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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Childhood tuberculosis: management and treatment outcomes among children in Northwest Ethiopia: a cross-sectional study</title><author><name sortKey="Kebede, Zemene Tigabu" sort="Kebede, Zemene Tigabu" uniqKey="Kebede Z" first="Zemene Tigabu" last="Kebede">Zemene Tigabu Kebede</name><affiliation><nlm:aff id="aff0001">Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Taye, Belaynew Wasie" sort="Taye, Belaynew Wasie" uniqKey="Taye B" first="Belaynew Wasie" last="Taye">Belaynew Wasie Taye</name><affiliation><nlm:aff id="aff0002">School of Public Health, College of Medicine, Bahir Dar University, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Matebe, Yohannes Hailu" sort="Matebe, Yohannes Hailu" uniqKey="Matebe Y" first="Yohannes Hailu" last="Matebe">Yohannes Hailu Matebe</name><affiliation><nlm:aff id="aff0001">Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28761601</idno><idno type="pmc">5516653</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516653</idno><idno type="RBID">PMC:5516653</idno><idno type="doi">10.11604/pamj.2017.27.25.10120</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002C10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Childhood tuberculosis: management and treatment outcomes among children in Northwest Ethiopia: a cross-sectional study</title><author><name sortKey="Kebede, Zemene Tigabu" sort="Kebede, Zemene Tigabu" uniqKey="Kebede Z" first="Zemene Tigabu" last="Kebede">Zemene Tigabu Kebede</name><affiliation><nlm:aff id="aff0001">Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Taye, Belaynew Wasie" sort="Taye, Belaynew Wasie" uniqKey="Taye B" first="Belaynew Wasie" last="Taye">Belaynew Wasie Taye</name><affiliation><nlm:aff id="aff0002">School of Public Health, College of Medicine, Bahir Dar University, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Matebe, Yohannes Hailu" sort="Matebe, Yohannes Hailu" uniqKey="Matebe Y" first="Yohannes Hailu" last="Matebe">Yohannes Hailu Matebe</name><affiliation><nlm:aff id="aff0001">Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</nlm:aff></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="s1"><title>Introduction</title><p>Childhood tuberculosis (TB) treatment is becoming a major challenge in the TB control efforts of the Ethiopian health system. This study assessed childhood tuberculosis management, and treatment outcomes among children who completed anti-TB treatment in Northwest Ethiopia.</p></sec><sec id="s2"><title>Methods</title><p>A cross-sectional study was conducted among children who completed their anti-TB treatment in Gondar University Referral Hospital and 6 satellite health centers. Data from each child with tuberculosis were obtained from review of medical records. P-values < 0.05 were considered statistically significant.</p></sec><sec id="s3"><title>Results</title><p>The commonest method of childhood TB diagnosis was clinical assessment combined with chest x-ray (48.5%). Absence of compliance with TB treatment guideline (98.7%), providing inadequate anti-TB regimen (1.8%), and poor adherence to treatment (22.5%) were challenges in management of childhood tuberculosis. Treatment success rate was 78.9%. In the bivariate regression, factors associated with TB treatment outcomes were permanent residence (OR=8.3, 95%CI: 4.1, 16.7), antiretroviral therapy (OR=4.5, 95%CI: 1.2, 16), and adherence to treatment (p < 0.001). After controlling for confounders, adherence to anti-TB treatment (OR=0.003, 95% CI: 0.001, 0.02) was independent predictor of treatment success.</p></sec><sec id="s4"><title>Conclusion</title><p>Anti-tuberculosis treatment success rate was still low among children in Northwest Ethiopia. The health centers and hospital shall enhance strong follow-up of children on anti-tuberculosis treatment to improve treatment success with focus on rural children.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, Jm" uniqKey="Ramos J">JM Ramos</name></author><author><name sortKey="Reyes, F" uniqKey="Reyes F">F Reyes</name></author><author><name sortKey="Tesfamariam, A" uniqKey="Tesfamariam A">A Tesfamariam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munoz Sellart, M" uniqKey="Munoz Sellart M">M Munoz-Sellart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramirez Cardich, Me" uniqKey="Ramirez Cardich M">ME Ramirez-Cardich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zwang, J" uniqKey="Zwang J">J Zwang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Addis Alene, K" uniqKey="Addis Alene K">K Addis Alene</name></author><author><name sortKey="Nega, A" uniqKey="Nega A">A Nega</name></author><author><name sortKey="Wasie Taye, B" uniqKey="Wasie Taye B">B Wasie Taye</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hailu, D" uniqKey="Hailu D">D Hailu</name></author><author><name sortKey="Abegaz, We" uniqKey="Abegaz W">WE Abegaz</name></author><author><name sortKey="Belay, M" uniqKey="Belay M">M Belay</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Amsalu, S" uniqKey="Amsalu S">S Amsalu</name></author><author><name sortKey="Hurrisa, Z" uniqKey="Hurrisa Z">Z Hurrisa</name></author><author><name sortKey="Nuri, S" uniqKey="Nuri S">S Nuri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castelnuovo, B" uniqKey="Castelnuovo B">B Castelnuovo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniel, O" uniqKey="Daniel O">O Daniel</name></author><author><name sortKey="Ogunfowora, Ob" uniqKey="Ogunfowora O">OB Ogunfowora</name></author><author><name