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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings</title><author><name sortKey="Scanlon, Michael L" sort="Scanlon, Michael L" uniqKey="Scanlon M" first="Michael L" last="Scanlon">Michael L. Scanlon</name><affiliation><nlm:aff id="af1-hiv-5-001">Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="af2-hiv-5-001">USAID, Academic Model Providing Access to Healthcare (AMPATH) Partnership, Eldoret, Kenya</nlm:aff></affiliation></author><author><name sortKey="Vreeman, Rachel C" sort="Vreeman, Rachel C" uniqKey="Vreeman R" first="Rachel C" last="Vreeman">Rachel C. Vreeman</name><affiliation><nlm:aff id="af1-hiv-5-001">Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="af2-hiv-5-001">USAID, Academic Model Providing Access to Healthcare (AMPATH) Partnership, Eldoret, Kenya</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23326204</idno><idno type="pmc">3544393</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544393</idno><idno type="RBID">PMC:3544393</idno><idno type="doi">10.2147/HIV.S28912</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002E47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings</title><author><name sortKey="Scanlon, Michael L" sort="Scanlon, Michael L" uniqKey="Scanlon M" first="Michael L" last="Scanlon">Michael L. Scanlon</name><affiliation><nlm:aff id="af1-hiv-5-001">Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="af2-hiv-5-001">USAID, Academic Model Providing Access to Healthcare (AMPATH) Partnership, Eldoret, Kenya</nlm:aff></affiliation></author><author><name sortKey="Vreeman, Rachel C" sort="Vreeman, Rachel C" uniqKey="Vreeman R" first="Rachel C" last="Vreeman">Rachel C. Vreeman</name><affiliation><nlm:aff id="af1-hiv-5-001">Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="af2-hiv-5-001">USAID, Academic Model Providing Access to Healthcare (AMPATH) Partnership, Eldoret, Kenya</nlm:aff></affiliation></author></analytic><series><title level="j">HIV/AIDS (Auckland, N.Z.)</title><idno type="eISSN">1179-1373</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The rollout of antiretroviral therapy (ART) significantly reduced human immunodeficiency virus (HIV)-related morbidity and mortality, but good clinical outcomes depend on access and adherence to treatment. In resource-limited settings, where over 90% of the world’s HIV-infected population resides, data on barriers to treatment are emerging that contribute to low rates of uptake in HIV testing, linkage to and retention in HIV care systems, and suboptimal adherence rates to therapy. A review of the literature reveals limited evidence to inform strategies to improve access and adherence with the majority of studies from sub-Saharan Africa. Data from observational studies and randomized controlled trials support home-based, mobile and antenatal care HIV testing, task-shifting from doctor-based to nurse-based and lower level provider care, and adherence support through education, counseling and mobile phone messaging services. Strategies with more limited evidence include targeted HIV testing for couples and family members of ART patients, decentralization of HIV care, including through home- and community-based ART programs, and adherence promotion through peer health workers, treatment supporters, and directly observed therapy. There is little evidence for improving access and adherence among vulnerable groups such as women, children and adolescents, and other high-risk populations and for addressing major barriers. Overall, studies are few in number and suffer from methodological issues. Recommendations for further research include health information technology, social-level factors like HIV stigma, and new research directions in cost-effectiveness, operations, and implementation. Findings from this review make a compelling case for more data to guide strategies to improve access and adherence to treatment in resource-limited settings.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Palella, Fj" uniqKey="Palella F">FJ Palella</name></author><author><name sortKey="Delaney, Km" uniqKey="Delaney K">KM Delaney</name></author><author><name sortKey="Moorman, Ac" uniqKey="Moorman A">AC Moorman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simoni, Jm" uniqKey="Simoni J">JM Simoni</name></author><author><name sortKey="Montgomery, A" uniqKey="Montgomery A">A Montgomery</name></author><author><name sortKey="Martin, E" uniqKey="Martin E">E Martin</name></author><author><name sortKey="New, M" uniqKey="New M">M New</name></author><author><name sortKey="Demas, Pa" uniqKey="Demas P">PA Demas</name></author><author><name sortKey="Rana, 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<front><journal-meta><journal-id journal-id-type="nlm-ta">HIV AIDS (Auckl)</journal-id><journal-id journal-id-type="iso-abbrev">HIV AIDS (Auckl)</journal-id><journal-title-group><journal-title>HIV/AIDS (Auckland, N.Z.)</journal-title></journal-title-group><issn pub-type="epub">1179-1373</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23326204</article-id><article-id pub-id-type="pmc">3544393</article-id><article-id pub-id-type="doi">10.2147/HIV.S28912</article-id><article-id pub-id-type="publisher-id">hiv-5-001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Scanlon</surname><given-names>Michael L</given-names></name><xref ref-type="aff" rid="af1-hiv-5-001">1</xref><xref ref-type="aff" rid="af2-hiv-5-001">2</xref></contrib><contrib contrib-type="author"><name><surname>Vreeman</surname><given-names>Rachel C</given-names></name><xref ref-type="aff" rid="af1-hiv-5-001">1</xref><xref ref-type="aff" rid="af2-hiv-5-001">2</xref><xref ref-type="corresp" rid="c1-hiv-5-001"></xref></contrib></contrib-group><aff id="af1-hiv-5-001"><label>1</label>Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA</aff><aff id="af2-hiv-5-001"><label>2</label>USAID, Academic Model Providing Access to Healthcare (AMPATH) Partnership, Eldoret, Kenya</aff><author-notes><corresp id="c1-hiv-5-001">Correspondence: Rachel C Vreeman, Children’s Health Services Research, Health Information and Translational Sciences Building, Suite #1000, 410 W, 10th St, Indianapolis, IN 46202, USA, Tel +1 317 278 0552, Fax +1 317 278 0456, Email <email>rvreeman@iupui.edu</email></corresp></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>07</day><month>1</month><year>2013</year></pub-date><volume>5</volume><fpage>1</fpage><lpage>17</lpage><permissions><copyright-statement>© 2013 Scanlon and Vreeman, publisher and licensee Dove Medical Press Ltd.</copyright-statement><copyright-year>2013</copyright-year><license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p></license></permissions><abstract><p>The rollout of antiretroviral therapy (ART) significantly reduced human immunodeficiency virus (HIV)-related morbidity and mortality, but good clinical outcomes depend on access and adherence to treatment. In resource-limited settings, where over 90% of the world’s HIV-infected population resides, data on barriers to treatment are emerging that contribute to low rates of uptake in HIV testing, linkage to and retention in HIV care systems, and suboptimal adherence rates to therapy. A review of the literature reveals limited evidence to inform strategies to improve access and adherence with the majority of studies from sub-Saharan Africa. Data from observational studies and randomized controlled trials support home-based, mobile and antenatal care HIV testing, task-shifting from doctor-based to nurse-based and lower level provider care, and adherence support through education, counseling and mobile phone messaging services. Strategies with more limited evidence include targeted HIV testing for couples and family members of ART patients, decentralization of HIV care, including through home- and community-based ART programs, and adherence promotion through peer health workers, treatment supporters, and directly observed therapy. There is little evidence for improving access and adherence among vulnerable groups such as women, children and adolescents, and other high-risk populations and for addressing major barriers. Overall, studies are few in number and suffer from methodological issues. Recommendations for further research include health information technology, social-level factors like HIV stigma, and new research directions in cost-effectiveness, operations, and implementation. Findings from this review make a compelling case for more data to guide strategies to improve access and adherence to treatment in resource-limited settings.</p></abstract><kwd-group><kwd>HIV</kwd><kwd>antiretroviral therapy</kwd><kwd>access</kwd><kwd>adherence</kwd><kwd>resource-limited settings</kwd></kwd-group></article-meta></front><body><sec><title>Introduction</title><p>In 2010, the World Health Organization (WHO) estimated there were 34 million people living with the human immunodeficiency virus (HIV).<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref> The emergence of antiretroviral therapy (ART) transformed HIV from a terminal illness to a chronic disease and resulted in significant decreases in HIV-related morbidity and mortality;<xref ref-type="bibr" rid="b2-hiv-5-001">2</xref>,<xref ref-type="bibr" rid="b3-hiv-5-001">3</xref> however, good clinical outcomes depend on access and adherence to treatment. In low- and middle-income countries (LMIC), home to over 90% of the HIV-infected population, access to ART has dramatically expanded in the last decade, yet it is estimated that only 47% of adults and 23% of children who are eligible are accessing treatment.