Mortality in women of reproductive age in rural South Africa
Identifieur interne : 002386 ( Pmc/Corpus ); précédent : 002385; suivant : 002387Mortality in women of reproductive age in rural South Africa
Auteurs : Dorean Nabukalu ; Kerstin Klipstein-Grobusch ; Kobus Herbst ; Marie-Louise NewellSource :
- Global Health Action [ 1654-9716 ] ; 2013.
Abstract
To determine causes of death and associated risk factors in women of reproductive age in rural South Africa.
Deaths and person-years of observation (pyo) were determined for females (aged 15–49 years) resident in 15,526 households in a rural South African Demographic and Health Surveillance site from 2000 to 2009. Cause of death was ascertained by verbal autopsy and ICD-10 coded; causes were categorized as HIV/TB, non-communicable, communicable/maternal/perinatal/nutrition, injuries, and undetermined (unknown). Characteristics of women were obtained from regularly updated household visits, while HIV and self-reported health status was obtained from the annual HIV surveillance. Overall and cause-specific mortality rates (MRs) with 95% confidence intervals (CI) were calculated. The Weibull regression model (HR, 95% CI) was used to determine risk factors associated with mortality.
A total of 42,703 eligible women were included; 3,098 deaths were reported for 212,607 pyo. Overall MRwas 14.6 deaths/1,000 pyo (95% CI: 14.1–15.1), peaking in 2003 (MR 18.2/1,000 pyo, 95% CI: 16.4–20.1) and declining thereafter (2009: MR 9.6/1,000 pyo, 95% CI: 8.4–10.9). Mortality was highest for HIV/TB (MR 10.6/1,000 pyo, 95% CI: 10.2–11.1), accounting for 73.1% of all deaths, ranging from 61.2% in 2009 to 82.7% in 2002. Adjusting for education level, marital status, age, employment status, area of residence, and migration, all-cause mortality was associated with external migration (adjusted hazard ratio, or aHR), 1.70, 95% CI: 1.41–2.05), self-reported poor health status (aHR 8.26, 95% CI: 2.94–23.15), and HIV-infection (aHR 7.84, 95% CI: 6.26–9.82); external migration and HIV infection were also associated with causes of mortality other than HIV/TB (aHR 1.62, 95% CI: 1.12–2.34 and aHR 2.59, 95% CI: 1.79–3.75).
HIV/TB was the leading cause of death among women of reproductive age, although rates declined with the rollout of HIV treatment in the area from 2004. Women's age, external migration status and HIV-positive status were significantly associated with all-cause and cause-specific mortality.
Url:
DOI: 10.3402/gha.v6i0.22834
PubMed: 24360403
PubMed Central: 3869952
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PMC:3869952Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mortality in women of reproductive age in rural South Africa</title><author><name sortKey="Nabukalu, Dorean" sort="Nabukalu, Dorean" uniqKey="Nabukalu D" first="Dorean" last="Nabukalu">Dorean Nabukalu</name><affiliation><nlm:aff id="AF0001">Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Klipstein Grobusch, Kerstin" sort="Klipstein Grobusch, Kerstin" uniqKey="Klipstein Grobusch K" first="Kerstin" last="Klipstein-Grobusch">Kerstin Klipstein-Grobusch</name><affiliation><nlm:aff id="AF0001">Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Herbst, Kobus" sort="Herbst, Kobus" uniqKey="Herbst K" first="Kobus" last="Herbst">Kobus Herbst</name><affiliation><nlm:aff id="AF0004">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation></author><author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name><affiliation><nlm:aff id="AF0004">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0005">Faculty of Medicine and Faculty of Social and Human Sciences, University of Southampton, Southampton, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24360403</idno><idno type="pmc">3869952</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869952</idno><idno type="RBID">PMC:3869952</idno><idno type="doi">10.3402/gha.v6i0.22834</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002386</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002386</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mortality in women of reproductive age in rural South Africa</title><author><name sortKey="Nabukalu, Dorean" sort="Nabukalu, Dorean" uniqKey="Nabukalu D" first="Dorean" last="Nabukalu">Dorean Nabukalu</name><affiliation><nlm:aff id="AF0001">Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0002">Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda</nlm:aff></affiliation></author><author><name sortKey="Klipstein Grobusch, Kerstin" sort="Klipstein Grobusch, Kerstin" uniqKey="Klipstein Grobusch K" first="Kerstin" last="Klipstein-Grobusch">Kerstin Klipstein-Grobusch</name><affiliation><nlm:aff id="AF0001">Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0003">Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Herbst, Kobus" sort="Herbst, Kobus" uniqKey="Herbst K" first="Kobus" last="Herbst">Kobus Herbst</name><affiliation><nlm:aff id="AF0004">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation></author><author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name><affiliation><nlm:aff id="AF0004">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="AF0005">Faculty of Medicine and Faculty of Social and Human Sciences, University of Southampton, Southampton, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Global Health Action</title><idno type="ISSN">1654-9716</idno><idno type="eISSN">1654-9880</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Objective</title><p>To determine causes of death and associated risk factors in women of reproductive age in rural South Africa.</p></sec><sec id="st2"><title>Methods</title><p>Deaths and person-years of observation (pyo) were determined for females (aged 15–49 years) resident in 15,526 households in a rural South African Demographic and Health Surveillance site from 2000 to 2009. Cause of death was ascertained by verbal autopsy and ICD-10 coded; causes were categorized as HIV/TB, non-communicable, communicable/maternal/perinatal/nutrition, injuries, and undetermined (unknown). Characteristics of women were obtained from regularly updated household visits, while HIV and self-reported health status was obtained from the annual HIV surveillance. Overall and cause-specific mortality rates (MRs) with 95% confidence intervals (CI) were calculated. The Weibull regression model (HR, 95% CI) was used to determine risk factors associated with mortality.</p></sec><sec id="st3"><title>Results</title><p>A total of 42,703 eligible women were included; 3,098 deaths were reported for 212,607 pyo. Overall MRwas 14.6 deaths/1,000 pyo (95% CI: 14.1–15.1), peaking in 2003 (MR 18.2/1,000 pyo, 95% CI: 16.4–20.1) and declining thereafter (2009: MR 9.6/1,000 pyo, 95% CI: 8.4–10.9). Mortality was highest for HIV/TB (MR 10.6/1,000 pyo, 95% CI: 10.2–11.1), accounting for 73.1% of all deaths, ranging from 61.2% in 2009 to 82.7% in 2002. Adjusting for education level, marital status, age, employment status, area of residence, and migration, all-cause mortality was associated with external migration (adjusted hazard ratio, or aHR), 1.70, 95% CI: 1.41–2.05), self-reported poor health status (aHR 8.26, 95% CI: 2.94–23.15), and HIV-infection (aHR 7.84, 95% CI: 6.26–9.82); external migration and HIV infection were also associated with causes of mortality other than HIV/TB (aHR 1.62, 95% CI: 1.12–2.34 and aHR 2.59, 95% CI: 1.79–3.75).</p></sec><sec id="st4"><title>Conclusion</title><p>HIV/TB was the leading cause of death among women of reproductive age, although rates declined with the rollout of HIV treatment in the area from 2004. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Glob Health Action</journal-id><journal-id journal-id-type="iso-abbrev">Glob Health Action</journal-id><journal-id journal-id-type="publisher-id">GHA</journal-id><journal-title-group><journal-title>Global Health Action</journal-title></journal-title-group><issn pub-type="ppub">1654-9716</issn><issn pub-type="epub">1654-9880</issn><publisher><publisher-name>Co-Action Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24360403</article-id><article-id pub-id-type="pmc">3869952</article-id><article-id pub-id-type="publisher-id">22834</article-id><article-id pub-id-type="doi">10.3402/gha.v6i0.22834</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Mortality in women of reproductive age in rural South Africa</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nabukalu</surname><given-names>Dorean</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Klipstein-Grobusch</surname><given-names>Kerstin</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0003">3</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Herbst</surname><given-names>Kobus</given-names></name><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Newell</surname><given-names>Marie-Louise</given-names></name><xref ref-type="aff" rid="AF0004">4</xref><xref ref-type="aff" rid="AF0005">5</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</aff><aff id="AF0002"><label>2</label>Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda</aff><aff id="AF0003"><label>3</label>Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="AF0004"><label>4</label>Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</aff><aff id="AF0005"><label>5</label>Faculty of Medicine and Faculty of Social and Human Sciences, University of Southampton, Southampton, UK</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Kerstin Klipstein-Grobusch, Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands, Tel:+31 88 75 684 42, Fax +31 88 75 554 85, Email: <email xlink:href="k.klipstein-grobusch@umcutrecht.nl">k.klipstein-grobusch@umcutrecht.nl</email></corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="collection"><year>2013</year></pub-date><volume>6</volume><elocation-id content-type="doi">10.3402/gha.v6i0.22834</elocation-id><history><date date-type="received"><day>14</day><month>9</month><year>2013</year></date><date date-type="rev-recd"><day>24</day><month>11</month><year>2013</year></date><date date-type="accepted"><day>25</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 Dorean Nabukalu et al.