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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Antiretroviral Therapy on Health-Related Quality of Life
among South African Women in the CAPRISA 002 Acute Infection
Study</title>
<author><name sortKey="Tomita, Andrew" sort="Tomita, Andrew" uniqKey="Tomita A" first="Andrew" last="Tomita">Andrew Tomita</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Columbia University Mailman School of Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garrett, Nigel" sort="Garrett, Nigel" uniqKey="Garrett N" first="Nigel" last="Garrett">Nigel Garrett</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Werner, Lise" sort="Werner, Lise" uniqKey="Werner L" first="Lise" last="Werner">Lise Werner</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burns, Jonathan K" sort="Burns, Jonathan K" uniqKey="Burns J" first="Jonathan K." last="Burns">Jonathan K. Burns</name>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ngcobo, Nelisiwe" sort="Ngcobo, Nelisiwe" uniqKey="Ngcobo N" first="Nelisiwe" last="Ngcobo">Nelisiwe Ngcobo</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zuma, Nomthandazo" sort="Zuma, Nomthandazo" uniqKey="Zuma N" first="Nomthandazo" last="Zuma">Nomthandazo Zuma</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mlisana, Koleka" sort="Mlisana, Koleka" uniqKey="Mlisana K" first="Koleka" last="Mlisana">Koleka Mlisana</name>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Medical Microbiology Department, National Health Laboratory Service, Durban</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Loggerenberg, Francois" sort="Van Loggerenberg, Francois" uniqKey="Van Loggerenberg F" first="Francois" last="Van Loggerenberg">Francois Van Loggerenberg</name>
<affiliation><nlm:aff id="A5">University of Oxford – The Global Health Network, Centre for Tropical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S." last="Abdool Karim">Salim S. Abdool Karim</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Columbia University Mailman School of Public Health</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24849623</idno>
<idno type="pmc">4127113</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127113</idno>
<idno type="RBID">PMC:4127113</idno>
<idno type="doi">10.1007/s10461-014-0800-5</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001F96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F96</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of Antiretroviral Therapy on Health-Related Quality of Life
among South African Women in the CAPRISA 002 Acute Infection
Study</title>
<author><name sortKey="Tomita, Andrew" sort="Tomita, Andrew" uniqKey="Tomita A" first="Andrew" last="Tomita">Andrew Tomita</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Columbia University Mailman School of Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garrett, Nigel" sort="Garrett, Nigel" uniqKey="Garrett N" first="Nigel" last="Garrett">Nigel Garrett</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Werner, Lise" sort="Werner, Lise" uniqKey="Werner L" first="Lise" last="Werner">Lise Werner</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burns, Jonathan K" sort="Burns, Jonathan K" uniqKey="Burns J" first="Jonathan K." last="Burns">Jonathan K. Burns</name>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ngcobo, Nelisiwe" sort="Ngcobo, Nelisiwe" uniqKey="Ngcobo N" first="Nelisiwe" last="Ngcobo">Nelisiwe Ngcobo</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zuma, Nomthandazo" sort="Zuma, Nomthandazo" uniqKey="Zuma N" first="Nomthandazo" last="Zuma">Nomthandazo Zuma</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mlisana, Koleka" sort="Mlisana, Koleka" uniqKey="Mlisana K" first="Koleka" last="Mlisana">Koleka Mlisana</name>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Medical Microbiology Department, National Health Laboratory Service, Durban</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Loggerenberg, Francois" sort="Van Loggerenberg, Francois" uniqKey="Van Loggerenberg F" first="Francois" last="Van Loggerenberg">Francois Van Loggerenberg</name>
<affiliation><nlm:aff id="A5">University of Oxford – The Global Health Network, Centre for Tropical Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S." last="Abdool Karim">Salim S. Abdool Karim</name>
<affiliation><nlm:aff id="A1">Centre for the AIDS Programme of Research in South Africa (CAPRISA)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Columbia University Mailman School of Public Health</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">AIDS and behavior</title>
<idno type="ISSN">1090-7165</idno>
<idno type="eISSN">1573-3254</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Concerns are often raised regarding potentially adverse effects of
antiretroviral therapy (ART) on health-related quality of life (HRQoL), but
there is limited longitudinal data to prove this. Building on our prior
investigation, we examined the impact of ART on HRQoL among HIV-infected South
