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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increase in Unemployment over the 2000’s: Comparison between People Living with HIV and the French General Population</title><author><name sortKey="Annequin, Margot" sort="Annequin, Margot" uniqKey="Annequin M" first="Margot" last="Annequin">Margot Annequin</name><affiliation><nlm:aff id="aff001"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Department of Social Epidemiology, F75012, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lert, France" sort="Lert, France" uniqKey="Lert F" first="France" last="Lert">France Lert</name><affiliation><nlm:aff id="aff002"><addr-line>INSERM, U1018, Center for Research in Epidemiology and Population Health, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name><affiliation><nlm:aff id="aff003"><addr-line>INSERM, UMR912, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff004"><addr-line>Aix Marseille University, UMR_S912, IRD, Marseille, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff005"><addr-line>ORS PACA, Southeastern Health Regional Observatory, Marseille, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dray Spira, Rosemary" sort="Dray Spira, Rosemary" uniqKey="Dray Spira R" first="Rosemary" last="Dray-Spira">Rosemary Dray-Spira</name><affiliation><nlm:aff id="aff001"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Department of Social Epidemiology, F75012, Paris, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27814374</idno><idno type="pmc">5096670</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096670</idno><idno type="RBID">PMC:5096670</idno><idno type="doi">10.1371/journal.pone.0165634</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002924</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002924</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increase in Unemployment over the 2000’s: Comparison between People Living with HIV and the French General Population</title><author><name sortKey="Annequin, Margot" sort="Annequin, Margot" uniqKey="Annequin M" first="Margot" last="Annequin">Margot Annequin</name><affiliation><nlm:aff id="aff001"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Department of Social Epidemiology, F75012, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lert, France" sort="Lert, France" uniqKey="Lert F" first="France" last="Lert">France Lert</name><affiliation><nlm:aff id="aff002"><addr-line>INSERM, U1018, Center for Research in Epidemiology and Population Health, Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name><affiliation><nlm:aff id="aff003"><addr-line>INSERM, UMR912, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff004"><addr-line>Aix Marseille University, UMR_S912, IRD, Marseille, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff005"><addr-line>ORS PACA, Southeastern Health Regional Observatory, Marseille, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dray Spira, Rosemary" sort="Dray Spira, Rosemary" uniqKey="Dray Spira R" first="Rosemary" last="Dray-Spira">Rosemary Dray-Spira</name><affiliation><nlm:aff id="aff001"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Department of Social Epidemiology, F75012, Paris, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Despite improved health, unemployment has increased among people living with HIV (PlwHIV) over the last decade. However, since the economic recession of 2008, unemployment also increased in the French general population. This paper aimed to determine if the increase in the unemployment rate in the HIV population was higher than that in the French general population.</p></sec><sec id="sec002"><title>Methods</title><p>We used data from the ANRS-Vespa study, a repeated cross-sectional survey among two national representative samples of PlwHIV followed at hospitals in France in 2003 and 2011. We compared employment and unemployment rates between HIV-infected people (overall and according to period of HIV diagnosis) and the French general population in 2003 and 2011, using multivariate Poisson regressions adjusted for individual sociodemographic characteristics.</p></sec><sec id="sec003"><title>Results</title><p>The employment rate among PlwHIV was consistently lower than that in the general population in 2003 and 2011. In contrast, there was a trend of an increasing unemployment rate difference between PlwHIV and the general population: PlwHIV’s unemployment rate was 1.48 (95% confidence interval [CI]: 1.16–1.90) times higher than that of the general population in 2003, versus 1.62 (95% CI: 1.34–1.96) times higher in 2011. This unemployment rate difference was the highest for PlwHIV diagnosed in or after 2008 (adjusted prevalence rate ratio: 2.06; 95% CI: 1.59–2.67).</p></sec><sec id="sec004"><title>Conclusions</title><p>These results suggest that in time of economic recession, an increasing proportion of PlwHIV may be excluded from the labor market although they are willing to re-enter it. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27814374</article-id><article-id pub-id-type="pmc">5096670</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0165634</article-id><article-id pub-id-type="publisher-id">PONE-D-16-21895</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject><subj-group><subject>Economics</subject><subj-group><subject>Labor Economics</subject><subj-group><subject>Labor Markets</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject><subj-group><subject>Economics</subject><subj-group><subject>Labor Economics</subject><subj-group><subject>Unemployment Rates</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject><subj-group><subject>Economics</subject><subj-group><subject>Macroeconomics</subject><subj-group><subject>Unemployment Rates</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and health sciences</subject><subj-group><subject>Diagnostic medicine</subject><subj-group><subject>HIV diagnosis and management</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject><subj-group><subject>Economics</subject><subj-group><subject>Labor Economics</subject><subj-group><subject>Employment</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Geographical Locations</subject><subj-group><subject>Europe</subject><subj-group><subject>France</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Population Groupings</subject><subj-group><subject>Ethnicities</subject><subj-group><subject>French People</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject><subj-group><subject>Economics</subject><subj-group><subject>Labor Economics</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Increase in Unemployment over the 2000’s: Comparison between People Living with HIV and the French General Population</article-title><alt-title alt-title-type="running-head">Comparison of Unemployment Rates between People Living with HIV and General Population</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Annequin</surname><given-names>Margot</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="author-notes" rid="currentaff001"><sup>¤</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author"><name><surname>Lert</surname><given-names>France</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spire</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dray-Spira</surname><given-names>Rosemary</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><collab>and the ANRS-Vespa2 Study Group</collab><xref ref-type="author-notes" rid="fn001"><sup>¶</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Department of Social Epidemiology, F75012, Paris, France</addr-line></aff><aff id="aff002"><label>2</label><addr-line>INSERM, U1018, Center for Research in Epidemiology and Population Health, Villejuif, France</addr-line></aff><aff id="aff003"><label>3</label><addr-line>INSERM, UMR912, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Aix Marseille University, UMR_S912, IRD, Marseille, France</addr-line></aff><aff id="aff005"><label>5</label><addr-line>ORS PACA, Southeastern Health Regional Observatory, Marseille, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Stienstra</surname><given-names>Ymkje</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Groningen, University Medical Center Groningen, NETHERLANDS</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold> MA FL RDS.</p></list-item><list-item><p><bold>Formal analysis:</bold> MA.</p></list-item><list-item><p><bold>Methodology:</bold> MA RDS.</p></list-item><list-item><p><bold>Writing – original draft:</bold> MA RDS.</p></list-item><list-item><p><bold>Writing – review & editing:</bold> MA FL BS RDS.</p></list-item></list></p></fn><fn fn-type="current-aff" id="currentaff001"><label>¤</label><p>Current address: INSERM U1136, 27 rue de Chaligny, 75571 Paris Cedex 12, France</p></fn><fn fn-type="other" id="fn001"><p>¶ Membership of the ANRS-Vespa2 Study Group is provided in the Appendix.</p></fn><corresp id="cor001">* E-mail: <email>margot.annequin@inserm.