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Objective</title><p>To determine causes of death and associated risk factors in women of reproductive age in rural South Africa.</p></sec><sec id="st2"><title>Methods</title><p>Deaths and person-years of observation (pyo) were determined for females (aged 15–49 years) resident in 15,526 households in a rural South African Demographic and Health Surveillance site from 2000 to 2009. Cause of death was ascertained by verbal autopsy and ICD-10 coded; causes were categorized as HIV/TB, non-communicable, communicable/maternal/perinatal/nutrition, injuries, and undetermined (unknown). Characteristics of women were obtained from regularly updated household visits, while HIV and self-reported health status was obtained from the annual HIV surveillance. Overall and cause-specific mortality rates (MRs) with 95% confidence intervals (CI) were calculated. The Weibull regression model (HR, 95% CI) was used to determine risk factors associated with mortality.</p></sec><sec id="st3"><title>Results</title><p>A total of 42,703 eligible women were included; 3,098 deaths were reported for 212,607 pyo. Overall MRwas 14.6 deaths/1,000 pyo (95% CI: 14.1–15.1), peaking in 2003 (MR 18.2/1,000 pyo, 95% CI: 16.4–20.1) and declining thereafter (2009: MR 9.6/1,000 pyo, 95% CI: 8.4–10.9). Mortality was highest for HIV/TB (MR 10.6/1,000 pyo, 95% CI: 10.2–11.1), accounting for 73.1% of all deaths, ranging from 61.2% in 2009 to 82.7% in 2002. Adjusting for education level, marital status, age, employment status, area of residence, and migration, all-cause mortality was associated with external migration (adjusted hazard ratio, or aHR), 1.70, 95% CI: 1.41–2.05), self-reported poor health status (aHR 8.26, 95% CI: 2.94–23.15), and HIV-infection (aHR 7.84, 95% CI: 6.26–9.82); external migration and HIV infection were also associated with causes of mortality other than HIV/TB (aHR 1.62, 95% CI: 1.12–2.34 and aHR 2.59, 95% CI: 1.79–3.75).</p></sec><sec id="st4"><title>Conclusion</title><p>HIV/TB was the leading cause of death among women of reproductive age, although rates declined with the rollout of HIV treatment in the area from 2004. Women's age, external migration status and HIV-positive status were significantly associated with all-cause and cause-specific mortality.</p></sec></abstract><kwd-group><kwd>reproductive age</kwd><kwd>women</kwd><kwd>mortality</kwd><kwd>rural South Africa</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front><body><p>In many settings, women are confronted by a dual burden of traditional health threats related to infectious diseases and maternal conditions alongside emerging challenges associated with non-communicable chronic diseases (NCD). Consequently, more than 30% of all deaths in resource-limited settings occur in women aged 15–49 years, while in resource-rich settings this is 15%. Maternal mortality is the lead cause of mortality in women of this age group in sub-Saharan Africa, and NCDs are the major cause of death in resource-rich countries (<xref ref-type="bibr" rid="CIT0001">1</xref>, <xref ref-type="bibr" rid="CIT0002">2</xref>).</p><p>Since maternal mortality is an important problem in sub-Saharan Africa (where fertility is also high with limited or no skilled birth-attended deliveries and poor antenatal clinic, or ANC, attendance), a number of studies responding to the Millennium Development Goals have been conducted to investigate maternal mortality and associated risk factors which include old age, poor ANC attendance, belonging to a lower socio economic class, low education level, distance to a health facility, and being resident in a rural area (<xref ref-type="bibr" rid="CIT0003">3</xref>–<xref ref-type="bibr" rid="CIT0007">7</xref>). Studies carried out in this part of rural South Africa have documented low fertility rates, high ANC attendance, high HIV incidence and prevalence, and high poverty levels in women of reproductive ages (<xref ref-type="bibr" rid="CIT0008">8</xref>–<xref ref-type="bibr" rid="CIT0010">10</xref>). Therefore, in this study, we look at mortality generally in all women of reproductive age and clarify causes of death and associated risk factors.</p><p>In resource-limited countries, deaths are often under-reported, and cause of death is frequently not available due to lack of vital registration systems (<xref ref-type="bibr" rid="CIT0011">11</xref>, <xref ref-type="bibr" rid="CIT0012">12</xref>). Such a lack of data hinders the understanding of risk factors for different causes of deaths, although HIV-related deaths have recently been studied in more detail, often within specific studies rather than from vital registration. To improve national vital registration, a number of countries intend to set up a nationally representative vital registration system sample, which has been recommended to represent an affordable, cost-effective, and sustainable short- and medium-term solution if applied in conjunction with validated verbal autopsy (VA) procedures as has been demonstrated by work conducted in Health and Demographic Surveillance Sites (<xref ref-type="bibr" rid="CIT0013">13</xref>, <xref ref-type="bibr" rid="CIT0014">14</xref>).</p><p>This study uses longitudinal data from a large ongoing surveillance study in rural South Africa, a setting with high HIV prevalence (27% in women) and incidence (3.2 per 100 person-years) in women aged 15–49 years (<xref ref-type="bibr" rid="CIT0008">8</xref>, <xref ref-type="bibr" rid="CIT0015">15</xref>), and quantifies mortality in women of reproductive age (aged 15–49 years).</p><sec sec-type="methods" id="S0001"><title>Methods</title><p>The Africa Centre for Health and Population Studies is located near the market town of Mtubatuba in the uMkhanyakude district of KwaZulu-Natal. The surveillance area covers an area of 438 km<sup>2</sup>, and within each surveillance round a population of approximately 90,000 people, of whom about two-thirds are resident in approximately 11,000 households (<xref ref-type="bibr" rid="CIT0008">8</xref>). The population is almost exclusively Zulu-speaking and the area is typical of many rural areas of South Africa in that while predominantly rural, it contains an urban township and informal peri-urban settlements (<xref ref-type="bibr" rid="CIT0008">8</xref>, <xref ref-type="bibr" rid="CIT0016">16</xref>). From 2000 to 2011, the Centre hosted a biannual (tri-annual since 2012) sociodemographic surveillance, in which all households in the area were visited and demographic indicators recorded, including household size and composition, fertility, migration, mortality, and marriage. The Africa Centre collects information on both resident and non-resident household members and makes a distinction between membership and residency. Household membership is self-defined on the basis of links to other household members while residency implies residing at a physical structure within the surveillance area at a particular point in time (<xref ref-type="bibr" rid="CIT0008">8</xref>). In addition, since 2003, adults aged 15 years and over, identified as residents in the household surveillance, are asked to participate in an annual HIV and health surveillance (<xref ref-type="bibr" rid="CIT0017">17</xref>). More information about the Africa Centre operations and profile is available elsewhere (<xref ref-type="bibr" rid="CIT0008">8</xref>, <xref ref-type="bibr" rid="CIT0017">17</xref>, <xref ref-type="bibr" rid="CIT0018">18</xref>).</p><p>The study sample constituted an open cohort of all women aged 15–49 years who were members of households within the demographic surveillance area (DSA) during the period 2000–2009, a period for which complete data was available at the time of analysis. All resident membership episodes of the females aged 15–49 years at any time during the period 2000–2009 were included. Household membership is as reported by the key household informant. It starts with a demographic surveillance system (DSS) entry, a birth or a membership start event and can only be terminated by DSS exit, a death or a membership end event. Non-resident episodes of members who exited and then returned were taken into account but person time was only computed for the period they were resident.