Neuropsychological performance in African children with HIV enrolled in a multi-site anti-retroviral clinical trial.
Identifieur interne : 000855 ( PubMed/Corpus ); précédent : 000854; suivant : 000856Neuropsychological performance in African children with HIV enrolled in a multi-site anti-retroviral clinical trial.
Auteurs : Michael J. Boivin ; Linda Barlow-Mosha ; Miriam Chernoff ; Barbara Laughton ; Bonnie Zimmer ; Celeste Joyce ; Mutsa Bwakura-Dangarembizi ; Mmule Ratswana ; Nasreen Abrahams ; Lee Fairlie ; Hermien Gous ; Portia Kamthunzi ; Katie Mccarthy ; Itziar Familiar-Lopez ; Patrick Jean-Phillippe ; Joan Coetzee ; Avy Violari ; Mark Cotton ; Paul PalumboSource :
- AIDS (London, England) [ 1473-5571 ] ; 2017.
Abstract
Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries.
DOI: 10.1097/QAD.0000000000001683
PubMed: 29112069
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Boivin</name><affiliation><nlm:affiliation>aMichigan State University bMakerere University-Johns Hopkins University cHarvard University dStellenbosch University eFrontier Science fUniversity of Witwatersrand gUniversity of Zimbabwe hWits RHI Shandukani Clinic, Johannesburg RSA iChris Hani HIV Unit, Soweto RSA jUniversity of North Carolina - Lilongwe Clinical Research Institute kFHI360; l NIH/NIAID mHitchcock Medical School of Dartmouth University.</nlm:affiliation></affiliation></author><author><name sortKey="Barlow Mosha, Linda" sort="Barlow Mosha, Linda" uniqKey="Barlow Mosha L" first="Linda" last="Barlow-Mosha">Linda Barlow-Mosha</name></author><author><name sortKey="Chernoff, Miriam" sort="Chernoff, Miriam" uniqKey="Chernoff M" first="Miriam" last="Chernoff">Miriam Chernoff</name></author><author><name sortKey="Laughton, Barbara" sort="Laughton, Barbara" uniqKey="Laughton B" first="Barbara" last="Laughton">Barbara Laughton</name></author><author><name sortKey="Zimmer, Bonnie" sort="Zimmer, Bonnie" uniqKey="Zimmer B" first="Bonnie" last="Zimmer">Bonnie Zimmer</name></author><author><name sortKey="Joyce, Celeste" sort="Joyce, Celeste" uniqKey="Joyce C" first="Celeste" last="Joyce">Celeste Joyce</name></author><author><name sortKey="Bwakura Dangarembizi, Mutsa" sort="Bwakura Dangarembizi, Mutsa" uniqKey="Bwakura Dangarembizi M" first="Mutsa" last="Bwakura-Dangarembizi">Mutsa Bwakura-Dangarembizi</name></author><author><name sortKey="Ratswana, Mmule" sort="Ratswana, Mmule" uniqKey="Ratswana M" first="Mmule" last="Ratswana">Mmule Ratswana</name></author><author><name sortKey="Abrahams, Nasreen" sort="Abrahams, Nasreen" uniqKey="Abrahams N" first="Nasreen" last="Abrahams">Nasreen Abrahams</name></author><author><name sortKey="Fairlie, Lee" sort="Fairlie, Lee" uniqKey="Fairlie L" first="Lee" last="Fairlie">Lee Fairlie</name></author><author><name sortKey="Gous, Hermien" sort="Gous, Hermien" uniqKey="Gous H" first="Hermien" last="Gous">Hermien Gous</name></author><author><name sortKey="Kamthunzi, Portia" sort="Kamthunzi, Portia" uniqKey="Kamthunzi P" first="Portia" last="Kamthunzi">Portia Kamthunzi</name></author><author><name sortKey="Mccarthy, Katie" sort="Mccarthy, Katie" uniqKey="Mccarthy K" first="Katie" last="Mccarthy">Katie Mccarthy</name></author><author><name sortKey="Familiar Lopez, Itziar" sort="Familiar Lopez, Itziar" uniqKey="Familiar Lopez I" first="Itziar" last="Familiar-Lopez">Itziar Familiar-Lopez</name></author><author><name sortKey="Jean Phillippe, Patrick" sort="Jean Phillippe, Patrick" uniqKey="Jean Phillippe P" first="Patrick" last="Jean-Phillippe">Patrick Jean-Phillippe</name></author><author><name sortKey="Coetzee, Joan" sort="Coetzee, Joan" uniqKey="Coetzee J" first="Joan" last="Coetzee">Joan Coetzee</name></author><author><name sortKey="Violari, Avy" sort="Violari, Avy" uniqKey="Violari A" first="Avy" last="Violari">Avy Violari</name></author><author><name sortKey="Cotton, Mark" sort="Cotton, Mark" uniqKey="Cotton M" first="Mark" last="Cotton">Mark Cotton</name></author><author><name sortKey="Palumbo, Paul" sort="Palumbo, Paul" uniqKey="Palumbo P" first="Paul" last="Palumbo">Paul Palumbo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29112069</idno><idno type="pmid">29112069</idno><idno type="doi">10.1097/QAD.0000000000001683</idno><idno type="wicri:Area/PubMed/Corpus">000855</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000855</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuropsychological performance in African children with HIV enrolled in a multi-site anti-retroviral clinical trial.