sortKey="Oladapo, Ot" uniqKey="Oladapo O">OT Oladapo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muture, Bn" uniqKey="Muture B">BN Muture</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Pan Afr Med J</journal-id><journal-id journal-id-type="iso-abbrev">Pan Afr Med J</journal-id><journal-id journal-id-type="publisher-id">PAMJ</journal-id><journal-title-group><journal-title>The Pan African Medical Journal</journal-title></journal-title-group><issn pub-type="epub">1937-8688</issn><publisher><publisher-name>The African Field Epidemiology Network</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28761601</article-id><article-id pub-id-type="pmc">5516653</article-id><article-id pub-id-type="publisher-id">PAMJ-27-25</article-id><article-id pub-id-type="doi">10.11604/pamj.2017.27.25.10120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Childhood tuberculosis: management and treatment outcomes among children in Northwest Ethiopia: a cross-sectional study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kebede</surname><given-names>Zemene Tigabu</given-names></name><xref ref-type="aff" rid="aff0001">1</xref><xref ref-type="corresp" rid="cor1">&</xref></contrib><contrib contrib-type="author"><name><surname>Taye</surname><given-names>Belaynew Wasie</given-names></name><xref ref-type="aff" rid="aff0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Matebe</surname><given-names>Yohannes Hailu</given-names></name><xref ref-type="aff" rid="aff0001">1</xref></contrib></contrib-group><aff id="aff0001"><label>1</label>Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</aff><aff id="aff0002"><label>2</label>School of Public Health, College of Medicine, Bahir Dar University, Ethiopia</aff><author-notes><corresp id="cor1"><label>&</label>Corresponding author: Zemene Tigabu Kebede, Department of Paediatrics, College of Medicine, University of Gondar, Ethiopia</corresp></author-notes><pub-date pub-type="epub"><day>10</day><month>5</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>27</volume><elocation-id>25</elocation-id><history><date date-type="received"><day>22</day><month>6</month><year>2016</year></date><date date-type="accepted"><day>29</day><month>3</month><year>2017</year></date></history><permissions><copyright-statement>© Zemene Tigabu Kebede et al.</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="s1"><title>Introduction</title><p>Childhood tuberculosis (TB) treatment is becoming a major challenge in the TB control efforts of the Ethiopian health system. This study assessed childhood tuberculosis management, and treatment outcomes among children who completed anti-TB treatment in Northwest Ethiopia.</p></sec><sec id="s2"><title>Methods</title><p>A cross-sectional study was conducted among children who completed their anti-TB treatment in Gondar University Referral Hospital and 6 satellite health centers. Data from each child with tuberculosis were obtained from review of medical records. P-values < 0.05 were considered statistically significant.</p></sec><sec id="s3"><title>Results</title><p>The commonest method of childhood TB diagnosis was clinical assessment combined with chest x-ray (48.5%). Absence of compliance with TB treatment guideline (98.7%), providing inadequate anti-TB regimen (1.8%), and poor adherence to treatment (22.5%) were challenges in management of childhood tuberculosis. Treatment success rate was 78.9%. In the bivariate regression, factors associated with TB treatment outcomes were permanent residence (OR=8.3, 95%CI: 4.1, 16.7), antiretroviral therapy (OR=4.5, 95%CI: 1.2, 16), and adherence to treatment (p < 0.001). After controlling for confounders, adherence to anti-TB treatment (OR=0.003, 95% CI: 0.001, 0.02) was independent predictor of treatment success.</p></sec><sec id="s4"><title>Conclusion</title><p>Anti-tuberculosis treatment success rate was still low among children in Northwest Ethiopia. The health centers and hospital shall enhance strong follow-up of children on anti-tuberculosis treatment to improve treatment success with focus on rural children.</p></sec></abstract><kwd-group><kwd>Treatment outcomes</kwd><kwd>determinants</kwd><kwd>children</kwd><kwd>developing country</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1"><title>Introduction</title><p>Ethiopia is one of the high tuberculosis (TB)/human immunodeficiency virus (HIV) and multidrugs resistant (MDR) TB burden countries. According to the 2014 World Health Organization (WHO) report, the prevalence and incidence of all forms of TB were 211 and 224 per 100,000 populations respectively. According to the recent national TB drug resistance surveillance report, 2.3% of new TB cases and 17.8% of previously treated TB cases were estimated to have MDR TB [<xref rid="cit0001" ref-type="bibr">1</xref>]. The extent of childhood TB is unknown but estimated between 9.6% and 11% out of all incident cases, with the majority of cases occurring in high TB burden countries. The difficulties in establishing a definitive diagnosis, the presence of extra-pulmonary disease, and the lower priority paid to smear negative TB are among many challenges to estimate the burden of TB in children [<xref rid="cit0002" ref-type="bibr">2</xref>]. The national TB prevalence is 572 cases per 1000 population and its incidence is 359 new cases per 1000 population at risk. Ethiopia has a low case detection rate of about 50% (42%–62%) [<xref rid="cit0003" ref-type="bibr">3</xref>]. Health institution reports revealed childhood TB constitutes up to 47% of all TB cases. Among children in Ethiopia, smear negative TB is the dominant type