<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref> Recent studies suggest adults and children in resource-limited settings maintain or achieve better rates of adherence compared to those in resource-rich settings,<xref ref-type="bibr" rid="b4-hiv-5-001">4</xref>–<xref ref-type="bibr" rid="b6-hiv-5-001">6</xref> but suboptimal adherence remains a threat for opportunistic infections,<xref ref-type="bibr" rid="b7-hiv-5-001">7</xref> HIV disease progression,<xref ref-type="bibr" rid="b8-hiv-5-001">8</xref>–<xref ref-type="bibr" rid="b10-hiv-5-001">10</xref> and viral resistance to ART.<xref ref-type="bibr" rid="b11-hiv-5-001">11</xref>–<xref ref-type="bibr" rid="b13-hiv-5-001">13</xref> Evidence-based strategies to improve access and adherence in LMIC are critically needed. This paper reviews the current scientific literature on strategies to improve access and adherence to ART in LMIC. Important gaps in the literature are highlighted and future directions for research are proposed.</p><p>Access to ART requires successful passage through various stages of care, including diagnosis, linkage, disease-stage monitoring, and finally initiation of treatment. Following treatment initiation, good clinical outcomes require retention in care and high rates of adherence to therapy.<xref ref-type="bibr" rid="b14-hiv-5-001">14</xref> A number of quantitative and qualitative studies reveal a myriad of barriers at all stages of access and adherence. While some barriers exist across settings, others act more frequently in resource-limited settings. Reviews of barriers to access and adherence often conceptualize and organize barriers according to levels of action<xref ref-type="bibr" rid="b15-hiv-5-001">15</xref>–<xref ref-type="bibr" rid="b17-hiv-5-001">17</xref> consistent with a social–ecological framework discussed elsewhere.<xref ref-type="bibr" rid="b18-hiv-5-001">18</xref>,<xref ref-type="bibr" rid="b19-hiv-5-001">19</xref><xref ref-type="table" rid="t1-hiv-5-001">Table 1</xref> summarizes commonly cited barriers to access and adherence in LMIC at the levels of intrapersonal, interpersonal/social, and system. Barriers more common to those living in resource-limited settings may include lack of knowledge of HIV status and treatment options, fear of stigma and discrimination, and system-level barriers, sometimes referred to as structural barriers,<xref ref-type="bibr" rid="b20-hiv-5-001">20</xref> that constrain individual and community-level efficacy to access and adhere to treatment through poor health care infrastructure and resources. Factors such as entrenched poverty and inequality operate at all levels and may especially affect treatment opportunities for women and children. Improving access and adherence to ART will require interventions that address barriers at each level of action while also considering how these barriers operate at the multiple stages of treatment, across different contexts, and among diverse populations.</p></sec><sec><title>Evidence-based strategies</title><p>A review of the literature reveals limited empirical data to guide strategies to improve access and adherence to ART (<xref ref-type="table" rid="t2-hiv-5-001">Table 2</xref>). Few randomized, controlled trials (RCTs), widely considered the gold standard in scientific rigor and methodology,<xref ref-type="bibr" rid="b21-hiv-5-001">21</xref>,<xref ref-type="bibr" rid="b22-hiv-5-001">22</xref> evaluate interventions in LMIC and strategies often rely on small case and observational studies. The most compelling data from well-designed observational studies and RCTs conducted in LMIC are reviewed here according to three stages of treatment: HIV testing and diagnosis; linkage to and retention in care; and adherence to ART.</p></sec><sec><title>HIV testing and diagnosis</title><p>As availability of ART in resource-limited settings expands, voluntary counseling and testing (VCT) services act as critical gateways to testing, early diagnosis and treatment.<xref ref-type="bibr" rid="b23-hiv-5-001">23</xref> Despite massive scale-ups in national HIV testing programs,<xref ref-type="bibr" rid="b24-hiv-5-001">24</xref>,<xref ref-type="bibr" rid="b25-hiv-5-001">25</xref> studies suggest that up to 80% of HIV-infected adults do not know their status in some sub-Saharan African settings,<xref ref-type="bibr" rid="b26-hiv-5-001">26</xref>,<xref ref-type="bibr" rid="b27-hiv-5-001">27</xref> although rates of testing vary substantially by country. A national survey in Lesotho found that the percentage of women who had been tested for HIV in the past 12 months had increased from 6.3% in 2004 to 42% in 2009, while a similar national survey in the Congo only showed rates of testing increasing from 3.2% in 2004 to 6.5% in 2009.<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref></p><p>Low uptake in testing and barriers to accessing traditional, client-initiated VCT services have led to new approaches in HIV testing, including provider-initiated, home-based and mobile or community testing.<xref ref-type="bibr" rid="b28-hiv-5-001">28</xref> Routine “opt-out” testing by providers, which is now recommended by the WHO as part of standard medical care in certain settings,<xref ref-type="bibr" rid="b29-hiv-5-001">29</xref> is reported to increase early diagnosis and access to treatment,<xref ref-type="bibr" rid="b30-hiv-5-001">30</xref> especially within antenatal care settings.<xref ref-type="bibr" rid="b31-hiv-5-001">31</xref> A number of observational studies show promising early results in increased testing uptake with home-based<xref ref-type="bibr" rid="b32-hiv-5-001">32</xref>–<xref ref-type="bibr" rid="b34-hiv-5-001">34</xref> and mobile<xref ref-type="bibr" rid="b24-hiv-5-001">24</xref>,<xref ref-type="bibr" rid="b35-hiv-5-001">35</xref> services. A large cohort study in rural Uganda found that 1 year after offering home-based testing services, receipt of HIV tests increased more than 5 times compared to previous clinic-based testing. <xref ref-type="bibr" rid="b36-hiv-5-001">36</xref> Studies assessing the cost-effectiveness and feasibility of home- and mobile-based testing in resource-limited settings have begun to emerge,<xref ref-type="bibr" rid="b37-hiv-5-001">37</xref>–<xref ref-type="bibr" rid="b39-hiv-5-001">39</xref> but more research is needed.</p><p>There are few RCTs evaluating interventions to increase uptake of HIV testing in LMIC. An RCT investigating inpatient testing found that patients in an urban hospital in Uganda were significantly more likely to receive testing if it was offered during their hospital stay (intervention = 98.8%) compared to patients who were offered referral cards and travel reimbursement for testing one week after discharge (control = 68.7%).<xref ref-type="bibr" rid="b40-hiv-5-001">40</xref> A randomized population-based study in Zambia found that individuals in the intervention group who were offered VCT at a location of their choice (84% chose home-based VCT) were 4.7 times more likely to be tested than individuals in the control who were offered VCT at the local health clinic.<xref ref-type="bibr" rid="b41-hiv-5-001">41</xref> In the largest RCT to date, Sweat et al reported on Project Accept, a community-based intervention among communities in Tanzania, Thailand and Zimbabwe.<xref ref-type="bibr" rid="b42-hiv-5-001">42</xref> Intervention components included community mobilization through HIV working groups and outreach coordinators, mobile VCT in community centers and other public places, and post-test support services.<xref ref-type="bibr" rid="b43-hiv-5-001">43</xref> A mean difference of 40.2% (95% confidence interval [CI]: 15.8–64.7) was reported in the proportion of patients receiving HIV testing in intervention versus control communities, plus intervention communities had more first-time testers compared to controls (Tanzania, 37% vs 9%; Thailand, 69% vs 23%; Zimbabwe, 51% vs 5%).<xref ref-type="bibr" rid="b42-hiv-5-001">42</xref> RCTs investigating on-site testing at occupational health clinics,<xref ref-type="bibr" rid="b44-hiv-5-001">44</xref> and home-based testing offered to family members of ART patients<xref ref-type="bibr" rid="b45-hiv-5-001">45</xref> also found significantly increased testing rates compared with controls. RCTs using antenatal care settings to encourage couples counseling and testing of sexual partners have revealed mixed success.<xref ref-type="bibr" rid="b46-hiv-5-001">46</xref>–<xref ref-type="bibr" rid="b48-hiv-5-001">48</xref></p></sec><sec><title>Linkage to and retention in HIV care</title><p>The potential benefits of early HIV diagnosis through increased uptake in counseling and testing rely on effective linkage to and retention in HIV care systems. There is growing evidence that individuals testing positive are not effectively linked to HIV care programs, leading to late presentation for treatment and increased risks of HIV-related morbidity and mortality.<xref ref-type="bibr" rid="b49-hiv-5-001">49</xref>–<xref ref-type="bibr" rid="b51-hiv-5-001">51</xref> Recent studies suggest between 30%–62% of individuals who test positive are linked to care in resource-limited settings.