SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001B94

Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy

Identifieur interne : 001B94 ( Pmc/Corpus ); précédent : 001B93; suivant : 001B95

Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy

Auteurs : Adam W. Carrico ; Peter W. Hunt ; Nneka I. Emenyonu ; Winnie Muyindike ; Christine Ngabirano ; Debbie M. Cheng ; Michael R. Winter ; Jeffrey H. Samet ; Judith A. Hahn

Source :

Alcoholism, clinical and experimental research [ 0145-6008 ] ; 2015.

RBID : PMC:4712082

Abstract

Background

Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated.

Methods

HIV-positive persons who were not on anti-retroviral therapy (ART) completed the baseline assessment for a longitudinal study examining the association of alcohol use with HIV disease markers. Oversampling drinkers, baseline samples were tested for markers of monocyte activation (sCD14), inflammation (IL-6), and coagulation (D-dimer). We defined “unhealthy alcohol use” as testing positive using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C; ≥ 3 for women and ≥ 4 for men) in the past 3 months or testing positive using a biomarker of heavy drinking, phophatidylethanol (PEth; ≥ 50 ng/ml). Multiple linear regression was used to examine the associations of unhealthy alcohol use with sCD14, Log₁₀ IL-6, and D-dimer.

Results

Compared to those who were abstinent from alcohol, unhealthy drinkers had significantly higher sCD14 levels (mean = 1,676 vs. 1,387 ng/ml; mean difference (95% CI) = 289 (83, 495), p < 0.01). In analyses adjusted for demographic factors, current cigarette smoking, and HIV disease markers, unhealthy drinkers continued to display significantly higher sCD14 levels compared to those who were abstinent from alcohol (adjusted mean = 1,670 vs. 1,406 ng/ml; adjusted mean difference (95% CI) = 264 (47, 480), p = 0.02). Unhealthy alcohol use was not significantly associated with IL-6 or D-dimer levels.

Conclusions

unhealthy alcohol use was independently associated with a marker of monocyte activation (i.e., higher sCD14) that predicts mortality in treated HIV infection. Longitudinal research should examine if unhealthy alcohol use predicts changes in sCD14 prior to and following ART initiation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712082