</p><sec id="S20002"><title>Mortality data</title><p>Although all deaths (of both resident and non-resident household members) reported in the household surveillance are followed by a VA interview with the closest caregiver of the deceased, for this study we looked at residents for causes of mortality since only resident episodes are taken into account while computing person time and thus mortality rates (MRs). VA is an epidemiological tool that is used to assess cause of death in settings where hospital-based records are lacking or inadequate. During the period of this study, a VA interview was conducted on average 9 months after a death was reported (<xref ref-type="bibr" rid="CIT0017">17</xref>, <xref ref-type="bibr" rid="CIT0019">19</xref>). In interviews conducted by a trained nurse, informants were asked to narrate the course of the illness or events leading to death. A structured interview was also administered. Two experienced clinicians independently assigned the underlying cause of death<xref ref-type="fn" rid="FN0001">1</xref> based on the information collected in the VA and their clinical judgment using the 10th version of the International Classification of Diseases (ICD-10) coding system (<xref ref-type="bibr" rid="CIT0017">17</xref>, <xref ref-type="bibr" rid="CIT0019">19</xref>–<xref ref-type="bibr" rid="CIT0022">22</xref>). Validation of VA as a tool for assigning cause of death has been documented by earlier studies (<xref ref-type="bibr" rid="CIT0011">11</xref>, <xref ref-type="bibr" rid="CIT0012">12</xref>, <xref ref-type="bibr" rid="CIT0023">23</xref>). Following the Global Burden of Disease classification, causes were divided into three broad categories: communicable, maternal, perinatal, and nutritional conditions (group I); non-communicable diseases (group II); and group III which contained injuries (<xref ref-type="bibr" rid="CIT0024">24</xref>). For the purposes of this study, group I causes of death were further categorized into HIV/TB-related, maternal, and other communicable causes. HIV/TB-related causes were grouped together because of the considerable overlap in mortality from HIV infection and tuberculosis (<xref ref-type="bibr" rid="CIT0025">25</xref>). Data – on age, education, pregnancy status and outcome, marital, and migration status – were collected during the household visits using a structured questionnaire administered to the key household informant (<xref ref-type="bibr" rid="CIT0008">8</xref>). Information on self-reported health and contraceptive use were collected during the annual individual surveillance using the ‘Woman's General Health’ (WGH) questionnaire (<xref ref-type="bibr" rid="CIT0018">18</xref>).</p><p>Household socioeconomic data (HSE) were collected once a year within the household surveillance, collecting information from the key informant on housing structure, sources of energy and amenities, education and employment of household members (<xref ref-type="bibr" rid="CIT0018">18</xref>).</p><p>HIV status data is updated once a year from the HIV surveillance visits for participating adults. After written informed consent, the field workers collect blood by finger prick and prepare dried blood spots for ano-nymized HIV testing (<xref ref-type="bibr" rid="CIT0008">8</xref>). HIV status is determined by antibody testing with a broad-based HIV-1/HIV-2 enzyme-linked immunosorbent assay (ELISA; Vironostika, Organon Teknika, Boxtel, the Netherlands) followed by a confirmatory ELISA (GAC-ELISA; Abbott, Abbott Park, Illinois, USA).</p><p>The risk factors, which varied over time, were fixed and measured at particular points in time. These factors include age of the woman at the birth of her most recent child (<xref ref-type="bibr" rid="CIT0005">5</xref>, <xref ref-type="bibr" rid="CIT0007">7</xref>, <xref ref-type="bibr" rid="CIT0012">12</xref>, <xref ref-type="bibr" rid="CIT0019">19</xref>, <xref ref-type="bibr" rid="CIT0021">21</xref>, <xref ref-type="bibr" rid="CIT0026">26</xref>), migration status (<xref ref-type="bibr" rid="CIT0020">20</xref>, <xref ref-type="bibr" rid="CIT0027">27</xref>, <xref ref-type="bibr" rid="CIT0028">28</xref>) (defined as: never moved, internal migration (within the surveillance area) only, external migration (migration in/out of the surveillance area) only, and both internal and external migration), HIV status (<xref ref-type="bibr" rid="CIT0021">21</xref>, <xref ref-type="bibr" rid="CIT0029">29</xref>, <xref ref-type="bibr" rid="CIT0030">30</xref>) (defined as: participated in the HIV surveillance and positive, participated in the HIV surveillance and negative, and unknown status for those who never participated in the HIV surveillance), area of residence (rural, urban, and peri-urban), parity at most recent birth, pregnancy outcome summarized across maternity history (<xref ref-type="bibr" rid="CIT0012">12</xref>, <xref ref-type="bibr" rid="CIT0031">31</xref>) (all live births, one or more pregnancy ended in a stillbirth, no pregnancy outcome reported), contraceptive use (ever or never use), marital status (ever married and never married), self-reported general health status (lowest self-reported health status over the period; defined as good, fair or poor), highest education level (<xref ref-type="bibr" rid="CIT0004">4</xref>, <xref ref-type="bibr" rid="CIT0019">19</xref>) (categorized as eight or more years in school, less than eight years in school and no school at all), employment status (ever or never employed) and wealth index of the household where the woman lives (minimum wealth index of all households a woman has ever stayed in during the study period; the derivation of the wealth index is explained below).</p><p>As a proxy to measure household wealth, a household asset index was used (<xref ref-type="bibr" rid="CIT0032">32</xref>). The household asset index is computed by principal component analysis (<xref ref-type="bibr" rid="CIT0028">28</xref>) using information on house ownership, water source, energy, toilet type, electricity and ownership of assets which included items that can be used for consumption, production or both, such as beds, bicycles, tables, telephones, television sets, sewing machines, block makers, wheelbarrows, tractors, cattle, and other livestock (<xref ref-type="bibr" rid="CIT0009">9</xref>, <xref ref-type="bibr" rid="CIT0033">33</xref>). Households were then categorized as either belonging to the poorest 40%, the middle 40% or the wealthiest 20% on the asset index scale (<xref ref-type="bibr" rid="CIT0009">9</xref>, <xref ref-type="bibr" rid="CIT0033">33</xref>). These three categories were chosen for comparison purposes with other studies since they have been found to capture wealth effects well in a number of studies in poor provinces of South Africa (<xref ref-type="bibr" rid="CIT0009">9</xref>, <xref ref-type="bibr" rid="CIT0034">34</xref>).</p></sec><sec id="S20003"><title>Statistical analysis</title><p>Cross tabulation of categorical variables and vital status was performed with Chi-square tests of significant differences within the variable groups and a woman's vital status; p-values were reported.</p><p>Data were set for survival analysis with vital status as the failure variable. The time variable was the difference in years between entry (the date at which an individual was first observed/visited) and exit date (the date an individual was last observed/visited; i.e. for deaths the exit date was the date of death while for the surviving participants, it was the end of the study date). Participants who left the study before the end point or before 31 December 2009 (due to out-migration or loss to follow-up) were censored on the dates last observed, and the person-years they contributed were computed up to their last observation dates. Percentage distributions of each of the different causes of death to the overall number of deaths were computed. MRs for the different causes of death and the overall MR were computed per 1,000 women years of observation (pyo). Causes of death were divided into two categories: deaths due to HIV/TB and deaths due to all other causes combined, because there were small numbers reported for deaths from other causes (<xref ref-type="bibr" rid="CIT0035">35</xref>). A Cox regression model was fitted to test for association between factors and mortality over time. Scaled Schoenfield residuals were used to test the final model for violation of the assumption of proportionality over the study time (2000–2009). HIV status, self-reported minimum health status, employment status, and woman's age at birth of most recent child violated the proportionality assumptions, the model was stratified by these variables but the assumptions remained violated. Thus, a parametric model (the Weibull distribution) was used (<xref ref-type="bibr" rid="CIT0035">35</xref>) to assess factors associated with all-cause mortality and cause-specific mortality at 5% level of significance. The Weibull model was chosen over other parametric models because of its flexibility and ability to model hazard functions that are decreasing, increasing or constant over time. The model was explored for interaction effects and age was found to modify the effect of general health on all-cause mortality as well as cause-specific mortality. This interaction term was included in the models and adjusted results are reported in <xref ref-type="bibr" rid="CIT0003">3</xref>–<xref ref-type="bibr" rid="CIT0005">5</xref>. All analyses were computed using STATA v 11 (<xref ref-type="bibr" rid="CIT0036">36</xref>).</p><p>This study was approved by the University of Witwatersrand Committee for Research on Human Subjects and ethical approval for the Africa Centre Surveillance was obtained from the Research Ethics Committee of the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal.</p></sec></sec><sec sec-type="results" id="S0004"><title>Results</title><p>A total of 42,703 women were enrolled, of whom 3,098 died during the period, with a total of 212,607 person-years of observation. Most deaths occurred in women aged 25–29 years (21.1%) and most participants lived in a rural setting (<xref ref-type="table" rid="T0001">Table 1</xref>). Although migration was common among women who were alive when last seen, most women who died (42.41%) had never moved either within (internally) or out of/into (externally) the surveillance area (<xref ref-type="table" rid="T0001">Table 1</xref>). While most of the women had completed 8 or more years in school, 31.4% of those who died had completed less than 8 years of education. There were significant differences between women who had died and those who were alive when last seen across the three categories of HIV status (<xref ref-type="table" rid="T0001">Table 1</xref>).
