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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Estimating cause of adult (15+ years) death using InterVA-4 in a rural district of southern Ghana</title><author><name sortKey="Awini, Elizabeth" sort="Awini, Elizabeth" uniqKey="Awini E" first="Elizabeth" last="Awini">Elizabeth Awini</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Sarpong, Doris" sort="Sarpong, Doris" uniqKey="Sarpong D" first="Doris" last="Sarpong">Doris Sarpong</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Adjei, Alexander" sort="Adjei, Alexander" uniqKey="Adjei A" first="Alexander" last="Adjei">Alexander Adjei</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Manyeh, Alfred Kwesi" sort="Manyeh, Alfred Kwesi" uniqKey="Manyeh A" first="Alfred Kwesi" last="Manyeh">Alfred Kwesi Manyeh</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Amu, Alberta" sort="Amu, Alberta" uniqKey="Amu A" first="Alberta" last="Amu">Alberta Amu</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Akweongo, Patricia" sort="Akweongo, Patricia" uniqKey="Akweongo P" first="Patricia" last="Akweongo">Patricia Akweongo</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Adongo, Philip" sort="Adongo, Philip" uniqKey="Adongo P" first="Philip" last="Adongo">Philip Adongo</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Kukula, Vida" sort="Kukula, Vida" uniqKey="Kukula V" first="Vida" last="Kukula">Vida Kukula</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Odonkor, Gabriel" sort="Odonkor, Gabriel" uniqKey="Odonkor G" first="Gabriel" last="Odonkor">Gabriel Odonkor</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Narh, Solomon" sort="Narh, Solomon" uniqKey="Narh S" first="Solomon" last="Narh">Solomon Narh</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Gyapong, Margaret" sort="Gyapong, Margaret" uniqKey="Gyapong M" first="Margaret" last="Gyapong">Margaret Gyapong</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25377337</idno><idno type="pmc">4220134</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220134</idno><idno type="RBID">PMC:4220134</idno><idno type="doi">10.3402/gha.v7.25543</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002406</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Estimating cause of adult (15+ years) death using InterVA-4 in a rural district of southern Ghana</title><author><name sortKey="Awini, Elizabeth" sort="Awini, Elizabeth" uniqKey="Awini E" first="Elizabeth" last="Awini">Elizabeth Awini</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Sarpong, Doris" sort="Sarpong, Doris" uniqKey="Sarpong D" first="Doris" last="Sarpong">Doris Sarpong</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Adjei, Alexander" sort="Adjei, Alexander" uniqKey="Adjei A" first="Alexander" last="Adjei">Alexander Adjei</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Manyeh, Alfred Kwesi" sort="Manyeh, Alfred Kwesi" uniqKey="Manyeh A" first="Alfred Kwesi" last="Manyeh">Alfred Kwesi Manyeh</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Amu, Alberta" sort="Amu, Alberta" uniqKey="Amu A" first="Alberta" last="Amu">Alberta Amu</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Akweongo, Patricia" sort="Akweongo, Patricia" uniqKey="Akweongo P" first="Patricia" last="Akweongo">Patricia Akweongo</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Adongo, Philip" sort="Adongo, Philip" uniqKey="Adongo P" first="Philip" last="Adongo">Philip Adongo</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Kukula, Vida" sort="Kukula, Vida" uniqKey="Kukula V" first="Vida" last="Kukula">Vida Kukula</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">INDEPTH Network, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Odonkor, Gabriel" sort="Odonkor, Gabriel" uniqKey="Odonkor G" first="Gabriel" last="Odonkor">Gabriel Odonkor</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Narh, Solomon" sort="Narh, Solomon" uniqKey="Narh S" first="Solomon" last="Narh">Solomon Narh</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Gyapong, Margaret" sort="Gyapong, Margaret" uniqKey="Gyapong M" first="Margaret" last="Gyapong">Margaret Gyapong</name><affiliation><nlm:aff id="AF0001">Dodowa Health Research Centre, Dodowa, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">School of Public Health, University of Ghana, Accra, Ghana</nlm:aff></affiliation></author></analytic><series><title level="j">Global Health Action</title><idno type="ISSN">1654-9716</idno><idno type="eISSN">1654-9880</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background</title><p>Data needed to estimate causes of death and the pattern of these deaths are scarce in sub-Saharan Africa. Such data are very important for targeting, monitoring, and evaluating health interventions.</p></sec><sec id="st2"><title>Objective</title><p>To estimate the mortality rate and determine causes of death among adults (aged 15 years and older) in a rural district of southern Ghana, using the InterVA-4 model.</p></sec><sec id="st3"><title>Design</title><p>Data used were generated from verbal autopsies conducted for registered adult members of the Dodowa Health and Demographic Surveillance System who died between 2006 and 2010. The InterVA-4 model was used to assign the cause of death.</p></sec><sec id="st4"><title>Results</title><p>Overall, the mortality rate for the period under review was 7.5/1,000 person-years (py) for the general population and 10.4/1,000 py for those aged 15 and older. The leading cause of death was communicable diseases (CDs), with a malaria-specific mortality rate of 1.06/1,000 py. Pulmonary tuberculosis (TB)-specific mortality rate was the next highest (1.01/1,000 py). HIV/AIDS attributed deaths were lower among males than females. Non-communicable diseases (NCDs) contributed to 28.3% of the deaths with cause-specific mortality rate of 2.93/1,000 py. Stroke topped the list with cause-specific mortality rate of 0.69/1,000 py. As expected, young males (15–49 years) contributed to more road traffic accident (RTA) deaths; they had a lower RTA cause-specific mortality rate than older males (50–64 years).</p></sec><sec id="st5"><title>Conclusions</title><p>Data indicate that CDs (e.g. malaria and TB) remain the major cause of death with NCDs (e.g. stroke) following closely behind. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Glob Health Action</journal-id><journal-id journal-id-type="iso-abbrev">Glob Health Action</journal-id><journal-id journal-id-type="publisher-id">GHA</journal-id><journal-title-group><journal-title>Global Health Action</journal-title></journal-title-group><issn pub-type="ppub">1654-9716</issn><issn pub-type="epub">1654-9880</issn><publisher><publisher-name>Co-Action Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25377337</article-id><article-id pub-id-type="pmc">4220134</article-id><article-id pub-id-type="publisher-id">25543</article-id><article-id pub-id-type="doi">10.3402/gha.v7.25543</article-id><article-categories><subj-group subj-group-type="heading"><subject>Indepth Network Cause-Specific Mortality</subject></subj-group></article-categories><title-group><article-title>Estimating cause of adult (15+ years) death using InterVA-4 in a rural district of southern Ghana</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Awini</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref><xref ref-type="aff" rid="AF0003">3</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Sarpong</surname><given-names>Doris</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Adjei</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Manyeh</surname><given-names>Alfred Kwesi</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Amu</surname><given-names>Alberta</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Akweongo</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Adongo</surname><given-names>Philip</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Kukula</surname><given-names>Vida</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Odonkor</surname><given-names>Gabriel</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Narh</surname><given-names>Solomon</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Gyapong</surname><given-names>Margaret</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Dodowa Health Research Centre, Dodowa, Ghana</aff><aff id="AF0002"><label>2</label>School of Public Health, University of Ghana, Accra, Ghana</aff><aff id="AF0003"><label>3</label>INDEPTH Network, Accra, Ghana</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Elizabeth Awini, Dodowa Health Research Centre, Box DD1 Dodowa, Accra, Ghana, Email: <email xlink:href="awini.elizabeth@gmail.com">awini.elizabeth@gmail.com</email></corresp><fn><p>Responsible Editors: Heiko Becher, University of Hamburg, Germany; Nawi Ng, Umeå University, Sweden.