Mass drug administration significantly reduces infection of Schistosoma mansoni and hookworm in school children in the national control program in Sierra Leone
Identifieur interne : 002177 ( Pmc/Curation ); précédent : 002176; suivant : 002178Mass drug administration significantly reduces infection of Schistosoma mansoni and hookworm in school children in the national control program in Sierra Leone
Auteurs : Mary H. Hodges [Sierra Leone] ; Nsa Dada [Royaume-Uni] ; Anna Warmsley [Royaume-Uni] ; Jusufu Paye [Sierra Leone] ; Momodu M. Bangura [Sierra Leone] ; Emanuel Nyorkor [Sierra Leone] ; Mustapha Sonnie [Sierra Leone] ; Yaobi Zhang [Sénégal]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2012.
Abstract
The first-ever round of school-based mass drug administration (MDA) with praziquantel together with mebendazole targeting school-aged children in endemic districts was conducted in 2009 by the National Neglected Tropical Diseases Control Program. To evaluate the impact of the treatment regimen, a cross-sectional sentinel site survey was conducted 6 months post-MDA.
Fifteen sentinel schools from six highly endemic districts (according to data from national and pre-MDA surveys) with
The overall prevalence (and intensity) in these sentinel sites pre-MDA of
Significant reduction in
Url:
DOI: 10.1186/1471-2334-12-16
PubMed: 22264258
PubMed Central: 3282666
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002178
Links to Exploration step
PMC:3282666Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mass drug administration significantly reduces infection of <italic>Schistosoma mansoni </italic>
and hookworm in school children in the national control program in Sierra Leone</title>
<author><name sortKey="Hodges, Mary H" sort="Hodges, Mary H" uniqKey="Hodges M" first="Mary H" last="Hodges">Mary H. Hodges</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dada, Nsa" sort="Dada, Nsa" uniqKey="Dada N" first="Nsa" last="Dada">Nsa Dada</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Liverpool School of Tropical Medicine, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Warmsley, Anna" sort="Warmsley, Anna" uniqKey="Warmsley A" first="Anna" last="Warmsley">Anna Warmsley</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Liverpool School of Tropical Medicine, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paye, Jusufu" sort="Paye, Jusufu" uniqKey="Paye J" first="Jusufu" last="Paye">Jusufu Paye</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bangura, Momodu M" sort="Bangura, Momodu M" uniqKey="Bangura M" first="Momodu M" last="Bangura">Momodu M. Bangura</name>
<affiliation wicri:level="1"><nlm:aff id="I3">National NTDCP, Ministry for Health and Sanitation, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>National NTDCP, Ministry for Health and Sanitation, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nyorkor, Emanuel" sort="Nyorkor, Emanuel" uniqKey="Nyorkor E" first="Emanuel" last="Nyorkor">Emanuel Nyorkor</name>
<affiliation wicri:level="1"><nlm:aff id="I4">School of Community Health and Clinical Sciences, Njala University, Bo, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>School of Community Health and Clinical Sciences, Njala University, Bo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sonnie, Mustapha" sort="Sonnie, Mustapha" uniqKey="Sonnie M" first="Mustapha" last="Sonnie">Mustapha Sonnie</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Yaobi" sort="Zhang, Yaobi" uniqKey="Zhang Y" first="Yaobi" last="Zhang">Yaobi Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Helen Keller International, Regional Office for Africa, Dakar, Senegal</nlm:aff>
<country xml:lang="fr">Sénégal</country>
<wicri:regionArea>Helen Keller International, Regional Office for Africa, Dakar</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22264258</idno>
<idno type="pmc">3282666</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282666</idno>
<idno type="RBID">PMC:3282666</idno>
<idno type="doi">10.1186/1471-2334-12-16</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002178</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002178</idno>
