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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Partnership Change on Microbicide Gel Adherence in HPTN 035</title><author><name sortKey="Gorbach, Pamina M" sort="Gorbach, Pamina M" uniqKey="Gorbach P" first="Pamina M." last="Gorbach">Pamina M. Gorbach</name><affiliation><nlm:aff id="A1">Department of Epidemiology, University of California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Cliff" sort="Kelly, Cliff" uniqKey="Kelly C" first="Cliff" last="Kelly">Cliff Kelly</name><affiliation><nlm:aff id="A2">SCHARP, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Borgerding, Joleen A" sort="Borgerding, Joleen A" uniqKey="Borgerding J" first="Joleen A" last="Borgerding">Joleen A. Borgerding</name><affiliation><nlm:aff id="A2">SCHARP, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Ramjee, Gita" sort="Ramjee, Gita" uniqKey="Ramjee G" first="Gita" last="Ramjee">Gita Ramjee</name><affiliation><nlm:aff id="A3">South African Medical Research Council, HIV Prevention Research Unit, Durban, South Africa</nlm:aff></affiliation></author><author><name sortKey="Tembo, Tchangani" sort="Tembo, Tchangani" uniqKey="Tembo T" first="Tchangani" last="Tembo">Tchangani Tembo</name><affiliation><nlm:aff id="A4">Kamuzu Central Hospital, Tidziwe Centre, UNC Project, Lilongwe, Malawi</nlm:aff></affiliation></author><author><name sortKey="Kumwenda, Newton" sort="Kumwenda, Newton" uniqKey="Kumwenda N" first="Newton" last="Kumwenda">Newton Kumwenda</name><affiliation><nlm:aff id="A5">College of Medicine - Johns Hopkins University Research Project at Queen Elizabeth Central Hospital, Blantyre, Malawi</nlm:aff></affiliation></author><author><name sortKey="Musara, Petina" sort="Musara, Petina" uniqKey="Musara P" first="Petina" last="Musara">Petina Musara</name><affiliation><nlm:aff id="A6">Spilhaus Clinical Research Site, Harare, Zimbabwe</nlm:aff></affiliation></author><author><name sortKey="Roberts, Sarah" sort="Roberts, Sarah" uniqKey="Roberts S" first="Sarah" last="Roberts">Sarah Roberts</name><affiliation><nlm:aff id="A7">Centre for Infectious Disease Research in Zambia, Lusaka, Zambia and University of Alabama at Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Maslankowski, Lisa" sort="Maslankowski, Lisa" uniqKey="Maslankowski L" first="Lisa" last="Maslankowski">Lisa Maslankowski</name><affiliation><nlm:aff id="A8">University of Pennsylvania, Philadelphia, PA, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24158488</idno><idno type="pmc">3988261</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988261</idno><idno type="RBID">PMC:3988261</idno><idno type="doi">10.1007/s10461-013-0651-5</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001F83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Partnership Change on Microbicide Gel Adherence in HPTN 035</title><author><name sortKey="Gorbach, Pamina M" sort="Gorbach, Pamina M" uniqKey="Gorbach P" first="Pamina M." last="Gorbach">Pamina M. Gorbach</name><affiliation><nlm:aff id="A1">Department of Epidemiology, University of California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Cliff" sort="Kelly, Cliff" uniqKey="Kelly C" first="Cliff" last="Kelly">Cliff Kelly</name><affiliation><nlm:aff id="A2">SCHARP, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Borgerding, Joleen A" sort="Borgerding, Joleen A" uniqKey="Borgerding J" first="Joleen A" last="Borgerding">Joleen A. Borgerding</name><affiliation><nlm:aff id="A2">SCHARP, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Ramjee, Gita" sort="Ramjee, Gita" uniqKey="Ramjee G" first="Gita" last="Ramjee">Gita Ramjee</name><affiliation><nlm:aff id="A3">South African Medical Research Council, HIV Prevention Research Unit, Durban, South Africa</nlm:aff></affiliation></author><author><name sortKey="Tembo, Tchangani" sort="Tembo, Tchangani" uniqKey="Tembo T" first="Tchangani" last="Tembo">Tchangani Tembo</name><affiliation><nlm:aff id="A4">Kamuzu Central Hospital, Tidziwe Centre, UNC Project, Lilongwe, Malawi</nlm:aff></affiliation></author><author><name sortKey="Kumwenda, Newton" sort="Kumwenda, Newton" uniqKey="Kumwenda N" first="Newton" last="Kumwenda">Newton Kumwenda</name><affiliation><nlm:aff id="A5">College of Medicine - Johns Hopkins University Research Project at Queen Elizabeth Central Hospital, Blantyre, Malawi</nlm:aff></affiliation></author><author><name