DOI: 10.1111/acer.12908
PubMed: 26509359
PubMed Central: 4712082

Links to Exploration step

PMC:4712082

Le document en format XML

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<author><name sortKey="Carrico, Adam W" sort="Carrico, Adam W" uniqKey="Carrico A" first="Adam W." last="Carrico">Adam W. Carrico</name>
<affiliation><nlm:aff id="A1">University of California, San Francisco School of Nursing, Department of Community Health Systems, San Francisco, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name>
<affiliation><nlm:aff id="A2">University of California, Division of HIV/AIDS, San Francisco General Hospital, San Francisco, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Emenyonu, Nneka I" sort="Emenyonu, Nneka I" uniqKey="Emenyonu N" first="Nneka I." last="Emenyonu">Nneka I. Emenyonu</name>
<affiliation><nlm:aff id="A2">University of California, Division of HIV/AIDS, San Francisco General Hospital, San Francisco, CA</nlm:aff>
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<author><name sortKey="Muyindike, Winnie" sort="Muyindike, Winnie" uniqKey="Muyindike W" first="Winnie" last="Muyindike">Winnie Muyindike</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda</nlm:aff>
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<author><name sortKey="Ngabirano, Christine" sort="Ngabirano, Christine" uniqKey="Ngabirano C" first="Christine" last="Ngabirano">Christine Ngabirano</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda</nlm:aff>
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<author><name sortKey="Cheng, Debbie M" sort="Cheng, Debbie M" uniqKey="Cheng D" first="Debbie M." last="Cheng">Debbie M. Cheng</name>
<affiliation><nlm:aff id="A4">Boston University School of Public Health, Boston, MA</nlm:aff>
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<author><name sortKey="Winter, Michael R" sort="Winter, Michael R" uniqKey="Winter M" first="Michael R." last="Winter">Michael R. Winter</name>
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<author><name sortKey="Samet, Jeffrey H" sort="Samet, Jeffrey H" uniqKey="Samet J" first="Jeffrey H." last="Samet">Jeffrey H. Samet</name>
<affiliation><nlm:aff id="A4">Boston University School of Public Health, Boston, MA</nlm:aff>
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<affiliation><nlm:aff id="A5">Boston University, School of Medicine, Boston, MA</nlm:aff>
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<author><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name>
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</affiliation>
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<author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name>
<affiliation><nlm:aff id="A2">University of California, Division of HIV/AIDS, San Francisco General Hospital, San Francisco, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Emenyonu, Nneka I" sort="Emenyonu, Nneka I" uniqKey="Emenyonu N" first="Nneka I." last="Emenyonu">Nneka I. Emenyonu</name>
<affiliation><nlm:aff id="A2">University of California, Division of HIV/AIDS, San Francisco General Hospital, San Francisco, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muyindike, Winnie" sort="Muyindike, Winnie" uniqKey="Muyindike W" first="Winnie" last="Muyindike">Winnie Muyindike</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ngabirano, Christine" sort="Ngabirano, Christine" uniqKey="Ngabirano C" first="Christine" last="Ngabirano">Christine Ngabirano</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheng, Debbie M" sort="Cheng, Debbie M" uniqKey="Cheng D" first="Debbie M." last="Cheng">Debbie M. Cheng</name>
<affiliation><nlm:aff id="A4">Boston University School of Public Health, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Winter, Michael R" sort="Winter, Michael R" uniqKey="Winter M" first="Michael R." last="Winter">Michael R. Winter</name>
<affiliation><nlm:aff id="A4">Boston University School of Public Health, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Samet, Jeffrey H" sort="Samet, Jeffrey H" uniqKey="Samet J" first="Jeffrey H." last="Samet">Jeffrey H. Samet</name>
<affiliation><nlm:aff id="A4">Boston University School of Public Health, Boston, MA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Boston University, School of Medicine, Boston, MA</nlm:aff>
</affiliation>
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<author><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name>
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<series><title level="j">Alcoholism, clinical and experimental research</title>
<idno type="ISSN">0145-6008</idno>
<idno type="eISSN">1530-0277</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">HIV-positive persons who were not on anti-retroviral therapy (ART) completed the baseline assessment for a longitudinal study examining the association of alcohol use with HIV disease markers. Oversampling drinkers, baseline samples were tested for markers of monocyte activation (sCD14), inflammation (IL-6), and coagulation (D-dimer). We defined “unhealthy alcohol use” as testing positive using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C; ≥ 3 for women and ≥ 4 for men) in the past 3 months or testing positive using a biomarker of heavy drinking, phophatidylethanol (PEth; ≥ 50 ng/ml). Multiple linear regression was used to examine the associations of unhealthy alcohol use with sCD14, Log<sub>10</sub>