<idno type="wicri:Area/Pmc/Curation">002177</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002177</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mass drug administration significantly reduces infection of <italic>Schistosoma mansoni </italic>
and hookworm in school children in the national control program in Sierra Leone</title>
<author><name sortKey="Hodges, Mary H" sort="Hodges, Mary H" uniqKey="Hodges M" first="Mary H" last="Hodges">Mary H. Hodges</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dada, Nsa" sort="Dada, Nsa" uniqKey="Dada N" first="Nsa" last="Dada">Nsa Dada</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Liverpool School of Tropical Medicine, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Warmsley, Anna" sort="Warmsley, Anna" uniqKey="Warmsley A" first="Anna" last="Warmsley">Anna Warmsley</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Liverpool School of Tropical Medicine, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paye, Jusufu" sort="Paye, Jusufu" uniqKey="Paye J" first="Jusufu" last="Paye">Jusufu Paye</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bangura, Momodu M" sort="Bangura, Momodu M" uniqKey="Bangura M" first="Momodu M" last="Bangura">Momodu M. Bangura</name>
<affiliation wicri:level="1"><nlm:aff id="I3">National NTDCP, Ministry for Health and Sanitation, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>National NTDCP, Ministry for Health and Sanitation, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nyorkor, Emanuel" sort="Nyorkor, Emanuel" uniqKey="Nyorkor E" first="Emanuel" last="Nyorkor">Emanuel Nyorkor</name>
<affiliation wicri:level="1"><nlm:aff id="I4">School of Community Health and Clinical Sciences, Njala University, Bo, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>School of Community Health and Clinical Sciences, Njala University, Bo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sonnie, Mustapha" sort="Sonnie, Mustapha" uniqKey="Sonnie M" first="Mustapha" last="Sonnie">Mustapha Sonnie</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Helen Keller International, PO Box 369, Freetown, Sierra Leone</nlm:aff>
<country xml:lang="fr">Sierra Leone</country>
<wicri:regionArea>Helen Keller International, PO Box 369, Freetown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Yaobi" sort="Zhang, Yaobi" uniqKey="Zhang Y" first="Yaobi" last="Zhang">Yaobi Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Helen Keller International, Regional Office for Africa, Dakar, Senegal</nlm:aff>
<country xml:lang="fr">Sénégal</country>
<wicri:regionArea>Helen Keller International, Regional Office for Africa, Dakar</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The first-ever round of school-based mass drug administration (MDA) with praziquantel together with mebendazole targeting school-aged children in endemic districts was conducted in 2009 by the National Neglected Tropical Diseases Control Program. To evaluate the impact of the treatment regimen, a cross-sectional sentinel site survey was conducted 6 months post-MDA.</p>
</sec>
<sec><title>Methods</title>
<p>Fifteen sentinel schools from six highly endemic districts (according to data from national and pre-MDA surveys) with <italic>Schistosoma mansoni </italic>
affecting over 50% of the population, and moderate to high prevalence of hookworms (> 20%). Approximately 30 children aged 9-14 years were selected from each school and stool samples (one per student) were examined by the Kato-Katz method.</p>
</sec>
<sec><title>Results</title>
<p>The overall prevalence (and intensity) in these sentinel sites pre-MDA of <italic>S. mansoni </italic>
was 69.0% (170.8 epg), hookworm: 41.7% (71.7 epg), <italic>Ascaris lumbricoides: 1.8% </italic>
and <italic>Trichuris trichiura: 3.8%</italic>
. Six months post MDA, the findings were <italic>S. mansoni</italic>
: 38.2% (47.3 epg) and hookworm: 14.5% (8.7 epg), representing a reduction from pre-MDA levels of 44.6% (65.2%) and 72.3% (87.9%) respectively. The proportion of children who were moderately or heavily infected with <italic>S. mansoni </italic>