<xref ref-type="bibr" rid="b40-hiv-5-001">40</xref>,<xref ref-type="bibr" rid="b52-hiv-5-001">52</xref>–<xref ref-type="bibr" rid="b54-hiv-5-001">54</xref> Data on retention in care is also concerning. A review of data from 15 large-scale HIV treatment programs in LMIC revealed an average of 21% of patients were lost to follow-up by 6 months and 4% were lost after receiving their first ART prescription.<xref ref-type="bibr" rid="b55-hiv-5-001">55</xref> In South Africa, home to over 17% of the world’s HIV-infected population, losses to follow-up have actually been increasing in recent years,<xref ref-type="bibr" rid="b56-hiv-5-001">56</xref> a possible indicator of the burden placed on under-resourced health care systems as more individuals access treatment.</p><p>Strategies to improve linkages and retention are emerging, although many studies suffer from weak study design and small sample sizes. In a case study in rural Tanzania, introduction of simple referral forms, along with transportation stipends and community navigators, showed success in increasing and monitoring linkages to care.<xref ref-type="bibr" rid="b57-hiv-5-001">57</xref> A cross-sectional study in Kenya supported mobile testing alongside patient navigators to improve linkage.<xref ref-type="bibr" rid="b58-hiv-5-001">58</xref> Utilization of point-of-care CD4 count technology is being evaluated to enhance CD4 monitoring, improve referral services for timely initiation of ART and decrease loss to follow-up.<xref ref-type="bibr" rid="b59-hiv-5-001">59</xref>–<xref ref-type="bibr" rid="b63-hiv-5-001">63</xref> In a cohort study in Mozambique, implementation of point-of-care CD4 testing at primary health centers resulted in a decrease in loss to follow-up before completion of CD4 staging (from 57% to 21%), decrease in loss to follow-up before treatment initiation (from 64% to 33%) and an increase in enrolled patients initiating ART (from 12% to 22%).<xref ref-type="bibr" rid="b64-hiv-5-001">64</xref> In accordance with global guidelines for HIV care in LMIC,<xref ref-type="bibr" rid="b65-hiv-5-001">65</xref> HIV care systems are implementing various system-level changes to improve linkage and retention. Observational studies generally report positive impacts on linkage, retention and overall treatment outcomes with task-shifting from doctor-based to nurse-based care,<xref ref-type="bibr" rid="b66-hiv-5-001">66</xref>–<xref ref-type="bibr" rid="b69-hiv-5-001">69</xref> decentralization of HIV services from higher level facilities to satellite clinics,<xref ref-type="bibr" rid="b70-hiv-5-001">70</xref>–<xref ref-type="bibr" rid="b72-hiv-5-001">72</xref> and integration of HIV care into tuberculosis (TB), antenatal and other primary care services.<xref ref-type="bibr" rid="b73-hiv-5-001">73</xref>,<xref ref-type="bibr" rid="b74-hiv-5-001">74</xref> Other studies highlight the need for careful implementation in the transition of these services to ensure personnel are trained properly and resources are available.<xref ref-type="bibr" rid="b75-hiv-5-001">75</xref>,<xref ref-type="bibr" rid="b76-hiv-5-001">76</xref></p><p>Evidence from RCTs evaluating linkage to and retention in HIV care is limited. A randomized trial in Uganda found that inpatient HIV testing resulted in only 56% of patients enrolling in HIV care, actually lower than the control group that was offered referral to outpatient testing.<xref ref-type="bibr" rid="b40-hiv-5-001">40</xref> An RCT in rural Uganda found that cash transfers (approximately US$5–$8 per patient per month) for transportation to clinic appointments significantly decreased loss to follow-up (<italic>P</italic> = 0.04) among the intervention group, although sample size was small.<xref ref-type="bibr" rid="b77-hiv-5-001">77</xref> Supporting the efficacy of task-shifting to nurse-managed care, a randomized non-inferiority trial in Uganda found that a nurse–peer model achieved comparable rates of adherence, viral load, and CD4 counts compared to standard clinician-based care.<xref ref-type="bibr" rid="b78-hiv-5-001">78</xref> An RCT in South Africa found nurse-based care to be equivalent to doctor-managed care in treatment failure and retention in care, with hazard ratios of 1.09 (95% CI: 0.89–1.33) and 1.13 (95% CI: 0.81–1.59), respectively.<xref ref-type="bibr" rid="b79-hiv-5-001">79</xref> A cluster-randomized trial found that home-based HIV care through trained lay workers who supported drug delivery and monitored clinical status and adherence in patients was as effective as standard clinic-based care in Uganda in achieving equivalence in its primary endpoint, viral failure (relative risk [RR] 1.04, 95% CI: 0.78–1.40), and in secondary endpoints, mortality (RR 0.95, 95% CI: 0.71–1.28) and proportion of patients who reported 100% adherence (94% in home-based intervention group versus 91% in standard care group).<xref ref-type="bibr" rid="b80-hiv-5-001">80</xref> While the study reported no significant difference in loss to follow-up, home-based ART reduced overall HIV care costs incurred by patients by 50% in the first year and by 66% in subsequent years compared to clinic-based care. An RCT in Kenya found that an intervention using trained HIV-infected individuals as community care coordinators delivering monthly home assessments with clinic visits every 3 months resulted in similar clinical outcomes, including viral load, CD4 count and risk of opportunistic infections, compared to a control group with monthly clinic visits.<xref ref-type="bibr" rid="b81-hiv-5-001">81</xref></p></sec><sec><title>Adherence to ART</title><p>A recent meta-analysis of adherence rates found 77% of adults achieved adequate adherence in sub-Saharan Africa compared to 55% in North America<xref ref-type="bibr" rid="b6-hiv-5-001">6</xref> but rates vary significantly by setting. The literature on adherence interventions is relatively broad. Major reviews of adherence interventions, conducted mostly in resource-rich settings, reveal that the most effective are typically patient-based, behavioral interventions designed to build patient knowledge and efficacy through practical medication management skills.<xref ref-type="bibr" rid="b82-hiv-5-001">82</xref>–<xref ref-type="bibr" rid="b84-hiv-5-001">84</xref> While the evidence base from resource-limited settings is much more limited, it is still significantly wider than for testing, linkage, and retention interventions and provides several RCTs for evaluation.</p><p>A number of patient-based counseling and education interventions have been evaluated in LMIC, and some show positive impacts on adherence.<xref ref-type="bibr" rid="b85-hiv-5-001">85</xref>,<xref ref-type="bibr" rid="b86-hiv-5-001">86</xref> Individual adherence counseling at ART initiation reduced the risk of poor adherence (<italic>P</italic> = 0.055) and viral failure (<italic>P</italic> = 0.01) at 18 months follow-up compared to controls in an RCT in Kenya, although only reduced risk of viral failure was statistically significant.<xref ref-type="bibr" rid="b86-hiv-5-001">86</xref> A small RCT in China found that using feedback from electronic dose monitoring (EDM) during counseling led to significant increases in mean adherence rates (<italic>P</italic> = 0.003) but not mean CD4 counts (<italic>P</italic> = 0.07) at 12-month followup compared to controls who received counseling only.<xref ref-type="bibr" rid="b87-hiv-5-001">87</xref> Busari et al investigated the effect of a structured teaching method compared to standard clinic care among 620 ART patients in Nigeria.<xref ref-type="bibr" rid="b85-hiv-5-001">85</xref> Intervention group members received education in 10 modules including benefits of treatment, adverse drug effects, self-efficacy, and social support. At 8 months follow-up, the intervention group achieved significantly higher rates of adherence (<italic>P</italic> < 0.001), CD4 counts (<italic>P</italic> < 0.001), decreased frequency of opportunistic infections (<italic>P</italic> = 0.002), and lower mortality (<italic>P</italic> = 0.008). Two Brazilian RCTs investigating interventions delivered by social workers showed no effectiveness in improving adherence or biological markers.<xref ref-type="bibr" rid="b88-hiv-5-001">88</xref>,<xref ref-type="bibr" rid="b89-hiv-5-001">89</xref> One study used social workers to deliver motivational interviews and counseling through home visits<xref ref-type="bibr" rid="b89-hiv-5-001">89</xref> while the other study compared the effect of small educational workshops versus group video sessions.<xref ref-type="bibr" rid="b88-hiv-5-001">88</xref> Supplementing counseling and education with material support to address poverty-related barriers needs further investigation. Cohort studies in Zambia<xref ref-type="bibr" rid="b90-hiv-5-001">90</xref> and Nigeria<xref ref-type="bibr" rid="b91-hiv-5-001">91</xref> support the use of food assistance for improving adherence among food-insecure patients.</p><p>Several RCTs have investigated the use of peer health workers, treatment supporters and directly observed therapy (DOT–ART), with mixed results. An RCT in Uganda using peer health workers to deliver clinic- and biweekly home-based adherence counseling and social support did not find significant improvements in adherence over controls, but did show significant decreases in the risk of viral failure after 96 weeks (RR 0.50, 95% CI: 0.44–1.49) until end of follow up at 192 weeks (RR 0.07, 95% CI: 0.006–0.71).