sortKey="Musara, Petina" sort="Musara, Petina" uniqKey="Musara P" first="Petina" last="Musara">Petina Musara</name><affiliation><nlm:aff id="A6">Spilhaus Clinical Research Site, Harare, Zimbabwe</nlm:aff></affiliation></author><author><name sortKey="Roberts, Sarah" sort="Roberts, Sarah" uniqKey="Roberts S" first="Sarah" last="Roberts">Sarah Roberts</name><affiliation><nlm:aff id="A7">Centre for Infectious Disease Research in Zambia, Lusaka, Zambia and University of Alabama at Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Maslankowski, Lisa" sort="Maslankowski, Lisa" uniqKey="Maslankowski L" first="Lisa" last="Maslankowski">Lisa Maslankowski</name><affiliation><nlm:aff id="A8">University of Pennsylvania, Philadelphia, PA, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">AIDS and behavior</title><idno type="ISSN">1090-7165</idno><idno type="eISSN">1573-3254</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background:</title><p id="P1">Use of HIV prevention methods may vary for women by types of sexual partners. In a microbicide safety and effectiveness trial (HPTN 035) differences in adherence to a microbicide study gel were compared between women with new versus ongoing partnerships over time.</p></sec><sec id="S2"><title>Methods:</title><p id="P2">1,757 women in the three HPTN 035 trial’s arms completed the Follow-up Partner Status (FPS) questionnaire at their last study visit. Women married at baseline were asked if they had the same husband, new husband or new partner. Unmarried women were asked if they had changed partners or married. Self-reported gel adherence during the last sex act was compared at each quarterly visit between women with ongoing versus new partners. High gel adherence was compared with low gel adherence (85-100% versus <85% of last vaginal sex acts reported with gel use, respectively) in multivariable models to assess associations with partner change.</p></sec><sec id="S3"><title>Results:</title><p id="P3">Overall 7% of women (n=123) reported a new partner and 41% (51) of those reported a new husband. Median gel adherence was reported to be 100% in women with ongoing partners and 75% for women with new partners (p<0.001). In women reporting no gel use in their last sex act, only 12.5% of the women with a new partner and none of those with an ongoing partner reported using condoms (p<0.001). Fewer women with new partners reported using both the gel and condom during the last sex act as compared to women with ongoing partners (median: 50 versus 71.4%, p<0.001). After adjusting for age, site, education level, and sexual frequency, women with ongoing partners were more likely to report high gel adherence than those with new partners (AOR 2.5, 95% CI: 1.6, 3.9). (95% CI: 1.6, 3.9) more likely to report high gel adherence than those with new partners. This pattern persisted when gel use over time was compared between women with new vs. ongoing partners.</p></sec><sec id="S4"><title>Conclusions:</title><p id="P4">In the HPTN 035 trial, women with new partners had higher HIV incidence and reported less gel use and higher condom use. Specific counseling and support are needed to help women use potential HIV prevention methods, including microbicides, when they are changing partners.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9712133</journal-id><journal-id journal-id-type="pubmed-jr-id">21042</journal-id><journal-id journal-id-type="nlm-ta">AIDS Behav</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Behav</journal-id><journal-title-group><journal-title>AIDS and behavior</journal-title></journal-title-group><issn pub-type="ppub">1090-7165</issn><issn pub-type="epub">1573-3254</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24158488</article-id><article-id pub-id-type="pmc">3988261</article-id><article-id pub-id-type="doi">10.1007/s10461-013-0651-5</article-id><article-id pub-id-type="manuscript">NIHMS535268</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effects of Partnership Change on Microbicide Gel Adherence in HPTN 035</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gorbach</surname><given-names>Pamina M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>Cliff</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Borgerding</surname><given-names>Joleen