with a frequency of 56-65% followed by extra-pulmonary TB (24-45%) and smear positive TB with prevalence of all forms of TB about 20% [<xref rid="cit0004" ref-type="bibr">4</xref>, <xref rid="cit0005" ref-type="bibr">5</xref>]. TB in children is affected by weight loss which is commonly due to under-nutrition and HIV infection. There is a need for more aggressive evaluation for TB among these groups of children [<xref rid="cit0006" ref-type="bibr">6</xref>, <xref rid="cit0007" ref-type="bibr">7</xref>]. With an increasing trend of MDR TB in the general population including children, assessing the risks for MDR TB is vital for the health care settings. There are studies on incidence and treatment outcome of TB in HIV infected patients and adults [<xref rid="cit0008" ref-type="bibr">8</xref>], but little evidence is available on the treatment outcomes and potential risks for MDR TB among children. This study, therefore, assessed the management, anti-TB treatment outcomes, and factors associated with treatment outcomes among children who completed their anti-TB treatment in the last 1 year at a referral hospital and 6 health centers.</p></sec><sec sec-type="methods" id="sec2"><title>Methods</title><p><bold>Study design:</bold> a cross-sectional study was conducted among children who completed anti-TB treatment in a referral hospital and six health centers in Northwest Ethiopia from September 2014 – March 2015.</p><p><bold>Study setting:</bold> the study was conducted in Gondar University Referral Hospital (GURH) and 6 satellite health centers. The GURH is a tertiary care and teaching hospital that has more than 478 beds of which 75 belong to the paediatric ward. TB is the third common cause of admission in the hospital. The hospital has a separate TB clinic that diagnoses, initiates treatment and follows-up for the period of treatment to see outcomes. Annually, about 120 children are treated for TB. The health centers are the central facilities in the primary care unit. The health centers also diagnose and treat children for TB. In addition, they serve children referred from hospitals for the purpose of follow-up as they are closer to the households than the referral hospital. Physicians, health officers (bachelor medical officers), and nurses perform diagnosis and treatment of TB at health centers and hospital [<xref rid="cit0009" ref-type="bibr">9</xref>, <xref rid="cit0010" ref-type="bibr">10</xref>].</p><p><bold>Study population:</bold> the initial sample was determined using formula for estimation of single population proportions with z statistic=1.96, margin of error, w=0.05, proportion of treatment success, p= 85.5% [<xref rid="cit0011" ref-type="bibr">11</xref>] and non-response rate of 10%. Since sample size is nearly similar to total number of children who took anti TB, all 227 children below age 15 years who completed anti-TB treatment in the last one year at GURH and the 6 satellite health centers were studied. However, children started anti-TB at the hospital and referred to other health facility for further follow-up and referral cases to the study facilities for special work-up consultations were excluded as these children will not complete their follow-up in the study sites to see the outcome of treatment.</p><p><bold>Study variables:</bold> the dependent variable is treatment outcome. Associated variables of the study included socio-demographic characters (age, sex, family residence, presence of parents),co-morbidity (stage of HIV disease, duration of HIV infection, history of TB in family, history of MDR TB in family, age at diagnosis of HIV infection),and treatment related factors (anti-retroviral treatment (ART) status, anti-TB treatment regimen, adherence, duration of therapy).</p><p><bold>Operational definitions:</bold> treatment success was defined as completion of full course of anti-TB with absence of symptoms and signs of TB or a child after completion are declared cured. Adherence was defined the extent to which a child on anti-TB is compliant to treatment. <italic>Good adherence</italic> was defined as adherence rate of 85% or above while those below were defined as having <italic>poor adherence to treatment</italic> [<xref rid="cit0012" ref-type="bibr">12</xref>].</p><sec id="sec2.1"><title>Data collection procedures</title><p>A pre-tested data extracted form developed in English, which contains socio-demographic characteristics, family conditions, HIV status, anti TB adherence, and co-morbidities was used to collect data on children and parents. Data were collected by clinicians practicing in the respective health facilities as clinical knowledge and onsite deployment were necessary for feasibility reasons. A close supervision was conducted throughout data collection along with cross-checking of filled data to minimize social desirability bias. Prior to actual data collection, training was provided to data collectors on the data collection techniques used and to familiarize the data extraction tool. The data extraction tools were prepared from the review of similar literature (9…) The data collectors extracted the required information from charts of children whose treatment status was known. The investigators supervised data collection directly during each day of data collection and checked the filled forms for completeness and accuracy. A code was used for children and guardians during data collection to maintain confidentiality of information.