fell from 35.6% pre MDA to 9.9% post MDA.</p>
</sec>
<sec><title>Conclusions</title>
<p>Significant reduction in <italic>S. mansoni </italic>
and hookworm infection was achieved by this first round MDA in school-going children in Sierra Leone. This reduction in infection burden can potentially contribute to a reduction of morbidity, such as anaemia, in these children.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bethony, J" uniqKey="Bethony J">J Bethony</name>
</author>
<author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name>
</author>
<author><name sortKey="Albonico, M" uniqKey="Albonico M">M Albonico</name>
</author>
<author><name sortKey="Geiger, Sm" uniqKey="Geiger S">SM Geiger</name>
</author>
<author><name sortKey="Loukas, A" uniqKey="Loukas A">A Loukas</name>
</author>
<author><name sortKey="Diemert, D" uniqKey="Diemert D">D Diemert</name>
</author>
<author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steinmann, P" uniqKey="Steinmann P">P Steinmann</name>
</author>
<author><name sortKey="Keiser, J" uniqKey="Keiser J">J Keiser</name>
</author>
<author><name sortKey="Bos, R" uniqKey="Bos R">R Bos</name>
</author>
<author><name sortKey="Tanner, M" uniqKey="Tanner M">M Tanner</name>
</author>
<author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J Utzinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name>
</author>
<author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
<author><name sortKey="Kumaresan, J" uniqKey="Kumaresan J">J Kumaresan</name>
</author>
<author><name sortKey="Sachs, Se" uniqKey="Sachs S">SE Sachs</name>
</author>
<author><name sortKey="Sachs, Jd" uniqKey="Sachs J">JD Sachs</name>
</author>
<author><name sortKey="Savioli, L" uniqKey="Savioli L">L Savioli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotez, P" uniqKey="Hotez P">P Hotez</name>
</author>
<author><name sortKey="Gupta, R" uniqKey="Gupta R">R Gupta</name>
</author>
<author><name sortKey="Mahoney, R" uniqKey="Mahoney R">R Mahoney</name>
</author>
<author><name sortKey="Poste, G" uniqKey="Poste G">G Poste</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name>
</author>
<author><name sortKey="Brindley, Pj" uniqKey="Brindley P">PJ Brindley</name>
</author>
<author><name sortKey="Bethony, Jm" uniqKey="Bethony J">JM Bethony</name>
</author>
<author><name sortKey="King, Ch" uniqKey="King C">CH King</name>
</author>
<author><name sortKey="Pearce, Ej" uniqKey="Pearce E">EJ Pearce</name>
</author>
<author><name sortKey="Jacobson, J" uniqKey="Jacobson J">J Jacobson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="King, Ch" uniqKey="King C">CH King</name>
</author>
<author><name sortKey="Dickman, K" uniqKey="Dickman K">K Dickman</name>
</author>
<author><name sortKey="Tisch, Dj" uniqKey="Tisch D">DJ Tisch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savioli, L" uniqKey="Savioli L">L Savioli</name>
</author>
<author><name sortKey="Albonico, M" uniqKey="Albonico M">M Albonico</name>
</author>
<author><name sortKey="Engels, D" uniqKey="Engels D">D Engels</name>
</author>
<author><name sortKey="Montresor, A" uniqKey="Montresor A">A Montresor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crompton, Dw" uniqKey="Crompton D">DW Crompton</name>
</author>
<author><name sortKey="Nesheim, Mc" uniqKey="Nesheim M">MC Nesheim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guyatt, H" uniqKey="Guyatt H">H Guyatt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name>
</author>
<author><name sortKey="Clements, Ac" uniqKey="Clements A">AC Clements</name>
</author>
<author><name sortKey="Bundy, Da" uniqKey="Bundy D">DA Bundy</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="White, Pt" uniqKey="White P">PT White</name>
</author>
<author><name sortKey="Gbakima, Aa" uniqKey="Gbakima A">AA Gbakima</name>
</author>