A</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ramjee</surname><given-names>Gita</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tembo</surname><given-names>Tchangani</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kumwenda</surname><given-names>Newton</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Musara</surname><given-names>Petina</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Roberts</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Maslankowski</surname><given-names>Lisa</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><collab>HPTN 035 Protocol Team</collab></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, University of California, Los Angeles, CA, USA</aff><aff id="A2"><label>2</label>SCHARP, Seattle, WA, USA</aff><aff id="A3"><label>3</label>South African Medical Research Council, HIV Prevention Research Unit, Durban, South Africa</aff><aff id="A4"><label>4</label>Kamuzu Central Hospital, Tidziwe Centre, UNC Project, Lilongwe, Malawi</aff><aff id="A5"><label>5</label>College of Medicine - Johns Hopkins University Research Project at Queen Elizabeth Central Hospital, Blantyre, Malawi</aff><aff id="A6"><label>6</label>Spilhaus Clinical Research Site, Harare, Zimbabwe</aff><aff id="A7"><label>7</label>Centre for Infectious Disease Research in Zambia, Lusaka, Zambia and University of Alabama at Birmingham, Alabama, USA</aff><aff id="A8"><label>8</label>University of Pennsylvania, Philadelphia, PA, USA.</aff><author-notes><corresp id="CR1">Correspondence to: Pamina M. Gorbach 650 Charles Young Dr. 41-295CHS Los Angeles, CA 90095-1722 Phone: (310) 794-2555 Fax: (310) 825-7387 <email>pgorbach@ucla.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2015</year></pub-date><volume>18</volume><issue>5</issue><fpage>855</fpage><lpage>861</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10461-013-0651-5</pmc-comment>
<abstract><sec id="S1"><title>Background:</title><p id="P1">Use of HIV prevention methods may vary for women by types of sexual partners. In a microbicide safety and effectiveness trial (HPTN 035) differences in adherence to a microbicide study gel were compared between women with new versus ongoing partnerships over time.</p></sec><sec id="S2"><title>Methods:</title><p id="P2">1,757 women in the three HPTN 035 trial’s arms completed the Follow-up Partner Status (FPS) questionnaire at their last study visit. Women married at baseline were asked if they had the same husband, new husband or new partner. Unmarried women were asked if they had changed partners or married. Self-reported gel adherence during the last sex act was compared at each quarterly visit between women with ongoing versus new partners. High gel adherence was compared with low gel adherence (85-100% versus <85% of last vaginal sex acts reported with gel use, respectively) in multivariable models to assess associations with partner change.</p></sec><sec id="S3"><title>Results:</title><p id="P3">Overall 7% of women (n=123) reported a new partner and 41% (51) of those reported a new husband. Median gel adherence was reported to be 100% in women with ongoing partners and 75% for women with new partners (p<0.001). In women reporting no gel use in their last sex act, only 12.5% of the women with a new partner and none of those with an ongoing partner reported using condoms (p<0.001). Fewer women with new partners reported using both the gel and condom during the last sex act as compared to women with ongoing partners (median: 50 versus 71.4%, p<0.001). After adjusting for age, site, education level, and sexual frequency, women with ongoing partners were more likely to report high gel adherence than those with new partners (AOR 2.5, 95% CI: 1.6, 3.9). (95% CI: 1.6, 3.9) more likely to report high gel adherence than those with new partners. This pattern persisted when gel use over time was compared between women with new vs. ongoing partners.</p></sec><sec id="S4"><title>Conclusions:</title><p id="P4">In the HPTN 035 trial, women with new partners had higher HIV incidence and reported less gel use and higher condom use. Specific counseling and support are needed to help women use potential HIV prevention methods, including microbicides, when they are changing partners.</p></sec></abstract><kwd-group><kwd>Adherence</kwd><kwd>microbicide</kwd><kwd>HIV</kwd><kwd>partner status</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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