</p></fn></author-notes><pub-date pub-type="epub"><day>29</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>7</volume><elocation-id content-type="doi">10.3402/gha.v7.25543</elocation-id><history><date date-type="received"><day>24</day><month>7</month><year>2014</year></date><date date-type="rev-recd"><day>12</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 Elizabeth Awini et al.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background</title><p>Data needed to estimate causes of death and the pattern of these deaths are scarce in sub-Saharan Africa. Such data are very important for targeting, monitoring, and evaluating health interventions.</p></sec><sec id="st2"><title>Objective</title><p>To estimate the mortality rate and determine causes of death among adults (aged 15 years and older) in a rural district of southern Ghana, using the InterVA-4 model.</p></sec><sec id="st3"><title>Design</title><p>Data used were generated from verbal autopsies conducted for registered adult members of the Dodowa Health and Demographic Surveillance System who died between 2006 and 2010. The InterVA-4 model was used to assign the cause of death.</p></sec><sec id="st4"><title>Results</title><p>Overall, the mortality rate for the period under review was 7.5/1,000 person-years (py) for the general population and 10.4/1,000 py for those aged 15 and older. The leading cause of death was communicable diseases (CDs), with a malaria-specific mortality rate of 1.06/1,000 py. Pulmonary tuberculosis (TB)-specific mortality rate was the next highest (1.01/1,000 py). HIV/AIDS attributed deaths were lower among males than females. Non-communicable diseases (NCDs) contributed to 28.3% of the deaths with cause-specific mortality rate of 2.93/1,000 py. Stroke topped the list with cause-specific mortality rate of 0.69/1,000 py. As expected, young males (15–49 years) contributed to more road traffic accident (RTA) deaths; they had a lower RTA cause-specific mortality rate than older males (50–64 years).</p></sec><sec id="st5"><title>Conclusions</title><p>Data indicate that CDs (e.g. malaria and TB) remain the major cause of death with NCDs (e.g. stroke) following closely behind. Verbal autopsy data can provide the causes of mortality in poorly resourced settings where access to timely and accurate data is scarce.</p></sec></abstract><kwd-group><kwd>adults</kwd><kwd>cause of death</kwd><kwd>verbal autopsy</kwd><kwd>InterVA-4</kwd><kwd>Health and Demographic Surveillance System</kwd><kwd>Dodowa</kwd><kwd>Ghana</kwd></kwd-group></article-meta><notes><fn-group><fn><p>This paper is part of the Special Issue: <italic>INDEPTH Network Cause-Specific Mortality</italic>. More papers from this issue can be found at <ext-link ext-link-type="uri" xlink:href="http://www.globalhealthaction.net/index.php/gha/issue/view/1602#INDEPTH%20Network%20Cause-Specific%20Mortality">http://www.globalhealthaction.net</ext-link></p></fn></fn-group></notes></front><body><p>The ability to have a healthy long life is an essential part of development. Survival can, thus, be said to be a measure of a country's development (<xref rid="CIT0001" ref-type="bibr">1</xref>). For interventions to be effectively implemented and tailored to the right people, it is important for policy makers and planners to be aware of what causes diseases and death among the population they serve, hence the need for accurate and timely data (<xref rid="CIT0002" ref-type="bibr">2</xref>). This will help in prioritizing interventions, using the most appropriate strategies for their delivery, and monitoring of their effectiveness (<xref rid="CIT0003" ref-type="bibr">3</xref>). Data for the estimation of causes of death and the pattern of these deaths are scarce in sub-Sahara Africa (SSA) (<xref rid="CIT0004" ref-type="bibr">4</xref>) unlike the developed countries where vital registration systems are well-developed and medical certifications of death are available (<xref rid="CIT0005" ref-type="bibr">5</xref>).</p><p>Studies have shown that conducting verbal autopsy (VA) is the best available approach in obtaining empirical information on the cause of many deaths in settings with poor or no routine death certification (<xref rid="CIT0005" ref-type="bibr">5</xref>, <xref rid="CIT0006" ref-type="bibr">6</xref>). The conducting of VA for community-reported death is a common practice among sites belonging to the International Network for Demographic Evaluation of Population and Their Health (INDEPTH) Network (<xref rid="CIT0007" ref-type="bibr">7</xref>, <xref rid="CIT0008" ref-type="bibr">8</xref>). VA is the process used to obtain information on the cause of death by interviewing close relatives or primary caregivers on the signs and symptoms experienced by the deceased and the sequence of events that led to the death of their relative (<xref rid="CIT0006" ref-type="bibr">6</xref>, <xref rid="CIT0009" ref-type="bibr">9</xref>).</p><p>The idea of VAs started in 1956 when WHO encouraged lay reporting of health information and a lay reporting form was developed. Diversity in the use of VA instruments demanded standardization; hence, in 2007 WHO standardized the VA form for use (<xref rid="CIT0010" ref-type="bibr">10</xref>). A detailed review of the process involved in the development of VA tools exists (<xref rid="CIT0011" ref-type="bibr">11</xref>). Traditionally, VAs are coded independently by at least two physicians to determine the cause of death. This has been demanding for sites in low- and middle-income countries where there is a lack of physicians to do clinical work, let alone code VAs. This creates huge backlogs of VAs that require coding. In fact, physician coding has been found to be an expensive and slow process (<xref rid="CIT0009" ref-type="bibr">9</xref>). Besides, physician's reliability and repeatability of interpreting the VAs has been questioned (<xref rid="CIT0012" ref-type="bibr">12</xref>). It is in this light that a probabilistic model has been developed to interpret VAs (InterVA) for the determination of causes of death (<xref rid="CIT0009" ref-type="bibr">9</xref>).</p><p>This model has been tested on data from both demographic surveillance sites and hospital records as well as in a number of studies and has been refined based on previous InterVA models (<xref rid="CIT0005" ref-type="bibr">5</xref>, <xref rid="CIT0009" ref-type="bibr">9</xref>, <xref rid="CIT0012" ref-type="bibr">12</xref>, <xref rid="CIT0013" ref-type="bibr">13</xref>). The revised InterVA-4 brings on a new standard of interpreting VA that fits into the WHO VA instrument in terms of cause of death categories and input indicators (<xref rid="CIT0014" ref-type="bibr">14</xref>). This new tool was used on the Dodowa Health and Demographic Surveillance System (DHDSS) data to estimate causes of deaths of those aged 15 and older for 2006–2010.</p><p>This paper therefore focuses on estimating the mortality rate and determining the causes of death among the adult population (15 years and older) in a rural district of southern Ghana using the revised InterVA-4 model.</p><sec sec-type="methods" id="S0002"><title>Methods</title><sec id="S0002-S20001"><title>Study area</title><p>The study area is the DHDSS site. The DHDSS operates within the boundaries of the former Dangme West District (now the Shai-Osudoku and Ningo-Prampram districts); one of the ten districts within the Greater Accra Region of Ghana located in the southeastern part of Ghana, lying between latitude 5°45′ S and 6°05′ N and longitude 0°05′ E and 0°20′ W. The district covers about 41.5% (1528.9/km<sup>2</sup>) of the total land size within the region. It is about 40.8 km from the national capital of Ghana, Accra.