<xref ref-type="bibr" rid="b92-hiv-5-001">92</xref> A mixed-methods evaluation of the intervention found that the use of peer health workers improved access to care, care delivery, and patient-provider communication.<xref ref-type="bibr" rid="b93-hiv-5-001">93</xref> In another RCT in Uganda, use of a patient-nominated treatment supporter, a family member, friend, or neighbor educated on HIV and who agreed to attend counseling and clinic sessions with the patient, did not significantly increase adherence or clinic attendance against a standard adherence support program.<xref ref-type="bibr" rid="b94-hiv-5-001">94</xref> A study in Tanzania evaluated the impact of a treatment supporter alongside standard adherence counseling and found no significant differences in adherence or mean CD4 counts compared to controls.<xref ref-type="bibr" rid="b95-hiv-5-001">95</xref> A clinic-based, once-daily DOT–ART intervention delivered by trained peers in Mozambique found mean adherence rates and CD4 counts at 6 and 12 months follow up did not increase significantly compared to controls although achieving >90% adherence was significantly more likely for the intervention arm at 6 months (odds ratio [OR] 2.0, 95% CI: 0.93–4.5).<xref ref-type="bibr" rid="b96-hiv-5-001">96</xref> RCTs in Nigeria<xref ref-type="bibr" rid="b97-hiv-5-001">97</xref> and South Africa<xref ref-type="bibr" rid="b98-hiv-5-001">98</xref> using patient-nominated DOT–ART treatment supporters and one in Kenya<xref ref-type="bibr" rid="b99-hiv-5-001">99</xref> using nurse-based DOT–ART revealed initial improvements in adherence, but failed to demonstrate significant increases in adherence, CD4 counts, and viral suppression at study endpoints.</p><p>While limited in number, studies assessing interventions using mobile phones have shown positive results. Two RCTs in Kenya investigated the use of mobile phone short message service (SMS) in improving adherence.<xref ref-type="bibr" rid="b100-hiv-5-001">100</xref>,<xref ref-type="bibr" rid="b101-hiv-5-001">101</xref> Pop-Eleches et al found that an intervention group receiving weekly SMS reminders to take ART were significantly more likely to achieve >90% adherence rates (<italic>P</italic> = 0.03) and less likely to experience treatment interruptions (<italic>P</italic> = 0.03) at 48 weeks’ follow-up compared to controls.<xref ref-type="bibr" rid="b101-hiv-5-001">101</xref> Lester et al found significant improvements in adherence (<italic>P</italic> = 0.006) and viral suppression (<italic>P</italic> = 0.04) among an intervention group that received weekly interactive SMS (inquiring about health and well-being), with follow-up calls for nonrespondents after 48 hours.<xref ref-type="bibr" rid="b100-hiv-5-001">100</xref> Another RCT in Pakistan found that weekly phone reminders significantly improved adherence and decreased viral load, although sample size and length of follow-up were significantly less than the studies in Kenya.<xref ref-type="bibr" rid="b102-hiv-5-001">102</xref> In an RCT in Uganda discussed previously investigating the impact of peer health workers,<xref ref-type="bibr" rid="b92-hiv-5-001">92</xref> a substudy evaluated a mobile phone intervention whereby health workers called and text messaged higher-level providers with patient-specific clinical information and adherence data.<xref ref-type="bibr" rid="b103-hiv-5-001">103</xref> While the intervention did not find significant improvements in adherence, biological markers or loss to follow-up in patients randomized to health workers in the intervention arm, a mixed-methods evaluation revealed mobile phones improved care delivery and was widely believed by patients, clinic staff, and peer health workers to improve clinical care. Two RCTs investigating the impact of SMS on adherence to ART are ongoing in Cameroon<xref ref-type="bibr" rid="b104-hiv-5-001">104</xref> and India.<xref ref-type="bibr" rid="b105-hiv-5-001">105</xref></p></sec><sec><title>Special populations</title><p>There are a number of populations that face higher burdens of HIV, worse clinical outcomes and additional and/ or unique barriers in accessing and adhering to ART. These populations require particular consideration, especially in LMIC where they may be further marginalized and isolated from HIV care.</p><sec><title>Women</title><p>In LMIC in 2010, women represented 51% of those still requiring treatment and 58% of those currently on ART.<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref> It is estimated that coverage – the percentage of individuals needing treatment who are receiving it – among women is higher than men, especially in Asia and sub-Saharan Africa, while coverage rates for women in Latin America are slightly lower. Young women face an especially high burden of HIV in sub-Saharan Africa, where women make up 71% of HIV-positive young adults aged 15–24 years old.<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref> Preventing mother-to-child transmission, which is the route of infection in 90% of HIV-positive children in LMIC, hinges on expanding access and adherence to ART among pregnant mothers. In 2010, only 35% of pregnant women in LMIC received an HIV test and 48% of HIV-infected pregnant women accessed ART regimens as recommended by the WHO to prevent vertical transmission.<xref ref-type="bibr" rid="b1-hiv-5-001">1</xref> Women in many settings face additional barriers to access and adherence to treatment. Qualitative studies suggest important sex-based barriers may dissuade women from accessing and adhering to HIV treatment, including requiring a male partner’s permission to seek testing and treatment services.<xref ref-type="bibr" rid="b106-hiv-5-001">106</xref> Women in some settings fear disclosing their HIV status to their partner because of potential negative consequences of emotional or physical abuse<xref ref-type="bibr" rid="b107-hiv-5-001">107</xref> or forcible displacement from their homes.<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref> In many LMIC, women are particularly vulnerable to poverty and socioeconomic inequalities that create additional barriers to access and adherence such as low levels of education, social status, and financial resources.</p><p>Few studies in LMIC evaluate interventions aimed specifically at improving women’s access and adherence to HIV care. Qualitative studies of home-based and mobile VCT services reveal that these approaches may be more available to women as they do not require travel to clinic or permission and/or money from partners.<xref ref-type="bibr" rid="b109-hiv-5-001">109</xref>,<xref ref-type="bibr" rid="b110-hiv-5-001">110</xref> Provider-initiated counseling and testing for women in antenatal care settings has been shown to be well-accepted and to significantly increase testing uptake and participation in prevention of mother-to-child transmission care.<xref ref-type="bibr" rid="b111-hiv-5-001">111</xref>,<xref ref-type="bibr" rid="b112-hiv-5-001">112</xref> A cluster RCT in Zambia found that counseling and testing services in hospital labor wards increased the number of women on ART during birth and improved adherence.<xref ref-type="bibr" rid="b113-hiv-5-001">113</xref></p></sec><sec><title>Children and adolescents</title><p>In 2010, there were an estimated 3.4 million children under 15 years living with HIV. Adolescents represent one of the fastest-growing HIV-infected populations in the world. Young people aged 15–24 years now make up 41% of new HIV infections in persons older than 15 years.<xref ref-type="bibr" rid="b114-hiv-5-001">114</xref> Children and adolescents in resource-limited settings bear an alarming burden of the HIV epidemic, but are less likely to achieve adequate adherence and to have good clinical outcomes compared to their adult counterparts.<xref ref-type="bibr" rid="b115-hiv-5-001">115</xref> Children and adolescents face complex barriers to access and adherence as the extent of their autonomy varies over the developmental course and they frequently rely on caregivers for treatment. Caregiver beliefs,<xref ref-type="bibr" rid="b116-hiv-5-001">116</xref> education,<xref ref-type="bibr" rid="b117-hiv-5-001">117</xref> and stress,<xref ref-type="bibr" rid="b118-hiv-5-001">118</xref> as well as type of family structure,<xref ref-type="bibr" rid="b117-hiv-5-001">117</xref> all influence pediatric access and adherence to ART. Vulnerable children, such as orphans, often face additional barriers to care.<xref ref-type="bibr" rid="b119-hiv-5-001">119</xref> Disclosure of the child’s HIV status, essential for long-term disease management, is associated with improved adherence,<xref ref-type="bibr" rid="b120-hiv-5-001">120</xref> emotional health,<xref ref-type="bibr" rid="b121-hiv-5-001">121</xref> and reduced conflict with caregivers,<xref ref-type="bibr" rid="b122-hiv-5-001">122</xref> but disclosure rates vary and are generally low in resource-limited settings (Vreeman et al, unpublished data, 2012). Children, as adults, report experiencing various levels of HIV-related discrimination.<xref ref-type="bibr" rid="b123-hiv-5-001">123</xref> Furthermore, issues that arise as children and adolescents transition from pediatric to adult care settings in LMIC have not been investigated sufficiently.