 IL-6, and D-dimer.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Compared to those who were abstinent from alcohol, unhealthy drinkers had significantly higher sCD14 levels (mean = 1,676 vs. 1,387 ng/ml; mean difference (95% CI) = 289 (83, 495), p < 0.01). In analyses adjusted for demographic factors, current cigarette smoking, and HIV disease markers, unhealthy drinkers continued to display significantly higher sCD14 levels compared to those who were abstinent from alcohol (adjusted mean = 1,670 vs. 1,406 ng/ml; adjusted mean difference (95% CI) = 264 (47, 480), p = 0.02). Unhealthy alcohol use was not significantly associated with IL-6 or D-dimer levels.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">unhealthy alcohol use was independently associated with a marker of monocyte activation (i.e., higher sCD14) that predicts mortality in treated HIV infection. Longitudinal research should examine if unhealthy alcohol use predicts changes in sCD14 prior to and following ART initiation.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">7707242</journal-id>
<journal-id journal-id-type="pubmed-jr-id">365</journal-id>
<journal-id journal-id-type="nlm-ta">Alcohol Clin Exp Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Alcohol. Clin. Exp. Res.</journal-id>
<journal-title-group><journal-title>Alcoholism, clinical and experimental research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0145-6008</issn>
<issn pub-type="epub">1530-0277</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26509359</article-id>
<article-id pub-id-type="pmc">4712082</article-id>
<article-id pub-id-type="doi">10.1111/acer.12908</article-id>
<article-id pub-id-type="manuscript">NIHMS725006</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Carrico</surname>
<given-names>Adam W.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunt</surname>
<given-names>Peter W.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Emenyonu</surname>
<given-names>Nneka I.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muyindike</surname>
<given-names>Winnie</given-names>
</name>
<degrees>MBChB, MMED</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ngabirano</surname>
<given-names>Christine</given-names>
</name>
<degrees>BA</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Debbie M.</given-names>
</name>
<degrees>ScD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Winter</surname>
<given-names>Michael R.</given-names>
</name>
<degrees>MPH</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Samet</surname>
<given-names>Jeffrey H.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hahn</surname>
<given-names>Judith A.</given-names>
</name>
<degrees>PhD, MA</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
University of California, San Francisco School of Nursing, Department of Community Health Systems, San Francisco, CA</aff>
<aff id="A2"><label>2</label>
University of California, Division of HIV/AIDS, San Francisco General Hospital, San Francisco, CA</aff>
<aff id="A3"><label>3</label>
Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda</aff>
<aff id="A4"><label>4</label>
Boston University School of Public Health, Boston, MA</aff>
<aff id="A5"><label>5</label>
Boston University, School of Medicine, Boston, MA</aff>
<author-notes><corresp id="FN1">Corresponding Author: Adam W. Carrico, Ph.D., University of California, San Francisco, School of Nursing, 2 Koret Way, N511M, San Francisco, CA 94143, <email>adam.carrico@ucsf.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>9</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>39</volume>
<issue>12</issue>
<fpage>2422</fpage>
<lpage>2426</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/acer.12908</pmc-comment>
      <abstract><sec id="S1"><title>Background</title>
<p id="P1">Alcohol use may accelerate HIV disease progression, but the plausible biological mechanisms have not been clearly elucidated.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">HIV-positive persons who were not on anti-retroviral therapy (ART) completed the baseline assessment for a longitudinal study examining the association of alcohol use with HIV disease markers. Oversampling drinkers, baseline samples were tested for markers of monocyte activation (sCD14), inflammation (IL-6), and coagulation (D-dimer). We defined “unhealthy alcohol use” as testing positive using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C; ≥ 3 for women and ≥ 4 for men) in the past 3 months or testing positive using a biomarker of heavy drinking, phophatidylethanol (PEth; ≥ 50 ng/ml). Multiple linear regression was used to examine the associations of unhealthy alcohol use with sCD14, Log<sub>10</sub>
 IL-6, and D-dimer.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Compared to those who were abstinent from alcohol, unhealthy drinkers had significantly higher sCD14 levels (mean = 1,676 vs. 1,387 ng/ml; mean difference (95% CI) = 289 (83, 495), p < 0.01). In analyses adjusted for demographic factors, current cigarette smoking, and HIV disease markers, unhealthy drinkers continued to display significantly higher sCD14 levels compared to those who were abstinent from alcohol (adjusted mean = 1,670 vs. 1,406 ng/ml; adjusted mean difference (95% CI) = 264 (47, 480), p = 0.02). Unhealthy alcohol use was not significantly associated with IL-6 or D-dimer levels.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">unhealthy alcohol use was independently associated with a marker of monocyte activation (i.e., higher sCD14) that predicts mortality in treated HIV infection. Longitudinal research should examine if unhealthy alcohol use predicts changes in sCD14 prior to and following ART initiation.</p>
</sec>
</abstract>
<kwd-group><kwd>Alcohol</kwd>
<kwd>HIV/AIDS</kwd>
<kwd>Immune Activation</kwd>
<kwd>Microbial Translocation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy

Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Anti-Retroviral Therapy

Source :

Abstract

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