</p><p>The site conducted its baseline survey in 2005. By the end of 2010, there were 22,767 households with 111,976 residents under surveillance. Persons younger than age 15 formed 40.5% of the population, which is similar to other developing countries (<xref rid="CIT0015" ref-type="bibr">15</xref>) with children younger than 5 years accounting for 15.2%. There were 87 males to every 100 females. Households headed by females constituted 39.1%. The district is fairly rural and the inhabitants are mainly fishermen, petty traders, and artisans, with a handful of civil servants. Detailed description of the study area is available elsewhere (<xref rid="CIT0016" ref-type="bibr">16</xref>). In total, 21 static health facilities delivered services in the district. Many inhabitants live more than 5 km away from government health facilities (<xref rid="CIT0017" ref-type="bibr">17</xref>). Malaria, diarrhea, Acute Respiratory Infection (ARI), hypertension, and skin diseases are the top five most common diseases seen at the outpatient departments in the district, with malaria ranking first (<xref rid="CIT0018" ref-type="bibr">18</xref>). Malaria prevalence in the district was estimated at about 7% in 2011 (<xref rid="CIT0019" ref-type="bibr">19</xref>). The national HIV/AIDS level was 2.0% in 2010, but that of the Greater Accra region was 2.6% (<xref rid="CIT0020" ref-type="bibr">20</xref>).</p></sec><sec id="S0002-S20002"><title>Death registration and VA procedures</title><p>The DHDSS collects vital statistics from all households in its Demographic Surveillance Area (DSA). Between 2006 and 2010, households were visited every 6 months and events such as pregnancies, births, deaths, and migration was registered. Community key informants (CKIs) were trained to pick the events in their communities to supplement those collected by the fieldworkers. Deaths of registered household members picked by fieldworkers and CKIs were followed up by trained field supervisors who conducted VAs using standard VA questionnaires, which are in three categories: neonatal (0–27 days), children (28 days to below 12 years), and adult (12 years and above). Once an interview was completed, VA forms were returned to the field office of the HDSS for cross checking of inconsistencies and blanks.</p></sec><sec id="S0002-S20003"><title>The InterVA model</title><p>The InterVA-4 model version 4.02 which was used to estimate the cause of death for this paper is computer-based, and uses the Bayes’ theorem, in an attempt to overcome the longstanding limitations of alternative methods (<xref rid="CIT0001" ref-type="bibr">1</xref>, <xref rid="CIT0004" ref-type="bibr">4</xref>, <xref rid="CIT0006" ref-type="bibr">6</xref>), such as physicians coding. To use this model, there is the need to categorize the local conditions of malaria and HIV into ‘high’ or ‘low’ (<xref rid="CIT0009" ref-type="bibr">9</xref>). Because malaria is persistently number one on the list of top 10 diseases in the study area (<xref rid="CIT0019" ref-type="bibr">19</xref>), malaria was categorized as ‘high’ and HIV as ‘low’ in this analysis. More information on the development of this probabilistic model and its robustness are available elsewhere (<xref rid="CIT0009" ref-type="bibr">9</xref>, <xref rid="CIT0022" ref-type="bibr">22</xref>). InterVA-4 generates up to three probable causes of death for each case with their assigned likelihoods or indeterminate result. If the sum of the three likelihoods is less than 1, then the residual component is assigned as indeterminate. For cases in which the information is limited or inconsistent, that case is assigned indeterminate with a likelihood of 1. Registered deaths without VAs were assigned as ‘VA not completed’. This group was, however, added to the indeterminate during analysis. The InterVA-4 model was applied to the dataset using the methods previously described (<xref rid="CIT0014" ref-type="bibr">14</xref>) and as described in detail in the introductory paper of this issue (<xref rid="CIT0023" ref-type="bibr">23</xref>).</p></sec></sec><sec sec-type="results" id="S0003"><title>Results</title><sec id="S0003-S20001"><title>General trends in mortality between 2006 and 2010</title><p>Between 2006 and 2010, 3,988 deaths were registered with the DSA. Of these, 3,005 had a VA completed. In total, 3,324 of the registered deaths were aged 15 and older, and of those, 2,547 had a VA completed (76.7%). Among the 15 years and older, 1,158 deaths did not have their causes determined. Of these, 777 did not have VA completed, whereas for 381 of them, InterVA-4 could not assign any cause.</p><p>The overall mortality rate for the period was 7.5/1,000 person-years (py) whereas that of 15 years and older was 10.4/1,000 py. The crude mortality rate declined from 9.8/1,000 in 2006 to 6.6/1,000 py in 2010 (data not shown).</p><p><xref ref-type="table" rid="T0001">Table 1</xref> presents the number of deaths, person-time observed, and the trends in mortality between 2006 and 2010. Mortality rates consistently declined for the age groups 15–49 and 65 years and older for the 5-year period. Males generally had higher mortality rates than females.</p><table-wrap id="T0001" position="float"><label>Table 1</label><caption><p>Number of deaths, person-time observed, and mortality rates by sex, age, and year 2010</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="3" rowspan="1">15–49 years</th><th align="center" colspan="3" rowspan="1">50–64 years</th><th align="center" colspan="3" rowspan="1">65+ years</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="3" rowspan="1"><hr></hr></th><th align="center" colspan="3" rowspan="1"><hr></hr></th><th align="center" colspan="3" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">Person year</th><th align="center" rowspan="1" colspan="1">Deaths</th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th><th align="center" rowspan="1" colspan="1">Person year</th><th align="center" rowspan="1" colspan="1">Deaths</th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th><th align="center" rowspan="1" colspan="1">Person year</th><th align="center" rowspan="1" colspan="1">Deaths</th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">20,462</td><td align="center" rowspan="1" colspan="1">124</td><td align="center" rowspan="1" colspan="1">6.06</td><td align="center" rowspan="1" colspan="1">2,771</td><td align="center" rowspan="1" colspan="1">75</td><td align="center" rowspan="1" colspan="1">27.07</td><td align="center" rowspan="1" colspan="1">1,848</td><td align="center" rowspan="1" colspan="1">153</td><td align="center" rowspan="1" colspan="1">82.80</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">24,327</td><td align="center" rowspan="1" colspan="1">153</td><td align="center" rowspan="1" colspan="1">6.29</td><td align="center" rowspan="1" colspan="1">3,737</td><td align="center" rowspan="1" colspan="1">66</td><td align="center" rowspan="1" colspan="1">17.66</td><td align="center" rowspan="1" colspan="1">3,389</td><td align="center" rowspan="1" colspan="1">207</td><td align="center" rowspan="1" colspan="1">61.08</td></tr><tr><td align="left" rowspan="1" colspan="1"> Total</td><td align="center" rowspan="1" colspan="1">44,789</td><td align="center" rowspan="1" colspan="1">277</td><td align="center" rowspan="1" colspan="1">6.18</td><td align="center" rowspan="1" colspan="1">6,508</td><td align="center" rowspan="1" colspan="1">141</td><td align="center" rowspan="1" colspan="1">21.67</td><td align="center" rowspan="1" colspan="1">5,237</td><td align="center" rowspan="1" colspan="1">360</td><td align="center" rowspan="1" colspan="1">68.74</td></tr><tr><td align="left" rowspan="1" colspan="1">2007</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">22,096</td><td align="center" rowspan="1" colspan="1">124</td><td align="center" rowspan="1" colspan="1">5.61</td><td align="center" rowspan="1" colspan="1">3,004</td><td align="center" rowspan="1" colspan="1">50</td><td align="center" rowspan="1" colspan="1">16.64</td><td align="center" rowspan="1" colspan="1">1,879</td><td align="center" rowspan="1" colspan="1">128</td><td align="center" rowspan="1" colspan="1">68.13</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">26,635</td><td