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>4</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>11</issue><elocation-id>e0165634</elocation-id><history><date date-type="received"><day>6</day><month>6</month><year>2016</year></date><date date-type="accepted"><day>14</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Annequin et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Annequin et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0165634.pdf"></self-uri><abstract><sec id="sec001"><title>Background</title><p>Despite improved health, unemployment has increased among people living with HIV (PlwHIV) over the last decade. However, since the economic recession of 2008, unemployment also increased in the French general population. This paper aimed to determine if the increase in the unemployment rate in the HIV population was higher than that in the French general population.</p></sec><sec id="sec002"><title>Methods</title><p>We used data from the ANRS-Vespa study, a repeated cross-sectional survey among two national representative samples of PlwHIV followed at hospitals in France in 2003 and 2011. We compared employment and unemployment rates between HIV-infected people (overall and according to period of HIV diagnosis) and the French general population in 2003 and 2011, using multivariate Poisson regressions adjusted for individual sociodemographic characteristics.</p></sec><sec id="sec003"><title>Results</title><p>The employment rate among PlwHIV was consistently lower than that in the general population in 2003 and 2011. In contrast, there was a trend of an increasing unemployment rate difference between PlwHIV and the general population: PlwHIV’s unemployment rate was 1.48 (95% confidence interval [CI]: 1.16–1.90) times higher than that of the general population in 2003, versus 1.62 (95% CI: 1.34–1.96) times higher in 2011. This unemployment rate difference was the highest for PlwHIV diagnosed in or after 2008 (adjusted prevalence rate ratio: 2.06; 95% CI: 1.59–2.67).</p></sec><sec id="sec004"><title>Conclusions</title><p>These results suggest that in time of economic recession, an increasing proportion of PlwHIV may be excluded from the labor market although they are willing to re-enter it. This constitutes a major issue relative to social consequences of chronic disease.</p></sec></abstract><funding-group><award-group id="award001"><funding-source><institution>Ecole des Hautes Etudes en Santé Publique(EHESP)</institution></funding-source><award-id>Phd Grant</award-id><principal-award-recipient><name><surname>Annequin</surname><given-names>Margot</given-names></name></principal-award-recipient></award-group><funding-statement>The ANRS-Vespa1 and ANRS-Vespa2 surveys were sponsored and funded by the ANRS (Agence Nationale de Recherches sur le SIDA et les Hépatites Virales). Margot Annequin is the recipient of a PhD grant from the EHESP (École des Hautes Études en Santé Publique [School of Public Health]), Rennes.</funding-statement></funding-group><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><page-count count="17"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front><body><sec sec-type="intro" id="sec005"><title>Introduction</title><p>Work and its absence are major determinants of individuals’ living condition by providing them–or lacking—with financial support, social status and identity[<xref rid="pone.0165634.ref001" ref-type="bibr">1</xref>]. Employment status and health are also intertwined processes[<xref rid="pone.0165634.ref002" ref-type="bibr">2</xref>]: working conditions and organization are major social determinant of health for those employed [<xref rid="pone.0165634.ref003" ref-type="bibr">3</xref>]; while unemployment has also been shown to cause a deterioration of health for those unemployed[<xref rid="pone.0165634.ref004" ref-type="bibr">4</xref>]. Furthermore, health-related selection operates at entry on the labor market for chronically ill individuals, marginalizing their participation in the labor market[<xref rid="pone.0165634.ref005" ref-type="bibr">5</xref>–<xref rid="pone.0165634.ref007" ref-type="bibr">7</xref>].</p><p>Regarding HIV-infection, studies conducted in various Western countries in the early 2000s provided evidence that, early in the combination antiretroviral therapy (cART) era, HIV infection negatively affected an individual’s chances of accessing, maintaining or returning to employment[<xref rid="pone.0165634.ref008" ref-type="bibr">8</xref>–<xref rid="pone.0165634.ref012" ref-type="bibr">12</xref>]. Disease severity and HIV-related discrimination were found to be the mechanisms at play in the negative effect of HIV-infection on employment [<xref rid="pone.0165634.ref013" ref-type="bibr">13</xref>], and this effect was shown to occur as early as the first few months following HIV diagnosis [<xref rid="pone.0165634.ref014" ref-type="bibr">14</xref>]. In addition, as in the general population, PlwHIV’s position in the labor market is also determined by sociodemographic characteristics of individuals such as age, sex, education or country of citizenship [<xref rid="pone.0165634.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0165634.ref015" ref-type="bibr">15</xref>].</p><p>Major advances in treatment over the past decade have resulted in an increased life expectancy for HIV-positive individuals and a reduction in treatment side effects [<xref rid="pone.0165634.ref016" ref-type="bibr">16</xref>,<xref rid="pone.0165634.ref017" ref-type="bibr">17</xref>]. Initial treatments and their subsequent improvements have reframed HIV as a chronic disease, a ‘manageable’ disease [<xref rid="pone.0165634.ref018" ref-type="bibr">18</xref>]. In addition to PlwHIV’s aging, in the past decade, changes in the HIV epidemic in Europe have resulted in an increasing proportion of women and individuals originating from a country of Sub-Saharan Africa among the HIV population[<xref rid="pone.0165634.ref019" ref-type="bibr">19</xref>,<xref rid="pone.0165634.ref020" ref-type="bibr">20</xref>]. Notwithstanding these changes, HIV still predominantly affects a population which is mostly of working age.</p><p>Despite the improved health of PlwHIV, the unemployment rate has increased in the past decade in France among PlwHIV [<xref rid="pone.0165634.ref021" ref-type="bibr">21</xref>]. Furthermore, individuals diagnosed in the most recent years were shown to be at a higher risk for job loss and to have less of a chance of re-entering the labor market than those diagnosed in the early 2000s [<xref rid="pone.0165634.ref021" ref-type="bibr">21</xref>]. Nevertheless, it has not been determined whether this increase in unemployment is similar to that reported in the general population. Indeed France, like other European countries, faces an increase of unemployment since the economic crisis of 2008, so it is not clear if HIV-infection has worsened or moderated the impact of the economic crisis on the employment situation of HIV-infected individuals.</p><p>This paper aimed to determine if the increase in the unemployment rate in the French HIV population was higher than that in the French general population, overall and according to period of HIV-diagnosis.</p></sec><sec sec-type="materials|methods" id="sec006"><title>Materials and Methods</title><sec id="sec007"><title>Data sources</title><p>We used data from a large repeated cross-sectional study conducted in 2003 (n = 2 942) and 2011(n = 3 022). The ANRS-Vespa study [VIH, enquête sur les personnes atteintes—HIV, survey on people living with HIV] was a repeated cross-sectional survey conducted among two large, nationally representative samples of HIV-infected people followed at hospitals in France in 2003 and 2011, with the primary aim of assessing the various dimensions of the socioeconomic conditions and health of PlwHIV in France. Full details regarding the study design are available elsewhere[<xref rid="pone.0165634.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0165634.ref023" ref-type="bibr">23</xref>].