</title><author><name sortKey="Boivin, Michael J" sort="Boivin, Michael J" uniqKey="Boivin M" first="Michael J" last="Boivin">Michael J. Boivin</name><affiliation><nlm:affiliation>aMichigan State University bMakerere University-Johns Hopkins University cHarvard University dStellenbosch University eFrontier Science fUniversity of Witwatersrand gUniversity of Zimbabwe hWits RHI Shandukani Clinic, Johannesburg RSA iChris Hani HIV Unit, Soweto RSA jUniversity of North Carolina - Lilongwe Clinical Research Institute kFHI360; l NIH/NIAID mHitchcock Medical School of Dartmouth University.</nlm:affiliation></affiliation></author><author><name sortKey="Barlow Mosha, Linda" sort="Barlow Mosha, Linda" uniqKey="Barlow Mosha L" first="Linda" last="Barlow-Mosha">Linda Barlow-Mosha</name></author><author><name sortKey="Chernoff, Miriam" sort="Chernoff, Miriam" uniqKey="Chernoff M" first="Miriam" last="Chernoff">Miriam Chernoff</name></author><author><name sortKey="Laughton, Barbara" sort="Laughton, Barbara" uniqKey="Laughton B" first="Barbara" last="Laughton">Barbara Laughton</name></author><author><name sortKey="Zimmer, Bonnie" sort="Zimmer, Bonnie" uniqKey="Zimmer B" first="Bonnie" last="Zimmer">Bonnie Zimmer</name></author><author><name sortKey="Joyce, Celeste" sort="Joyce, Celeste" uniqKey="Joyce C" first="Celeste" last="Joyce">Celeste Joyce</name></author><author><name sortKey="Bwakura Dangarembizi, Mutsa" sort="Bwakura Dangarembizi, Mutsa" uniqKey="Bwakura Dangarembizi M" first="Mutsa" last="Bwakura-Dangarembizi">Mutsa Bwakura-Dangarembizi</name></author><author><name sortKey="Ratswana, Mmule" sort="Ratswana, Mmule" uniqKey="Ratswana M" first="Mmule" last="Ratswana">Mmule Ratswana</name></author><author><name sortKey="Abrahams, Nasreen" sort="Abrahams, Nasreen" uniqKey="Abrahams N" first="Nasreen" last="Abrahams">Nasreen Abrahams</name></author><author><name sortKey="Fairlie, Lee" sort="Fairlie, Lee" uniqKey="Fairlie L" first="Lee" last="Fairlie">Lee Fairlie</name></author><author><name sortKey="Gous, Hermien" sort="Gous, Hermien" uniqKey="Gous H" first="Hermien" last="Gous">Hermien Gous</name></author><author><name sortKey="Kamthunzi, Portia" sort="Kamthunzi, Portia" uniqKey="Kamthunzi P" first="Portia" last="Kamthunzi">Portia Kamthunzi</name></author><author><name sortKey="Mccarthy, Katie" sort="Mccarthy, Katie" uniqKey="Mccarthy K" first="Katie" last="Mccarthy">Katie Mccarthy</name></author><author><name sortKey="Familiar Lopez, Itziar" sort="Familiar Lopez, Itziar" uniqKey="Familiar Lopez I" first="Itziar" last="Familiar-Lopez">Itziar Familiar-Lopez</name></author><author><name sortKey="Jean Phillippe, Patrick" sort="Jean Phillippe, Patrick" uniqKey="Jean Phillippe P" first="Patrick" last="Jean-Phillippe">Patrick Jean-Phillippe</name></author><author><name sortKey="Coetzee, Joan" sort="Coetzee, Joan" uniqKey="Coetzee J" first="Joan" last="Coetzee">Joan Coetzee</name></author><author><name sortKey="Violari, Avy" sort="Violari, Avy" uniqKey="Violari A" first="Avy" last="Violari">Avy Violari</name></author><author><name sortKey="Cotton, Mark" sort="Cotton, Mark" uniqKey="Cotton M" first="Mark" last="Cotton">Mark Cotton</name></author><author><name sortKey="Palumbo, Paul" sort="Palumbo, Paul" uniqKey="Palumbo P" first="Paul" last="Palumbo">Paul Palumbo</name></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="eISSN">1473-5571</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29112069</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>07</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Nov</Month><Day>02</Day></PubDate></JournalIssue><Title>AIDS (London, England)</Title><ISOAbbreviation>AIDS</ISOAbbreviation></Journal><ArticleTitle>Neuropsychological performance in African children with HIV enrolled in a multi-site anti-retroviral clinical trial.