align="center" rowspan="1" colspan="1">130</td><td align="center" rowspan="1" colspan="1">4.88</td><td align="center" rowspan="1" colspan="1">4,015</td><td align="center" rowspan="1" colspan="1">57</td><td align="center" rowspan="1" colspan="1">14.20</td><td align="center" rowspan="1" colspan="1">3,471</td><td align="center" rowspan="1" colspan="1">162</td><td align="center" rowspan="1" colspan="1">46.68</td></tr><tr><td align="left" rowspan="1" colspan="1"> Total</td><td align="center" rowspan="1" colspan="1">48,731</td><td align="center" rowspan="1" colspan="1">254</td><td align="center" rowspan="1" colspan="1">5.21</td><td align="center" rowspan="1" colspan="1">7,019</td><td align="center" rowspan="1" colspan="1">107</td><td align="center" rowspan="1" colspan="1">15.24</td><td align="center" rowspan="1" colspan="1">5,349</td><td align="center" rowspan="1" colspan="1">290</td><td align="center" rowspan="1" colspan="1">54.21</td></tr><tr><td align="left" rowspan="1" colspan="1">2008</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">23,876</td><td align="center" rowspan="1" colspan="1">117</td><td align="center" rowspan="1" colspan="1">4.90</td><td align="center" rowspan="1" colspan="1">3,232</td><td align="center" rowspan="1" colspan="1">63</td><td align="center" rowspan="1" colspan="1">19.49</td><td align="center" rowspan="1" colspan="1">1,933</td><td align="center" rowspan="1" colspan="1">106</td><td align="center" rowspan="1" colspan="1">54.83</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">28,956</td><td align="center" rowspan="1" colspan="1">124</td><td align="center" rowspan="1" colspan="1">4.28</td><td align="center" rowspan="1" colspan="1">4,311</td><td align="center" rowspan="1" colspan="1">63</td><td align="center" rowspan="1" colspan="1">14.61</td><td align="center" rowspan="1" colspan="1">3,576</td><td align="center" rowspan="1" colspan="1">184</td><td align="center" rowspan="1" colspan="1">51.45</td></tr><tr><td align="left" rowspan="1" colspan="1"> Total</td><td align="center" rowspan="1" colspan="1">52,832</td><td align="center" rowspan="1" colspan="1">241</td><td align="center" rowspan="1" colspan="1">4.56</td><td align="center" rowspan="1" colspan="1">7,543</td><td align="center" rowspan="1" colspan="1">126</td><td align="center" rowspan="1" colspan="1">16.70</td><td align="center" rowspan="1" colspan="1">5,509</td><td align="center" rowspan="1" colspan="1">290</td><td align="center" rowspan="1" colspan="1">52.64</td></tr><tr><td align="left" rowspan="1" colspan="1">2009</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">24,310</td><td align="center" rowspan="1" colspan="1">102</td><td align="center" rowspan="1" colspan="1">4.20</td><td align="center" rowspan="1" colspan="1">3,299</td><td align="center" rowspan="1" colspan="1">62</td><td align="center" rowspan="1" colspan="1">18.80</td><td align="center" rowspan="1" colspan="1">1,921</td><td align="center" rowspan="1" colspan="1">107</td><td align="center" rowspan="1" colspan="1">55.69</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">29,668</td><td align="center" rowspan="1" colspan="1">129</td><td align="center" rowspan="1" colspan="1">4.35</td><td align="center" rowspan="1" colspan="1">4,397</td><td align="center" rowspan="1" colspan="1">57</td><td align="center" rowspan="1" colspan="1">12.96</td><td align="center" rowspan="1" colspan="1">3,580</td><td align="center" rowspan="1" colspan="1">170</td><td align="center" rowspan="1" colspan="1">47.48</td></tr><tr><td align="left" rowspan="1" colspan="1"> Total</td><td align="center" rowspan="1" colspan="1">53,978</td><td align="center" rowspan="1" colspan="1">231</td><td align="center" rowspan="1" colspan="1">4.28</td><td align="center" rowspan="1" colspan="1">7,696</td><td align="center" rowspan="1" colspan="1">119</td><td align="center" rowspan="1" colspan="1">15.46</td><td align="center" rowspan="1" colspan="1">5,502</td><td align="center" rowspan="1" colspan="1">277</td><td align="center" rowspan="1" colspan="1">50.35</td></tr><tr><td align="left" rowspan="1" colspan="1">2010</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">24,859</td><td align="center" rowspan="1" colspan="1">87</td><td align="center" rowspan="1" colspan="1">3.50</td><td align="center" rowspan="1" colspan="1">3,516</td><td align="center" rowspan="1" colspan="1">76</td><td align="center" rowspan="1" colspan="1">21.61</td><td align="center" rowspan="1" colspan="1">1,986</td><td align="center" rowspan="1" colspan="1">105</td><td align="center" rowspan="1" colspan="1">52.86</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">30,488</td><td align="center" rowspan="1" colspan="1">111</td><td align="center" rowspan="1" colspan="1">3.64</td><td align="center" rowspan="1" colspan="1">4,719</td><td align="center" rowspan="1" colspan="1">65</td><td align="center" rowspan="1" colspan="1">13.78</td><td align="center" rowspan="1" colspan="1">3,644</td><td align="center" rowspan="1" colspan="1">167</td><td align="center" rowspan="1" colspan="1">45.83</td></tr><tr><td align="left" rowspan="1" colspan="1"> Total</td><td align="center" rowspan="1" colspan="1">55,346</td><td align="center" rowspan="1" colspan="1">198</td><td align="center" rowspan="1" colspan="1">3.58</td><td align="center" rowspan="1" colspan="1">8,235</td><td align="center" rowspan="1" colspan="1">141</td><td align="center" rowspan="1" colspan="1">17.12</td><td align="center" rowspan="1" colspan="1">5,631</td><td align="center" rowspan="1" colspan="1">272</td><td align="center" rowspan="1" colspan="1">48.31</td></tr></tbody></table></table-wrap></sec><sec id="S0003-S20002"><title>Cause-specific mortality as determined by InterVA-4</title><p>Malaria was found to be the leading cause of death with a cause-specific mortality rate of 1.06/1,000 py, followed by pulmonary tuberculosis (TB), with 1.01/1,000 py. Cause-specific mortality rate for stroke was 0.69/1,000 py, whereas that of ARIs and digestive neoplasms were 0.54/1,000 py and 0.47/1,000 py, respectively. The cause-specific mortality rates for acute cardiac diseases and acute abdomen were 0.46/1,000 py and 0.44/1,000 py, respectively (<xref ref-type="table" rid="T0002">Table 2</xref>).</p><table-wrap id="T0002" position="float"><label>Table 2</label><caption><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Cause of death</th><th align="center" rowspan="1" colspan="1">Deaths<xref ref-type="table-fn" rid="TF0001">*</xref></th><th align="center" rowspan="1" colspan="1">CSMFs (%)</th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Malaria</td><td align="center" rowspan="1" colspan="1">339</td><td align="center" rowspan="1" colspan="1">10.21</td><td align="center" rowspan="1" colspan="1">1.06</td></tr><tr><td align="left" rowspan="1" colspan="1">Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">322</td><td align="center" rowspan="1" colspan="1">9.7</td><td align="center" rowspan="1" colspan="1">1.01</td></tr><tr><td align="left" rowspan="1" colspan="1">Stroke</td><td align="center" rowspan="1" colspan="1">220</td><td align="center" rowspan="1" colspan="1">6.62</td><td align="center" rowspan="1" colspan="1">0.69</td></tr><tr><td align="left" rowspan="1" colspan="1">ARIs</td><td align="center" rowspan="1" colspan="1">174</td><td align="center" rowspan="1" colspan="1">5.22</td><td align="center" rowspan="1" colspan="1">0.54</td></tr><tr><td align="left" rowspan="1" colspan="1">Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">150</td><td align="center" rowspan="1" colspan="1">4.52</td><td align="center" rowspan="1" colspan="1">0.47</td></tr><tr><td align="left" rowspan="1" colspan="1">Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">146</td><td align="center" rowspan="1" colspan="1">4.4</td><td align="center" rowspan="1" colspan="1">0.46</td></tr><tr><td align="left" rowspan="1" colspan="1">Acute abdomen</td><td align="center" rowspan="1" colspan="1">141</td><td align="center" rowspan="1" colspan="1">4.25</td><td align="center" rowspan="1" colspan="1">0.44</td></tr><tr><td align="left" rowspan="1" colspan="1">Other and unspecified infect diseases</td><td align="center" rowspan="1" colspan="1">120</td><td align="center" rowspan="1" colspan="1">3.61</td><td