</p><p>Briefly, the surveys were conducted among random samples of hospital outpatients aged 18 or older who had a diagnosis of an HIV-infection for at least 6 months and who were either French citizens or immigrants having lived in France for at least 6 months. In both surveys, participants answered a standardized questionnaire in French, on socioeconomic status, living conditions, health status and healthcare use, which was administered face-to-face by a trained interviewer. A number of key questions were kept with the same wording between ANRS-Vespa1 and ANRS-Vespa2 surveys in order to conduct comparison. The ANRS-Vespa1 survey was conducted between December 2002 and September 2003 among 2932 PlwHIV recruited in 73 hospital departments in mainland France. The ANRS-Vespa2 survey was conducted between April 2011 and January 2012 among 3022 PlwHIV recruited in 73 hospital departments in mainland France, using a similar design. In both surveys and each participating hospital department, a sample of eligible patients (5080 in 2003 and 5617 in 2011), randomly selected according to the order of their appointment, were invited to participate by their physician[<xref rid="pone.0165634.ref022" ref-type="bibr">22</xref>]. In the ANRS-Vespa1 and ANRS-Vespa2 studies, after having being informed of the survey by their physician, eligible patients who agreed to participate signed a letter of informed consent in duplicate. Among eligible patients, 1767 in 2003 and 2217 in 2011 declined to participate. Both in 2003 and in 2011, non-participants were more likely than participants to have been HIV-infected through a way other than homo/bisexual contacts, to be employed at the time of the study and to have an impaired immunological status (CD4 cell count<500/mm<sup>3</sup>). In addition, in 2011 non-participants were more likely than participants to be non-French citizens. In both surveys data were weighted to account for the sampling design and participation bias. Details regarding the weighting procedure are provided elsewhere [<xref rid="pone.0165634.ref022" ref-type="bibr">22</xref>]. Both surveys received approval from the French Advisory Committee on Information Processing in Material Research in the Field of Health (CCTIRS) and met the ethical requirements of the French National Commission for Computing and Liberties (CNIL).</p><p>Information on the general population were obtained from the French Labor Survey, which is conducted each year by the National Institute of Statistics and Economic Studies (INSEE) among a national representative sample of individuals who live in private households[<xref rid="pone.0165634.ref024" ref-type="bibr">24</xref>]. Estimates are generalizable to residents in private households within the French metropolitan territory [<xref rid="pone.0165634.ref025" ref-type="bibr">25</xref>].For the present analyses, we used data form the 2003 (n = 281 541) and 2011 (n = 426 597) surveys.</p></sec><sec id="sec008"><title>Measures</title><p>Employment status at the time of the interview was documented for all the participants, using similar questions in both surveys. In line with the International Labor Organization’s definition, employment status was categorized in two steps. First, participants were considered employed if they reported having a job (either paid or voluntary), regardless of their occupational status (self-employed or employed) and working hours (full time/part time), or if they had been on sick leave for less than 6 months. Next, the participants who were not employed were categorized as unemployed if they were available to work and reported having actively sought work within the previous 3 months. Otherwise, individuals not at work and not unemployed were categorized as inactive, including students, retirees, people on disability, and those with family responsibilities.</p><p>Data on sociodemographic characteristics, including age, sex, citizenship, educational level and household composition, were collected in both surveys. The following indicators were collected using the same sets of questions: age, which was categorized in three groups of approximately the same size according to the distribution of age of PlwHIV in 2011 (25–39, 40–49 and 50–64 years); citizenship, also categorized into three groups (French, sub-Saharan African countries and other) considering that foreign citizens from other regions that Sub-Saharan Africa account for a minority and heterogeneous group of PlwHIV in France; educational level, which was the highest attained level of education in Vespa1-2003 and the highest degree obtained in Vespa2-2011, and which was dichotomized as low (primary or secondary education in Vespa1-2003; high school diploma or lower in Vespa2-2011) or high (higher education in Vespa1-2003; tertiary degree in Vespa2-2011); and household composition, which was categorized into five groups (single with no children; single with children; cohabiting partner, no children; cohabiting partner with children; and other cohabiting adults).</p><p>Information pertaining to discrimination was available only in the Vespa2-2011 survey, which asked about workplace discrimination during the previous two years (yes/no) and discrimination in job-seeking (yes/no). Details on the definition of the discrimination variables are provided elsewhere[<xref rid="pone.0165634.ref026" ref-type="bibr">26</xref>].</p></sec><sec id="sec009"><title>Statistical Analysis</title><p>The study population included HIV and non-HIV individuals of working age (25–64 years) at the time of the survey. Only HIV-individuals who had been diagnosed with HIV-infection in or after 1996, i.e., when cART was available, were included. Individuals with missing information for variables with < 1% missing values were excluded.</p><p>Differences in employment and unemployment rates between the general population and HIV-population were measured using adjusted prevalence rate ratios (aPRRs) comparing overall employment and unemployment rates between HIV-infected individuals and the general population in 2003 and 2011. Because our interest was to assess if the increase of unemployment rate in the HIV population was of same magnitude to that of the general population we ran different models to compare the probability of being employed (vs. unemployed and inactive) and unemployed (vs. employed or inactive) in the HIV population versus the general population. Prevalence rate ratio were computed with multivariate Poisson regression models with a robust variance estimator [<xref rid="pone.0165634.ref027" ref-type="bibr">27</xref>]. We estimated the parameters for 2003 and 2011 with <xref ref-type="disp-formula" rid="pone.0165634.e001">Eq 1</xref> below:
<disp-formula id="pone.0165634.e001"><alternatives><graphic xlink:href="pone.0165634.e001.jpg" id="pone.0165634.e001g" mimetype="image" position="anchor" orientation="portrait"></graphic><mml:math id="M1"><mml:msub><mml:mrow><mml:mi>Y</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:mi>x</mml:mi><mml:mi mathvariant="normal">′</mml:mi><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>X</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>ε</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></alternatives><label>(eq 1)</label></disp-formula></p><p>The units of observation are individuals (i) in years (t) 2003 or 2011. Where <italic>Y</italic> is the outcome (employment or unemployment); <italic>HIV</italic> represents a variable that equals 0 for the general population and 1 for the HIV population; <italic>X</italic> represents a vector of control variables (age, sex, citizenship and household composition) and <italic>ε</italic> residual error.</p><p>In a second step to investigate changes over time and to determine whether the differences in unemployment and employment rates between the populations were different in 2003 and 2011, we estimated the previous model adding an interaction term with <xref ref-type="disp-formula" rid="pone.0165634.e002">Eq 2</xref>.
<disp-formula id="pone.0165634.e002"><alternatives><graphic xlink:href="pone.0165634.e002.jpg" id="pone.0165634.e002g" mimetype="image" position="anchor" orientation="portrait"></graphic><mml:math id="M2"><mml:msub><mml:mrow><mml:mi>Y</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>y</mml:mi><mml:mi>e</mml:mi><mml:mi>a</mml:mi><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>*</mml:mo><mml:msub><mml:mrow><mml:mi>y</mml:mi><mml:mi>e</mml:mi><mml:mi>a</mml:mi><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:mi>x</mml:mi><mml:mi mathvariant="normal">′</mml:mi><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>X</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub><mml:mo>+</mml:mo><mml:msub><mml:mrow><mml:mi>ε</mml:mi></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub></mml:math></alternatives><label>(eq 2)</label></disp-formula>Where <italic>Y</italic> is the outcome, <italic>HIV</italic> represents a variable that takes 0 for general population and 1 for HIV population; <italic>year</italic> takes 0 for survey year 2003 and 1 for survey year 2011, and <italic>HIV*year</italic> is an interaction term between type of population (general population vs. HIV population) and survey years (2003 vs. 2011). <italic>X</italic> represents a vector of control variables (age, sex, citizenship and household composition) and <italic>ε</italic> residual error. The p-value of the interaction term determines if the magnitude of the difference of unemployment rate between the HIV population and general population is different in 2003 and 2011. Table 2 reports the aPRR for the variable HIV of <xref ref-type="disp-formula" rid="pone.0165634.e001">Eq 1</xref> for 2003 and 2011 and the aPRR of control variables are those from <xref ref-type="disp-formula" rid="pone.0165634.e002">Eq 2</xref>.