<author><name sortKey="Amara, Sv" uniqKey="Amara S">SV Amara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Onabamiro, Sd" uniqKey="Onabamiro S">SD Onabamiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Onabamiro, Sd" uniqKey="Onabamiro S">SD Onabamiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koroma, Jb" uniqKey="Koroma J">JB Koroma</name>
</author>
<author><name sortKey="Peterson, J" uniqKey="Peterson J">J Peterson</name>
</author>
<author><name sortKey="Gbakima, Aa" uniqKey="Gbakima A">AA Gbakima</name>
</author>
<author><name sortKey="Nylander, Fe" uniqKey="Nylander F">FE Nylander</name>
</author>
<author><name sortKey="Sahr, F" uniqKey="Sahr F">F Sahr</name>
</author>
<author><name sortKey="Soares Magalhaes, Rj" uniqKey="Soares Magalhaes R">RJ Soares Magalhaes</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Hodges, Mh" uniqKey="Hodges M">MH Hodges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
<author><name sortKey="Dada, N" uniqKey="Dada N">N Dada</name>
</author>
<author><name sortKey="Wamsley, A" uniqKey="Wamsley A">A Wamsley</name>
</author>
<author><name sortKey="Paye, J" uniqKey="Paye J">J Paye</name>
</author>
<author><name sortKey="Nyorkor, E" uniqKey="Nyorkor E">E Nyorkor</name>
</author>
<author><name sortKey="Sonnie, M" uniqKey="Sonnie M">M Sonnie</name>
</author>
<author><name sortKey="Barnish, G" uniqKey="Barnish G">G Barnish</name>
</author>
<author><name sortKey="Bockarie, M" uniqKey="Bockarie M">M Bockarie</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Williams, Ra" uniqKey="Williams R">RA Williams</name>
</author>
<author><name sortKey="Koroma, Mm" uniqKey="Koroma M">MM Koroma</name>
</author>
<author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koroma, Mm" uniqKey="Koroma M">MM Koroma</name>
</author>
<author><name sortKey="Williams, Ra" uniqKey="Williams R">RA Williams</name>
</author>
<author><name sortKey="De La Haye, Rr" uniqKey="De La Haye R">RR de la Haye</name>
</author>
<author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bayoh, Mn" uniqKey="Bayoh M">MN Bayoh</name>
</author>
<author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bayoh, Mn" uniqKey="Bayoh M">MN Bayoh</name>
</author>
<author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gbakima, Aa" uniqKey="Gbakima A">AA Gbakima</name>
</author>
<author><name sortKey="Sherpard, M" uniqKey="Sherpard M">M Sherpard</name>
</author>
<author><name sortKey="White, Pt" uniqKey="White P">PT White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gbakima, Aa" uniqKey="Gbakima A">AA Gbakima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hodges, M" uniqKey="Hodges M">M Hodges</name>
</author>
<author><name sortKey="Koroma, Jb" uniqKey="Koroma J">JB Koroma</name>
</author>
<author><name sortKey="Sonnie, M" uniqKey="Sonnie M">M Sonnie</name>
</author>
<author><name sortKey="Kennedy, N" uniqKey="Kennedy N">N Kennedy</name>
</author>
<author><name sortKey="Cotter, E" uniqKey="Cotter E">E Cotter</name>
</author>
<author><name sortKey="Macarthur, C" uniqKey="Macarthur C">C MacArthur</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Newcombe, Rg" uniqKey="Newcombe R">RG Newcombe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koukounari, A" uniqKey="Koukounari A">A Koukounari</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
<author><name sortKey="Whawell, S" uniqKey="Whawell S">S Whawell</name>
</author>
<author><name sortKey="Kabatereine, Nb" uniqKey="Kabatereine N">NB Kabatereine</name>
</author>
<author><name sortKey="Kazibwe, F" uniqKey="Kazibwe F">F Kazibwe</name>
</author>
<author><name sortKey="Tukahebwa, Em" uniqKey="Tukahebwa E">EM Tukahebwa</name>
</author>
<author><name sortKey="Stothard, Jr" uniqKey="Stothard J">JR Stothard</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koukounari, A" uniqKey="Koukounari A">A Koukounari</name>
</author>
<author><name sortKey="Gabrielli, Af" uniqKey="Gabrielli A">AF Gabrielli</name>
</author>
<author><name sortKey="Toure, S" uniqKey="Toure S">S Toure</name>
</author>
<author><name sortKey="Bosque Oliva, E" uniqKey="Bosque Oliva E">E Bosque-Oliva</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Sellin, B" uniqKey="Sellin B">B Sellin</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