align="center" rowspan="1" colspan="1">0.38</td></tr><tr><td align="left" rowspan="1" colspan="1">Road traffic accident</td><td align="center" rowspan="1" colspan="1">70</td><td align="center" rowspan="1" colspan="1">2.11</td><td align="center" rowspan="1" colspan="1">0.22</td></tr><tr><td align="left" rowspan="1" colspan="1">Other and unspecified cardiac diseases</td><td align="center" rowspan="1" colspan="1">61</td><td align="center" rowspan="1" colspan="1">1.82</td><td align="center" rowspan="1" colspan="1">0.19</td></tr><tr><td align="left" rowspan="1" colspan="1">HIV/AIDS-related death</td><td align="center" rowspan="1" colspan="1">59</td><td align="center" rowspan="1" colspan="1">1.76</td><td align="center" rowspan="1" colspan="1">0.18</td></tr><tr><td align="left" rowspan="1" colspan="1">Other and unspecified neoplasms</td><td align="center" rowspan="1" colspan="1">38</td><td align="center" rowspan="1" colspan="1">1.14</td><td align="center" rowspan="1" colspan="1">0.12</td></tr><tr><td align="left" rowspan="1" colspan="1">Accidental fall</td><td align="center" rowspan="1" colspan="1">29</td><td align="center" rowspan="1" colspan="1">0.86</td><td align="center" rowspan="1" colspan="1">0.09</td></tr><tr><td align="left" rowspan="1" colspan="1">Respiratory neoplasms</td><td align="center" rowspan="1" colspan="1">26</td><td align="center" rowspan="1" colspan="1">0.78</td><td align="center" rowspan="1" colspan="1">0.08</td></tr><tr><td align="left" rowspan="1" colspan="1">Indeterminate</td><td align="center" rowspan="1" colspan="1">381</td><td align="center" rowspan="1" colspan="1">11.45</td><td align="center" rowspan="1" colspan="1">1.19</td></tr><tr><td align="left" rowspan="1" colspan="1">VA not completed</td><td align="center" rowspan="1" colspan="1">777</td><td align="center" rowspan="1" colspan="1">23.38</td><td align="center" rowspan="1" colspan="1">2.43</td></tr></tbody></table><table-wrap-foot><fn id="TF0001"><label>*</label><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number.</p></fn></table-wrap-foot></table-wrap></sec><sec id="S0003-S20003"><title>Causes of deaths and mortality rates for males and females aged 15 and above</title><p><xref ref-type="table" rid="T0003">Table 3</xref> shows the leading causes of deaths for males and females by mortality rates and age groups. TB was the first leading cause of death for males in all the age groups, whereas malaria was the leading cause of death in females within the 15–49 and 65 years and above age groups. However, mortality rate attributable to stroke was the leading cause of death for the females in the 50–64 years age group. Mortality rate due to deaths from road traffic accident (RTA) was higher in males than females. HIV/AIDs mortality rate was higher in females than in males. Unexpectedly, digestive neoplasms were among the leading causes of death. Males in the age group 50 years and above had higher mortality rates than females, whereas in the 15–49 years age group females had a higher mortality rate.</p><table-wrap id="T0003" position="float"><label>Table 3</label><caption><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1">Male</th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1">Female</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1"><hr></hr></th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Cause of deaths</th><th align="center" rowspan="1" colspan="1">Deaths<xref ref-type="table-fn" rid="TF0002">*</xref></th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th><th align="center" rowspan="1" colspan="1">Cause of deaths</th><th align="center" rowspan="1" colspan="1">Deaths<xref ref-type="table-fn" rid="TF0002">*</xref></th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">15–49 years</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">72</td><td align="center" rowspan="1" colspan="1">0.62</td><td align="left" rowspan="1" colspan="1">Malaria</td><td align="center" rowspan="1" colspan="1">103</td><td align="center" rowspan="1" colspan="1">0.74</td></tr><tr><td align="left" rowspan="1" colspan="1"> Malaria</td><td align="center" rowspan="1" colspan="1">51</td><td align="center" rowspan="1" colspan="1">0.45</td><td align="left" rowspan="1" colspan="1">Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">64</td><td align="center" rowspan="1" colspan="1">0.45</td></tr><tr><td align="left" rowspan="1" colspan="1"> Road traffic accident</td><td align="center" rowspan="1" colspan="1">36</td><td align="center" rowspan="1" colspan="1">0.31</td><td align="left" rowspan="1" colspan="1">HIV/AIDS-related death</td><td align="center" rowspan="1" colspan="1">32</td><td align="center" rowspan="1" colspan="1">0.23</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified infections</td><td align="center" rowspan="1" colspan="1">28</td><td align="center" rowspan="1" colspan="1">0.24</td><td align="left" rowspan="1" colspan="1">Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">26</td><td align="center" rowspan="1" colspan="1">0.18</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute abdomen</td><td align="center" rowspan="1" colspan="1">23</td><td align="center" rowspan="1" colspan="1">0.2</td><td align="left" rowspan="1" colspan="1">Acute abdomen</td><td align="center" rowspan="1" colspan="1">26</td><td align="center" rowspan="1" colspan="1">0.18</td></tr><tr><td align="left" rowspan="1" colspan="1"> ARIs</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">0.19</td><td align="left" rowspan="1" colspan="1">ARIs</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">0.18</td></tr><tr><td align="left" rowspan="1" colspan="1"> Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">0.14</td><td align="left" rowspan="1" colspan="1">Stroke</td><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">0.12</td></tr><tr><td align="left" rowspan="1" colspan="1"> Stroke</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">0.11</td><td align="left" rowspan="1" colspan="1">Other unspecified infections</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">0.10</td></tr><tr><td align="left" rowspan="1" colspan="1"> Accidental drowning</td><td align="center" rowspan="1" colspan="1">12</td><td align="center" rowspan="1" colspan="1">0.10</td><td align="left" rowspan="1" colspan="1">Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">0.10</td></tr><tr><td align="left" rowspan="1" colspan="1"> HIV/AIDS-related death</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">0.08</td><td align="left" rowspan="1" colspan="1">Obstetric hemorrhage</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">0.09</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">0.08</td><td align="left" rowspan="1" colspan="1">Road traffic accident</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">0.07</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">62</td><td align="center" rowspan="1" colspan="1">0.54</td><td align="left" rowspan="1" colspan="1">Indeterminate</td><td align="center" rowspan="1" colspan="1">71</td><td align="center" rowspan="1" colspan="1">0.5</td></tr><tr><td align="left" rowspan="1" colspan="1"> VA not completed</td><td align="center" rowspan="1" colspan="1">141</td><td align="center" rowspan="1" colspan="1">1.22</td><td align="left" rowspan="1" colspan="1">VA not completed</td><td align="center" rowspan="1" colspan="1">152</td><td align="center" rowspan="1" colspan="1">1.09</td></tr><tr><td align="left" rowspan="1" colspan="1">50–64 years</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">35</td><td align="center" rowspan="1" colspan="1">2.20</td><td align="left" rowspan="1" colspan="1">Stroke</td><td align="center" rowspan="1" colspan="1">30</td><td align="center" rowspan="1" colspan="1">1.42</td></tr><tr><td align="left" rowspan="1" colspan="1"> Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">26</td><td align="center" rowspan="1" colspan="1">1.62</td><td align="left" rowspan="1" colspan="1">Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">29</td><td align="center" rowspan="1" colspan="1">1.36</td></tr><tr><td align="left" rowspan="1" colspan="1"> ARIs</td><td align="center" rowspan="1" colspan="1">23</td><td align="center" rowspan="1" colspan="1">1.44</td><td