</p><p>To investigate differences according to the period of HIV diagnosis, PlwHIV included in the Vespa2-2011 study were categorized into three subgroups based on individuals’ date of HIV diagnosis as reported in their medical record: PlwHIV diagnosed in 1996–2003, i.e. during the early era of combined antiretroviral treatment; PlwHIV diagnosed in 2004–2007; and PlwHIV diagnosed in 2008–2011, i.e. during the first years of economic recession in France. In a model restricted to data collected in 2011, we compared the probability of being unemployed between each of these three subgroups of PlwHIV and the general population, controlling for sociodemographic characteristics. Wald tests were then used to compare the magnitude of the difference in unemployment rates between PlwHIV and the general population across the three subgroups of PlwHIV.</p><p>The choice of controlling variables was guided by the need to take into account major sociodemographic differences between survey populations and major determinants of employment situation. However, the choice was restricted in that they needed to be common to both the Vespa and the Labor Force Survey datasets. This resulted in models adjusted for sex, age, citizenship, educational level and household composition. Sex was introduced as a control variable because figures show a weaker participation of women in the labor market, due in part to their more recent incorporation into the French labor market. Young individuals are disadvantaged compared to older individuals due to inferior work experiences. Higher level of education increases chances of being employed due to higher qualifications. French citizens are also better integrated compared to non-nationals partly due to restriction according to citizenship on labor market and to discrimination; and single individuals are less integrated into the labor market, especially singles with children due to difficulties of conciliation between work and family lives.</p><p>Finally, sensitivity analyses were conducted to estimate the extent to which differences in the proportion and characteristics of African nationals between PlwHIV and the general population may explain our findings: 1) We adjusted the models for immigrant status rather than citizenships, as foreign citizenship can be a proxy of a more recent immigration; and 2) We restricted the analysis to French citizens.</p><p>All the analyses were performed using Stata 12® (Stata Corporation, College Station, TX) and accounted for the complex sampling design and the data weighting so that the estimates are representative of the entire population of HIV-infected individuals followed at hospitals in France.</p></sec></sec><sec sec-type="results" id="sec010"><title>Results</title><sec id="sec011"><title>Characteristics of population</title><p>Three out of a total of 2 676 participants (1 010 participants in Vespa1-2003 and 1 666 participants in Vespa2-2011) who were of working age at the time of the interview and who had been diagnosed with HIV-infection in or after 1996 were excluded because of missing data on their educational level. The sample of the general population included 175 648 and 265 697 individuals in 2003 and 2011, aged between 25 and 64 years old.</p><p>Compared to the general population (<xref ref-type="table" rid="pone.0165634.t001">Table 1</xref>), in 2003 and 2011, PlwHIV were more frequently men (67.9% and 62.2% versus 49.1% and 48.9%), were more often living alone (37.7% and 37.1% versus 12.8% and 15.6%) and more often had sub-Saharan citizenship (22.9% and 31.1% versus 0.7% and 0.9%). In 2003, they were younger than the general population (median age: 39 versus 43), and in 2011, they were of similar age (median age: 43 versus 45).</p><table-wrap id="pone.0165634.t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0165634.t001</object-id><label>Table 1</label><caption><title>Participants’ sociodemographic determinants of labor market position in 2003 and 2011 across people living with HIV and the French general population.</title></caption><alternatives><graphic id="pone.0165634.t001g" xlink:href="pone.0165634.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="justify" rowspan="1" colspan="1"> </th><th align="center" colspan="3" rowspan="1">2003</th><th align="center" colspan="3" rowspan="1">2011</th></tr><tr><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">PlwHIV</th><th align="center" rowspan="1" colspan="1">General Pop</th><th align="center" rowspan="1" colspan="1"><italic>P</italic>-value<xref ref-type="table-fn" rid="t001fn003">**</xref></th><th align="center" rowspan="1" colspan="1">PlwHIV</th><th align="center" rowspan="1" colspan="1">General Pop</th><th align="center" rowspan="1" colspan="1"><italic>P</italic>-value<xref ref-type="table-fn" rid="t001fn003">**</xref></th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">(N = 1 010)</th><th align="center" rowspan="1" colspan="1">(N = 175 648)</th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">(N = 1 663)</th><th align="center" rowspan="1" colspan="1">(N = 265 697)</th><th align="center" rowspan="1" colspan="1"></th></tr><tr><th align="justify" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">%<xref ref-type="table-fn" rid="t001fn002">*</xref></th><th align="center" rowspan="1" colspan="1">%<xref ref-type="table-fn" rid="t001fn002">*</xref></th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">%<xref ref-type="table-fn" rid="t001fn002">*</xref></th><th align="center" rowspan="1" colspan="1">%<xref ref-type="table-fn" rid="t001fn002">*</xref></th><th align="center" rowspan="1" colspan="1"></th></tr></thead><tbody><tr><td align="justify" rowspan="1" colspan="1"><bold>Sex</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="justify" rowspan="1" colspan="1">Male</td><td align="center" rowspan="1" colspan="1">67.9</td><td align="center" rowspan="1" colspan="1">49.1</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">62.2</td><td align="center" rowspan="1" colspan="1">48.9</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Female</td><td align="center" rowspan="1" colspan="1">32.1</td><td align="center" rowspan="1" colspan="1">50.9</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">37.8</td><td align="center" rowspan="1" colspan="1">51.1</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Educational level</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">0.109</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">0.658</td></tr><tr><td align="justify" rowspan="1" colspan="1">High</td><td align="center" rowspan="1" colspan="1">31.1</td><td align="center" rowspan="1" colspan="1">28.6</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">29.1</td><td align="center" rowspan="1" colspan="1">29.7</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Low</td><td align="center" rowspan="1" colspan="1">68.9</td><td align="center" rowspan="1" colspan="1">71.4</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">70.9</td><td align="center" rowspan="1" colspan="1">70.3</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Country of citizenship</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="justify" rowspan="1" colspan="1">Sub-Saharan Africa</td><td align="center" rowspan="1" colspan="1">22.9</td><td align="center" rowspan="1" colspan="1">0.7</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">31.1</td><td align="center" rowspan="1" colspan="1">0.9</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Other</td><td align="center" rowspan="1" colspan="1">9.9</td><td align="center" rowspan="1" colspan="1">5.8</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">6.5</td><td align="center" rowspan="1" colspan="1">6.2</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">France</td><td align="center" rowspan="1" colspan="1">67.2</td><td align="center" rowspan="1" colspan="1">93.5</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">62.3</td><td align="center" rowspan="1" colspan="1">92.9</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Age (years)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="justify" rowspan="1" colspan="1">25–39</td><td align="center" rowspan="1" colspan="1">52.4</td><td align="center" rowspan="1" colspan="1">39.6</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">35.0</td><td align="center" rowspan="1" colspan="1">36.2</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">40–49</td><td align="center" rowspan="1" colspan="1">29.5</td><td align="center" rowspan="1" colspan="1">27.2</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">35.9</td><td align="center" rowspan="1" colspan="1">26.5</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">50–64</td><td align="center" rowspan="1" colspan="1">18.1</td><td align="center" rowspan="1" colspan="1">33.1</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">29.1</td><td align="center" rowspan="1" colspan="1">37.3</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Household composition</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="justify" rowspan="1" colspan="1">Single with no children</td><td align="center" rowspan="1" colspan="1">37.7</td><td