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0000000000001683</ELocationID><Abstract><AbstractText Label="OBJECTIVE & DESIGN" NlmCategory="OBJECTIVE">Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age. This study (P1104 s) enrolled P1060 children at 5-11 years of age and evaluated their neuropsychological performance over 2 years using the KABC-II, TOVA, BOT-2, and parent-reported BRIEF. Cohorts were compared using GEE least-squares means adjusted for site, child age and gender, and personal and social characteristics for child and caregiver.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">611 (246 HIV+, 183 HEU, 182 HU) of the 615 enrolled at 6 sites (South Africa [3], Zimbabwe, Malawi, Uganda) were available for analysis. Mean age was 7.2 years, 48% male, 69% in school. Unadjusted and adjusted comparisons were consistent. HIV+ children performed significantly worse than HEU and HUU on KABC-II, TOVA, BOT-2 (P < 0.001), but not on the BRIEF. HUU and HEU cohorts were comparable on cognitive outcomes. HIV+ children initiated on ARV treatment before one year of age had significantly better only in BOT-2 total motor proficiency compared to those started after.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Significant cognitive deficits were documented among HIV+ children. Earlier HIV treatment, neuropsychological monitoring and rehabilitative interventions are needed. Subsequent testing for 2 more years will help evaluate how HIV infection and exposure affect the developmental trajectory.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boivin</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>aMichigan State University bMakerere University-Johns Hopkins University cHarvard University dStellenbosch University eFrontier Science fUniversity of Witwatersrand gUniversity of Zimbabwe hWits RHI Shandukani Clinic, Johannesburg RSA iChris Hani HIV Unit, Soweto RSA jUniversity of North Carolina - Lilongwe Clinical Research Institute kFHI360; l NIH/NIAID mHitchcock Medical School of Dartmouth University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barlow-Mosha</LastName><ForeName>Linda</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chernoff</LastName><ForeName>Miriam</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Laughton</LastName><ForeName>Barbara</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Zimmer</LastName><ForeName>Bonnie</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Joyce</LastName><ForeName>Celeste</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Bwakura-Dangarembizi</LastName><ForeName>Mutsa</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ratswana</LastName><ForeName>Mmule</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Abrahams</LastName><ForeName>Nasreen</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Fairlie</LastName><ForeName>Lee</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Gous</LastName><ForeName>Hermien</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kamthunzi</LastName><ForeName>Portia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Katie</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Familiar-Lopez</LastName><ForeName>Itziar</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Jean-Phillippe</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Coetzee</LastName><ForeName>Joan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Violari</LastName><ForeName>Avy</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cotton</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Palumbo</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><CollectiveName>and the impaact P1104s Study Team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>AIDS</MedlineTA><NlmUniqueID>8710219</NlmUniqueID><ISSNLinking>0269-9370</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29112069</ArticleId><ArticleId IdType="doi">10.1097/QAD.0000000000001683</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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