align="left" rowspan="1" colspan="1">Malaria</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">1.18</td></tr><tr><td align="left" rowspan="1" colspan="1"> Stroke</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">1.42</td><td align="left" rowspan="1" colspan="1">Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">0.70</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">1.36</td><td align="left" rowspan="1" colspan="1">Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">0.70</td></tr><tr><td align="left" rowspan="1" colspan="1"> Malaria</td><td align="center" rowspan="1" colspan="1">21</td><td align="center" rowspan="1" colspan="1">1.32</td><td align="left" rowspan="1" colspan="1">Other unspecified infections</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">0.63</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified infections</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">0.93</td><td align="left" rowspan="1" colspan="1">ARIs</td><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">0.61</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute abdomen</td><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">0.86</td><td align="left" rowspan="1" colspan="1">HIV/AIDS-related death</td><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">0.41</td></tr><tr><td align="left" rowspan="1" colspan="1"> Road traffic accident</td><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">0.56</td><td align="left" rowspan="1" colspan="1">Acute abdomen</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">0.39</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified cardiac disease</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">0.43</td><td align="left" rowspan="1" colspan="1">Other unspecified cardiac disease</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">0.39</td></tr><tr><td align="left" rowspan="1" colspan="1"> HIV/AIDS-related death</td><td align="center" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">0.3</td><td align="left" rowspan="1" colspan="1">Road traffic accident</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">0.32</td></tr><tr><td align="left" rowspan="1" colspan="1"> Diabetes mellitus</td><td align="center" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">0.26</td><td align="left" rowspan="1" colspan="1">Severe anemia</td><td align="center" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">0.2</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">38</td><td align="center" rowspan="1" colspan="1">2.41</td><td align="left" rowspan="1" colspan="1">Indeterminate</td><td align="center" rowspan="1" colspan="1">28</td><td align="center" rowspan="1" colspan="1">1.32</td></tr><tr><td align="left" rowspan="1" colspan="1"> VA not completed</td><td align="center" rowspan="1" colspan="1">70</td><td align="center" rowspan="1" colspan="1">4.42</td><td align="left" rowspan="1" colspan="1">VA not completed</td><td align="center" rowspan="1" colspan="1">79</td><td align="center" rowspan="1" colspan="1">3.73</td></tr><tr><td align="left" rowspan="1" colspan="1">65+ years</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">59</td><td align="center" rowspan="1" colspan="1">6.17</td><td align="left" rowspan="1" colspan="1">Malaria</td><td align="center" rowspan="1" colspan="1">92</td><td align="center" rowspan="1" colspan="1">5.24</td></tr><tr><td align="left" rowspan="1" colspan="1"> Stroke</td><td align="center" rowspan="1" colspan="1">47</td><td align="center" rowspan="1" colspan="1">4.93</td><td align="left" rowspan="1" colspan="1">Stroke</td><td align="center" rowspan="1" colspan="1">90</td><td align="center" rowspan="1" colspan="1">5.09</td></tr><tr><td align="left" rowspan="1" colspan="1"> Malaria</td><td align="center" rowspan="1" colspan="1">46</td><td align="center" rowspan="1" colspan="1">4.83</td><td align="left" rowspan="1" colspan="1">Pulmonary tuberculosis</td><td align="center" rowspan="1" colspan="1">64</td><td align="center" rowspan="1" colspan="1">3.62</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">41</td><td align="center" rowspan="1" colspan="1">4.3</td><td align="left" rowspan="1" colspan="1">ARIs</td><td align="center" rowspan="1" colspan="1">53</td><td align="center" rowspan="1" colspan="1">3.00</td></tr><tr><td align="left" rowspan="1" colspan="1"> ARIs</td><td align="center" rowspan="1" colspan="1">39</td><td align="center" rowspan="1" colspan="1">4.03</td><td align="left" rowspan="1" colspan="1">Acute cardiac disease</td><td align="center" rowspan="1" colspan="1">46</td><td align="center" rowspan="1" colspan="1">2.60</td></tr><tr><td align="left" rowspan="1" colspan="1"> Acute abdomen</td><td align="center" rowspan="1" colspan="1">33</td><td align="center" rowspan="1" colspan="1">3.44</td><td align="left" rowspan="1" colspan="1">Acute abdomen</td><td align="center" rowspan="1" colspan="1">38</td><td align="center" rowspan="1" colspan="1">2.14</td></tr><tr><td align="left" rowspan="1" colspan="1"> Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">32</td><td align="center" rowspan="1" colspan="1">3.37</td><td align="left" rowspan="1" colspan="1">Digestive neoplasms</td><td align="center" rowspan="1" colspan="1">35</td><td align="center" rowspan="1" colspan="1">1.99</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified infections</td><td align="center" rowspan="1" colspan="1">21</td><td align="center" rowspan="1" colspan="1">2.24</td><td align="left" rowspan="1" colspan="1">Other unspecified infections</td><td align="center" rowspan="1" colspan="1">28</td><td align="center" rowspan="1" colspan="1">1.60</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified cardiac disease</td><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">1.48</td><td align="left" rowspan="1" colspan="1">Other unspecified cardiac disease</td><td align="center" rowspan="1" colspan="1">24</td><td align="center" rowspan="1" colspan="1">1.34</td></tr><tr><td align="left" rowspan="1" colspan="1"> Other unspecified neoplasms</td><td align="center" rowspan="1" colspan="1">11</td><td align="center" rowspan="1" colspan="1">1.18</td><td align="left" rowspan="1" colspan="1">Accidental fall</td><td align="center" rowspan="1" colspan="1">16</td><td align="center" rowspan="1" colspan="1">0.90</td></tr><tr><td align="left" rowspan="1" colspan="1"> Diabetes mellitus</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">0.78</td><td align="left" rowspan="1" colspan="1">Other unspecified neoplasms</td><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">0.84</td></tr><tr><td align="left" rowspan="1" colspan="1"> Asthma</td><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">0.62</td><td align="left" rowspan="1" colspan="1">Severe malnutrition</td><td align="center" rowspan="1" colspan="1">11</td><td align="center" rowspan="1" colspan="1">0.61</td></tr><tr><td align="left" rowspan="1" colspan="1"> Respiratory neoplasms</td><td align="center" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">0.56</td><td align="left" rowspan="1" colspan="1">Severe anemia</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">0.55</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">65</td><td align="center" rowspan="1" colspan="1">6.82</td><td align="left" rowspan="1" colspan="1">Indeterminate</td><td align="center" rowspan="1" colspan="1">116</td><td align="center" rowspan="1" colspan="1">6.59</td></tr><tr><td align="left" rowspan="1" colspan="1"> VA not completed</td><td align="center" rowspan="1" colspan="1">141</td><td align="center" rowspan="1" colspan="1">14.74</td><td align="left" rowspan="1" colspan="1">VA not completed</td><td align="center" rowspan="1" colspan="1">194</td><td align="center" rowspan="1" colspan="1">10.99</td></tr></tbody></table><table-wrap-foot><fn id="TF0002"><label>*</label><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number.</p></fn></table-wrap-foot></table-wrap></sec><sec id="S0003-S20004"><title>Distribution of causes of deaths by cause category</title><p>Considering cause categories, communicable diseases (CDs) were the leading causes of death, with a cause-specific mortality rate of 3.29/1,000 py. Non-communicable diseases (NCDs) (hypertension, stroke, acute cardiac disease, diabetes mellitus, severe anemia, sickle cell disease, chronic obstructive pulmonary disease, asthma, acute abdomen, liver cirrhosis, renal failure, epilepsy, neoplasm, severe malnutrition, other unspecified cardiac disease, and other unspecified NCD) had a mortality rate of 2.93/1,000 py. Trauma or injury-specific mortality rate was 0.47/1,000 py, whereas that of maternal-related causes was 0.08/1,000 py (data not shown).