align="center" rowspan="1" colspan="1">12.8</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">37.1</td><td align="center" rowspan="1" colspan="1">15.6</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Single with children</td><td align="center" rowspan="1" colspan="1">9.6</td><td align="center" rowspan="1" colspan="1">6.9</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">11.7</td><td align="center" rowspan="1" colspan="1">7.6</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Cohabiting partner with children</td><td align="center" rowspan="1" colspan="1">16.3</td><td align="center" rowspan="1" colspan="1">50.8</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">17.2</td><td align="center" rowspan="1" colspan="1">47.1</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Cohabiting partner, no children</td><td align="center" rowspan="1" colspan="1">23.9</td><td align="center" rowspan="1" colspan="1">25.9</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">23.2</td><td align="center" rowspan="1" colspan="1">26.5</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Other cohabiting adults</td><td align="center" rowspan="1" colspan="1">12.4</td><td align="center" rowspan="1" colspan="1">3.5</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">10.9</td><td align="center" rowspan="1" colspan="1">3.1</td><td align="center" rowspan="1" colspan="1"></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t001fn001"><p>PlwHIV, People living with HIV; General Pop, French general population</p></fn><fn id="t001fn002"><p>* Weighted percentages</p></fn><fn id="t001fn003"><p>**χ<sup>2</sup> test of comparison across people living with HIV and general population in 2003 and 2011</p></fn></table-wrap-foot></table-wrap><p>Among PlwHIV, over the last decade, men who have sex with men accounted for 37.2% and 35.6% of the study population in 2003 and 2011, respectively, while former or current injection drug users accounted for 5.5% and 4.1% respectively. The median age was 39 years in 2003 and 43 years in 2011. In 2003, the median time since diagnosis was 3.8 years, while in 2011, it was 7.4 years. The proportion of the participants being treated was 74.4% in 2003 and 87.3% in 2011.</p><p>Among the 2011 PlwHIV, those diagnosed in or after 2008 were younger (54.5% of those diagnosed between 2008 and 2011, 41.1% of those diagnosed between 2004 and 2007, and 22.4% of those diagnosed between 1996 and 2003 were 25 to 39 years old) and more often had sub-Saharan citizenship (respectively, 36.4% versus 36.0% and 25.9%)</p></sec><sec id="sec012"><title>Employment and unemployment rates</title><p>On the subject of employment (<xref ref-type="fig" rid="pone.0165634.g001">Fig 1</xref>), in 2003, 60.9% of PlwHIV were employed versus 71.9% of the general population (absolute difference: -11.0%, <italic>p</italic>-value: <0.001). In 2011, 59.5% of PlwHIV were employed versus 71.6% of the general population (absolute difference: -12.1%, <italic>p</italic>-value: <0.001). Details of employment rates according to sociodemographic characteristics are provided as supplementary information (Table A in <xref ref-type="supplementary-material" rid="pone.0165634.s001">S1 File</xref>).</p><fig id="pone.0165634.g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0165634.g001</object-id><label>Fig 1</label><caption><title>Employment, unemployment and inactivity rates in 2003 and 2011 among people living with HIV and the French general population.</title><p>%, Weighted percentages; General Pop, French general population; PlwHIV, People living with HIV.</p></caption><graphic xlink:href="pone.0165634.g001"></graphic></fig><p>With regards to unemployment, in 2003, 12.6% of PlwHIV were unemployed versus 5.7% of the general population (absolute difference: +6.9%, <italic>p</italic>-value: <0.001). In 2011, 15.9% of PlwHIV were unemployed versus 6.1% of the general population (absolute difference: +9.7%, <italic>p</italic>-value: <0.001). Among PlwHIV in 2011, those most recently diagnosed had a higher rate of unemployment than those diagnosed earlier (22.7% of those diagnosed in or after 2008, 16.4% of those diagnosed between 2004 and 2007, and 12.6% of those diagnosed between 1996 and 2003; <italic>p</italic> = 0.002). Furthermore unemployment rates were higher in women (20.9% vs. 12.8% in men), in individuals with a low level of education (17.1% vs. 13.0% in those highly educated), and in foreign citizens (26.7% in African nationals, 20.8% in foreign citizens from other regions, vs. 10.1% in French citizens). Unemployment rates also differed according to age, with higher rates among the youngest (22.8% for those aged between 25 and 39 years old; 15.6% among those aged between 40–49 years old and 8.2% among those aged between 50–64 years old). Singles with children were approximately one third (31.7%) unemployed versus 8.3% among those with a cohabiting partner and no children (Table B in <xref ref-type="supplementary-material" rid="pone.0165634.s001">S1 File</xref>).</p><p>Discrimination in job-seeking during the previous two years was reported by 28.7% of the PlwHIV.</p></sec><sec id="sec013"><title>Changes over the 2000’s in difference in unemployment rates between HIV-infected individuals and the general population</title><p>After adjustment for sociodemographic determinants of labor market position (sex, age, country of citizenship, educational level and household composition), the employment rate among PlwHIV was lower than in the general population in 2003 and 2011 (2003 aPRR: 0.86, 95% confidence interval [95% CI]: 0.81–0.90; 2011 aPRR: 0.86 [95% CI]: 0.82–0.91). The magnitude of this difference remained stable between 2003 and 2011 (interaction term <italic>p</italic>-value: 0. 705).</p><p>With regard to unemployment (<xref ref-type="table" rid="pone.0165634.t002">Table 2</xref>), after adjustment for sociodemographic determinants of labor market position, unemployment was significantly higher in PlwHIV compared to the general population both in 2003 (aPRR: 1.48 [95% CI]: 1.16–1.90) and 2011 (aPRR: 1.62 [95% CI]: 1.34–1.96). This difference tended to increase between 2003 and 2011, although this was not statistically significant (interaction term <italic>p</italic>-value: 0.080).</p><table-wrap id="pone.0165634.t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0165634.t002</object-id><label>Table 2</label><caption><title>Prevalence rate ratios for unemployment among people living with HIV versus the French general population in 2003 and 2011, adjusted for individual sociodemographic determinants of labor market position.</title></caption><alternatives><graphic id="pone.0165634.t002g" xlink:href="pone.0165634.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="justify" rowspan="1" colspan="1"> </th><th align="left" colspan="3" rowspan="1">Unemployment</th></tr><tr><th align="justify" rowspan="1" colspan="1"></th><th align="justify" colspan="2" rowspan="1">aPRR</th><th align="justify" rowspan="1" colspan="1">[95% CI]</th></tr></thead><tbody><tr><td align="justify" rowspan="1" colspan="1"><bold>Survey</bold></td><td align="justify" colspan="2" rowspan="1"> </td><td align="justify" rowspan="1" colspan="1"> </td></tr><tr><td align="justify" rowspan="1" colspan="1">General population 2003</td><td align="justify" colspan="2" rowspan="1">1</td><td align="justify" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">PlwHIV in 2003</td><td align="justify" colspan="2" rowspan="1">1.48<xref ref-type="table-fn" rid="t002fn002">**</xref></td><td align="justify" rowspan="1" colspan="1">[1.16,1.90]</td></tr><tr><td align="justify" rowspan="1" colspan="1">General population 2011</td><td align="justify" colspan="2" rowspan="1">1</td><td align="justify" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">PlwHIV in 2011</td><td align="justify" colspan="2" rowspan="1">1.62<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" rowspan="1" colspan="1">[1.34,1.96]</td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold><italic>Sociodemographic determinants of labor market position</italic></bold></td><td align="justify" colspan="2" rowspan="1"></td><td align="justify" rowspan="1" colspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Sex</bold></td><td align="justify" rowspan="1" colspan="1"></td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Male</td><td align="justify" rowspan="1" colspan="1">1</td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Female</td><td align="justify" rowspan="1" colspan="1">0.94</td><td align="justify" colspan="2" rowspan="1">[0.82,1.07]</td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Age (years)</bold></td><td align="justify" rowspan="1" colspan="1"></td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">25–39</td><td align="justify" rowspan="1" colspan="1">1.26<xref ref-type="table-fn" rid="t002fn002">**</xref></td><td align="justify" colspan="2" rowspan="1">[1.09,1.46]</td></tr><tr><td