<xref ref-type="bibr" rid="b124-hiv-5-001">124</xref></p><p>Evidence for strategies to improve access and adherence to ART for children and adolescents is lacking. Two major reviews of interventions to improve adherence among children revealed limited support for home-based nursing care, peer support, and education sessions for caregivers and children to improve adherence; however, many studies suffered from weak methodologies, small sample sizes, and few were conducted in LMIC.<xref ref-type="bibr" rid="b125-hiv-5-001">125</xref>,<xref ref-type="bibr" rid="b126-hiv-5-001">126</xref> Other reviews suggest that, along with child and caregiver-level interventions, improved ART regimens for children (palatability, pill burden/ size) and relationships with providers can lead to better adherence to ART in children.<xref ref-type="bibr" rid="b127-hiv-5-001">127</xref> Fewer studies evaluate access to treatment in children. An RCT in Swaziland showed the effectiveness of a school-based educational intervention in increasing HIV testing rates among students.<xref ref-type="bibr" rid="b128-hiv-5-001">128</xref> A comprehensive care program in Kenya offering individual and group psychosocial support and treatment literacy for children and caregivers within a tailored, child-centered care model found improved clinical outcomes; however, individual components of the program could not be evaluated.<xref ref-type="bibr" rid="b129-hiv-5-001">129</xref> Evaluation of a clinic-based DOT–ART program in Cambodia showed significantly improved CD4 counts (<italic>P</italic> < 0.001) after 18 months for orphaned children.<xref ref-type="bibr" rid="b130-hiv-5-001">130</xref> Few studies examine the impact of disclosure on emotional health and adherence,<xref ref-type="bibr" rid="b131-hiv-5-001">131</xref> but evaluation of one clinic-based disclosure program in Puerto Rico found improved rates of adherence after implementation<xref ref-type="bibr" rid="b132-hiv-5-001">132</xref> and disclosure was linked to higher rates of adherence among children in Zambia.<xref ref-type="bibr" rid="b133-hiv-5-001">133</xref></p></sec><sec><title>Other high-risk populations</title><p>Additional high-risk populations for HIV that need to be considered for targeted interventions include: individuals with comorbidities such as HIV–TB, substance abusers and individuals with mental disorders, men who have sex with men (MSM), sex workers, and prisoners. In 2010, there were 8 million new cases of TB worldwide with 13% of newly infected individuals also being HIV-positive.<xref ref-type="bibr" rid="b134-hiv-5-001">134</xref> The vast majority of individuals living with HIV–TB, an estimated 82%, reside in sub-Saharan Africa.<xref ref-type="bibr" rid="b134-hiv-5-001">134</xref> The prevalence of substance abuse and psychiatric disorders is high among HIV-infected individuals, with many suffering from all three comorbidities.<xref ref-type="bibr" rid="b135-hiv-5-001">135</xref> While substance abuse and mental disorders are associated with poorer adherence and treatment outcomes in resource-rich settings,<xref ref-type="bibr" rid="b136-hiv-5-001">136</xref> less is known about prevalence and impact in LMIC.<xref ref-type="bibr" rid="b137-hiv-5-001">137</xref> A recent meta-analysis of studies from LMIC found MSM were almost 20 times more likely to be infected with HIV than the general population, highlighting the risks faced by this population.<xref ref-type="bibr" rid="b138-hiv-5-001">138</xref> In LMIC, prevalence of HIV among female sex workers was estimated at 11.8% (95% CI: 11.6–12.0) while among the 26 countries with the highest HIV burden, the overall prevalence jumped to 30.7% (95% CI: 30.2–31.3).<xref ref-type="bibr" rid="b139-hiv-5-001">139</xref> Finally, prisoners represent another high-risk population for HIV, but there is little data on HIV prevalence and treatment in LMIC. Small surveys in sub-Saharan Africa suggest high rates of HIV among prison populations, as high as 40% in a sample in South Africa.<xref ref-type="bibr" rid="b140-hiv-5-001">140</xref></p><p>These populations face significant and, in some cases, unique barriers to HIV treatment, for example, criminalization in the case of homosexuality and lack of control over treatment for prisoners. Research to improve access and adherence among these populations is virtually nonexistent in LMIC. Interventions that fail to show effectiveness in general populations may prove efficacious among targeted populations. While the evidence from RCTs for DOT–ART is not convincing among the general population, targeted DOT–ART, such as for HIV–TB patients, may be more effective and has demonstrated feasibility and efficacy in small observational studies in resource-limited settings.<xref ref-type="bibr" rid="b141-hiv-5-001">141</xref>–<xref ref-type="bibr" rid="b143-hiv-5-001">143</xref> Evidence from RCTs in resource-rich settings supports the use of DOT–ART for individuals with substance abuse disorders<xref ref-type="bibr" rid="b144-hiv-5-001">144</xref>–<xref ref-type="bibr" rid="b146-hiv-5-001">146</xref> and prisoners.<xref ref-type="bibr" rid="b147-hiv-5-001">147</xref> Depression, one of the most common mental disorders worldwide,<xref ref-type="bibr" rid="b148-hiv-5-001">148</xref> has been shown to be associated with nonadherence to ART and poor engagement in care in all settings.<xref ref-type="bibr" rid="b149-hiv-5-001">149</xref> Evidence from resource-rich settings suggests improved adherence and clinical outcomes with combined adherence and mental health counseling.<xref ref-type="bibr" rid="b150-hiv-5-001">150</xref>,<xref ref-type="bibr" rid="b151-hiv-5-001">151</xref> No major studies have been conducted among MSM, sex workers, and prisoners, as most research and recommendations focus on prevention.<xref ref-type="bibr" rid="b152-hiv-5-001">152</xref> A small observational study in London found a targeted multimedia campaign aimed at young gay men resulted in increased uptake in clinicbased HIV testing.<xref ref-type="bibr" rid="b153-hiv-5-001">153</xref> Another small observational study in Vancouver found increased adherence and viral suppression with a peer-delivered intervention including support groups, patient advocates, outreach, and onsite nursing care among a group of female sex workers using illicit substances, although there was no comparison group.<xref ref-type="bibr" rid="b154-hiv-5-001">154</xref></p></sec></sec><sec><title>Evaluating the evidence base</title><p>While there is increasing data on barriers to treatment, a review of the scientific literature reveals limited evidence for strategies to improve access and adherence to ART in resource-limited settings. Interventions broadening HIV testing approaches, such as home-based, community, and mobile testing, show early evidence of increasing HIV testing and diagnosis. Observational and case studies generally support shifts in HIV care to improve retention through decentralization and integration of services, but only task-shifting to nurse- and peer health worker-based care is supported by RCTs. A larger evidence base is found for interventions directed at improving adherence. Adherence counseling and education interventions have been effective in some settings, and recent evidence supports a role for mobile phone technologies. RCTs to date do not provide sufficient evidence for using treatment supporters and DOT–ART to improve adherence among general populations; however, these strategies may be efficacious for certain populations such as children, HIV–TB patients, and substance abusers.</p><p>Studies assessing interventions directed at women, children, and adolescents and other special populations are scarce in LMIC. Provider-initiated inpatient testing has demonstrated feasibility and improved access for women in antenatal care settings, but few other interventions have been investigated adequately. This review also highlights the limited geographic variability among intervention studies to improve access and adherence, with the vast majority of the studies conducted in a few sub-Saharan African countries, including Kenya, South Africa, Uganda, and Zambia. While sub-Saharan Africa represents the epicenter of the HIV epidemic, studies investigating access and adherence are needed in other resource-constrained parts of the world where population and system-level contextual factors necessitate different approaches.</p><p>There are a number of critical weaknesses in studies evaluated for this review. A lack of standardization in evaluating linkage, retention, and adherence is an issue for both research and delivery of clinical care. While there are no common protocols to assess linkage, retention may be measured through gaps in care, clinic visits per interval of time, and number of missed visits.<xref ref-type="bibr" rid="b155-hiv-5-001">155</xref> Further, individuals with HIV are a mobile population, moving through different stages of care, but also to different clinics and providers for care.<xref ref-type="bibr" rid="b156-hiv-5-001">156</xref>,<xref ref-type="bibr" rid="b157-hiv-5-001">157</xref> Systems that monitor and link patients between points of care are essential for improving treatment and continuity of care. Adherence measures vary in different settings and common measures include self and proxy reports, pill counts, pharmacy refills, EDM, virologic markers (CD4 counts, viral loads), and blood draws for drug concentrations. No gold standard for measuring adherence has been proposed,<xref ref-type="bibr" rid="b158-hiv-5-001">158</xref> and studies often use multiple measure to improve estimates.