</p><table-wrap id="T0001" position="float"><label>Table 1</label><caption><p>Sociodemographic characteristics of women of reproductive age during the study period, ACDIS</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Women alive (0) (n)%</th><th align="center" rowspan="1" colspan="1">Women dead (1) (n)%</th><th align="center" rowspan="1" colspan="1">P-value</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Overall (n = 42,703)</td><td align="center" rowspan="1" colspan="1">(n = 39,605) 92.75</td><td align="center" rowspan="1" colspan="1">(n = 3,098) 7.25</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Age in years at entry</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> 15–19</td><td align="center" rowspan="1" colspan="1">(18,220) 46.0</td><td align="center" rowspan="1" colspan="1">(491) 15.85</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 20–24</td><td align="center" rowspan="1" colspan="1">(6,174) 15.59</td><td align="center" rowspan="1" colspan="1">(615) 19.85</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 25–29</td><td align="center" rowspan="1" colspan="1">(4,722) 11.92</td><td align="center" rowspan="1" colspan="1">(655) 21.14</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 30–34</td><td align="center" rowspan="1" colspan="1">(3,579) 9.04</td><td align="center" rowspan="1" colspan="1">(534) 17.24</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 35–39</td><td align="center" rowspan="1" colspan="1">(2,895) 7.31</td><td align="center" rowspan="1" colspan="1">(402) 12.98</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 40–44</td><td align="center" rowspan="1" colspan="1">(2,346) 5.92</td><td align="center" rowspan="1" colspan="1">(293) 9.46</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> 45–49</td><td align="center" rowspan="1" colspan="1">(1,669) 4.21</td><td align="center" rowspan="1" colspan="1">(108) 3.49</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Area of residence</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> Rural</td><td align="center" rowspan="1" colspan="1">(22,737) 57.4</td><td align="center" rowspan="1" colspan="1">(1,802) 58.17</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Urban</td><td align="center" rowspan="1" colspan="1">(4,023) 10.16</td><td align="center" rowspan="1" colspan="1">(142) 4.58</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Peri-urban</td><td align="center" rowspan="1" colspan="1">(12,753) 32.20</td><td align="center" rowspan="1" colspan="1">(1,154) 37.25</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Migration status</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> Never moved</td><td align="center" rowspan="1" colspan="1">(11,495) 29.02</td><td align="center" rowspan="1" colspan="1">(1,314) 42.41</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Internal only</td><td align="center" rowspan="1" colspan="1">(3,982) 10.05</td><td align="center" rowspan="1" colspan="1">(273) 8.81</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> External only</td><td align="center" rowspan="1" colspan="1">(7,237) 18.27</td><td align="center" rowspan="1" colspan="1">(606) 19.56</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Internal and external</td><td align="center" rowspan="1" colspan="1">(16,891) 42.65</td><td align="center" rowspan="1" colspan="1">(905) 29.21</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Minimum HSE class index</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> Upper 20%</td><td align="center" rowspan="1" colspan="1">(4,568) 12.73</td><td align="center" rowspan="1" colspan="1">(225) 7.59</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Middle 40%</td><td align="center" rowspan="1" colspan="1">(12,064) 33.61</td><td align="center" rowspan="1" colspan="1">(1,007) 33.96</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Lower 40%</td><td align="center" rowspan="1" colspan="1">(19,263) 53.66</td><td align="center" rowspan="1" colspan="1">(1,733) 58.45</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Ever married</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">0.015</td></tr><tr><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">(32,752) 82.7</td><td align="center" rowspan="1" colspan="1">(2,615) 84.41</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">(6,853) 17.3</td><td align="center" rowspan="1" colspan="1">(483) 15.59</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Ever employed</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">0.353</td></tr><tr><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">(29,701) 74.99</td><td align="center" rowspan="1" colspan="1">(2,300) 74.24</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">(9,904) 25.01</td><td align="center" rowspan="1" colspan="1">(798) 25.76</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Highest level of education</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> More than 8 years</td><td align="center" rowspan="1" colspan="1">(24,647) 71.88</td><td align="center" rowspan="1" colspan="1">(1,469) 62.25</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Less than 8 years</td><td align="center" rowspan="1" colspan="1">(8,083) 23.57</td><td align="center" rowspan="1" colspan="1">(742) 31.44</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> No school</td><td align="center" rowspan="1" colspan="1">(1,559) 4.55</td><td align="center" rowspan="1" colspan="1">(149) 6.31</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Self-reported minimum general health</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> Good</td><td align="center" rowspan="1" colspan="1">(17,095) 79.68</td><td align="center" rowspan="1" colspan="1">(770) 69.43</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Fair</td><td align="center" rowspan="1" colspan="1">(3,808) 17.75</td><td align="center" rowspan="1" colspan="1">(253) 22.81</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Poor</td><td align="center" rowspan="1" colspan="1">(5,51) 2.57</td><td align="center" rowspan="1" colspan="1">(86) 7.75</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Woman HIV status</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> HIV tested and negative</td><td align="center" rowspan="1" colspan="1">(9,532) 24.07</td><td align="center" rowspan="1" colspan="1">(117) 3.78</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> HIV tested and positive</td><td align="center" rowspan="1" colspan="1">(4,645) 11.73</td><td align="center" rowspan="1" colspan="1">(532) 17.17</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Never tested</td><td align="center" rowspan="1" colspan="1">(25,428) 64.20</td><td align="center" rowspan="1" colspan="1">(2,449) 79.05</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Maximum parity (M, SD)</td><td align="center" rowspan="1" colspan="1">1.79, 2.13</td><td align="center" rowspan="1" colspan="1">2.28, 2.06</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Pregnancy outcome summarized from maternity history</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"> All live births</td><td align="center" rowspan="1" colspan="1">(22,005) 55.56</td><td align="center" rowspan="1" colspan="1">(1,917) 61.88</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> ≥ 1 pregnancy was a still birth</td><td align="center" rowspan="1" colspan="1">(29,68) 7.49</td><td align="center" rowspan="1" colspan="1">(317) 10.23</td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> No outcome reported</td><td align="center" rowspan="1" colspan="1">(14,632) 36.94</td><td align="center" rowspan="1" colspan="1">(864) 27.89</td><td align="center" rowspan="1" colspan="1"></td></tr></tbody></table></table-wrap><sec id="S20005"><title>Causes of death</title><p>HIV/TB-related causes of death were most common with a MR of 10.64 per 1,000 person-years (95% CI: 10.21–11.08), contributing almost 73% of all deaths to women of reproductive age over the entire period (<xref ref-type="table" rid="T0002">Table 2</xref>). There was a significant difference in the mortality fraction due to HIV/TB-related causes ranging from as high as 82.7% in 2002 to as low as 61.2% in 2009. Women who died while pregnant contributed 0.45% of all deaths in women of reproductive age with a MR of 0.07 per 1,000 person-years (95% CI: 0.04–0.11) and non-communicable diseases (mainly cancers) contributed 8.42% with a MR of 1.22 per 1,000 person-years (95% CI: 1.08–1.438).
</p><table-wrap id="T0002" position="float"><label>Table 2</label><caption><p>Causes of death in women of reproductive age, 2000–2009, ACDIS</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="2" rowspan="1">95% confidence intervals</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th colspan="2" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Causes of death</th><th align="center" rowspan="1" colspan="1">Cause-specific numbers</th><th align="center" rowspan="1" colspan="1">Mortality fraction (%)</th><th align="center" rowspan="1" colspan="1">Mortality rate /1,000 person-years</th><th align="center" rowspan="1" colspan="1">Lower</th><th align="center" rowspan="1" colspan="1">Upper</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">HIV/TB</td><td align="center" rowspan="1" colspan="1">2,266</td><td align="center" rowspan="1" colspan="1">73.14</td><td align="center" rowspan="1" colspan="1">10.64</td><td align="center" rowspan="1" colspan="1">10.21</td><td align="center" rowspan="1" colspan="1">11.08</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="table-fn" rid="TF0001">*</xref>Pregnancy</td><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">0.45</td><td align="center" rowspan="1" colspan="1">0.07</td><td align="center" rowspan="1" colspan="1">0.04</td><td align="center" rowspan="1" colspan="1">0.11</td></tr><tr><td align="left" rowspan="1" colspan="1">Other communicable</td><td align="center" rowspan="1" colspan="1">266</td><td align="center" rowspan="1" colspan="1">8.59</td><td align="center" rowspan="1" colspan="1">1.25</td><td align="center" rowspan="1" colspan="1">1.11</td><td align="center" rowspan="1" colspan="1">1.41</td></tr><tr><td align="left" rowspan="1" colspan="1">Injuries</td><td align="center" rowspan="1" colspan="1">109</td><td align="center" rowspan="1" colspan="1">3.52</td><td align="center" rowspan="1" colspan="1">0.51</td><td align="center" rowspan="1" colspan="1">0.42</td><td align="center" rowspan="1" colspan="1">0.62</td></tr><tr><td align="left" rowspan="1" colspan="1">Non communicable</td><td align="center" rowspan="1" colspan="1">261</td><td align="center" rowspan="1" colspan="1">8.42</td><td align="center" rowspan="1" colspan="1">1.22</td><td align="center" rowspan="1" colspan="1">1.08</td><td align="center" rowspan="1" colspan="1">1.38</td></tr><tr><td align="left" rowspan="1" colspan="1">Unknown</td><td align="center" rowspan="1" colspan="1">182</td><td align="center" rowspan="1" colspan="1">5.87</td><td align="center" rowspan="1" colspan="1">0.86</td><td align="center" rowspan="1" colspan="1">0.74</td><td align="center" rowspan="1" colspan="1">0.99</td></tr></tbody></table><table-wrap-foot><fn id="TF0001"><label>*</label><p>This refers to deaths that happened to women while they were pregnant.</p></fn></table-wrap-foot></table-wrap></sec><sec id="S20006"><title>Mortality patterns</title><p>The all-cause crude MR for women of reproductive age was 14.6 per 1,000 person-years (95% CI: 14.1–15.1), varying from 9.6 (in 2009) per 1,000 person-years to 18.2 (in 2003) per 1,000 pyo (95% CI: 16.4–20.1) (<xref ref-type="fig" rid="F0001">Fig. 1</xref>). The overall pattern was similar to that seen for HIV/TB-related causes only, but differed significantly for other causes. All-cause crude MRs were highest in women 30–34 years old, while MRs due to causes other than HIV/TB-related were highest for women aged 45–49 years (<xref ref-type="fig" rid="F0002">Fig. 2</xref>).</p><fig id="F0001" position="float"><label>Fig. 1</label><caption><p>All-cause and cause-specific mortality rates for women of reproductive age from 2000 to 2009, ACDIS.</p></caption><graphic xlink:href="GHA-6-22834-g001"></graphic></fig><fig id="F0002" position="float"><label>Fig. 2</label><caption><p>All-cause and cause-specific mortality rates by age group from 2000 to 2009, ACDIS.</p></caption><graphic xlink:href="GHA-6-22834-g002"></graphic></fig></sec><sec id="S20007"><title>Risk factors of mortality</title><p>Increasing age was significantly associated with both all-cause and cause-specific mortality, in the unadjusted model and after adjusting for all other sociodemographic indicators. The risk of all-cause mortality and of mortality related to HIV/TB was highest for women aged 30–34 years; for mortality due to causes not related to HIV/TB, the risk was highest for women aged 25–29 years (Tables (<xref ref-type="bibr" rid="CIT0003">3</xref>–<xref ref-type="bibr" rid="CIT0005">5</xref>)). For all-cause mortality and mortality due to HIV/TB, the hazards of dying were almost four- and five-times increased in women aged 30–34 years compared to the reference group of those aged 15–19 years, keeping all other sociodemographic factors constant.