align="justify" rowspan="1" colspan="1">40–49</td><td align="justify" rowspan="1" colspan="1">1</td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">50–64</td><td align="justify" rowspan="1" colspan="1">0.59<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" colspan="2" rowspan="1">[0.49,0.72]</td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Country of citizenship</bold></td><td align="justify" rowspan="1" colspan="1"></td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">France</td><td align="justify" rowspan="1" colspan="1">1</td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Sub-Saharan Africa</td><td align="justify" rowspan="1" colspan="1">2.09<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" colspan="2" rowspan="1">[1.69,2.59]</td></tr><tr><td align="justify" rowspan="1" colspan="1">Other</td><td align="justify" rowspan="1" colspan="1">1.68<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" colspan="2" rowspan="1">[1.37,2.06]</td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Educational level</bold></td><td align="justify" rowspan="1" colspan="1"></td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">High</td><td align="justify" rowspan="1" colspan="1">1</td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Low</td><td align="justify" rowspan="1" colspan="1">1.15</td><td align="justify" colspan="2" rowspan="1">[0.98,1.35]</td></tr><tr><td align="justify" rowspan="1" colspan="1"><bold>Household composition</bold></td><td align="justify" rowspan="1" colspan="1"></td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Single with no children</td><td align="justify" rowspan="1" colspan="1">1.38<xref ref-type="table-fn" rid="t002fn002">**</xref></td><td align="justify" colspan="2" rowspan="1">[1.11,1.73]</td></tr><tr><td align="justify" rowspan="1" colspan="1">Single with children</td><td align="justify" rowspan="1" colspan="1">2.09<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" colspan="2" rowspan="1">[1.65,2.65]</td></tr><tr><td align="justify" rowspan="1" colspan="1">Cohabiting partner with children</td><td align="justify" rowspan="1" colspan="1">1.17</td><td align="justify" colspan="2" rowspan="1">[0.96,1.43]</td></tr><tr><td align="justify" rowspan="1" colspan="1">Cohabiting partner, no children</td><td align="justify" rowspan="1" colspan="1">1</td><td align="justify" colspan="2" rowspan="1"></td></tr><tr><td align="justify" rowspan="1" colspan="1">Other cohabiting adults</td><td align="justify" rowspan="1" colspan="1">1.78<xref ref-type="table-fn" rid="t002fn003">***</xref></td><td align="justify" colspan="2" rowspan="1">[1.37,2.32]</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t002fn001"><p>aPRR, Adjusted prevalence rate ratio; PlwHIV, People living with HIV; CI, Confidence interval</p></fn><fn id="t002fn002"><p>** p<0.01</p></fn><fn id="t002fn003"><p>*** p<0.001</p></fn></table-wrap-foot></table-wrap><p>Results remained unchanged after adjustment for immigrant status rather than citizenship (Table C in <xref ref-type="supplementary-material" rid="pone.0165634.s001">S1 File</xref>) and when the analysis was restricted to French nationals (Table D in <xref ref-type="supplementary-material" rid="pone.0165634.s001">S1 File</xref>), suggesting that differences in African nationals proportion and characteristics between PlwHIV and the general population are unlikely to explain our findings.</p><p>As for the sociodemographic determinants of unemployment, individuals with a higher rate of unemployment were those under 40 years of age (aPRR: 1.26 [95% CI]: 1.09–1.46), those with foreign citizenship (for sub-Saharan Africa citizenships, aPRR: 2.09 [95% CI]: 1.69–2.59; for other citizenships, aPRR: 1.68 [95% CI]: 1.37–2.06), and those living alone, with or without children (respectively, aPRR: 2.09 [95% CI]: 1.65–2.65, and aPRR: 1.38 [95% CI]: 1.11–1.73), and those living with other cohabiting adults (aPRR: 1.78 [95% CI]: 1.37–2.32).</p><p>As shown in (<xref ref-type="fig" rid="pone.0165634.g002">Fig 2</xref>), among PlwHIV surveyed in 2011 although the unemployment rate was higher than that of the general population regardless of the period of diagnosis, the magnitude of this difference was not consistent across periods of diagnosis. Indeed, the aPRR comparing unemployment rates between PlwHIV and the general population was significantly higher for HIV-infected individuals diagnosed in or after 2008 compared to those diagnosed between 1996 and 2003 (aPRR: 2.06 [95% CI]: 1.59–2.67 versus 1.44 [95% CI]: 1.11–1.87, respectively; Wald test: <italic>p = 0</italic>.<italic>02</italic>). In contrast, the aPRR did not differ between HIV-infected individuals diagnosed between 2004 and 2007 and those diagnosed between 1996 and 2003 (aPRR: 1.60 [95% CI]: 1.22–2.09 versus 1.44 [95% CI]: 1.11–1.87, respectively; Wald test: <italic>p = 0</italic>.<italic>52</italic>).</p><fig id="pone.0165634.g002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0165634.g002</object-id><label>Fig 2</label><caption><title>Prevalence rate ratios for unemployment among people living with HIV versus the French general population in 2011 according to the period of diagnosis, adjusted for individual sociodemographic determinants of labor market position.</title><p>aPRR, prevalence rate ratio adjusted for sex, age, country of citizenship, educational level and household composition; PlwHIV diag 96–2003, People living with HIV diagnosed HIV-infected between 1996 and 2003; PlwHIV diag 2004–07, People living with HIV diagnosed HIV-infected between 2004 and 2007; PlwHIV diag 2008–11, People living with HIV diagnosed HIV-infected between 2008 and 2011; General pop., French general population</p></caption><graphic xlink:href="pone.0165634.g002"></graphic></fig></sec></sec><sec sec-type="conclusions" id="sec014"><title>Discussion</title><p>Our results show that, overall, in France, the unemployment rate is still higher in PlwHIV compared to the general population, even after taking into account sociodemographic differences between the two populations. This unemployment gap has tended to increase over the past decade. Furthermore in 2011, this unemployment gap is more marked for those diagnosed in or after 2008, that is, at a time of worsening employment conditions in the labor market.</p><p>The Vespa surveys, conducted at two different points in time and nationally representative of HIV-infected hospital outpatients, constitute a unique dataset for studying PlwHIV’s living conditions and health. Furthermore detailed individual information on various indicators such as sociodemographic characteristics and employment situation made it possible to both account for i) changes within the HIV population over the last decade and ii) differences with the French general population. However some limitations should be noted. First, our results do not apply to the small proportion of HIV-infected individuals not followed at hospitals (less than 10% as estimated previously[<xref rid="pone.0165634.ref028" ref-type="bibr">28</xref>]). Nevertheless, HIV care is predominantly provided at hospitals and since 2006, annual medical checkups at hospital have been recommended by experts for PlwHIV [<xref rid="pone.0165634.ref029" ref-type="bibr">29</xref>]. Therefore, our results are likely to be generalizable to the vast majority of HIV-infected individuals being followed at hospitals in France. Secondly, due to the cross-sectional nature of our data, a causal interpretation of our results should be viewed with caution. Notably, we could not assess the extent to which the adverse employment situation of PlwHIV we report is related to HIV-infection itself or to other factors, e.g. discrimination or sector of employment. Third, our study was based on data collected in 2011. Since changes have occurred to the French labor market since then, notably a consistent increase in unemployment, our results may be slightly different in 2016. More specifically, it might be hypothesized that in the current context the unemployment gap between HIV-infected people and the general population may even be more marked than reported in our study. New studies conducted in the current context would be needed to properly answer this question.</p><sec id="sec015"><title>Weaker participation of HIV-individuals on the labor market over the last decade</title><p>Since disclosure of HIV-infection is not mandatory in the workplace, nor at job interviews, employment and unemployment rates of PlwHIV, should be similar to that of the French general population until complications due to the disease arise. However, our results show a weaker participation in the labor market of HIV-infected individuals. Our results are consistent with those of another recent study comparing HIV and non-HIV employment rates, in Denmark [<xref rid="pone.0165634.ref030" ref-type="bibr">30</xref>]. Similarly to our findings, they report that the employment rate in the HIV-infected population is still lower than in the general population.