<xref ref-type="bibr" rid="b159-hiv-5-001">159</xref> Long-term, routine monitoring of adherence is required to ensure optimal delivery of care, as adherence often decreases over time,<xref ref-type="bibr" rid="b160-hiv-5-001">160</xref>,<xref ref-type="bibr" rid="b161-hiv-5-001">161</xref> but also to evaluate the effectiveness of interventions to improve adherence. Improving the methods that studies and care systems utilize to monitor linkage to and retention in care and adherence to ART will strengthen findings of intervention effectiveness.</p></sec><sec><title>Directions for future research</title><p>There are several critical gaps in the current evidence base that need to be addressed in future research. As HIV care systems transition through task shifting, decentralization, and integration and as more individuals need to be retained in treatment, monitoring of patients is critical to improving and expanding delivery of HIV care. Early rollout of health information systems, including electronic medical records, has been mostly positive in LMIC,<xref ref-type="bibr" rid="b162-hiv-5-001">162</xref>–<xref ref-type="bibr" rid="b166-hiv-5-001">166</xref> but more research on technology-based information and surveillance systems and their potential to monitor and track patients throughout care is needed, along with how patient navigators and community outreach workers may supplement these systems. As HIV care systems horizontally integrate with other primary care services, there is an opportunity to implement various technologies into patient-based care that will improve not only HIV care, but strengthen local health care systems more broadly.</p><p>HIV-related stigma and discrimination remain major barriers to HIV treatment in LMIC, but this review found no major studies evaluating interventions to improve access and adherence through reducing stigma and discrimination against people living with HIV. A recent systematic review of interventions aimed at reducing HIV stigma evaluated 19 studies, of which nine were conducted in LMIC; however, studies suffered from various methodological weaknesses and no studies examined the association between reduced HIV stigma and health outcomes such as access and adherence to treatment.<xref ref-type="bibr" rid="b167-hiv-5-001">167</xref> Very few studies investigating interventions to improve access and adherence include measures of stigma as secondary outcomes, although this review did find two such studies: a cohort study in Peru using community health workers delivering DOT–ART<xref ref-type="bibr" rid="b168-hiv-5-001">168</xref> and an RCT in Kenya discussed previously assessing nurse-based DOT–ART.<xref ref-type="bibr" rid="b169-hiv-5-001">169</xref> Further research on interventions aiming to reduce stigma, validation of stigma measures, and examining the association between intervention effects and health outcomes such as access and adherence are vital for addressing the significant challenges in HIV treatment due to stigma and discrimination. Issues in disclosure of HIV status, impacted by levels of perceived stigma, also deserve further investigation.</p><p>Social support networks have been identified in qualitative studies as important facilitators of HIV treatment, including adherence.<xref ref-type="bibr" rid="b170-hiv-5-001">170</xref>–<xref ref-type="bibr" rid="b172-hiv-5-001">172</xref> Evidence for treatment supporters among qualitative and observational studies generally reveals more positive impacts on adherence and treatment outcomes than RCTs,<xref ref-type="bibr" rid="b173-hiv-5-001">173</xref>–<xref ref-type="bibr" rid="b178-hiv-5-001">178</xref> and their findings warrant further investigation into the potential role for patient-nominated, family, friend or peer supporters in improving access and adherence. In sub-Saharan Africa, O’Laughlin et al suggest that treatment partners go beyond encouraging adherence to restoring access to social and community resources.<xref ref-type="bibr" rid="b179-hiv-5-001">179</xref> In this way, treatment supports are sources of social capital and are important for obtaining treatment-sustaining resources such as money for transportation or food.<xref ref-type="bibr" rid="b180-hiv-5-001">180</xref> As more patients in LMIC become ART experienced, “expert patients” from the community can likely play a crucial role in interventions to increase access and adherence as they have intimate knowledge of barriers and facilitators of care.<xref ref-type="bibr" rid="b181-hiv-5-001">181</xref> This review only found two studies using persons living with HIV to deliver interventions.<xref ref-type="bibr" rid="b81-hiv-5-001">81</xref>,<xref ref-type="bibr" rid="b182-hiv-5-001">182</xref> Increased involvement of this population in the design and implementation of interventions deserves investigation.</p><p>Simple, low-cost adherence tools such as pillboxes, medication planners, and calendars have not been investigated thoroughly in resource-limited settings. The use of pillboxes has shown efficacy in improving adherence in a US cohort,<xref ref-type="bibr" rid="b183-hiv-5-001">183</xref> but has not been investigated in resource-limited settings. There may be variations in efficacy of such tools in settings where keeping medications secret is highly prized or where health literacy is more limited. Educational treatment calendars showed no impact on adherence or CD4 counts in an RCT in Tanzania comparing adherence counseling versus adherence counseling plus calendar.<xref ref-type="bibr" rid="b95-hiv-5-001">95</xref> While electronic dose-timing alarms show positive effects in resource-rich settings,<xref ref-type="bibr" rid="b184-hiv-5-001">184</xref>,<xref ref-type="bibr" rid="b185-hiv-5-001">185</xref> an RCT in Kenya found that the use of an alarm device did not significantly improve adherence.<xref ref-type="bibr" rid="b86-hiv-5-001">86</xref> A small pretest–posttest intervention study reported on the delivery of a culturally sensitive educational videotape to improve adherence to ART in South Africa and showed increased knowledge of ART, side effects, and overall adherence strategies, although there was no control group.<xref ref-type="bibr" rid="b186-hiv-5-001">186</xref> Combining low-cost adherence tools with counseling and education may offer benefits to adherence, but are not well studied in resource-limited settings. Another low-cost strategy to increase uptake in testing and utilization of services is mass media campaigns that can educate communities, raise awareness of availability of services,<xref ref-type="bibr" rid="b187-hiv-5-001">187</xref> and may address issues of stigma.<xref ref-type="bibr" rid="b188-hiv-5-001">188</xref> A Cochrane systematic review of mass media campaigns to increase uptake in HIV testing found that these interventions can increase testing rates, although no studies included in the review were from LMIC.<xref ref-type="bibr" rid="b189-hiv-5-001">189</xref> This review found one study conducted in a resource-limited setting – a retrospective cohort study in Kenya.<xref ref-type="bibr" rid="b190-hiv-5-001">190</xref> Further research is needed on the efficacy of mass media campaigns and their potential to increase access and adherence.</p><p>Cost-effectiveness research is needed to evaluate the feasibility of implementing effective interventions in resource-limited settings and is just beginning to emerge. Overall, cost models have shown that high levels of adherence are associated with overall lower total health care costs in the US<xref ref-type="bibr" rid="b191-hiv-5-001">191</xref> and in South Africa.<xref ref-type="bibr" rid="b192-hiv-5-001">192</xref> There is limited research available on the cost-effectiveness in LMIC of various HIV-testing approaches,<xref ref-type="bibr" rid="b35-hiv-5-001">35</xref>,<xref ref-type="bibr" rid="b37-hiv-5-001">37</xref>,<xref ref-type="bibr" rid="b38-hiv-5-001">38</xref> task-shifting to nurse-based care,<xref ref-type="bibr" rid="b67-hiv-5-001">67</xref> and home-based ART care.<xref ref-type="bibr" rid="b193-hiv-5-001">193</xref> There is a need to expand cost research in terms of overall reductions in health care costs associated with improved access and adherence to ART and the cost-effectiveness of efficacious strategies. With these data, programs can reliably estimate overall cost savings projections for efforts to improve access and adherence. Still, cost factors related to the price of ART remain outside the control of local HIV programs. Global partners, pharmaceutical companies, and national governments in LMIC need to continue to work together to create favorable global markets for ART whereby HIV programs in resource-limited settings gain increased access to the best available HIV medicines in line with WHO guidelines.