African women with extensive follow-up in the CAPRISA 002 Acute Infection Cohort
Study. Overall HRQoL and five sub-domains [physical well-being (PWB),
emotional well-being (EWB), functional and global well-being (FGWB), social
well-being (SWB) and cognitive functioning (CF)] were assessed using the
Functional Assessment of HIV Infection (FAHI) instrument. Our analyses comparing
FAHI scores between pre-ART (established infection) and ART phases using paired
Wilcoxon signed-rank tests and adjusted mixed-effects regression models revealed
improvements on ART in overall HRQoL, and in PWB, EWB, and SWB, but not in FGWB
and CF. No long-term adverse impact of ART on HRQoL was detected, providing
additional non-biomedical support to early treatment strategies.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9712133</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21042</journal-id>
<journal-id journal-id-type="nlm-ta">AIDS Behav</journal-id>
<journal-id journal-id-type="iso-abbrev">AIDS Behav</journal-id>
<journal-title-group><journal-title>AIDS and behavior</journal-title>
</journal-title-group>
<issn pub-type="ppub">1090-7165</issn>
<issn pub-type="epub">1573-3254</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24849623</article-id>
<article-id pub-id-type="pmc">4127113</article-id>
<article-id pub-id-type="doi">10.1007/s10461-014-0800-5</article-id>
<article-id pub-id-type="manuscript">NIHMS599872</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Impact of Antiretroviral Therapy on Health-Related Quality of Life
among South African Women in the CAPRISA 002 Acute Infection
Study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tomita</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN3" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garrett</surname>
<given-names>Nigel</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Werner</surname>
<given-names>Lise</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burns</surname>
<given-names>Jonathan K.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ngcobo</surname>
<given-names>Nelisiwe</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zuma</surname>
<given-names>Nomthandazo</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mlisana</surname>
<given-names>Koleka</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Loggerenberg</surname>
<given-names>Francois</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abdool Karim</surname>
<given-names>Salim S.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Centre for the AIDS Programme of Research in South Africa (CAPRISA)</aff>
<aff id="A2"><label>2</label>
University of KwaZulu-Natal, Nelson R Mandela School of Clinical Medicine</aff>
<aff id="A3"><label>3</label>
Columbia University Mailman School of Public Health</aff>
<aff id="A4"><label>4</label>
Medical Microbiology Department, National Health Laboratory Service, Durban</aff>
<aff id="A5"><label>5</label>
University of Oxford – The Global Health Network, Centre for Tropical Medicine</aff>
<author-notes><corresp id="FN3"><label>*</label>
Corresponding author: Andrew Tomita, Ph.D.,
<email>tomita@ukzn.ac.za</email>
, Centre for the AIDS Programme of Research
in South Africa, Doris Duke Medical Research Institute, University of
KwaZulu-Natal, Private Bag X7, Congella, 4013, South Africa</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>10</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>18</volume>
<issue>9</issue>
<fpage>1801</fpage>
<lpage>1807</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s10461-014-0800-5</pmc-comment>
<permissions><copyright-statement>© Springer Science+Business Media New York
2014</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p id="P1">Concerns are often raised regarding potentially adverse effects of
antiretroviral therapy (ART) on health-related quality of life (HRQoL), but
there is limited longitudinal data to prove this. Building on our prior
investigation, we examined the impact of ART on HRQoL among HIV-infected South
African women with extensive follow-up in the CAPRISA 002 Acute Infection Cohort
Study. Overall HRQoL and five sub-domains [physical well-being (PWB),
emotional well-being (EWB), functional and global well-being (FGWB), social
well-being (SWB) and cognitive functioning (CF)] were assessed using the
Functional Assessment of HIV Infection (FAHI) instrument. Our analyses comparing
FAHI scores between pre-ART (established infection) and ART phases using paired
Wilcoxon signed-rank tests and adjusted mixed-effects regression models revealed
improvements on ART in overall HRQoL, and in PWB, EWB, and SWB, but not in FGWB
and CF. No long-term adverse impact of ART on HRQoL was detected, providing
additional non-biomedical support to early treatment strategies.</p>
</abstract>
<kwd-group><kwd>Health-related quality of life</kwd>
<kwd>South Africa</kwd>
<kwd>Acute HIV infection</kwd>
<kwd>Functional assessment of HIV infection</kwd>
<kwd>ART</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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