</p><p>This persistent and rising unemployment gap observed between PlwHIV and the French general population over the past decade is consistent with other studies that report low employment rates and high unemployment rates among individuals with various chronic conditions, including HIV[<xref rid="pone.0165634.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0165634.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0165634.ref031" ref-type="bibr">31</xref>], cancer[<xref rid="pone.0165634.ref032" ref-type="bibr">32</xref>], mental health problems[<xref rid="pone.0165634.ref033" ref-type="bibr">33</xref>], and limiting illnesses[<xref rid="pone.0165634.ref034" ref-type="bibr">34</xref>]. A major strength of our analysis is that it controls for differences in individual sociodemographic characteristics between the two populations. However, we were unable to adjust for prior periods of unemployment because such information was not available in both datasets.</p><p>To our knowledge, no study has compared the unemployment rate among PlwHIV with the background population. Most studies only focus on employment and disability or non-employment with no distinction between unemployment and inactivity. Because the rate of unemployment identifies the proportion of individuals willing to re-enter the labor market as they search for a job but are excluded from it, unemployment is a key indicator in the context of chronic disease affecting a working age population. This is especially true in the case of HIV, a disease that is less physically visible and less a health burden, but that continues to have a social impact.</p><p>However characterized by a high level of employment protection, French welfare protection may have limited the impact of the economic recession for those who were already employed, explaining this rising but moderate unemployment gap. Studies comparing the unemployment gap across countries have found that those characterized by a more regulated labor market with associated health and social policies, such as Sweden or Norway, were found to protect the employment of chronically ill individuals better in times of economic downturn than those with a deregulated labor market, such as the UK and Canada[<xref rid="pone.0165634.ref035" ref-type="bibr">35</xref>–<xref rid="pone.0165634.ref037" ref-type="bibr">37</xref>].</p><p>On the other hand, France is classified 23<sup>rd</sup> out of 38 according to “the Migration policy Index Score” that measures the labor market mobility of immigrants[<xref rid="pone.0165634.ref038" ref-type="bibr">38</xref>]. This low ranking is related to the fact that 5.3 million jobs are “closed” to non-EU immigrants. Primarily in the public sector, but also in the private sector where foreign qualifications and experiences are rarely fully acknowledged or accepted for professional and licensed occupations. Thus, differences in economic integration of immigrants according to labor market policies arise. It appears, for example, that the UK more successfully integrates immigrants from sub-Saharan Africa than France, Italy or Spain where sub-Saharan immigrants predominately work in low-skilled jobs [<xref rid="pone.0165634.ref039" ref-type="bibr">39</xref>]. In addition, according to a recent study on changes over the last decades in the French labor market, the labor market has become more segmented between a stable and an unstable part [<xref rid="pone.0165634.ref040" ref-type="bibr">40</xref>]. The labor turnover is now concentrated on young adults and on few occupations. While in the past, fixed-term contracts used to be a stepping stone towards more stable contracts, they now appear as a trap for those who work under them. This dual labor market may then affect PlwHIV as the general population. Some individuals, especially immigrants originating from Sub-Saharan Africa and young PlwHIV, seem to be trapped within the unstable part of the labor market.</p></sec><sec id="sec016"><title>Worsening situation for individuals diagnosed during economic recession</title><p>Although there is a high level of employment protection in France, we found that the unemployment gap has worsened for individuals diagnosed in or after 2008, that is, during a period of economic recession. This higher gap is in line with previous studies showing that the postdiagnosis years are critical in terms of the person’s employment situation[<xref rid="pone.0165634.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0165634.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0165634.ref030" ref-type="bibr">30</xref>]. Contrary to people with other chronic diseases, where a longer duration of illness is associated with a higher risk of work exits[<xref rid="pone.0165634.ref041" ref-type="bibr">41</xref>], HIV-individuals are at higher risk for being unemployed at the beginning of their illness, even though physical limitations due to HIV infection are likely to still be limited, with the exception of individuals who have already reached an advanced stage of HIV disease at the time of diagnosis.</p><p>The increased risk of unemployment among HIV individuals in recent years could therefore be related to various mechanisms. First, those recently diagnosed have faced an unfavorable economic context leading to the exclusion of chronically-ill individuals from the labor market. Studies have assessed the worsening employment gap between ill and non-ill individuals, in recent periods [<xref rid="pone.0165634.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0165634.ref034" ref-type="bibr">34</xref>,<xref rid="pone.0165634.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0165634.ref043" ref-type="bibr">43</xref>]. In time of economic recession, it has been showed that employment protection of disabled and chronically-ill individuals are less applied by companies[<xref rid="pone.0165634.ref044" ref-type="bibr">44</xref>]. This rising unemployment gap suggests that the increase in unemployment among PlwHIV is partly due to the general increase in the unemployment rate in France. Secondly, it can be seen from their work conditions that PlwHIV are more often employed under temporary contracts, which puts them at greater risk for job loss. In 2011, 15.8% of PlwHIV and 18.4% of those diagnosed in or after 2008 were employed under interim or fixed-term contracts versus 9.7% in the general population. Third, our results indicate that the ‘biographical disruption’ due to being diagnosed with a chronic illness theorized in the sociological literature, which describes how the structure of everyday life is disturbed by the diagnosis[<xref rid="pone.0165634.ref045" ref-type="bibr">45</xref>], may be exacerbated by the socioeconomic context. However due to the nature of our data, we were unable to properly disentangle the ‘great recession effect’ from the ‘biographical disruption’ effect. Finally, discrimination and stigmatization are still probably barriers to returning to work and to stay in the workplace. In 2011, in the Vespa-2 study almost one third of unemployed PlwHIV reported discrimination in job-seeking. However, major reasons of discrimination cited by respondents when applying for a job were origin or nationality and skin color [<xref rid="pone.0165634.ref026" ref-type="bibr">26</xref>]. If HIV-infection seems to be less a physical burden in everyday life for infected individuals, social and contextual factors continue to shape living conditions of PlwHIV, among whom a substantial and increasing proportion are individuals already socially disadvantaged on the labor market.</p><p>Further studies with a longitudinal design and detailed data both on HIV-infected patients’ health status and living conditions, and comparisons across countries are needed to fully understand the possible mechanisms at the individual and macro levels underlying the situation. Comparison with other chronic conditions would also be interesting to help better disentangle the numerous mechanisms at play in the social consequences of chronic disease.</p></sec><sec id="sec017"><title>Conclusions</title><p>In conclusion, our study indicates that, the unemployment rate among PlwHIV is still higher than in the general population, a difference which tended to increase over the past decade. Because HIV-infection affects a large population of adults of prime working age, our findings have public health and social implications and contribute to the discussion of how chronically ill individuals are integrated into the labor market. Unemployment among chronically-ill individuals should be studied further, as this identifies ill individuals who are willing to re-enter the labor market but are excluded from it. Identifying protective factors from the risk of unemployment at the individual and macro level, may contribute to diminishing the social consequences of chronic disease.