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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: Event-level findings from a daily diary study</title><author><name sortKey="Sileo, Katelyn M" sort="Sileo, Katelyn M" uniqKey="Sileo K" first="Katelyn M." last="Sileo">Katelyn M. Sileo</name><affiliation><nlm:aff id="A1">Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States</nlm:aff></affiliation></author><author><name sortKey="Simbayi, Leickness C" sort="Simbayi, Leickness C" uniqKey="Simbayi L" first="Leickness C." last="Simbayi">Leickness C. Simbayi</name><affiliation><nlm:aff id="A2">Human Sciences Research Council, Cape Town, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Psychiatry & Mental Health, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Abrams, Amber" sort="Abrams, Amber" uniqKey="Abrams A" first="Amber" last="Abrams">Amber Abrams</name><affiliation><nlm:aff id="A4">Cochrane South Africa, South African Medical Research Council; School of Anthropology and Conservation, University of Kent</nlm:aff></affiliation></author><author><name sortKey="Cloete, Allanise" sort="Cloete, Allanise" uniqKey="Cloete A" first="Allanise" last="Cloete">Allanise Cloete</name><affiliation><nlm:aff id="A2">Human Sciences Research Council, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Kiene, Susan M" sort="Kiene, Susan M" uniqKey="Kiene S" first="Susan M." last="Kiene">Susan M. Kiene</name><affiliation><nlm:aff id="A1">Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27567968</idno><idno type="pmc">5037036</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037036</idno><idno type="RBID">PMC:5037036</idno><idno type="doi">10.1016/j.drugalcdep.2016.07.028</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001B68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: Event-level findings from a daily diary study</title><author><name sortKey="Sileo, Katelyn M" sort="Sileo, Katelyn M" uniqKey="Sileo K" first="Katelyn M." last="Sileo">Katelyn M. Sileo</name><affiliation><nlm:aff id="A1">Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States</nlm:aff></affiliation></author><author><name sortKey="Simbayi, Leickness C" sort="Simbayi, Leickness C" uniqKey="Simbayi L" first="Leickness C." last="Simbayi">Leickness C. Simbayi</name><affiliation><nlm:aff id="A2">Human Sciences Research Council, Cape Town, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Psychiatry & Mental Health, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Abrams, Amber" sort="Abrams, Amber" uniqKey="Abrams A" first="Amber" last="Abrams">Amber Abrams</name><affiliation><nlm:aff id="A4">Cochrane South Africa, South African Medical Research Council; School of Anthropology and Conservation, University of Kent</nlm:aff></affiliation></author><author><name sortKey="Cloete, Allanise" sort="Cloete, Allanise" uniqKey="Cloete A" first="Allanise" last="Cloete">Allanise Cloete</name><affiliation><nlm:aff id="A2">Human Sciences Research Council, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Kiene, Susan M" sort="Kiene, Susan M" uniqKey="Kiene S" first="Susan M." last="Kiene">Susan M. Kiene</name><affiliation><nlm:aff id="A1">Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States</nlm:aff></affiliation></author></analytic><series><title level="j">Drug and alcohol dependence</title><idno type="ISSN">0376-8716</idno><idno type="eISSN">1879-0046</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Using daily diary methods, we aimed to test the hypothesis that at the event-level consuming alcohol increases the likelihood that antiretrovirals (ARV) will be missed on a particular day.</p></sec><sec id="S2"><title>Methods</title><p id="P2">This prospective cohort study of 74 (52 female, 22 male) PLHIV in South Africa collected event-level data on ARV adherence and alcohol consumption using structured daily phone interviews over a period of 42 days generating 2,718 data points. We used generalized estimating equations (GEE) analyses to assess univariate and multivariate associations between alcohol and adherence, controlling for sociodemographics and testing for effect modification.</p></sec><sec id="S3"><title>Results</title><p id="P3">Controlling for sociodemographics, each alcohol measure was a statistically significant predictor of non-adherence on a particular day; any drinking compared to no drinking (daytime: AOR = 3.18, 95% CI = 2.25–4.49; evening: AOR = 3.43, 95% CI = 2.13–5.53), consuming more alcohol than one normally consumes (daytime: AOR = 1.06, 95% CI = 1.02–1.11; evening: AOR = 1.10, 95% CI = 1.05–1.15), and drinking at low to moderate risk level (daytime: 4.29, 95% CI = 2.81–6.56; evening: AOR = 4.24, 95% CI =2.38–7.54) and high to very high risk levels (daytime: AOR = 2.31, 95% CI = 1.56–3.42; evening: AOR = 3.08, 95% CI = 1.91–4.98) were all significantly related to missing ARVs in the daytime and evening.