</p></sec><sec id="sec2.2"><title>Statistical analysis</title><p>Data were entered in to Epi Info version 3.5.3 software for windows and analysed using statistical package for social sciences (SPSS) version 20.0 statistical package. Descriptive statistics were used to describe basic characteristics of children and guardians and comorbidities of children. The proportion of outcomes of anti-TB treatment was also computed. Bivariate and multivariable logistic regression analyses were calculated to identify independent predictors of treatment success. <italic>P-values</italic> less than 0.05 and 95% CI not including the null value 1 were considered as statistically significant.</p></sec><sec id="sec2.3"><title>Ethical issues</title><p>The study was conducted after ethical approval was obtained from Institutional Review Board of the University of Gondar. Letter of permission to data collection was obtained from the offices of medical director and heads of health centers and delivered to the departments /clinics serving children. Informed consent was obtained from the guardian/caregiver of each child after detailed explanation and confirmation of understanding. To maintain confidentiality of information, the questionnaires were anonymous and code numbers were used to identify each child. Caregivers were given brief education on adherence to treatment and prevention of TB transmission after each interview.</p></sec></sec><sec sec-type="results" id="sec3"><title>Results</title><sec id="sec3.1"><title>Socio-demographic characteristics</title><p><bold><xref ref-type="table" rid="t0001">Table 1</xref></bold> presents the basic characteristics of children and caregivers. A total of 227 (54.2% male and 45.8% female) children were studied. The mean (+ s.d) age of children, at start of treatment, was 6.8(+ 4.1) years with the age range of 2 months to 14 years. Nearly three-forth (73.6%) were from urban residence. A quarter (24.7%) of TB infected children were HIV positive (<xref ref-type="table" rid="t0001">Table 1</xref>).</p><table-wrap id="t0001" orientation="portrait" position="float"><label>Table 1</label><caption><p>Basic characteristics of children who completed anti tuberculosis treatment in Northwest Ethiopia, September 2014-March 2015</p></caption><table frame="border" rules="all"><thead><tr><th align="left" rowspan="1" colspan="1">Characteristic</th><th align="center" rowspan="1" colspan="1">Number</th><th align="center" rowspan="1" colspan="1">Percent</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Age group of children(years): (mean=6.8, st.d.=4.1)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">11.0</td></tr><tr><td align="left" rowspan="1" colspan="1">2-5</td><td align="center" rowspan="1" colspan="1">64</td><td align="center" rowspan="1" colspan="1">28.2</td></tr><tr><td align="left" rowspan="1" colspan="1">6-10</td><td align="center" rowspan="1" colspan="1">87</td><td align="center" rowspan="1" colspan="1">38.3</td></tr><tr><td align="left" rowspan="1" colspan="1">11-15</td><td align="center" rowspan="1" colspan="1">51</td><td align="center" rowspan="1" colspan="1">22.5</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Sex</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Male</td><td align="center" rowspan="1" colspan="1">123</td><td align="center" rowspan="1" colspan="1">54.2</td></tr><tr><td align="left" rowspan="1" colspan="1">Female</td><td align="center" rowspan="1" colspan="1">104</td><td align="center" rowspan="1" colspan="1">45.8</td></tr><tr><td align="left" rowspan="1" colspan="1">Residence</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Urban</td><td align="center" rowspan="1" colspan="1">167</td><td align="center" rowspan="1" colspan="1">73.6</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Rural</bold></td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">26.4</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>HIV infection in the child</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">56</td><td align="center" rowspan="1" colspan="1">24.6</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">135</td><td align="center" rowspan="1" colspan="1">59.5</td></tr><tr><td align="left" rowspan="1" colspan="1">Status not known</td><td align="center" rowspan="1" colspan="1">36</td><td align="center" rowspan="1" colspan="1">15.9</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>ART status (n=56)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">On ART</td><td align="center" rowspan="1" colspan="1">31</td><td align="center" rowspan="1" colspan="1">55.4</td></tr><tr><td align="left" rowspan="1" colspan="1">Not on ART</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">44.6</td></tr></tbody></table></table-wrap></sec><sec id="sec3.2"><title>Tuberculosis diagnosis and treatment among children in Northwest Ethiopia</title><p>The commonest diagnostic procedures followed were chest x-ray with clinical assessment comprising of nearly half (48.5%) of children diagnosed for TB. Sputum testing with chest x-ray and clinical assessment were used in 8 (3.5%) children diagnosed with TB. Almost all, 221 (97.4%) children were started on first line regimen. Only one child was initiated with retreatment regimen. Among children who were followed for the course of treatment, 48(21.1%) were defaulters while 170 (74.9%) completed treatment and 9(4.0%) of them were declared cured. The overall treatment success rate was 78.9% (<xref ref-type="table" rid="t0002">Table 2</xref>).