<author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kabatereine, Nb" uniqKey="Kabatereine N">NB Kabatereine</name>
</author>
<author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name>
</author>
<author><name sortKey="Koukounari, A" uniqKey="Koukounari A">A Koukounari</name>
</author>
<author><name sortKey="Kazibwe, F" uniqKey="Kazibwe F">F Kazibwe</name>
</author>
<author><name sortKey="Tukahebwa, Em" uniqKey="Tukahebwa E">EM Tukahebwa</name>
</author>
<author><name sortKey="Fleming, Fm" uniqKey="Fleming F">FM Fleming</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name>
</author>
<author><name sortKey="Stothard, Jr" uniqKey="Stothard J">JR Stothard</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Koukounari, A" uniqKey="Koukounari A">A Koukounari</name>
</author>
<author><name sortKey="Kabatereine, N" uniqKey="Kabatereine N">N Kabatereine</name>
</author>
<author><name sortKey="Fleming, F" uniqKey="Fleming F">F Fleming</name>
</author>
<author><name sortKey="Kazibwe, F" uniqKey="Kazibwe F">F Kazibwe</name>
</author>
<author><name sortKey="Tukahebwa, E" uniqKey="Tukahebwa E">E Tukahebwa</name>
</author>
<author><name sortKey="Stothard, Jr" uniqKey="Stothard J">JR Stothard</name>
</author>
<author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tohon, Zb" uniqKey="Tohon Z">ZB Tohon</name>
</author>
<author><name sortKey="Mainassara, Hb" uniqKey="Mainassara H">HB Mainassara</name>
</author>
<author><name sortKey="Garba, A" uniqKey="Garba A">A Garba</name>
</author>
<author><name sortKey="Mahamane, Ae" uniqKey="Mahamane A">AE Mahamane</name>
</author>
<author><name sortKey="Bosque Oliva, E" uniqKey="Bosque Oliva E">E Bosque-Oliva</name>
</author>
<author><name sortKey="Ibrahim, Ml" uniqKey="Ibrahim M">ML Ibrahim</name>
</author>
<author><name sortKey="Duchemin, Jb" uniqKey="Duchemin J">JB Duchemin</name>
</author>
<author><name sortKey="Chanteau, S" uniqKey="Chanteau S">S Chanteau</name>
</author>
<author><name sortKey="Boisier, P" uniqKey="Boisier P">P Boisier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toure, S" uniqKey="Toure S">S Toure</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Bosque Oliva, E" uniqKey="Bosque Oliva E">E Bosque-Oliva</name>
</author>
<author><name sortKey="Ky, C" uniqKey="Ky C">C Ky</name>
</author>
<author><name sortKey="Ouedraogo, A" uniqKey="Ouedraogo A">A Ouedraogo</name>
</author>
<author><name sortKey="Koukounari, A" uniqKey="Koukounari A">A Koukounari</name>
</author>
<author><name sortKey="Gabrielli, Af" uniqKey="Gabrielli A">AF Gabrielli</name>
</author>
<author><name sortKey="Bertrand, S" uniqKey="Bertrand S">S Bertrand</name>
</author>
<author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name>
</author>
<author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shaw, C" uniqKey="Shaw C">C Shaw</name>
</author>
<author><name sortKey="Su, Z" uniqKey="Su Z">Z Su</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id>
<journal-title-group><journal-title>BMC Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2334</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22264258</article-id>
<article-id pub-id-type="pmc">3282666</article-id>
<article-id pub-id-type="publisher-id">1471-2334-12-16</article-id>
<article-id pub-id-type="doi">10.1186/1471-2334-12-16</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Mass drug administration significantly reduces infection of <italic>Schistosoma mansoni </italic>
and hookworm in school children in the national control program in Sierra Leone</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Hodges</surname>
<given-names>Mary H</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>mhodges@hki.org</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Dada</surname>
<given-names>Nsa</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>nsadada@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Warmsley</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>a.wamsley@doctors.org.uk</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Paye</surname>
