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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions</title><author><name sortKey="Williams, Emily C" sort="Williams, Emily C" uniqKey="Williams E" first="Emily C." last="Williams">Emily C. Williams</name><affiliation><nlm:aff id="A1">Veterans Health Administration (VA) Health Services Research and Development, Center of Innovation for Veteran-Centered and Value-Driven Care, Seattle, WA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University of Washington, Department of Health Services, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name><affiliation><nlm:aff id="A3">Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco; San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Saitz, Richard" sort="Saitz, Richard" uniqKey="Saitz R" first="Richard" last="Saitz">Richard Saitz</name><affiliation><nlm:aff id="A4">Department of Community Health Sciences, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bryant, Kendall" sort="Bryant, Kendall" uniqKey="Bryant K" first="Kendall" last="Bryant">Kendall Bryant</name><affiliation><nlm:aff id="A6">Consortiums for HIV/AIDS and Alcohol Research Translation (CHAART) National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Lira, Marlene C" sort="Lira, Marlene C" uniqKey="Lira M" first="Marlene C." last="Lira">Marlene C. Lira</name><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Samet, Jeffrey H" sort="Samet, Jeffrey H" uniqKey="Samet J" first="Jeffrey H." last="Samet">Jeffrey H. Samet</name><affiliation><nlm:aff id="A4">Department of Community Health Sciences, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27696523</idno><idno type="pmc">5119641</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119641</idno><idno type="RBID">PMC:5119641</idno><idno type="doi">10.1111/acer.13204</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001B96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions</title><author><name sortKey="Williams, Emily C" sort="Williams, Emily C" uniqKey="Williams E" first="Emily C." last="Williams">Emily C. Williams</name><affiliation><nlm:aff id="A1">Veterans Health Administration (VA) Health Services Research and Development, Center of Innovation for Veteran-Centered and Value-Driven Care, Seattle, WA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University of Washington, Department of Health Services, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name><affiliation><nlm:aff id="A3">Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco; San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Saitz, Richard" sort="Saitz, Richard" uniqKey="Saitz R" first="Richard" last="Saitz">Richard Saitz</name><affiliation><nlm:aff id="A4">Department of Community Health Sciences, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bryant, Kendall" sort="Bryant, Kendall" uniqKey="Bryant K" first="Kendall" last="Bryant">Kendall Bryant</name><affiliation><nlm:aff id="A6">Consortiums for HIV/AIDS and Alcohol Research Translation (CHAART) National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Lira, Marlene C" sort="Lira, Marlene C" uniqKey="Lira M" first="Marlene C." last="Lira">Marlene C. Lira</name><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Samet, Jeffrey H" sort="Samet, Jeffrey H" uniqKey="Samet J" first="Jeffrey H." last="Samet">Jeffrey H. Samet</name><affiliation><nlm:aff id="A4">Department of Community Health Sciences, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</nlm:aff></affiliation></author></analytic><series><title level="j">Alcoholism, clinical and experimental research</title><idno type="ISSN">0145-6008</idno><idno type="eISSN">1530-0277</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol’s impact on transmission, care, co-infections and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV-related comorbidities. We find that interventions to modify drinking and improve HIV-related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV-relevant outcomes. This should include studies regarding whether state-of-the-art medications used to treat common co-infections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self-report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90-90-90 goals for engagement in the HIV treatment cascade.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7707242</journal-id><journal-id journal-id-type="pubmed-jr-id">365</journal-id><journal-id journal-id-type="nlm-ta">Alcohol Clin Exp Res</journal-id><journal-id journal-id-type="iso-abbrev">Alcohol. Clin. Exp. Res.</journal-id><journal-title-group><journal-title>Alcoholism, clinical and experimental research</journal-title></journal-title-group><issn pub-type="ppub">0145-6008</issn><issn pub-type="epub">1530-0277</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27696523</article-id><article-id pub-id-type="pmc">5119641</article-id><article-id pub-id-type="doi">10.1111/acer.13204</article-id><article-id pub-id-type="manuscript">NIHMS807361</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Emily C.</given-names></name><degrees>PhD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hahn</surname><given-names>Judith A.</given-names></name><degrees>PhD, MA</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Saitz</surname><given-names>Richard</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bryant</surname><given-names>Kendall</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lira</surname><given-names>Marlene C.</given-names></name><degrees>BA</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Samet</surname><given-names>Jeffrey H.</given-names></name><degrees>MD, MA, MPH</degrees><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Veterans Health Administration (VA) Health Services Research and Development, Center of Innovation for Veteran-Centered and Value-Driven Care, Seattle, WA</aff><aff id="A2"><label>2</label>University of Washington, Department of Health Services, Seattle, WA</aff><aff id="A3"><label>3</label>Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco; San Francisco, CA</aff><aff id="A4"><label>4</label>Department of Community Health Sciences, Boston University School of Public Health, Boston, MA</aff><aff id="A5"><label>5</label>Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA</aff><aff id="A6"><label>6</label>Consortiums for HIV/AIDS and Alcohol Research Translation (CHAART) National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD</aff><author-notes><corresp id="cor1">Correspondence should be addressed to: Jeffrey H. Samet, MD, MA, MPH, Boston University Schools of Medicine and Public Health, Boston Medical Center, 801 Massachusetts Ave, 2nd Floor, Boston, MA 02118, Phone: 617-414-7288, Fax: 617-414-4676, <email>jsamet@bu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>22</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2017</year></pub-date><volume>40</volume><issue>10</issue><fpage>2056</fpage><lpage>2072</lpage><pmc-comment>elocation-id from pubmed: 10.1111/acer.13204</pmc-comment>
<abstract><p id="P1">Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol’s impact on transmission, care, co-infections and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV-related comorbidities. We find that interventions to modify drinking and improve HIV-related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV-relevant outcomes. This should include studies regarding whether state-of-the-art medications used to treat common co-infections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self-report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90-90-90 goals for engagement in the HIV treatment cascade.</p></abstract><kwd-group><kwd>alcohol</kwd><kwd>alcohol use</kwd><kwd>substance use</kwd><kwd>HIV</kwd><kwd>HIV-related comorbidities</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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