</p></sec></sec><sec id="sec018"><title>Appendix</title><p><bold>Members of the ANRS-VESPA2 Study Group are:</bold> France Lert (INSERM UMR-S 1018, <email>France.Lert@inserm.fr</email>) and Bruno Spire (INSERM UMR-S 912/ORS PACA), scientific coordinators; Patrizia Carrieri (INSERM UMR-S 912/ORS PACA), Rosemary Dray-Spira (INSERM UMR-S 1136), Christine Hamelin (University Versailles Saint-Quentin-en-Yvelines), Nicolas Lorente (INSERM UMR-S 912/ORS PACA), Marie Préau (INSERM UMR-S 912/ORS PACA), Marie Suzan-Monti (INSERM UMR-S 912/ORS PACA); with the collaboration of Marion Mora (INSERM UMR-S 912/ORS PACA).</p><p><bold>Participating hospitals and investigators:</bold> Aix-en-Provence, CH Pays d’Aix (T. Allègre, P. Mours, J.M. Riou, M. Sordage); Angers, CHU Hôtel-Dieu (J.M. Chennebault, P. Fialaire, V. Rabier); Annemasse, CH Alpes-Léman (M. Froidure, D. Huguet, D. Leduc); Avignon, Hôpital Henri Duffaut (G. P ichancourt, A. Wajsbrot); Besançon, Hôpital Saint-Jacques (C. Bourdeaux, A. Foltzer, B. Hoen, L. Hustache-Mathieu); Bobigny, Hôpital Avicenne (S. Abgrall, R. Barruet, O. Bouchaud, A. Chabrol, S. Mattioni, F. Mechai); Bondy, Hôpital Jean Verdier (V. Jeantils); Bordeaux, Hôpital Saint-André (N. Bernard, F. Bonnet, M. Hessamfar, D. Lacoste, D. Malvy, P. Mercié, P. Morlat, F. Paccalin, M.C. Pertusa, T. Pistone, M.C. Receveur, M.A. Vandenhende); Boulogne-Billancourt, Hôpital Ambroise Paré (C. Dupont, A. Freire Maresca, J. Leporrier, E. Rouveix); Caen, Hôpital Clémenceau (S. Dargere, A. de la Blanchardière, A. Martin, V. Noyon, R. Verdon); CH de Chambéry (O. Rogeaux); Clermont-Ferrand, CHU Gabriel Montpied (J. Beytout, F. Gourdon, H. Laurichesse); Colombes, Hôpital Louis-Mourier (F. Meier, E. Mortier, A.M. Simonpoli); Creil, CH Laennec (F. Cordier); Créteil, CHIC (I. Delacroix, V. Garrait, B. Elharrar), Hôpital Henri Mondor (S. Dominguez, A.S. Lascaux, J.D. Lelièvre, Y. Levy, G. Melica); Dijon, Hôpital du Bocage (M. Buisson, L. Piroth, A. Waldner); Eaubonne, Hôpital Simone Veil (N. Gruat, A. Leprêtre); Garches, Hôpital Raymond-Poincaré (P. de Truchis, D. Le Du, J.Cl. Melchior); CH de Gonesse (R. Sehouane, D. Troisvallets); CHU de Grenoble (M. Blanc, I. Boccon-Gibod, A. Bosseray, J.P. Brion, F. Durand, P. Leclercq, F. Marion, P. Pavese); La Rochelle, Hôpital Saint- Louis (E. Brottier-Mancini, L. Faba, M. Roncato-Saberan); La Roche-sur-Yon, CHD Les Oudairies (O. Bollengier-Stragier, J.L. Esnault, S. Leautez-Nainville, P. P erré); CH de Lagny Marne-la-Vallée (E. Froguel, M. Nguessan, P. Simon); Le Chesnay, CH de Versailles (P. Colardelle, J. Doll, C. Godin-Collet, S. Roussin-Bretagne); Le Kremlin-Bicêtre, Hôpital de Bicêtre (J.F. Delfraissy, M. Duracinsky, C. Goujard, D. Peretti, Y. Quertainmont); CH du Mans (J. Marionneau); Lens, CH Dr. Schaffner (E. Aissi, N. Van Grunderbeeck); Limoges, CHU Dupuytren (E. Denes, S. Ducroix-Roubertou, C. Genet, P. Weinbreck); Lyon, Hôpital de la Croix-Rousse (C. Augustin-Normand, A. Boibieux, L. Cotte, T. Ferry, J. Koffi, P. Miailhes, T. Perpoint, D. Peyramond, I. Schlienger); Hôpital Édouard-Herriot (J.M. Brunel, E. Carbonnel, P. Chiarello, J.M. Livrozet, D. Makhloufi); Marseille, Hôpital de la Conception (C. Dhiver, H. Husson, A. Madrid, I. Ravaux, M.L. de Severac, M. Thierry Mieg, C. Tomei), Hôpital Nord (S. Hakoun, J. Moreau, S. Mokhtari, M.J. Soavi), Hôpital Sainte Marguerite (O. Faucher, A. Ménard, M. Orticoni, I. Poizot-Martin, M.J. Soavi); Montpellier, Hôpital Gui de Chauliac (N. Atoui, V. Baillat, V. Faucherre, C. Favier, J.M. Jacquet, V. Le Moing, A. Makinson, R. Mansouri, C. Merle); Montivilliers, Hôpital Jacques Monod (N. Elforzli); Nantes, Hôtel-Dieu (C. Allavena, O. Aubry, M. Besnier, E. Billaud, B. Bonnet, S. Bouchez, D. Boutoille, C. Brunet, N. Feuillebois, M. Lefebvre, P. Morineau-Le Houssine, O. Mounoury, P. Point, F. Raffi, V. Reliquet, J.P. Talarmin); Nice, Hôpital l’Archet (C. Ceppi, E. Cua, P. Dellamonica, F. De Salvador-Guillouet, J. Durant, S. Ferrando, V. Mondain-Miton, I. Perbost, S. Pillet, B. Prouvost-Keller, C. Pradier, P. Pugliese, V. Rahelinirina, P.M. Roger, E. Rosenthal, F. Sanderson); Orléans, Hôpital de La Source (L. Hocqueloux, M. Niang, T. Prazuck), Hôpital Porte Madeleine (P. Arsac, M.F. Barrault-Anstett); Paris, Hôpital Bichat—Claude-Bernard (M. Ahouanto, E. Bouvet, G. Castanedo, C. Charlois-Ou, A. Dia Kotuba, Z. Eid-Antoun, C. Jestin, K. Jidar, V. Joly, M.A. Khuong-Josses, N. Landgraf, R. Landman, S. Lariven, A. Leprêtre, F. L’hériteau, M. Machado, S. Matheron, F. Michard, G. Morau, G. Pahlavan, B.C. Phung, M.H. Prévot, C. Rioux, P. Yéni), Hôpital Cochin-Tarnier (F. Bani-Sadr, A. Calboreanu, E. Chakvetadze, D. Salmon, B. Silbermann), Hôpital européen Georges-Pompidou (D. Batisse, M. Beumont, M. Buisson, P. Castiel, J. Derouineau, M. Eliaszewicz, G. Gonzalez, D. Jayle, M. Karmochkine, P. Kousignian, J. Pavie, I. Pierre, L. Weiss), Hôpital Lariboisière (E. Badsi, M. Bendenoun, J. Cervoni, M. Diemer, A. Durel, A. Rami, P. Sellier), Hôpital Pitié-Salpêtrière (H. Ait-Mohand, N. Amirat, M. Bonmarchand, F. Bourdillon, G. Breton, F. Caby, J.P. Grivois, C. Katlama, M. Kirstetter, L. Paris, F. Pichon, L. Roudière, L. Schneider, M.C. Samba, S. Seang, A. Simon, H. Stitou, R. Tubiana, M.A. Valantin), Hôpital Saint-Antoine (D. Bollens, J. Bottero, E. Bui, P. Campa, L. Fonquernie, S. Fournier, P.M. Girard, A. Goetschel, H.F. Guyon, K. Lacombe, F. Lallemand, B. Lefebvre, J.L. Maynard, M.C. Meyohas, Z. Ouazene, J. Pacanowski, O. Picard, G. Raguin, P. Roussard, M. Tourneur, J. Tredup, N. Valin); Hôpital Saint-Louis (S. Balkan, F. Clavel, N. Colin de Verdière, N. De Castro, V. de Lastours, S. Ferret, S. Gallien, V. Garrait, L. Gérard, J. Goguel, M. Lafaurie, C. Lascoux-Combe, J.M. Molina, E. Oksenhendler, J. Pavie, C. Pintado, D. Ponscarme, W. Rozenbaum, A. Scemla), Hôpital Tenon (P. Bonnard, L. Lassel, M.G. Lebrette, T. Lyavanc, P. Mariot, R. Missonnier, M. Ohayon, G. Pialoux, M.P. Treilhou, J.P. Vincensini); Hôtel-Dieu (J. Gilquin, B. Hadacek, L. Nait-Ighil, T.H. Nguyen, C. Pintado, A. Sobel, J.P. Viard, O. Zak Dit Zbar); Perpignan, Hôpital Saint-Jean (H. Aumaître, A. Eden, M. Ferreyra, F. Lopez, M. Medus, S. Neuville, M. Saada); Pontoise, CH René Dubos (L. Blum); Quimper, Hôpital Laennec (P. Perfezou); Rennes, Hôpital de Pontchaillou (C. Arvieux, J.M. Chapplain, M. Revest, F. Souala, P. Tattevin); Rouen, Hôpital Charles-Nicolle (S. Bord, F. Borsa-Lebas, F. Caron, C. Chapuzet, Y. Debab, I. Gueit, M. Etienne, C. Fartoukh, K. Feltgen, C. Joly, S. Robaday-Voisin, P. Suel); Saint-Denis, CH Delafontaine (M.A. Khuong, J. Krausse, M. Poupard, G. Tran Van); Saint-Étienne, CHU Nord (C. Cazorla, F. Daoud, P. Fascia, A. Frésard, C. Guglielminotti, F. Lucht); Strasbourg, Nouvel hôpital civil (C. Bernard-Henry, C. Cheneau, J.M. Lang, E. de Mautort, M. P artisani, M. Priester, D. Rey); Suresnes, Hôpital Foch (C. Majerholc, D. Zucman); Toulon, CHI Chalucet (A. Assi, A. Lafeuillade), Hôpital Sainte-Anne (J.P. de Jaureguiberry, O. Gisserot); Toulouse, Hôpital de La Grave (C. Aquilina, F. Prevoteau du Clary), Hôpital Purpan (M. Alvarez, M. Chauveau, L. Cuzin, P. Delobel, D. Garipuy, E. Labau, B. Marchou, P. Massip, M. Mularczyk, M. Obadia); Tourcoing, CH Gustave Dron (F. Ajana, C. Allienne, V. Baclet, X. de la Tribonnière, T. Huleux, H. Melliez, A. Meybeck, B. Riff, M. Valette, N. Viget); Tours, CHRU Bretonneau (F. Bastides, L. Bernard, G. Gras, P. Guadagnin); Vandoeuvre-lès-Nancy, CHU Brabois (T. May, C. Rabaud); Vannes, CH Bretagne Atlantique (A. Dos Santos, Y. P oinsignon); Villejuif, Hôpital Paul-Brousse, (O. Derradji, L. Escaut, E. Teicher, D. Vittecoq); CHI de Villeneuve-Saint-Georges, (J. Bantsima, P. Caraux-Paz, O. Patey).</p></sec><sec sec-type="supplementary-material" id="sec019"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pone.0165634.s001"><label>S1 File</label><caption><title>Supplementary Tables.</title><p>(DOCX)</p></caption><media xlink:href="pone.0165634.s001.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0165634.s002"><label>S2 File</label><caption><title>Translation of survey questions used to define the employment situation from the ANRS-Vespa1 and ANRS-Vespa2 questionnaires.</title><p>(DOCX)</p></caption><media xlink:href="pone.0165634.s002.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0165634.s003"><label>S3 File</label><caption><title>Full ANRS-Vespa1 questionnaire (in French).</title><p>(PDF)</p></caption><media xlink:href="pone.0165634.s003.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0165634.s004"><label>S4 File</label><caption><title>Full ANRS-Vespa2 questionnaire (in French).</title><p>(PDF)</p></caption><media xlink:href="pone.0165634.s004.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ack><p>The authors are deeply grateful to people living with HIV who agreed to participate in the ANRS-Vespa2 study and to all investigators in participating hospitals.</p><p>They also thank Yann Le Strat (InVS, Saint-Maurice), Lise Cuzin (Hopital Purpan, Toulouse) and Laurence Meyer (INSERM UMR-S 1018,Le Kremlin Bicêtre) for their methodological support; 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