</p><table-wrap id="T0003" position="float"><label>Table 3</label><caption><p>Univariable and multivariable hazard ratios (95% CI) for risk factors associated with all-cause mortality, 2000–2009, ACDIS</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="3" rowspan="1">Univariable analysis</th><th align="center" colspan="3" rowspan="1">Multivariable analysis</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th colspan="3" rowspan="1"><hr></hr></th><th colspan="3" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Explanatory variables</th><th align="center" rowspan="1" colspan="1">Categories of explanatory variables</th><th align="center" rowspan="1" colspan="1">Crude hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th><th align="center" rowspan="1" colspan="1">Adjusted hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Women age</td><td align="center" rowspan="1" colspan="1">15–19</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">20–24</td><td align="center" rowspan="1" colspan="1">4.267</td><td align="center" rowspan="1" colspan="1">3.506, 5.194</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.186</td><td align="center" rowspan="1" colspan="1">1.435, 3.330</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">25–29</td><td align="center" rowspan="1" colspan="1">9.336</td><td align="center" rowspan="1" colspan="1">7.742, 11.257</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.457</td><td align="center" rowspan="1" colspan="1">1.980, 6.036</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">30–34</td><td align="center" rowspan="1" colspan="1">11.910</td><td align="center" rowspan="1" colspan="1">9.873, 14.367</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.615</td><td align="center" rowspan="1" colspan="1">1.726, 7.573</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">35–39</td><td align="center" rowspan="1" colspan="1">10.309</td><td align="center" rowspan="1" colspan="1">8.491, 12.516</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.857</td><td align="center" rowspan="1" colspan="1">1.123, 7.269</td><td align="center" rowspan="1" colspan="1">0.028</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">40–44</td><td align="center" rowspan="1" colspan="1">9.205</td><td align="center" rowspan="1" colspan="1">7.541, 11.237</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.528</td><td align="center" rowspan="1" colspan="1">0.489, 4.775</td><td align="center" rowspan="1" colspan="1">0.465</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">45–49</td><td align="center" rowspan="1" colspan="1">9.908</td><td align="center" rowspan="1" colspan="1">8.083, 12.145</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.563</td><td align="center" rowspan="1" colspan="1">0.411, 5.946</td><td align="center" rowspan="1" colspan="1">0.512</td></tr><tr><td align="left" rowspan="1" colspan="1">Self-reported minimum general health</td><td align="left" rowspan="1" colspan="1">Good</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Fair</td><td align="center" rowspan="1" colspan="1">1.293</td><td align="center" rowspan="1" colspan="1">1.122, 1.491</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.302</td><td align="center" rowspan="1" colspan="1">1.215, 4.358</td><td align="center" rowspan="1" colspan="1">0.010</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Poor</td><td align="center" rowspan="1" colspan="1">2.927</td><td align="center" rowspan="1" colspan="1">2.343, 3.658</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">8.256</td><td align="center" rowspan="1" colspan="1">2.944, 23.151</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever employed</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.622</td><td align="center" rowspan="1" colspan="1">0.574, 0.675</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.779</td><td align="center" rowspan="1" colspan="1">0.681, 0.891</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever married</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.665</td><td align="center" rowspan="1" colspan="1">0.604, 0.733</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.500</td><td align="center" rowspan="1" colspan="1">0.419, 0.598</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Migration status</td><td align="left" rowspan="1" colspan="1">Never moved</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Internal only</td><td align="center" rowspan="1" colspan="1">0.451</td><td align="center" rowspan="1" colspan="1">0.396, 0.514</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.647</td><td align="center" rowspan="1" colspan="1">0.527, 0.796</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">External only</td><td align="center" rowspan="1" colspan="1">1.549</td><td align="center" rowspan="1" colspan="1">1.405, 1.709</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.698</td><td align="center" rowspan="1" colspan="1">1.408, 2.046</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Both internal and external</td><td align="center" rowspan="1" colspan="1">0.377</td><td align="center" rowspan="1" colspan="1">0.346, 0.410</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.476</td><td align="center" rowspan="1" colspan="1">0.406, 0.557</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Minimum household index class</td><td align="left" rowspan="1" colspan="1">Upper 20%</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Middle 40%</td><td align="center" rowspan="1" colspan="1">1.505</td><td align="center" rowspan="1" colspan="1">1.302, 1.739</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.077</td><td align="center" rowspan="1" colspan="1">0.809, 1.433</td><td align="center" rowspan="1" colspan="1">0.611</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Lower 40%</td><td align="center" rowspan="1" colspan="1">1.527</td><td align="center" rowspan="1" colspan="1">1.329, 1.754</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.167</td><td align="center" rowspan="1" colspan="1">0.872, 1.563</td><td align="center" rowspan="1" colspan="1">0.298</td></tr><tr><td align="left" rowspan="1" colspan="1">Highest education level</td><td align="left" rowspan="1" colspan="1">More than 8 years</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Less than 8 years</td><td align="center" rowspan="1" colspan="1">1.855</td><td align="center" rowspan="1" colspan="1">1.698, 2.026</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.338</td><td align="center" rowspan="1" colspan="1">1.139, 1.572</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never gone to school</td><td align="center" rowspan="1" colspan="1">1.618</td><td align="center" rowspan="1" colspan="1">1.367, 1.915</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.334</td><td align="center" rowspan="1" colspan="1">1.023, 1.739</td><td align="center" rowspan="1" colspan="1">0.033</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever used contraception</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">1.211</td><td align="center" rowspan="1" colspan="1">1.128, 1.301</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.201</td><td align="center" rowspan="1" colspan="1">1.039, 1.387</td><td align="center" rowspan="1" colspan="1">0.013</td></tr><tr><td align="left" rowspan="1" colspan="1">Pregnancy outcome history</td><td align="left" rowspan="1" colspan="1">All live births</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">>1 pregnancy a still birth/Abortion</td><td align="center" rowspan="1" colspan="1">1.202</td><td align="center" rowspan="1" colspan="1">1.068,1.354</td><td align="center" rowspan="1" colspan="1">0.002</td><td align="center" rowspan="1" colspan="1">1.082</td><td align="center" rowspan="1" colspan="1">0.895, 1.308</td><td align="center" rowspan="1" colspan="1">0.417</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">No outcome reported</td><td align="center" rowspan="1" colspan="1">1.239</td><td align="center" rowspan="1" colspan="1">1.142,1.344</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.306</td><td align="center" rowspan="1" colspan="1">1.046, 1.629</td><td align="center" rowspan="1" colspan="1">0.018</td></tr><tr><td align="left" rowspan="1" colspan="1">Maximum parity</td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.021</td><td align="center" rowspan="1" colspan="1">1.005, 1.037</td><td align="center" rowspan="1" colspan="1">0.009</td><td align="center" rowspan="1" colspan="1">0.486</td><td align="center" rowspan="1" colspan="1">0.395, 0.597</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Area of residence</td><td align="left" rowspan="1" colspan="1">Rural</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Urban</td><td align="center" rowspan="1" colspan="1">0.635</td><td align="center" rowspan="1" colspan="1">0.535, 0.753</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.808</td><td align="center" rowspan="1" colspan="1">0.554, 1.178</td><td align="center" rowspan="1" colspan="1">0.269</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Peri-urban</td><td align="center" rowspan="1" colspan="1">1.281</td><td align="center" rowspan="1" colspan="1">1.189, 1.379</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.194</td><td align="center" rowspan="1" colspan="1">1.037, 1.374</td><td align="center" rowspan="1" colspan="1">0.014</td></tr><tr><td align="left" rowspan="1" colspan="1">HIV status</td><td align="left" rowspan="1" colspan="1">HIV tested and negative</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">HIV tested and positive</td><td align="center" rowspan="1" colspan="1">11.425</td><td align="center" rowspan="1" colspan="1">9.348, 13.963</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">7.842</td><td align="center" rowspan="1" colspan="1">6.261, 9.823</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never tested</td><td align="center" rowspan="1" colspan="1">5.421</td><td align="center" rowspan="1" colspan="1">4.485, 6.551</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.275</td><td align="center" rowspan="1" colspan="1">2.615, 4.103</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr></tbody></table></table-wrap><p>External migration (whether in- or out-migration) was positively associated with all-cause mortality, and with HIV-related and all other cause-specific mortality separately with increased hazards of more than 61%. While a minimum self-reported poor health status was significantly associated with increased hazards of all-cause mortality and mortality due to HIV/TB-related causes (<xref ref-type="bibr" rid="CIT0003">Tables 3</xref>–<xref ref-type="bibr" rid="CIT0005">5</xref>), no significant association was found with mortality due to causes not related to HIV/TB. A positive HIV status was associated with an increased hazard of dying from all-causes and specific causes of death, with the greatest magnitude in women who died from HIV/TB-related causes (<xref ref-type="bibr" rid="CIT0003">Tables 3</xref>–<xref ref-type="bibr" rid="CIT0005">5</xref>). On the other hand, ever having been employed and ever been married were associated with decreased hazards of dying from all-causes as well as from HIV/TB-related causes of death (<xref ref-type="table" rid="T0003">Tables 3</xref> and <xref ref-type="table" rid="T0004">4</xref>).