</p><table-wrap id="t0002" orientation="portrait" position="float"><label>Table 2</label><caption><p>Tuberculosis diagnosis and treatment related characteristics of children treated for tuberculosis in Northwest Ethiopia, September 2014-March 2015</p></caption><table frame="border" rules="all"><thead><tr><th align="left" rowspan="1" colspan="1">Characteristic</th><th align="center" rowspan="1" colspan="1">Number</th><th align="center" rowspan="1" colspan="1">Percent</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Diagnosis technique</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">CXR plus clinical</td><td align="center" rowspan="1" colspan="1">110</td><td align="center" rowspan="1" colspan="1">48.5</td></tr><tr><td align="left" rowspan="1" colspan="1">FNAC + CXR +clinical</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">9.7</td></tr><tr><td align="left" rowspan="1" colspan="1">Sputum +CXR +clinical</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">3.5</td></tr><tr><td align="left" rowspan="1" colspan="1">Contact Hx + CXR + clinical</td><td align="center" rowspan="1" colspan="1">11</td><td align="center" rowspan="1" colspan="1">4.8</td></tr><tr><td align="left" rowspan="1" colspan="1">Sign and Symptoms alone</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">0.9</td></tr><tr><td align="left" rowspan="1" colspan="1">Others</td><td align="center" rowspan="1" colspan="1">74</td><td align="center" rowspan="1" colspan="1">32.6</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Type of treatment</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">New treatment regimen</td><td align="center" rowspan="1" colspan="1">221</td><td align="center" rowspan="1" colspan="1">97.4</td></tr><tr><td align="left" rowspan="1" colspan="1">Retreatment regimen</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">0.4</td></tr><tr><td align="left" rowspan="1" colspan="1">Others</td><td align="center" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">2.2</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Past history of treatment</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">5.7</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">214</td><td align="center" rowspan="1" colspan="1">94.3</td></tr><tr><td align="left" rowspan="1" colspan="1">Type of drug currently taken</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">RHZE +RH</td><td align="center" rowspan="1" colspan="1">226</td><td align="center" rowspan="1" colspan="1">99.6</td></tr><tr><td align="left" rowspan="1" colspan="1">Intensive phase other than RHZE +RH</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">0.4</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>TB treatment outcome</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Cured</td><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">4.0</td></tr><tr><td align="left" rowspan="1" colspan="1">Completed</td><td align="center" rowspan="1" colspan="1">170</td><td align="center" rowspan="1" colspan="1">74.9</td></tr><tr><td align="left" rowspan="1" colspan="1">Defaulter</td><td align="center" rowspan="1" colspan="1">48</td><td align="center" rowspan="1" colspan="1">21.1</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>TB treatment success</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">179</td><td align="center" rowspan="1" colspan="1">78.9</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">48</td><td align="center" rowspan="1" colspan="1">21.1</td></tr></tbody></table></table-wrap></sec><sec id="sec3.3"><title>Challenges in management of childhood tuberculosis</title><p><bold><xref ref-type="table" rid="t0003">Table 3</xref></bold> presents the challenges in management of childhood tuberculosis in the paediatric TB clinics. The guidelines for treatment of children with TB were at hand in all health facilities but there was no compliance to the national guidelines, in 98.7% of the cases, where the recommendations for diagnosis and treatment were not strictly followed. Training, supervision and treatment monitoring were there in all of the cases. The regimens provided were adequate (full combination of drugs for adequate period of time) in 223(98.2%) of children treated for TB while inadequate regimens were used in 4 (1.8%) children. Other factors that may predispose to MDR TB were poor storage of drugs (0.4%), poor adherence to treatment, (22.5%), and presence of side effects of anti TB drugs (0.9%) (<xref ref-type="table" rid="t0003">Table 3</xref>).</p><table-wrap id="t0003" orientation="portrait" position="float"><label>Table 3</label><caption><p>Health care provider and drug related challenges in TB treatment among children in Northwest Ethiopia, September 2014-March 2015</p></caption><table frame="border" rules="all"><thead><tr><th align="left" rowspan="1" colspan="1">Character</th><th align="center" rowspan="1" colspan="1">Number</th><th align="center" rowspan="1" colspan="1">Percent</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>National Tb treatment guideline at hand while treating child</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">227</td><td align="center" rowspan="1" colspan="1">100.00</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">0</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Health workers complied with the guideline while diagnosing and treating child\</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">1.3</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">224</td><td align="center" rowspan="1" colspan="1">98.7</td></tr><tr><td align="left" rowspan="1" colspan="1">Health workers trained on national guideline treated child</td><td align="center" rowspan="1" colspan="1">227</td><td align="center" rowspan="1" colspan="1">100.0</td></tr><tr><td align="left" rowspan="1" colspan="1">Presence of regular