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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Role of Depression in Work-Related Outcomes of HIV Treatment in Uganda</title><author><name sortKey="Wagner, Glenn J" sort="Wagner, Glenn J" uniqKey="Wagner G" first="Glenn J." last="Wagner">Glenn J. Wagner</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Ghosh Dastidar, Bonnie" sort="Ghosh Dastidar, Bonnie" uniqKey="Ghosh Dastidar B" first="Bonnie" last="Ghosh-Dastidar">Bonnie Ghosh-Dastidar</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Slaughter, Mary" sort="Slaughter, Mary" uniqKey="Slaughter M" first="Mary" last="Slaughter">Mary Slaughter</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Dickens, Akena" sort="Dickens, Akena" uniqKey="Dickens A" first="Akena" last="Dickens">Akena Dickens</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Nakasujja, Noeline" sort="Nakasujja, Noeline" uniqKey="Nakasujja N" first="Noeline" last="Nakasujja">Noeline Nakasujja</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Okello, Elialilia" sort="Okello, Elialilia" uniqKey="Okello E" first="Elialilia" last="Okello">Elialilia Okello</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Musisi, Seggane" sort="Musisi, Seggane" uniqKey="Musisi S" first="Seggane" last="Musisi">Seggane Musisi</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24402775</idno><idno type="pmc">4337391</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337391</idno><idno type="RBID">PMC:4337391</idno><idno type="doi">10.1007/s12529-013-9379-x</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Role of Depression in Work-Related Outcomes of HIV Treatment in Uganda</title><author><name sortKey="Wagner, Glenn J" sort="Wagner, Glenn J" uniqKey="Wagner G" first="Glenn J." last="Wagner">Glenn J. Wagner</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Ghosh Dastidar, Bonnie" sort="Ghosh Dastidar, Bonnie" uniqKey="Ghosh Dastidar B" first="Bonnie" last="Ghosh-Dastidar">Bonnie Ghosh-Dastidar</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Slaughter, Mary" sort="Slaughter, Mary" uniqKey="Slaughter M" first="Mary" last="Slaughter">Mary Slaughter</name><affiliation><nlm:aff id="A1">RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</nlm:aff></affiliation></author><author><name sortKey="Dickens, Akena" sort="Dickens, Akena" uniqKey="Dickens A" first="Akena" last="Dickens">Akena Dickens</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Nakasujja, Noeline" sort="Nakasujja, Noeline" uniqKey="Nakasujja N" first="Noeline" last="Nakasujja">Noeline Nakasujja</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Okello, Elialilia" sort="Okello, Elialilia" uniqKey="Okello E" first="Elialilia" last="Okello">Elialilia Okello</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Musisi, Seggane" sort="Musisi, Seggane" uniqKey="Musisi S" first="Seggane" last="Musisi">Seggane Musisi</name><affiliation><nlm:aff id="A2">Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of behavioral medicine</title><idno type="ISSN">1070-5503</idno><idno type="eISSN">1532-7558</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">The primary goal of this analysis was to examine the influence of depression above and beyond the effects of HIV treatment on work activity and function.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We combined data from three longitudinal studies of patients starting antiretroviral therapy (ART) and/or entering HIV care in Uganda. Assessments were conducted at baseline and months 6 and 12. The 9-item Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms, as well as Major (scores > 9) and Minor (scores 5–9) Depression status; work functioning was assessed using a sub-scale of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Multivariate random-effects logistic regression models for longitudinal data were used to examine the impact of treatment on work status and optimal work functioning, with measures of both baseline and change in physical health functioning, cognitive functioning and depression in the models, controlling for baseline demographics and CD4 cell count.</p></sec><sec id="S3"><title>Results</title><p id="P3">The sample of 1,731 participants consisted of 1,204 starting ART and 527 not yet eligible for ART. At baseline, 35% were not working and 37% had sub-optimal work functioning. Intention-to-treat analyses revealed that those on ART experienced greater improvement in both work outcomes over 12 months relative to non-ART patients, and that baseline and change in physical health functioning, continuous and categorical depression were all independently associated with improvement in both work outcomes, even after accounting for the direct effect of ART.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Improvement in physical and mental health plays a key role in the positive impact of HIV treatment on work activity and function, suggesting potential economic benefits of integrating depression treatment into HIV care.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9421097</journal-id><journal-id journal-id-type="pubmed-jr-id">29760</journal-id><journal-id journal-id-type="nlm-ta">Int J Behav Med</journal-id><journal-id journal-id-type="iso-abbrev">Int J Behav Med</journal-id><journal-title-group><journal-title>International journal of behavioral medicine</journal-title></journal-title-group><issn pub-type="ppub">1070-5503</issn><issn pub-type="epub">1532-7558</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24402775</article-id><article-id pub-id-type="pmc">4337391</article-id><article-id pub-id-type="doi">10.1007/s12529-013-9379-x</article-id><article-id pub-id-type="manuscript">NIHMS663484</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Role of Depression in Work-Related Outcomes of HIV Treatment in Uganda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>Glenn J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ghosh-Dastidar</surname><given-names>Bonnie</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Slaughter</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dickens</surname><given-names>Akena</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nakasujja</surname><given-names>Noeline</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Okello</surname><given-names>Elialilia</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Musisi</surname><given-names>Seggane</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407</aff><aff id="A2"><label>2</label>Department of Psychiatry, Makerere University, College of Health Sciences, P.O. Box 7072, Mulago Hill, Kampala, Uganda</aff><author-notes><corresp id="cor1">Corresponding Author: Glenn Wagner; RAND Corporation, 1776 Main St., Santa Monica, CA, USA 90407; (310) 393-0411, x7698; fax: (310) 260-8159; <email>gwagner@rand.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>2</month><year>2015</year></pub-date><volume>21</volume><issue>6</issue><fpage>946</fpage><lpage>955</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s12529-013-9379-x</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">The primary goal of this analysis was to examine the influence of depression above and beyond the effects of HIV treatment on work activity and function.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We combined data from three longitudinal studies of patients starting antiretroviral therapy (ART) and/or entering HIV care in Uganda. Assessments were conducted at baseline and months 6 and 12. The 9-item Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms, as well as Major (scores > 9) and Minor (scores 5–9) Depression status; work functioning was assessed using a sub-scale of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Multivariate random-effects logistic regression models for longitudinal data were used to examine the impact of treatment on work status and optimal work functioning, with measures of both baseline and change in physical health functioning, cognitive functioning and depression in the models, controlling for baseline demographics and CD4 cell count.</p></sec><sec id="S3"><title>Results</title><p id="P3">The sample of 1,731 participants consisted of 1,204 starting ART and 527 not yet eligible for ART. At baseline, 35% were not working and 37% had sub-optimal work functioning. Intention-to-treat analyses revealed that those on ART experienced greater improvement in both work outcomes over 12 months relative to non-ART patients, and that baseline and change in physical health functioning, continuous and categorical depression were all independently associated with improvement in both work outcomes, even after accounting for the direct effect of ART.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Improvement in physical and mental health plays a key role in the positive impact of HIV treatment on work activity and function, suggesting potential economic benefits of integrating depression treatment into HIV care.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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