</p><table-wrap id="T0004" position="float"><label>Table 4</label><caption><p>Risk factors associated with HIV and /or TB-related mortality, ACDIS</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="3" rowspan="1">Univariable analysis</th><th align="center" colspan="3" rowspan="1">Multivariable analysis</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th colspan="3" rowspan="1"><hr></hr></th><th colspan="3" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Explanatory variables</th><th align="center" rowspan="1" colspan="1">Categories of explanatory variables</th><th align="center" rowspan="1" colspan="1">Crude hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th><th align="center" rowspan="1" colspan="1">Adjusted Hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Women age</td><td align="center" rowspan="1" colspan="1">15–19</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1">,</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">20–24</td><td align="center" rowspan="1" colspan="1">6.127</td><td align="center" rowspan="1" colspan="1">4.705, 7.980</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.668</td><td align="center" rowspan="1" colspan="1">1.522, 4.678</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">25–29</td><td align="center" rowspan="1" colspan="1">14.863</td><td align="center" rowspan="1" colspan="1">11.545, 19.137</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">4.682</td><td align="center" rowspan="1" colspan="1">2.294, 9.559</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">30–34</td><td align="center" rowspan="1" colspan="1">18.910</td><td align="center" rowspan="1" colspan="1">14.683, 24.355</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">5.342</td><td align="center" rowspan="1" colspan="1">2.117, 13.481</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">35–39</td><td align="center" rowspan="1" colspan="1">16.172</td><td align="center" rowspan="1" colspan="1">12.476, 2.963</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">4.114</td><td align="center" rowspan="1" colspan="1">1.294, 13.074</td><td align="center" rowspan="1" colspan="1">0.017</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">40–44</td><td align="center" rowspan="1" colspan="1">13.823</td><td align="center" rowspan="1" colspan="1">10.594, 18.036</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.362</td><td align="center" rowspan="1" colspan="1">0.582, 9.592</td><td align="center" rowspan="1" colspan="1">0.229</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">45–49</td><td align="center" rowspan="1" colspan="1">14.056</td><td align="center" rowspan="1" colspan="1">10.705, 18.459</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.416</td><td align="center" rowspan="1" colspan="1">0.469, 12.425</td><td align="center" rowspan="1" colspan="1">0.291</td></tr><tr><td align="left" rowspan="1" colspan="1">Self-reported minimum general health</td><td align="left" rowspan="1" colspan="1">Good</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Fair</td><td align="center" rowspan="1" colspan="1">1.519</td><td align="center" rowspan="1" colspan="1">1.285,1.797</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.485</td><td align="center" rowspan="1" colspan="1">1.635,7.428,</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Poor</td><td align="center" rowspan="1" colspan="1">3.675</td><td align="center" rowspan="1" colspan="1">2.857,4.729</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">9.928</td><td align="center" rowspan="1" colspan="1">3.063, 32.184</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever employed</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.553</td><td align="center" rowspan="1" colspan="1">0.501, 0.610</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.710</td><td align="center" rowspan="1" colspan="1">0.604, 0.836</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever married</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.625</td><td align="center" rowspan="1" colspan="1">0.556, 0.702</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.482</td><td align="center" rowspan="1" colspan="1">0.387, 0.600</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Migration status</td><td align="left" rowspan="1" colspan="1">Never moved</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Internal only</td><td align="center" rowspan="1" colspan="1">0.475</td><td align="center" rowspan="1" colspan="1">0.409, 0.553</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.665</td><td align="center" rowspan="1" colspan="1">0.517, 0.857</td><td align="center" rowspan="1" colspan="1">0.002</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">External only</td><td align="center" rowspan="1" colspan="1">1.602</td><td align="center" rowspan="1" colspan="1">1.432, 1.793</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.711</td><td align="center" rowspan="1" colspan="1">1.363, 2.148</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Both internal and external</td><td align="center" rowspan="1" colspan="1">0.377</td><td align="center" rowspan="1" colspan="1">0.341, 0.417</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.541</td><td align="center" rowspan="1" colspan="1">0.448, 0.654</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Minimum household index class</td><td align="left" rowspan="1" colspan="1">Upper 20%</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Middle 40%</td><td align="center" rowspan="1" colspan="1">1.904</td><td align="center" rowspan="1" colspan="1">1.579, 2.294</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.425</td><td align="center" rowspan="1" colspan="1">0.967, 2.099</td><td align="center" rowspan="1" colspan="1">0.073</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Lower 40%</td><td align="center" rowspan="1" colspan="1">1.999</td><td align="center" rowspan="1" colspan="1">1.669, 2.394</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.505</td><td align="center" rowspan="1" colspan="1">1.014, 2.234</td><td align="center" rowspan="1" colspan="1">0.042</td></tr><tr><td align="left" rowspan="1" colspan="1">Highest education level</td><td align="left" rowspan="1" colspan="1">More than 8 years</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Less than 8 years</td><td align="center" rowspan="1" colspan="1">1.972</td><td align="center" rowspan="1" colspan="1">1.778, 2.187</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.378</td><td align="center" rowspan="1" colspan="1">1.137, 1.669</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never gone to school</td><td align="center" rowspan="1" colspan="1">1.645</td><td align="center" rowspan="1" colspan="1">1.347, 2.009</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.372</td><td align="center" rowspan="1" colspan="1">1.000, 1.884,</td><td align="center" rowspan="1" colspan="1">0.050</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever used contraception</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">1.316</td><td align="center" rowspan="1" colspan="1">1.211, 1.431</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.314</td><td align="center" rowspan="1" colspan="1">1.099, 1.569</td><td align="center" rowspan="1" colspan="1"><0.003</td></tr><tr><td align="left" rowspan="1" colspan="1">Pregnancy outcome history</td><td align="left" rowspan="1" colspan="1">All live births</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">>1 pregnancy a still birth/abortion</td><td align="center" rowspan="1" colspan="1">1.124</td><td align="center" rowspan="1" colspan="1">0.976, 1.295</td><td align="center" rowspan="1" colspan="1">0.091</td><td align="center" rowspan="1" colspan="1">1.066</td><td align="center" rowspan="1" colspan="1">0.847, 1.341</td><td align="center" rowspan="1" colspan="1">0.587</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">No outcome reported</td><td align="center" rowspan="1" colspan="1">1.144</td><td align="center" rowspan="1" colspan="1">1.039, 1.259</td><td align="center" rowspan="1" colspan="1">0.008</td><td align="center" rowspan="1" colspan="1">1.346</td><td align="center" rowspan="1" colspan="1">1.022,1.774</td><td align="center" rowspan="1" colspan="1">0.035</td></tr><tr><td align="left" rowspan="1" colspan="1">Maximum parity</td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.036</td><td align="center" rowspan="1" colspan="1">1.018, 1.055</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.505</td><td align="center" rowspan="1" colspan="1">0.394, 0.649</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Area of residence</td><td align="left" rowspan="1" colspan="1">Rural</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Urban</td><td align="center" rowspan="1" colspan="1">0.517</td><td align="center" rowspan="1" colspan="1">0.415, 0.643</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.733</td><td align="center" rowspan="1" colspan="1">0.438, 1.227</td><td align="center" rowspan="1" colspan="1">0.237</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Peri-urban</td><td align="center" rowspan="1" colspan="1">1.296</td><td align="center" rowspan="1" colspan="1">1.189, 1.412</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.252</td><td align="center" rowspan="1" colspan="1">1.058, 1.482</td><td align="center" rowspan="1" colspan="1">0.009</td></tr><tr><td align="left" rowspan="1" colspan="1">HIV status</td><td align="left" rowspan="1" colspan="1">HIV