supportive supervision</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">100.0</td></tr><tr><td align="left" rowspan="1" colspan="1">Regular monitoring treatment provision</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">100.0</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Anti-TB Regimen is adequate</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">223</td><td align="center" rowspan="1" colspan="1">98.2</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">1.8</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>All regimens available in paediatric preparations</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">100.0</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">0</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Poor storage condition</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">0.4</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">99.6</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Adherence to treatment</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Poor</td><td align="center" rowspan="1" colspan="1">51</td><td align="center" rowspan="1" colspan="1">22.5</td></tr><tr><td align="left" rowspan="1" colspan="1">Good</td><td align="center" rowspan="1" colspan="1">176</td><td align="center" rowspan="1" colspan="1">77.5</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Health education given to child /caregiver/</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">227</td><td align="center" rowspan="1" colspan="1">100.00</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">0</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Lack of transportation/money support</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">0.9</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">225</td><td align="center" rowspan="1" colspan="1">99.1</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Drug adverse effect observed</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">0.9</td></tr><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">225</td><td align="center" rowspan="1" colspan="1">99.1</td></tr></tbody></table></table-wrap></sec><sec id="sec3.4"><title>Factors associated with TB treatment outcomes</title><p>The factors associated with treatment outcomes among children taking anti TB are presented in <xref ref-type="table" rid="t0004">Table 4</xref>. Permanent residence of child and hence family was significantly associated with treatment success in the bivariate analysis (crude odds ratio (COR)=8.3, 95% CI: 4.1, 16.7). In the multivariable regression, urban residents were 1.2 times more likely to be cured/ treatment completed as compared to rural children but was not statistically significant (adjusted odds ratio(AOR)=1.2, 95% CI: 0.24,5.93). Children from urban areas had a treatment success rate of 89.2% while among rural children treatment success rate was 50%.</p><table-wrap id="t0004" orientation="portrait" position="float"><label>Table 4</label><caption><p>Bivariate and multivariable logistic regression analysis of factors associated with anti-Tuberculosis treatment outcomes among children in Northwest Ethiopia, September 2014-March 2015</p></caption><table frame="border" rules="all"><thead><tr><th rowspan="2" align="left" colspan="1">Independent variables</th><th colspan="2" align="center" rowspan="1">Treatment outcome</th><th rowspan="2" align="center" colspan="1">Crude Odds ratio (95% CI)</th><th rowspan="2" align="center" colspan="1">Adjusted Odds Ratio (95% C.I.)</th></tr><tr><th align="center" rowspan="1" colspan="1">Cured /completed</th><th align="center" rowspan="1" colspan="1">Defaulter</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Residence of children</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Urban</td><td align="center" rowspan="1" colspan="1">149</td><td align="center" rowspan="1" colspan="1">18</td><td align="center" rowspan="1" colspan="1">8.3 (4.1, 16.7)</td><td align="center" rowspan="1" colspan="1">1.2(0.24, 5.93)</td></tr><tr><td align="left" rowspan="1" colspan="1">Rural</td><td align="center" rowspan="1" colspan="1">30</td><td align="center" rowspan="1" colspan="1">30</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Age group of children</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><5years</td><td align="center" rowspan="1" colspan="1">57</td><td align="center" rowspan="1" colspan="1">20</td><td align="center" rowspan="1" colspan="1">0.7(0.34,1.26)</td><td align="center" rowspan="1" colspan="1">0.99(0.26, 3.77)</td></tr><tr><td align="left" rowspan="1" colspan="1"><underline>></underline>5years</td><td align="center" rowspan="1" colspan="1">122</td><td align="center" rowspan="1" colspan="1">28</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Adherence to treatment</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Good</td><td align="center" rowspan="1" colspan="1">171</td><td align="center" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1">Poor</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">43</td><td align="center" rowspan="1" colspan="1">0.005 (0.002, 0.017)</td><td align="center" rowspan="1" colspan="1">0.003(0.001, 0.02)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>HAART status</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">On ART</td><td align="center" rowspan="1" colspan="1">27</td><td align="center" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">4.5(1.2, 16)</td><td align="center" rowspan="1" colspan="1">0.43 (0.5, 3.