<xref ref-type="bibr" rid="b194-hiv-5-001">194</xref></p><p>Finally, new and creative directions in research are needed to address challenges in identifying effective strategies to improve access and adherence to ART in LMIC. RCTs are commonly considered the gold standard, but as research on HIV interventions moves forward, it is important to balance the strengths and weaknesses of RCTs against those of well-designed observational studies. For public health and sociobehavioral interventions, there is a place for observational studies, and complete reliance on RCTs is not always good practice.<xref ref-type="bibr" rid="b195-hiv-5-001">195</xref> The use of qualitative data alongside RCTs is still relatively uncommon and not without methodological issues,<xref ref-type="bibr" rid="b196-hiv-5-001">196</xref> but may be positioned to evaluate complex and multicomponent interventions. Beyond the scope of studies assessing intervention effectiveness is operational and implementation research. Operational research, using systematic research techniques to improve program operations and decision-making<xref ref-type="bibr" rid="b197-hiv-5-001">197</xref> will be a critical endeavor for health care systems in LMIC to strengthen health infrastructure, human resources and capacity for local program design and evaluation.<xref ref-type="bibr" rid="b198-hiv-5-001">198</xref> Implementation research, investigating how health systems implement and deliver evidence-based interventions,<xref ref-type="bibr" rid="b199-hiv-5-001">199</xref> will be critical to guide governments and policy makers in replicating, adapting, and scaling up interventions.</p></sec><sec><title>Conclusion</title><p>Individuals living with HIV encounter many barriers to access and adherence to treatment. This nonsystematic review revealed few effective evidence-based strategies to guide clinicians, public health practitioners, and other health care providers. These findings make a compelling case for more data on improving delivery of ART in LMIC.</p></sec></body><back><fn-group><fn id="fn1-hiv-5-001"><p><bold>Disclosure</bold></p><p>The authors report no conflicts of interest in this work. The views expressed in this article are those of the authors and do not necessarily represent the view of the Indiana University School of Medicine. 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person-group-type="author"><name><surname>Sidney</surname><given-names>K</given-names></name><name><surname>Antony</surname><given-names>J</given-names></name><name><surname>Rodrigues</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>Supporting patient adherence to antiretrovirals using mobile phone reminders: patient responses from South India</article-title><source>AIDS Care</source><year>2012</year><volume>24</volume><issue>5</issue><fpage>612</fpage><lpage>617</lpage><pub-id pub-id-type="pmid">22150088</pub-id></element-citation></ref></ref-list></back><floats-group><table-wrap id="t1-hiv-5-001" position="float"><label>Table 1</label><caption><p>Barriers to access and adherence to antiretroviral therapy in low- and middle-income countries</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Level of action</th><th align="left" valign="top" rowspan="1" colspan="1">Barriers</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Intrapersonal</td><td align="left" valign="top" rowspan="1" colspan="1">Knowledge of serostatus and treatment options<xref ref-type="bibr" rid="b200-hiv-5-001">200</xref>–<xref ref-type="bibr" rid="b204-hiv-5-001">204</xref>,<xref ref-type="table-fn" rid="tfn3-hiv-5-001">**</xref><break></break>Difficulty understanding/managing treatment,<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref>,<xref ref-type="bibr" rid="b116-hiv-5-001">116</xref>,<xref ref-type="bibr" rid="b117-hiv-5-001">117</xref>,<xref ref-type="bibr" rid="b120-hiv-5-001">120</xref>,<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>–<xref ref-type="bibr" rid="b207-hiv-5-001">207</xref>,<xref ref-type="table-fn" rid="tfn3-hiv-5-001">**</xref> complicated regimens,<xref ref-type="bibr" rid="b116-hiv-5-001">116</xref>,<xref ref-type="bibr" rid="b207-hiv-5-001">207</xref>–<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref> ART side effects<xref ref-type="bibr" rid="b117-hiv-5-001">117</xref>,<xref ref-type="bibr" rid="b208-hiv-5-001">208</xref>–<xref ref-type="bibr" rid="b210-hiv-5-001">210</xref>,<xref ref-type="bibr" rid="b212-hiv-5-001">212</xref>–<xref ref-type="bibr" rid="b218-hiv-5-001">218</xref><break></break>Simply forgetting to come to clinic or take medicines,<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>,<xref ref-type="bibr" rid="b207-hiv-5-001">207</xref>,<xref ref-type="bibr" rid="b208-hiv-5-001">208</xref>,<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref>–<xref ref-type="bibr" rid="b215-hiv-5-001">215</xref>,<xref ref-type="bibr" rid="b219-hiv-5-001">219</xref> falling asleep<xref ref-type="bibr" rid="b210-hiv-5-001">210</xref>,<xref ref-type="bibr" rid="b214-hiv-5-001">214</xref>,<xref ref-type="bibr" rid="b219-hiv-5-001">219</xref><break></break>Emotional distress (eg, depression),<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref>,<xref ref-type="bibr" rid="b214-hiv-5-001">214</xref>,<xref ref-type="bibr" rid="b217-hiv-5-001">217</xref>,<xref ref-type="bibr" rid="b220-hiv-5-001">220</xref> substance addiction<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>,<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref>,<xref ref-type="bibr" rid="b221-hiv-5-001">221</xref>,<xref ref-type="bibr" rid="b222-hiv-5-001">222</xref><break></break>Perceptions of health,<xref ref-type="bibr" rid="b206-hiv-5-001">206</xref>,<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref>,<xref ref-type="bibr" rid="b214-hiv-5-001">214</xref>,<xref ref-type="bibr" rid="b223-hiv-5-001">223</xref>,<xref ref-type="bibr" rid="b224-hiv-5-001">224</xref> treatment,<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>,<xref ref-type="bibr" rid="b217-hiv-5-001">217</xref>,<xref ref-type="bibr" rid="b225-hiv-5-001">225</xref>,<xref ref-type="bibr" rid="b226-hiv-5-001">226</xref> and alternative/traditional medicines<xref ref-type="bibr" rid="b227-hiv-5-001">227</xref>–<xref ref-type="bibr" rid="b229-hiv-5-001">229</xref><break></break>Available financial resources,<xref ref-type="bibr" rid="b230-hiv-5-001">230</xref>,<xref ref-type="bibr" rid="b231-hiv-5-001">231</xref>,<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref> food insecurity<xref ref-type="bibr" rid="b232-hiv-5-001">232</xref>–<xref ref-type="bibr" rid="b234-hiv-5-001">234</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Interpersonal/ social</td><td align="left" valign="top" rowspan="1" colspan="1">Lack of family or social support,<xref ref-type="bibr" rid="b180-hiv-5-001">180</xref>,<xref ref-type="bibr" rid="b235-hiv-5-001">235</xref>,<xref ref-type="bibr" rid="b236-hiv-5-001">236</xref> dependency on partners for financial resources<xref ref-type="bibr" rid="b201-hiv-5-001">201</xref>,<xref ref-type="bibr" rid="b237-hiv-5-001">237</xref>,<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref> or permission for treatment<xref ref-type="bibr" rid="b106-hiv-5-001">106</xref>,<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref><break></break>Household conflict,<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref>,<xref ref-type="bibr" rid="b116-hiv-5-001">116</xref>,<xref ref-type="bibr" rid="b216-hiv-5-001">216</xref>,<xref ref-type="table-fn" rid="tfn3-hiv-5-001">**</xref> Low parental education level<xref ref-type="bibr" rid="b117-hiv-5-001">117</xref>,<xref ref-type="table-fn" rid="tfn3-hiv-5-001">**</xref><break></break>Fear of violence and/or abandonment<xref ref-type="bibr" rid="b202-hiv-5-001">202</xref>,<xref ref-type="bibr" rid="b238-hiv-5-001">238</xref>,<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref><break></break>Lack of disclosure of own<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref> or child’s status<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref>,<xref ref-type="bibr" rid="b120-hiv-5-001">120</xref>,<xref ref-type="bibr" rid="b207-hiv-5-001">207</xref>,<xref ref-type="bibr" rid="b211-hiv-5-001">211</xref>–<xref ref-type="bibr" rid="b214-hiv-5-001">214</xref>,<xref ref-type="bibr" rid="b216-hiv-5-001">216</xref>,<xref ref-type="bibr" rid="b217-hiv-5-001">217</xref>,<xref ref-type="bibr" rid="b220-hiv-5-001">220</xref>,<xref ref-type="bibr" rid="b239-hiv-5-001">239</xref>,<xref ref-type="bibr" rid="b240-hiv-5-001">240</xref>,<xref ref-type="table-fn" rid="tfn3-hiv-5-001">**</xref><break></break>Negative perception of providers<xref ref-type="bibr" rid="b206-hiv-5-001">206</xref>,<xref ref-type="bibr" rid="b241-hiv-5-001">241</xref> and poor patient–provider communication<xref ref-type="bibr" rid="b242-hiv-5-001">242</xref>,<xref ref-type="bibr" rid="b243-hiv-5-001">243</xref><break></break>Lack of community involvement in ART programs<xref ref-type="bibr" rid="b16-hiv-5-001">16</xref>,<xref ref-type="bibr" rid="b201-hiv-5-001">201</xref><break></break>Stigma and discrimination<xref ref-type="bibr" rid="b108-hiv-5-001">108</xref>,<xref ref-type="bibr" rid="b207-hiv-5-001">207</xref>,<xref ref-type="bibr" rid="b216-hiv-5-001">216</xref>,<xref ref-type="bibr" rid="b220-hiv-5-001">220</xref>,<xref ref-type="bibr" rid="b239-hiv-5-001">239</xref>,<xref ref-type="table-fn" rid="tfn2-hiv-5-001">*</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">System</td><td align="left" valign="top" rowspan="1" colspan="1">Costs of care and treatment,<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>,<xref