<given-names>Jusufu</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>gentlemanpaye@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Bangura</surname>
<given-names>Momodu M</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>msonnie@hki.org</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Nyorkor</surname>
<given-names>Emanuel</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>emmandessde@yahoo.co.uk</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Sonnie</surname>
<given-names>Mustapha</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>msonnie@hki.org</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Zhang</surname>
<given-names>Yaobi</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
<email>yzhang@hki.org</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Helen Keller International, PO Box 369, Freetown, Sierra Leone</aff>
<aff id="I2"><label>2</label>
Liverpool School of Tropical Medicine, Liverpool, UK</aff>
<aff id="I3"><label>3</label>
National NTDCP, Ministry for Health and Sanitation, Freetown, Sierra Leone</aff>
<aff id="I4"><label>4</label>
School of Community Health and Clinical Sciences, Njala University, Bo, Sierra Leone</aff>
<aff id="I5"><label>5</label>
Helen Keller International, Regional Office for Africa, Dakar, Senegal</aff>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>22</day>
<month>1</month>
<year>2012</year>
</pub-date>
<volume>12</volume>
<fpage>16</fpage>
<lpage>16</lpage>
<history><date date-type="received"><day>15</day>
<month>6</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>22</day>
<month>1</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2012 Hodges et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Hodges et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-2334/12/16"></self-uri>
<abstract><sec><title>Background</title>
<p>The first-ever round of school-based mass drug administration (MDA) with praziquantel together with mebendazole targeting school-aged children in endemic districts was conducted in 2009 by the National Neglected Tropical Diseases Control Program. To evaluate the impact of the treatment regimen, a cross-sectional sentinel site survey was conducted 6 months post-MDA.</p>
</sec>
<sec><title>Methods</title>
<p>Fifteen sentinel schools from six highly endemic districts (according to data from national and pre-MDA surveys) with <italic>Schistosoma mansoni </italic>
affecting over 50% of the population, and moderate to high prevalence of hookworms (> 20%). Approximately 30 children aged 9-14 years were selected from each school and stool samples (one per student) were examined by the Kato-Katz method.</p>
</sec>
<sec><title>Results</title>
<p>The overall prevalence (and intensity) in these sentinel sites pre-MDA of <italic>S. mansoni </italic>
was 69.0% (170.8 epg), hookworm: 41.7% (71.7 epg), <italic>Ascaris lumbricoides: 1.8% </italic>
and <italic>Trichuris trichiura: 3.8%</italic>
. Six months post MDA, the findings were <italic>S. mansoni</italic>
: 38.2% (47.3 epg) and hookworm: 14.5% (8.7 epg), representing a reduction from pre-MDA levels of 44.6% (65.2%) and 72.3% (87.9%) respectively. The proportion of children who were moderately or heavily infected with <italic>S. mansoni </italic>
fell from 35.6% pre MDA to 9.9% post MDA.</p>
</sec>
<sec><title>Conclusions</title>
<p>Significant reduction in <italic>S. mansoni </italic>
and hookworm infection was achieved by this first round MDA in school-going children in Sierra Leone. This reduction in infection burden can potentially contribute to a reduction of morbidity, such as anaemia, in these children.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002177 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002177 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:3282666 |texte= Mass drug administration significantly reduces infection of Schistosoma mansoni and hookworm in school children in the national control program in Sierra Leone }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22264258" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |