly-C stretch between position 303 and 315 nucleotides (D310) which has been identified recently as a frequent hot-spot of deletion/insertion mutations in tumors. Our results demonstrate that site 73 plays a central role in distinguishing between haplogroups. We show that the subset of sequences carrying adenine at site 73 belongs to haplogroups H and V and has a much more recent common mitochondrial DNA ancestor than the subset of sequences with guanine at that site. The polymorphism of the 303-315 mitochondrial microsatellite in the two communities shows that this mitochondrial C-stretch is a frequent hot spot of mononucleotide insertions. The results showed that the two haplotypes 309.1 315.1 and 309-315.1 are the most frequent in all studied populations. Our results also confirm the high diversity of the population of Sejnane compared with Takrouna and other populations.</EA>
<CC>52922; 529</CC>
<FD>Afrique du Nord; Tunisie; Polymorphisme; Caractère; Génétique; Génétique des populations; Méthode quantitative; Comparaison; Berbère; Séquence</FD>
<ED>North Africa; Tunisia; Polymorphism; Character; Genetics; Population genetics; Quantitative method; Comparison; Berber</ED>
<LO>INIST-23697.354000192533690110</LO>
<ID>11-0316128</ID>
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INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS

INVESTIGATION OF POLYMORPHISMS IN HYPERVARIABLE REGION II (HVII) SEQUENCES OF HUMAN MITOCHONDRIAL DNA IN TWO NORTH-AFRICAN POPULATIONS

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