tested and negative</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">HIV tested and positive</td><td align="center" rowspan="1" colspan="1">25.567</td><td align="center" rowspan="1" colspan="1">18.606,35.134</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">17.767</td><td align="center" rowspan="1" colspan="1">12.290, 25.685</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never tested</td><td align="center" rowspan="1" colspan="1">10.232</td><td align="center" rowspan="1" colspan="1">7.509, 13.942</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">6.49</td><td align="center" rowspan="1" colspan="1">4.479, 9.425</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr></tbody></table></table-wrap><table-wrap id="T0005" position="float"><label>Table 5</label><caption><p>Risk factors associated with other causes (Combined) other than HIV and /or TB, ACDIS</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th align="center" colspan="3" rowspan="1">Univariable analysis</th><th align="center" colspan="3" rowspan="1">Multivariable analysis</th></tr><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1"></th><th colspan="3" rowspan="1"><hr></hr></th><th colspan="3" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Explanatory variables</th><th align="center" rowspan="1" colspan="1">Categories of explanatory variables</th><th align="center" rowspan="1" colspan="1">Crude hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th><th align="center" rowspan="1" colspan="1">Adjusted hazards ratio</th><th align="center" rowspan="1" colspan="1">95% CI</th><th align="center" rowspan="1" colspan="1">P value</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Women age</td><td align="center" rowspan="1" colspan="1">15–19</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">20–24</td><td align="center" rowspan="1" colspan="1">2.111</td><td align="center" rowspan="1" colspan="1">1.513, 2.945</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.761</td><td align="center" rowspan="1" colspan="1">0.965, 3.211</td><td align="center" rowspan="1" colspan="1">0.065</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">25–29</td><td align="center" rowspan="1" colspan="1">3.429</td><td align="center" rowspan="1" colspan="1">2.484, 4.733</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.649</td><td align="center" rowspan="1" colspan="1">1.974, 6.744</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">30–34</td><td align="center" rowspan="1" colspan="1">4.050</td><td align="center" rowspan="1" colspan="1">2.919, 5.620</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.344</td><td align="center" rowspan="1" colspan="1">1.739, 6.429</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">35–39</td><td align="center" rowspan="1" colspan="1">3.644</td><td align="center" rowspan="1" colspan="1">2.576, 5.155</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">3.277</td><td align="center" rowspan="1" colspan="1">1.647, 6.520</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">40–44</td><td align="center" rowspan="1" colspan="1">4.318</td><td align="center" rowspan="1" colspan="1">3.063, 6.086</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.937</td><td align="center" rowspan="1" colspan="1">0.895, 4.189</td><td align="center" rowspan="1" colspan="1">0.093</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">45–49</td><td align="center" rowspan="1" colspan="1">5.388</td><td align="center" rowspan="1" colspan="1">3.824, 7.591</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.184</td><td align="center" rowspan="1" colspan="1">0.909, 5.247</td><td align="center" rowspan="1" colspan="1">0.081</td></tr><tr><td align="left" rowspan="1" colspan="1">Self-reported minimum general health</td><td align="left" rowspan="1" colspan="1">Good</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Fair</td><td align="center" rowspan="1" colspan="1">0.836</td><td align="center" rowspan="1" colspan="1">0.608, 1.149</td><td align="center" rowspan="1" colspan="1">0.269</td><td align="center" rowspan="1" colspan="1">0.564</td><td align="center" rowspan="1" colspan="1">0.399, 0.797</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Poor</td><td align="center" rowspan="1" colspan="1">1.694</td><td align="center" rowspan="1" colspan="1">0.986, 2.908</td><td align="center" rowspan="1" colspan="1">0.056</td><td align="center" rowspan="1" colspan="1">0.815</td><td align="center" rowspan="1" colspan="1">0.437, 1.520</td><td align="center" rowspan="1" colspan="1">0.521</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever employed</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.814</td><td align="center" rowspan="1" colspan="1">0.689, 0.961</td><td align="center" rowspan="1" colspan="1">0.015</td><td align="center" rowspan="1" colspan="1">1.040</td><td align="center" rowspan="1" colspan="1">0.796, 1.360</td><td align="center" rowspan="1" colspan="1">0.769</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever married</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.794</td><td align="center" rowspan="1" colspan="1">0.651, 0.969</td><td align="center" rowspan="1" colspan="1">0.023</td><td align="center" rowspan="1" colspan="1">0.572</td><td align="center" rowspan="1" colspan="1">0.408, 0.804</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Migration status</td><td align="left" rowspan="1" colspan="1">Never moved</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Internal only</td><td align="center" rowspan="1" colspan="1">0.405</td><td align="center" rowspan="1" colspan="1">0.306, 0.536</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.575</td><td align="center" rowspan="1" colspan="1">0.388, 0.853</td><td align="center" rowspan="1" colspan="1">0.006</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">External only</td><td align="center" rowspan="1" colspan="1">1.255</td><td align="center" rowspan="1" colspan="1">1.008, 1.568</td><td align="center" rowspan="1" colspan="1">0.045</td><td align="center" rowspan="1" colspan="1">1.621</td><td align="center" rowspan="1" colspan="1">1.121, 2.343</td><td align="center" rowspan="1" colspan="1">0.010</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Both internal and external</td><td align="center" rowspan="1" colspan="1">0.312</td><td align="center" rowspan="1" colspan="1">0.259, 0.375</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">0.329</td><td align="center" rowspan="1" colspan="1">0.239, 0.453</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Minimum household index class</td><td align="left" rowspan="1" colspan="1">Upper 20%</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Middle 40%</td><td align="center" rowspan="1" colspan="1">1.116</td><td align="center" rowspan="1" colspan="1">0.846, 1.473</td><td align="center" rowspan="1" colspan="1">0.437</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Lower 40%</td><td align="center" rowspan="1" colspan="1">1.055</td><td align="center" rowspan="1" colspan="1">0.809, 1.375</td><td align="center" rowspan="1" colspan="1">0.690</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Highest education level</td><td align="left" rowspan="1" colspan="1">More than 8 years</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Less than 8 years</td><td align="center" rowspan="1" colspan="1">1.636</td><td align="center" rowspan="1" colspan="1">1.351, 1.982</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.248</td><td align="center" rowspan="1" colspan="1">0.899, 1.730</td><td align="center" rowspan="1" colspan="1">0.184</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never gone to school</td><td align="center" rowspan="1" colspan="1">1.547</td><td align="center" rowspan="1" colspan="1">1.082, 2.211</td><td align="center" rowspan="1" colspan="1">0.017</td><td align="center" rowspan="1" colspan="1">1.364</td><td align="center" rowspan="1" colspan="1">0.812, 2.303</td><td align="center" rowspan="1" colspan="1">0.240</td></tr><tr><td align="left" rowspan="1" colspan="1">Ever used contraception</td><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">0.976</td><td align="center" rowspan="1" colspan="1">0.833, 1.143</td><td align="center" rowspan="1" colspan="1">0.762</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Pregnancy outcome history</td><td align="left" rowspan="1" colspan="1">All live births</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">>1 pregnancy a still birth/abortion</td><td align="center" rowspan="1" colspan="1">1.554</td><td align="center" rowspan="1" colspan="1">1.219, 1.982</td><td align="center" rowspan="1" colspan="1">0.002</td><td align="center" rowspan="1" colspan="1">1.311</td><td align="center" rowspan="1" colspan="1">0.915, 1.876</td><td align="center" rowspan="1" colspan="1">0.140</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">No outcome reported</td><td align="center" rowspan="1" colspan="1">1.586</td><td align="center" rowspan="1" colspan="1">1.332, 1.888</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.143</td><td align="center" rowspan="1" colspan="1">0.756,1.728</td><td align="center" rowspan="1" colspan="1">0.526</td></tr><tr><td align="left" rowspan="1" colspan="1">Maximum parity</td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">0.985</td><td align="center" rowspan="1" colspan="1">0.949, 1.021</td><td align="center" rowspan="1" colspan="1">0.415</td><td align="center" rowspan="1" colspan="1">0.363</td><td