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Not on ART</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>HIV status</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Have HIV infection</td><td align="center" rowspan="1" colspan="1">42</td><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">1.68(0.7, 4.1)</td><td align="center" rowspan="1" colspan="1">2.2 (0.3, 16)</td></tr><tr><td align="left" rowspan="1" colspan="1">Have no HIV infection</td><td align="center" rowspan="1" colspan="1">115</td><td align="center" rowspan="1" colspan="1">20</td><td align="center" rowspan="1" colspan="1">3.14(1.4, 7.0)</td><td align="center" rowspan="1" colspan="1">1.4 (0.3, 7.3)</td></tr><tr><td align="left" rowspan="1" colspan="1">Status not known</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td></tr></tbody></table></table-wrap><p>Children under the age of 5 years were less likely to have treatment completed or cured as compared to children > 5 years. There was no significant association between age group of children and treatment outcomes (AOR=0.99, 95% CI: 0.26, 3.77). Children without HIV infection were more than 3times more likely to complete treatment or cured from TB than those with unknown HIV status (OR=3.14, 95% CI: 1.4, 7.0). Among HIV infected children TB treatment defaulter rate was 25% while among HIV negative children the defaulter rate was 15.2%. Children who have poor adherence to anti TB treatment and care were more than 90% less likely to cure from TB as compared to TB infected children with good treatment adherence (<xref ref-type="table" rid="t0004">Table 4</xref>).</p></sec></sec><sec sec-type="discussion" id="sec4"><title>Discussion</title><p>This study assessed the methods of diagnosis used to diagnose TB among children, the challenges of management, treatment outcomes and determinants among TB infected children. The commonest diagnostic method in this study was chest x-ray combined with clinical evaluation (48.5%). This is because pulmonary TB is the commonest TB in children [<xref rid="cit0004" ref-type="bibr">4</xref>, <xref rid="cit0005" ref-type="bibr">5</xref>]. The other reasons are the difficulty to get sputum samples from children, rarity of smear positive TB in children, and inability to do Acid Fast Staining which is the gold standard in the diagnosis of childhood TB [<xref rid="cit0002" ref-type="bibr">2</xref>]. The study also employed sign and symptoms only as diagnostic method in 2 children. This is because of the urgency in the need for diagnosis of TB before the laboratory tests and x-ray examinations are ready to be used.</p><p>The type of anti-TB treatment among children was predominantly new treatment regimen (97%) because children did not have longer exposure and majority didn’t have past treatment history (<xref ref-type="table" rid="t0002">Table 2</xref>). A study in Addis Ababa on a five years retrospective study also found the majority (88.1%) of children were registered as new TB patients whereas twenty-three (0.9%) children with TB were retreatment cases [<xref rid="cit0011" ref-type="bibr">11</xref>]. This similar finding from another Ethiopian setting signifies that the commonest type is new treatment category in Ethiopia.</p><p>The anti TB treatment success rate among children in this study was 78.9%. This is lower than a study from Addis Ababa [<xref rid="cit0011" ref-type="bibr">11</xref>] where 85.5% were successfully treated. This discrepancy may be due to the access to distance from the health facilities is favourable in the Addis Ababa study while our study included 60 (26.4%) children from rural areas and children have to pay for transport and travel long to get to the health centers (<xref ref-type="table" rid="t0001">Table 1</xref>).</p><p>In this study the proportion of TB treatment success rate among urban children (89.2%) is comparable to the Addis Ababa study. This shows us that success rates among rural children are lower and need special attention. A study from Gondar University Referral Hospital [<xref rid="cit0013" ref-type="bibr">13</xref>] also found a higher proportion (90%) of treatment success rates among children with TB than this study. This may be due to the fact that the GURH study included children only from the tertiary care center with better diagnostic and treatment facilities. This study, however, included children from health centers with only minimal primary health care packages that may lead to poorer success rates and increased defaulter rates.</p><p>A study from Sidama zone has revealed a similar treatment success rate (77%) for children with tuberculosis [<xref rid="cit0005" ref-type="bibr">5</xref>]. The similar rates may be due to inclusion of multiple centers with children having similar backgrounds of socioeconomic status, distance from health facility. The anti TB treatment defaulter rate among children in this study was 21.1%. This is a very high rate as compared to studies elsewhere. Studies from Addis Ababa (3.8%) [<xref rid="cit0011" ref-type="bibr">11</xref>], Southern Ethiopia [<xref rid="cit0005" ref-type="bibr">5</xref>] identified lower defaulter rates than this study. This is because the study participants from the Addis Ababa study were from urban area where they have closer access to collect drugs and adhere to appointment for care.</p><p>A systematic review of compliance to anti-TB treatment and risk factors found out the proportion of patients defaulting varied from 11.3% (8) to 29.6% from different studies [<xref rid="cit0014" ref-type="bibr">14</xref>]. This is in line with our study finding of 21.1%. This reflects the contexts of studies are similar the being in Sub Saharan Africa and inclusion of populations that are related to the study participants of our study.