ref-type="bibr" rid="b208-hiv-5-001">208</xref>,<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref>,<xref ref-type="bibr" rid="b215-hiv-5-001">215</xref>,<xref ref-type="bibr" rid="b244-hiv-5-001">244</xref>,<xref ref-type="bibr" rid="b245-hiv-5-001">245</xref> distance to clinic<xref ref-type="bibr" rid="b205-hiv-5-001">205</xref>,<xref ref-type="bibr" rid="b212-hiv-5-001">212</xref>,<xref ref-type="bibr" rid="b213-hiv-5-001">213</xref>,<xref ref-type="bibr" rid="b219-hiv-5-001">219</xref>,<xref ref-type="bibr" rid="b246-hiv-5-001">246</xref>–<xref ref-type="bibr" rid="b251-hiv-5-001">251</xref><break></break>Lack of integration/coordination with other health services<xref ref-type="bibr" rid="b252-hiv-5-001">252</xref>,<xref ref-type="bibr" rid="b253-hiv-5-001">253</xref><break></break>Drug shortages and stock-outs<xref ref-type="bibr" rid="b218-hiv-5-001">218</xref>,<xref ref-type="bibr" rid="b254-hiv-5-001">254</xref>,<xref ref-type="bibr" rid="b255-hiv-5-001">255</xref><break></break>Long waiting times at clinics<xref ref-type="bibr" rid="b229-hiv-5-001">229</xref>,<xref ref-type="bibr" rid="b234-hiv-5-001">234</xref>,<xref ref-type="bibr" rid="b256-hiv-5-001">256</xref><break></break>Inadequate laboratory infrastructure/resources<xref ref-type="bibr" rid="b257-hiv-5-001">257</xref><break></break>Confidentiality of services<xref ref-type="bibr" rid="b258-hiv-5-001">258</xref></td></tr></tbody></table><table-wrap-foot><fn id="tfn1-hiv-5-001"><p><bold>Notes:</bold></p></fn><fn id="tfn2-hiv-5-001"><label>*</label><p>Significant barrier for women;</p></fn><fn id="tfn3-hiv-5-001"><label>**</label><p>significant barrier for children and adolescents.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-hiv-5-001" position="float"><label>Table 2</label><caption><p>Evidence base for strategies to improve access and adherence in LMIC</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Level of support</th><th colspan="3" align="left" valign="top" rowspan="1">Stage of care</th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th colspan="3" align="left" valign="top" rowspan="1"><hr></hr></th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th align="left" valign="top" rowspan="1" colspan="1">Testing and diagnosis</th><th align="left" valign="top" rowspan="1" colspan="1">Linkage to and retention in care</th><th align="left" valign="top" rowspan="1" colspan="1">Adherence</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Limited or weak evidence</td><td align="left" valign="top" rowspan="1" colspan="1">Provider-initiated testing<xref ref-type="bibr" rid="b30-hiv-5-001">30</xref>,<xref ref-type="bibr" rid="b259-hiv-5-001">259</xref><break></break>Targeted HIV testing:<break></break>Inpatient testing<xref ref-type="bibr" rid="b40-hiv-5-001">40</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Couples’ testing<xref ref-type="bibr" rid="b46-hiv-5-001">46</xref>–<xref ref-type="bibr" rid="b48-hiv-5-001">48</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Workplace testing<xref ref-type="bibr" rid="b44-hiv-5-001">44</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Testing of family members of<break></break>ART patients<xref ref-type="bibr" rid="b45-hiv-5-001">45</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Mass-media campaigns<xref ref-type="bibr" rid="b190-hiv-5-001">190</xref><break></break>School-based HIV educational programs<xref ref-type="bibr" rid="b128-hiv-5-001">128</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref></td><td align="left" valign="top" rowspan="1" colspan="1">Referral programs (referral forms, transport stipends, patient navigators);<xref ref-type="bibr" rid="b57-hiv-5-001">57</xref> patient navigators<xref ref-type="bibr" rid="b58-hiv-5-001">58</xref><break></break>Point-of-care CD4 testing;<xref ref-type="bibr" rid="b60-hiv-5-001">60</xref>–<xref ref-type="bibr" rid="b62-hiv-5-001">62</xref>,<xref ref-type="bibr" rid="b64-hiv-5-001">64</xref> pre-ART prophylaxis<xref ref-type="bibr" rid="b260-hiv-5-001">260</xref><break></break>Free services;<xref ref-type="bibr" rid="b261-hiv-5-001">261</xref> cash transfers for transportation to clinic;<xref ref-type="bibr" rid="b77-hiv-5-001">77</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref> food-assistance programs<xref ref-type="bibr" rid="b262-hiv-5-001">262</xref><break></break>Home-based ART program;<xref ref-type="bibr" rid="b80-hiv-5-001">80</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref> community group-based ART program<xref ref-type="bibr" rid="b182-hiv-5-001">182</xref><break></break>Patient-centered care (ex-child-friendly clinics,<xref ref-type="bibr" rid="b129-hiv-5-001">129</xref> family-based care<xref ref-type="bibr" rid="b263-hiv-5-001">263</xref>,<xref ref-type="bibr" rid="b264-hiv-5-001">264</xref>)<break></break>Health information systems (ie, electronic medical records)<xref ref-type="bibr" rid="b162-hiv-5-001">162</xref>–<xref ref-type="bibr" rid="b166-hiv-5-001">166</xref><break></break>Decentralization of HIV services<xref ref-type="bibr" rid="b70-hiv-5-001">70</xref>–<xref ref-type="bibr" rid="b72-hiv-5-001">72</xref> and integration into primary care, TB, antenatal services<xref ref-type="bibr" rid="b72-hiv-5-001">72</xref>–<xref ref-type="bibr" rid="b74-hiv-5-001">74</xref>,<xref ref-type="bibr" rid="b76-hiv-5-001">76</xref></td><td align="left" valign="top" rowspan="1" colspan="1">Adherence support through peer health workers<xref ref-type="bibr" rid="b92-hiv-5-001">92</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref> and treatment supporters<xref ref-type="bibr" rid="b94-hiv-5-001">94</xref>,<xref ref-type="bibr" rid="b95-hiv-5-001">95</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Peer-delivered DOT–ART<xref ref-type="bibr" rid="b96-hiv-5-001">96</xref>–<xref ref-type="bibr" rid="b98-hiv-5-001">98</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref> and nurse-delivered DOT–ART<xref ref-type="bibr" rid="b99-hiv-5-001">99</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Targeted DOT–ART for HIV–TB patients<xref ref-type="bibr" rid="b141-hiv-5-001">141</xref>–<xref ref-type="bibr" rid="b143-hiv-5-001">143</xref> and children<xref ref-type="bibr" rid="b130-hiv-5-001">130</xref><break></break>Adherence counseling with EDM<xref ref-type="bibr" rid="b87-hiv-5-001">87</xref>,<xref ref-type="table-fn" rid="tfn5-hiv-5-001">*</xref><break></break>Disclosure of HIV status to children<xref ref-type="bibr" rid="b133-hiv-5-001">133</xref><break></break>Food-assistance programs<xref ref-type="bibr" rid="b90-hiv-5-001">90</xref>,<xref ref-type="bibr" rid="b91-hiv-5-001">91</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Strongest evidence</td><td align="left" valign="top" rowspan="1" colspan="1">Non-standard approaches to VCT:<break></break>Home-based testing<xref ref-type="bibr" rid="b32-hiv-5-001">32</xref>–<xref ref-type="bibr" rid="b34-hiv-5-001">34</xref>,<xref ref-type="bibr" rid="b36-hiv-5-001">36</xref>–<xref ref-type="bibr" rid="b38-hiv-5-001">38</xref>,<xref ref-type="bibr" rid="b41-hiv-5-001">41</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref><break></break>Mobile or community-based testing<xref ref-type="bibr" rid="b24-hiv-5-001">24</xref>,<xref ref-type="bibr" rid="b35-hiv-5-001">35</xref>,<xref ref-type="bibr" rid="b37-hiv-5-001">37</xref>,<xref ref-type="bibr" rid="b42-hiv-5-001">42</xref>,<xref ref-type="bibr" rid="b109-hiv-5-001">109</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref><break></break>Testing in antenatal care settings<xref ref-type="bibr" rid="b111-hiv-5-001">111</xref>–<xref ref-type="bibr" rid="b113-hiv-5-001">113</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref></td><td align="left" valign="top" rowspan="1" colspan="1">Task-shifting to nurse-based, PHW care<xref ref-type="bibr" rid="b66-hiv-5-001">66</xref>–<xref ref-type="bibr" rid="b69-hiv-5-001">69</xref>,<xref ref-type="bibr" rid="b78-hiv-5-001">78</xref>,<xref ref-type="bibr" rid="b79-hiv-5-001">79</xref>,<xref ref-type="bibr" rid="b81-hiv-5-001">81</xref>,<xref ref-type="bibr" rid="b265-hiv-5-001">265</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref></td><td align="left" valign="top" rowspan="1" colspan="1">Adherence counseling/ education<xref ref-type="bibr" rid="b85-hiv-5-001">85</xref>,<xref ref-type="bibr" rid="b86-hiv-5-001">86</xref>,<xref ref-type="bibr" rid="b266-hiv-5-001">266</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref><break></break>Mobile phone SMS<xref ref-type="bibr" rid="b100-hiv-5-001">100</xref>–<xref ref-type="bibr" rid="b102-hiv-5-001">102</xref>,<xref ref-type="bibr" rid="b267-hiv-5-001">267</xref>,<xref ref-type="bibr" rid="b268-hiv-5-001">268</xref>,<xref ref-type="table-fn" rid="tfn6-hiv-5-001">†</xref></td></tr></tbody></table><table-wrap-foot><fn id="tfn4-hiv-5-001"><p><bold>Notes:</bold></p></fn><fn id="tfn5-hiv-5-001"><label>*</label><p>Evidence from RCTs;</p></fn><fn id="tfn6-hiv-5-001"><label>†</label><p>evidence from RCTs and observational studies.</p></fn><fn id="tfn7-hiv-5-001"><p><bold>Abbreviations:</bold> DOT–ART, directly observed antiretroviral therapy; HIV, human immunodeficiency virus; PHW, peer health worker; SMS, short message services; RCT, randomized controlled trial; VCT, voluntary counseling and testing; TB, tuberculosis.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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