align="center" rowspan="1" colspan="1">0.240,0.549</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">Area of residence</td><td align="left" rowspan="1" colspan="1">Rural</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Urban</td><td align="center" rowspan="1" colspan="1">0.701</td><td align="center" rowspan="1" colspan="1">0.488, 1.006</td><td align="center" rowspan="1" colspan="1">0.067</td><td align="center" rowspan="1" colspan="1">0.608</td><td align="center" rowspan="1" colspan="1">0.316,1.172</td><td align="center" rowspan="1" colspan="1">0.137</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Peri-urban</td><td align="center" rowspan="1" colspan="1">1.287</td><td align="center" rowspan="1" colspan="1">1.095, 1.513</td><td align="center" rowspan="1" colspan="1">0.025</td><td align="center" rowspan="1" colspan="1">1.215</td><td align="center" rowspan="1" colspan="1">0.939, 1.573</td><td align="center" rowspan="1" colspan="1">0.139</td></tr><tr><td align="left" rowspan="1" colspan="1">HIV status</td><td align="left" rowspan="1" colspan="1">HIV tested and negative</td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.000</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">HIV tested and positive</td><td align="center" rowspan="1" colspan="1">3.315</td><td align="center" rowspan="1" colspan="1">2.387, 4.604</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">2.590</td><td align="center" rowspan="1" colspan="1">1.790, 3.750</td><td align="center" rowspan="1" colspan="1"><0.001</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Never tested</td><td align="center" rowspan="1" colspan="1">2.399</td><td align="center" rowspan="1" colspan="1">1.822, 3.159</td><td align="center" rowspan="1" colspan="1"><0.001</td><td align="center" rowspan="1" colspan="1">1.703</td><td align="center" rowspan="1" colspan="1">1.218, 2.382</td><td align="center" rowspan="1" colspan="1">0.002</td></tr></tbody></table></table-wrap></sec></sec><sec sec-type="discussion" id="S0008"><title>Discussion</title><p>Overall, MR was 14.6 per 1,000 person-years in women of reproductive age in this area over the period 2000–2009. HIV/TB was the leading cause of mortality among women of reproductive age in this rural area over the period 2000–2009, and it accounted for nearly three-quarters of deaths overall (73%). The most important factors associated with all-cause and cause-specific mortality were a woman's age, migration status, HIV status, and self-reported health; the effect and/or magnitude of effect of these variables varied significantly within the different mortality groups (all-cause, HIV/TB-related causes and causes other than HIV/TB).</p><p>MRs due to HIV/TB-related causes significantly differed across the years, from as low as 5.9 per 1,000 pyo in 2009 to as high as 14.5 per 1,000 pyo in 2003. As for this study follow-up ceased at the end of 2009, there was little time to assess the impact of the public HIV Treatment and Care Program on MR at population level. More recent studies from the Africa Centre have documented an association between declining HIV/TB-related MR and the introduction of HIV treatment in public health facilities within the study area (<xref ref-type="bibr" rid="CIT0016">16</xref>, <xref ref-type="bibr" rid="CIT0037">37</xref>, <xref ref-type="bibr" rid="CIT0038">38</xref>).</p><p>Results presented here confirm the findings of an earlier study (<xref ref-type="bibr" rid="CIT0021">21</xref>) in this setting, when 73% of deaths in women aged 15–44 years were related to HIV over the period 2000–2004 (<xref ref-type="bibr" rid="CIT0021">21</xref>). Although this study has shown that HIV-related mortality declines with the introduction and roll-out of ART over the years, a woman who was, for example, aged 20 years when she became infected and who would have died by age 35 in the absence of ART, may now with ART die by age 49 and therefore still contribute to the number of deaths within this age group. While maternal mortality reportedly dominates the mortality in women of reproductive age in sub-Saharan Africa, (<xref ref-type="bibr" rid="CIT0001">1</xref>, <xref ref-type="bibr" rid="CIT0039">39</xref>, <xref ref-type="bibr" rid="CIT0040">40</xref>) in South Africa HIV-related mortality has been dominant in these women (<xref ref-type="bibr" rid="CIT0041">41</xref>), due to the high HIV prevalence in South Africa and in particular in KwaZulu-Natal province (<xref ref-type="bibr" rid="CIT0030">30</xref>).</p><p>Compared to women aged 15–19 years, older women had an increased risk of dying from all-causes and specific causes of death. These results confirm earlier findings from the same setting which showed that women aged 26 years and older were more likely to die of HIV/TB and injury-related causes than their younger counterparts (<xref ref-type="bibr" rid="CIT0019">19</xref>, <xref ref-type="bibr" rid="CIT0020">20</xref>), which is in line with the pattern of HIV acquisition by age (<xref ref-type="bibr" rid="CIT0042">42</xref>).</p><p>Women with a minimum self-reported poor health were significantly more likely to die from all-cause and/or HIV/TB-related mortality than those who reported to be in good health. This variable is based on perceived health status at the time of interview and for this study, we considered the minimum reported status over the study duration; although this may not be the best estimate of a person's health status, we have previously shown that self-reported health is a good proxy for risk of death in the subsequent 4–6 years (<xref ref-type="bibr" rid="CIT0043">43</xref>).</p><p>An association between mortality and external migration has been reported previously from this setting; likely due to the findings that migrants have a higher risk of becoming HIV infected (<xref ref-type="bibr" rid="CIT0009">9</xref>) and migrants have been shown to come home to die (<xref ref-type="bibr" rid="CIT0020">20</xref>), similar to findings in a study carried out in the Agincourt Health and Demographic Surveillance Site (<xref ref-type="bibr" rid="CIT0028">28</xref>) in which annually, the odds of dying from all-causes for external migrants was between 1.1 and 1.9 times higher than for residents. Thus, it is important that in settings with high HIV prevalence and substantial migration, this relationship is taken into account in evaluating mortality statistics and planning for health care services.</p><p>A surveillance HIV-positive status was associated with a higher risk of all-cause and cause-specific mortality than seen in surveillance HIV-negative status; the magnitude of the effect was highest in women who died from HIV/TB-related causes. These results agree with the findings from other studies elsewhere in sub-Saharan Africa (South Africa, Kenya, and Zimbabwe), confirming the impact of HIV infection on the mortality patterns observed in this study (<xref ref-type="bibr" rid="CIT0021">21</xref>, <xref ref-type="bibr" rid="CIT0029">29</xref>, <xref ref-type="bibr" rid="CIT0044">44</xref>).</p></sec><sec id="S0009"><title>Conclusion and recommendations</title><p>HIV/TB was the leading cause of death in women of reproductive age from 2000 to 2009 in this rural, high HIV-prevalence area of South Africa. Age, self-reported poor health status, external migration status, being HIV positive and unknown HIV status (among HIV surveillance participants) were the most significant risk factors associated with increased hazards of all-cause mortality and cause-specific mortality. It is likely that the roll-out of HIV treatment in this area, where HIV continues to be the main cause of death in women of reproductive age, will further reduce the risk of dying in this age group. The recently increased criteria for treatment eligibility in HIV infected adults will further contribute to this goal. To reduce the spread of HIV and other sexually transmitted diseases, increased community awareness and sensitization messages continue to be important.</p></sec></body><back><ack><title>Acknowledgements</title><p>The authors wish to extend their appreciation to the Africa Centre research operations team. We thank Colin Newell and the rest of the ACDIS data management team. The INDEPTH Network is thanked for awarding a training fellowship to Dorean Nabukalu for MSc. training at the University of the Witwatersrand (January–December 2010) and for supporting the internship at the Africa Centre for Health and Population Studies (January–June 2011). The Africa Centre Surveillance is funded by a grant from the Wellcome Trust, UK, grant number GR065377MA. These results were presented at the INDEPTH AGM 2011 and also at the PHASA conference 2011.</p></ack><fn-group><fn id="FN0001"><label>1</label><p>Underlying cause of death is defined by the World Health Organization (WHO) as the disease or injury that initiated the chain of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury.</p></fn></fn-group><sec id="S0010"><title>Conflict of interest and funding</title><p>The authors have not received any funding or benefits from industry or elsewhere to conduct this study.</p></sec><ref-list><title>References</title><ref id="CIT0001"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lopez</surname><given-names>AD</given-names></name><name><surname>Mathers</surname><given-names>CD</given-names></name></person-group><article-title>Measuring the global burden of disease and epidemiological transitions: 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