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These data provide support for an event-level relationship between alcohol and non-adherence. Interventions that mitigate alcohol use among people on ARVs or provide strategies to maintain optimal adherence among those who drink are needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7513587</journal-id><journal-id journal-id-type="pubmed-jr-id">3445</journal-id><journal-id journal-id-type="nlm-ta">Drug Alcohol Depend</journal-id><journal-id journal-id-type="iso-abbrev">Drug Alcohol Depend</journal-id><journal-title-group><journal-title>Drug and alcohol dependence</journal-title></journal-title-group><issn pub-type="ppub">0376-8716</issn><issn pub-type="epub">1879-0046</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27567968</article-id><article-id pub-id-type="pmc">5037036</article-id><article-id pub-id-type="doi">10.1016/j.drugalcdep.2016.07.028</article-id><article-id pub-id-type="manuscript">NIHMS812943</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: Event-level findings from a daily diary study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sileo</surname><given-names>Katelyn M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Simbayi</surname><given-names>Leickness C.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Abrams</surname><given-names>Amber</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cloete</surname><given-names>Allanise</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kiene</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States</aff><aff id="A2"><label>2</label>Human Sciences Research Council, Cape Town, South Africa</aff><aff id="A3"><label>3</label>Department of Psychiatry & Mental Health, University of Cape Town, South Africa</aff><aff id="A4"><label>4</label>Cochrane South Africa, South African Medical Research Council; School of Anthropology and Conservation, University of Kent</aff><author-notes><corresp id="cor1">Corresponding author: Susan M. Kiene, Graduate School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA 92182. Phone: 619-594-1314. Fax: (619) 594-6112. <email>skiene@mail.sdsu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>10</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2017</year></pub-date><volume>167</volume><fpage>103</fpage><lpage>111</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.drugalcdep.2016.07.028</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">Using daily diary methods, we aimed to test the hypothesis that at the event-level consuming alcohol increases the likelihood that antiretrovirals (ARV) will be missed on a particular day.</p></sec><sec id="S2"><title>Methods</title><p id="P2">This prospective cohort study of 74 (52 female, 22 male) PLHIV in South Africa collected event-level data on ARV adherence and alcohol consumption using structured daily phone interviews over a period of 42 days generating 2,718 data points. We used generalized estimating equations (GEE) analyses to assess univariate and multivariate associations between alcohol and adherence, controlling for sociodemographics and testing for effect modification.</p></sec><sec id="S3"><title>Results</title><p id="P3">Controlling for sociodemographics, each alcohol measure was a statistically significant predictor of non-adherence on a particular day; any drinking compared to no drinking (daytime: AOR = 3.18, 95% CI = 2.25–4.49; evening: AOR = 3.43, 95% CI = 2.13–5.53), consuming more alcohol than one normally consumes (daytime: AOR = 1.06, 95% CI = 1.02–1.11; evening: AOR = 1.10, 95% CI = 1.05–1.15), and drinking at low to moderate risk level (daytime: 4.29, 95% CI = 2.81–6.56; evening: AOR = 4.24, 95% CI =2.38–7.54) and high to very high risk levels (daytime: AOR = 2.31, 95% CI = 1.56–3.42; evening: AOR = 3.08, 95% CI = 1.91–4.98) were all significantly related to missing ARVs in the daytime and evening.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These data provide support for an event-level relationship between alcohol and non-adherence. Interventions that mitigate alcohol use among people on ARVs or provide strategies to maintain optimal adherence among those who drink are needed.</p></sec></abstract><kwd-group><kwd>Alcohol</kwd><kwd>ART</kwd><kwd>Adherence</kwd><kwd>HIV/AIDS</kwd><kwd>Event-level analysis</kwd><kwd>South Africa</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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