</p><p>Residence of the child and caregiver was significantly associated with TB treatment outcomes of the child. Children who were from rural areas were 8.3 times more likely to default from treatment than children from the urban areas (crude odds ratio (COR) =8.3, 95%CI: 4.1, 16.7). The major reason to more defaulter rates in rural children is the distance from the health facility is far and may not reach in time to collect the INH drugs. The other reason is that the rural children and care takers may not have money to pay for the round trip transportation and could miss schedules. A review of TB treatment compliance in Sub Saharan Africa also identified distance from health facility as an important determinant of treatment success [<xref rid="cit0014" ref-type="bibr">14</xref>].</p><p>The study also found out that persons who used public transport were more likely to be defaulters of anti TB treatment as compared to persons using private or rented transportation systems. This signifies the role of physical accessibility to treatment in improving outcomes of therapy. This tells us the importance of task shifting to initiate IPT at lower level facilities to reach persons from rural areas.</p><p>HIV infection increased the risk of defaulter from anti TB treatment. HIV infection causes additional morbidity and discomfort leading to lesser adherence to treatment. Hailu, et’al also found out that HIV infection and unknown HIV status were predictors of poor treatment outcomes [<xref rid="cit0011" ref-type="bibr">11</xref>]. This may be due to the opportunity to treat children with HIV infection and higher chance of disclosure of their HIV status that leads to better adherence to treatment. Study from Nigeria also revealed an increased mortality from HIV infected TB patients [<xref rid="cit0015" ref-type="bibr">15</xref>]. Another study from Kenya also found HIV co-infection is an independent predictor of default from treatment. HIV infected persons were 1.56 times more likely to be defaulters from treatment than non-infected ones [<xref rid="cit0016" ref-type="bibr">16</xref>].</p><p>Antiretroviral therapy improves treatment completion/cure from TB (COR=4.5, 95%CI: 1.2, 16) in the bivariate analysis, but turned out to be non-significant and even negatively associated in multivariable regression. This was due to the effect of confounding variables. The negative association reflects the possible pill burden and adverse effects of both anti-TB and ART drugs among children who are taking anti-retroviral medication. Due to the nature of data collection more independent variables couldn’t be explored through different data collection methods and sources and were not tested.</p></sec><sec sec-type="conclusions" id="sec5"><title>Conclusion</title><p>The commonest methods of diagnosis of childhood TB were clinical assessment with chest x-ray which lacks in almost all health centers in Ethiopia due to absence of x-ray facility. TB treatment success rate is still low in Northwest Ethiopia. Lack of follow up of national guideline, lack of anti TB regimen and poor adherence to treatment were major challenges in the management of TB among children. Adherence to anti-TB treatment was an independent predictor of treatment success. Health centers and district health offices shall work hard to improve compliance to national TB treatment guideline. Children started on anti-TB shall be linked to the nearby health facility to improve treatment success. Focus shall be given to rural children and those with HIV infection.</p><sec id="sec5.1"><title>What is known about this topic</title><list list-type="bullet"><list-item><p>Success of childhood TB treatment is determined by undernutrition and HIV infection;</p></list-item><list-item><p>Emergence of MDR TB causes additional challenge to childhood TB treatment.</p></list-item></list></sec><sec id="sec5.2"><title>What this study adds</title><list list-type="bullet"><list-item><p>Low level of adherence to the national TB treatment guideline by health care workers in treating child TB;</p></list-item><list-item><p>Antiretroviral therapy is associated with the treatment completion/cure from TB;</p></list-item><list-item><p>Adherence to anti-TB treatment is independent predictor of treatment success.</p></list-item></list></sec></sec><sec><title>Competing interests</title><p>The authors declare no competing interest.</p></sec></body><back><ack><title>Acknowledgments</title><p>The investigators would like to forward their thanks to the University of Gondar for providing the time to conduct the study and for providing ethical clearance. Our gratitude also goes to the Amhara regional WHO office for financial support. The investigators want also to appreciate the study participants and data collectors.</p></ack><sec><title>Authors’ contributions</title><p>Zemene Tigabu wrote the proposal, involved in the data collection, analysis and interpretation. Belaynew Wasie was involved in data collection, analysis and interpretation of statistical outputs and drafted the manuscript. Yohannes Hailu was involved in data collection, analysis and interpretation of statistical outputs. All authors read and approved the final manuscript.</p></sec><ref-list><title>References</title><ref id="cit0001"><label>1</label><element-citation publication-type="book"><person-group person-group-type="author"><collab>WHO Regional office for Africa</collab></person-group><source>W. 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