</p></sec><sec id="S0003-S20005"><title>Cause of death by cause group by sex</title><p>The mortality rates and the pattern of distribution of causes of death were virtually the same in both males and females except with trauma (<xref ref-type="fig" rid="F0001">Fig. 1</xref>). Mortality rate was highest in CDs, followed by NCDs, and then trauma. The rates of CDs (3.30/1,000 py) and NCDs (2.99/1,000 py) in females (3.28/1,000 py) were slightly higher than in males (2.86/1,000 py). Males had higher mortality rate from trauma (0.68/1,000 py) than females (0.30/1,000 py).</p><fig id="F0001" position="float"><label>Fig. 1</label><caption><p>Mortality rates per 1,000 person-years by cause group by sex (2006–2010).</p></caption><graphic xlink:href="GHA-7-25543-g001"></graphic></fig></sec><sec id="S0003-S20006"><title>Cause of death by age</title><p>The pattern of cause of death differed for the various age groups (<xref ref-type="table" rid="T0004">Table 4</xref>). Generally, mortality rates for all cause groups, except maternal mortality, increased with age. Mortality rates from NCDs were higher in males than in females for the 50 and above age groups, whereas for the 15–49 years age group, the rate was higher in females. Among the same age group, mortality rate for maternal causes was 0.19/1,000 py.</p><table-wrap id="T0004" position="float"><label>Table 4</label><caption><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1">Male</th><th align="center" colspan="2" rowspan="1">Female</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1"><hr></hr></th><th align="center" colspan="2" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Cause of deaths</th><th align="center" rowspan="1" colspan="1">Deaths<xref ref-type="table-fn" rid="TF0003">*</xref></th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th><th align="center" rowspan="1" colspan="1">CSMFs</th><th align="center" rowspan="1" colspan="1">Rate/1,000 py</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">15–49 years</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Communicable</td><td align="center" rowspan="1" colspan="1">219</td><td align="center" rowspan="1" colspan="1">1.89</td><td align="center" rowspan="1" colspan="1">253</td><td align="center" rowspan="1" colspan="1">1.80</td></tr><tr><td align="left" rowspan="1" colspan="1"> Non-communicable</td><td align="center" rowspan="1" colspan="1">92</td><td align="center" rowspan="1" colspan="1">0.79</td><td align="center" rowspan="1" colspan="1">122</td><td align="center" rowspan="1" colspan="1">0.87</td></tr><tr><td align="left" rowspan="1" colspan="1"> Maternal</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">26</td><td align="center" rowspan="1" colspan="1">0.19</td></tr><tr><td align="left" rowspan="1" colspan="1"> Trauma</td><td align="center" rowspan="1" colspan="1">68</td><td align="center" rowspan="1" colspan="1">0.59</td><td align="center" rowspan="1" colspan="1">24</td><td align="center" rowspan="1" colspan="1">0.17</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">203</td><td align="center" rowspan="1" colspan="1">1.76</td><td align="center" rowspan="1" colspan="1">223</td><td align="center" rowspan="1" colspan="1">1.59</td></tr><tr><td align="left" rowspan="1" colspan="1">50–64 years</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Communicable</td><td align="center" rowspan="1" colspan="1">98</td><td align="center" rowspan="1" colspan="1">6.22</td><td align="center" rowspan="1" colspan="1">121</td><td align="center" rowspan="1" colspan="1">5.72</td></tr><tr><td align="left" rowspan="1" colspan="1"> Non-communicable</td><td align="center" rowspan="1" colspan="1">103</td><td align="center" rowspan="1" colspan="1">6.53</td><td align="center" rowspan="1" colspan="1">102</td><td align="center" rowspan="1" colspan="1">4.82</td></tr><tr><td align="left" rowspan="1" colspan="1"> Maternal</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td></tr><tr><td align="left" rowspan="1" colspan="1"> Trauma</td><td align="center" rowspan="1" colspan="1">16</td><td align="center" rowspan="1" colspan="1">1.02</td><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">0.41</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">108</td><td align="center" rowspan="1" colspan="1">6.84</td><td align="center" rowspan="1" colspan="1">107</td><td align="center" rowspan="1" colspan="1">5.06</td></tr><tr><td align="left" rowspan="1" colspan="1">65+ years</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Communicable</td><td align="center" rowspan="1" colspan="1">174</td><td align="center" rowspan="1" colspan="1">18.14</td><td align="center" rowspan="1" colspan="1">247</td><td align="center" rowspan="1" colspan="1">13.98</td></tr><tr><td align="left" rowspan="1" colspan="1"> Non-communicable</td><td align="center" rowspan="1" colspan="1">208</td><td align="center" rowspan="1" colspan="1">21.74</td><td align="center" rowspan="1" colspan="1">311</td><td align="center" rowspan="1" colspan="1">17.62</td></tr><tr><td align="left" rowspan="1" colspan="1"> Maternal</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td><td align="center" rowspan="1" colspan="1">0.00</td></tr><tr><td align="left" rowspan="1" colspan="1"> Trauma</td><td align="center" rowspan="1" colspan="1">11</td><td align="center" rowspan="1" colspan="1">1.16</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">1.22</td></tr><tr><td align="left" rowspan="1" colspan="1"> Indeterminate</td><td align="center" rowspan="1" colspan="1">206</td><td align="center" rowspan="1" colspan="1">21.56</td><td align="center" rowspan="1" colspan="1">310</td><td align="center" rowspan="1" colspan="1">17.57</td></tr></tbody></table><table-wrap-foot><fn id="TF0003"><label>*</label><p>Deaths calculated as sum of fractional likelihoods, then rounded to nearest whole number.</p></fn></table-wrap-foot></table-wrap></sec><sec id="S0003-S20007"><title>Mortality rates and causes of death by cause group by year</title><p>The information in <xref ref-type="fig" rid="F0002">Fig. 2</xref> shows that with the exception of maternal-related causes, mortality rates attributable to all causes of death by cause group recorded the same pattern in the 5-year period. There was no recorded maternal-related death in 2008, whereas the highest mortality rate was recorded in 2006 (0.17/1,000 py). Indeterminate rate was highest in 2007 (4.71/1,000 py) and lowest in 2010 (2.39/1,000 py).</p><fig id="F0002" position="float"><label>Fig. 2</label><caption><p>Mortality rates per 1,000 person-years by cause group by year (2006–2010).</p></caption><graphic xlink:href="GHA-7-25543-g002"></graphic></fig></sec></sec><sec sec-type="discussion" id="S0004"><title>Discussion</title><p>Our results show that the major causes of death among adults in the study area from 2006 to 2010 remain CDs followed by NCDs. The main causes of CDs are malaria and TB, and for NCDs, stroke and digestive neoplasms. These are largely preventable and treatable diseases.</p><sec id="S0004-S20001"><title>Mortality rates</title><p>The findings indicate a decline of mortality from 9.8/1,000 py in 2006 to 6.6/1,000 py in 2010. According to the 2012 World Bank Report, the crude death rate for Ghana was 8/1,000 people in 2010. The death rate for the year 2010 is lower than that of the national rate, an indication of low mortality rates in the study area (<xref rid="CIT0024" ref-type="bibr">24</xref>). It must, however, be noted that the methods used for estimating the death rates are slightly different. Whereas, the World Bank used the midyear population as the denominator, this study used person-years contributed. Mortality rates are lower in the 15–49 years age group and highest among the 65 years and older. This finding is similar to what was reported by Becher et al. that mortality rates were lowest in the 15–49 years age group and highest in the 60 years and above in a malaria endemic area of West Africa.</p><p>Generally, mortality rates in males are higher than in females. The sex differential in mortality rates confirms what has been documented in other studies (<xref rid="CIT0025" ref-type="bibr">25</xref>). Obermeyer et al. also showed higher mortality in males than females for Ghana in their study, which covered 44 countries (<xref rid="CIT0026" ref-type="bibr">26</xref>). There are a number of explanations given for the sex difference in mortality that are based on biological, psychological, and social interpretations (<xref rid="CIT0027" ref-type="bibr">27</xref>).</p></sec><sec id="S0004-S20002"><title>Causes of deaths</title><p>The predominant cause of death is CDs with cause-specific rate of 3.29/1,000 py in the 5-year period. This reflects what pertains in the rural and less industrial settings in many developing countries, including Ghana (<xref rid="CIT0016" ref-type="bibr">16</xref>). The trends over the 5-year period in this study suggest that there has been a decrease in all causes of death by cause
group even though the trend has not been progressive. Nevertheless, studies indicate that although the threats of communicable and poverty-related diseases (malaria, infant mortality, cholera, malnutrition) are still in existence (<xref rid="CIT0028" ref-type="bibr">28</xref>, <xref rid="CIT0029" ref-type="bibr">29</xref>) chronic disease prevalence was increasing in SSA countries such as Ghana, Nigeria, and South Africa.</p><p>Although, Group II causes which are NCDs are the leading causes of death worldwide, Group I causes which are CDs, maternal, neonatal, and nutritional causes are the leading causes of death in SSA (<xref rid="CIT0028" ref-type="bibr">28</xref>). Lozano et al. estimated that CDs, maternal, neonatal, and nutritional causes accounted for 76% of deaths in SSA in 2010 and 24.9% of deaths worldwide (<xref rid="CIT0005" ref-type="bibr">5</xref>). In estimating cause-specific mortality rates in SSA, Adjuik et al. found that in most of the countries, including Ghana, deaths were caused mainly by CDs (<xref rid="CIT0007" ref-type="bibr">7</xref>). The double burden of NCDs and CDs in developing countries like Ghana has been reported by other studies (<xref rid="CIT0030" ref-type="bibr">30</xref>, <xref rid="CIT0031" ref-type="bibr">31</xref>) and has a long-term impact on its public health which can lead to the collapse of the health system due to the further stretching of limited resources in terms of infrastructure and finance (<xref rid="CIT0028" ref-type="bibr">28</xref>).</p><p>This study found that mortality rates attributable to NCDs were higher in females than in males. However, BeLue et al. reported that men were more likely to develop NCDs as a result of lifestyle behaviors such as smoking and alcoholism for which those living in low socioeconomic settings are not excluded (<xref rid="CIT0028" ref-type="bibr">28</xref>). This can be attributed to nutritional transitions resulting in obesity or overweight, which has been found to be increasing in some rural areas (<xref rid="CIT0032" ref-type="bibr">32</xref>, <xref rid="CIT0033" ref-type="bibr">33</xref>).</p><p>Malaria in this study is the leading cause of death in the 15–49 and the 65 years and above age groups among females. These findings were least expected since malaria is known to be more prevalent in children. However, the same concerns were raised in the findings of a systematic analysis of global malaria mortality from 1989 to 2010. It was found that 20% of malaria deaths in 2010 was contributed by adults aged 15–49 years (<xref rid="CIT0034" ref-type="bibr">34</xref>).</p><p>Pulmonary TB was the leading cause of death among males and also among the top three causes of mortality among females. According to the WHO 2013 Global TB report, Africa is one of the regions, which currently is not on track in achieving the mortality and prevalence targets of 50% reduction by 2015 (<xref rid="CIT0035" ref-type="bibr">35</xref>). From the report, TB was the leading cause of deaths among men globally and remains among the top three killers of women; these were confirmed in the study being discussed.</p><p>The proportion of HIV/AIDS deaths in this study is very low and is not different from Ghana's HIV prevalence in 2009 (1.9%), which dropped further to 1.5%, respectively, in 2010 and 2011 (<xref rid="CIT0020" ref-type="bibr">20</xref>). It is possible that some of the HIV cases may be comorbid and diagnosed as TB by the model. This can be attributed to the fact that measuring TB mortality is very difficult among HIV-positive people even in cases where vital registration systems are complete (<xref rid="CIT0035" ref-type="bibr">35</xref>). According to the WHO 2013 Global TB report, causes of death by TB are usually not reliably recorded (<xref rid="CIT0035" ref-type="bibr">35</xref>).</p><p>With RTA as one of the emerging causes of death, the global status report on road safety showed that more than 90% of fatalities on the road occur in low- and middle-income countries where only 48% of the world's registered vehicles can be found (<xref rid="CIT0036" ref-type="bibr">36</xref>). According to the report, RTAs were among the 10 leading causes of death, ranking first and third, respectively, among the age groups 15–29 and 30–44. In this study, RTA is among the top three causes of death among males aged 15–49. This finding is comparable to what was found by Ohene et al., and in the 2012 UNODC report that males contribute more to injury deaths than female (<xref rid="CIT0037" ref-type="bibr">37</xref>, <xref rid="CIT0038" ref-type="bibr">38</xref>).</p></sec><sec id="S0004-S20003"><title>Strengths of the study</title><p>This study covered the whole population in the two districts under study, and data collected at the household level closely following the death event. It is therefore representative of the two districts and can be extrapolated to the districts with similar ecological and demographic characteristics.</p></sec><sec id="S0004-S20004"><title>Study limitation</title><p>About 23% of deaths did not have VA completed because of inability to find a relative or individual who was with or knew the deceased to be interviewed. Additionally, 11.5% of the forms had very limited information or the description of the type of ailment or symptoms made it difficult for a cause to be assigned. The narrative part of VA and open-ended questions are excluded from the InterVA model, but these questions may be more appropriate in settings where there is poor knowledge of symptoms of certain diseases, and especially in cases where more local terms maybe relevant (<xref rid="CIT0022" ref-type="bibr">22</xref>).</p></sec></sec><sec id="S0005"><title>Conclusion</title><p>This work has demonstrated that VA can provide data for estimating causes of death in settings where the civil vital registration system is poor or nonexistent. The leading cause of death among the study population was CDs with malaria topping the list. The findings also indicate variations in the patterns of mortality and causes of death and have provided useful empirical information, which is instrumental in understanding disease burden, health planning, and prioritization of health interventions in resource-poor settings where access to timely and accurate data is scarce. To unravel and understand the sources of differential vulnerability in the distribution and patterns of mortality and causes of death among adult rural dwellers, additional research is needed.</p></sec></body><back><ack><title>Acknowledgements</title><p>The INDEPTH Network supported this research. We thank Peter Byass for taking us through the use of InterVA-4 model. The authors express their profound gratitude to the community members, opinion leaders, and all other stakeholders of the Shai-Osudoku and Ningo-Prampram districts of the Greater Accra Region of Ghana who continue to support the research work of the Dodowa Health Research Center. This work could not have been possible without the Dodowa Health and Demographic Surveillance System; the authors extend their appreciation to all field staff of the DHDSS, the ISDPU, and the entire staff of the DHRC. 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